Browse the failure-mode index

2 real negative results, null findings, and replication failures in Ophthalmology · Failed Experiment Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Failed Experiment ReportOpen accessOphthalmology

Puntoplastia en el tratamiento de la queratoconjuntivitis seca Punctum surgery for the treatment of keratoconjunctivitis sicca

Nereyda G. Martínez Suárez, Ileana A. Agramonte Centelles, Ileana A. Agramonte Centelles · 2008 · Revista Cubana de Oftalmología

OBJETIVO: Evaluar clínicamente de pacientes portadores de queratoconjuntivitis seca posterior a puntoplastia con la técnica de parche del punto lagrimal. MÉTODOS: Se realizó puntoplastia con la técnica de parche del punto lagrimal a 31 pacientes (62 ojos) portadores de queratoconjuntivitis seca grado 2, que acudieron a la consulta en el año 2006, y se utilizó conjuntiva autóloga en 16 pacientes (32 ojos) y mucosa labial, en 15 casos (30 ojos), y se les evaluó clínicamente al mes y a los tres meses de realizada la cirugía. RESULTADOS: En 26 pacientes se observó una mejoría subjetiva y objetiva

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Failed Experiment ReportOpen accessOphthalmology

CANBERRA: A Phase II Randomized Clinical Trial to Test the Therapeutic Potential of Oral Vicasinabin in Diabetic Retinopathy

Beatriz G. Armendariz, PhD, Ulrich F.O. Luhman, PhD, Brian Berger, MD et al. · 2025 · Ophthalmology Science

Objective: Nonproliferative diabetic retinopathy (NPDR) is a progressive disease that can lead to blindness. Current therapies for NPDR are invasive and not extensively used or accessible until the disease progresses, pointing to the need for an early noninvasive treatment. The objective of CANBERRA was to assess the safety, tolerability, and efficacy of oral administration of vicasinabin (RG7774) on the severity of diabetic retinopathy (DR) in participants with moderately severe to severe NPDR and good vision. Design: CANBERRA was a global, multicentric randomized, double-masked, parallel-gro

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