223 real negative results, null findings, and replication failures in Neuroscience · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
So-Yeon Kim, Kelly S. Giovanello · 2011 · Journal of Cognitive Neuroscience
Numerous studies have documented that older adults (OAs) do not perform as well as young adults (YAs) when task demands require the establishment or retrieval of a novel link between previously unrelated information (relational memory:…
View details →Alejandro Gella, Mònica Segura, Núria Durany et al. · 2011 · BMC Psychiatry
BACKGROUND: Genome wide association studies reported two single nucleotide polymorphisms in ANK3 (rs9804190 and rs10994336) as independent genetic risk factors for bipolar disorder. Another SNP in ANK3 (rs10761482) was associated with schizophrenia in a large European sample. Within the debate on common susceptibility genes for schizophrenia and bipolar disorder, we tried to investigate common findings by analyzing association of ANK3 with schizophrenia, bipolar disorder and unipolar depression. METHODS: We genotyped three single nucleotide polymorphisms (SNPs) in ANK3 (rs9804190, rs10994336,
View details →Harrison E. Vieth, Katie L. McMahon, Greig I. de Zubicaray · 2014 · Quarterly Journal of Experimental Psychology
How does the presence of a categorically related word influence picture naming latencies? In order to test competitive and noncompetitive accounts of lexical selection in spoken word production, we employed the picture-word interference…
View details →John D. Tompkins, Todd A. Clason, Jean C. Hardwick et al. · 2016 · American Journal of Physiology-Cell Physiology
Pituitary adenylate cyclase (PAC)-activating polypeptide (PACAP) peptides ( Adcyap1) signaling at the selective PAC1 receptor ( Adcyap1r1) participate in multiple homeostatic and stress-related responses, yet the cellular mechanisms…
View details →Huaxin Fan, Hewei Wang, Zhengxu Lian et al. · 2026 · Journal of Stroke
BACKGROUND AND PURPOSE: Therapeutic target selection in noninvasive brain stimulation for poststroke motor recovery typically relies on the interhemispheric inhibition model, which is effective for mildly affected patients but offers…
View details →Tong He, Ru Kong, Avram J. Holmes et al. · 2018
In recent years, deep learning has transformed the field of machine learning. In the field of neuroimaging, there are increasing interests in adopting deep learning techniques. However, deep neural networks (DNNs) usually need large…
View details →Recep A. Ozdemir, Sofia Kirkman, Justine R. Magnuson et al. · 2022 · Neuroimage Reports
Prior studies have suggested that oscillatory activity in cortical networks can modulate stimulus-evoked responses through time-varying fluctuations in neural excitation-inhibition dynamics. Studies combining transcranial magnetic…
View details →Alba Di Pardo, Elena Ciaglia, Monica Cattaneo et al. · 2020 · Cell Death and Disease
Abstract The longevity-associated variant (LAV) of the bactericidal/permeability-increasing fold-containing family B member 4 (BPIFB4) has been found significantly enriched in long-living individuals. Neuroinflammation is a key player in Huntington’s disease (HD), a neurodegenerative disorder caused by neural death due to expanded CAG repeats encoding a long polyglutamine tract in the huntingtin protein (Htt). Herein, we showed that striatal-derived cell lines with expanded Htt (STHdh Q 111/111 ) expressed and secreted lower levels of BPIFB4, when compared with Htt expressing cells (STHdh Q 7/
View details →Annelies Spek, Evert Scholte, Ina A. van Berckelaer‐Onnes · 2010 · Journal of Autism and Developmental Disorders
Local information processing in 42 adults with high functioning autism, 41 adults with Asperger syndrome and 41 neurotypical adults was examined. Contrary to our expectations, the disorder groups did not outperform the neurotypical group…
View details →Mark Alfano · 2018 · PhilPapers (PhilPapers Foundation)
Virtues are dispositions that make their bearers admirable. Dispositions can be studied scientifically by systematically varying whether their alleged bearers are in (or take themselves to be in) the dispositions' eliciting conditions. In…
View details →Julia D. Hur, Loran F. Nordgren · 2016 · Journal of Personality and Social Psychology
The current research examines how exposure to performance incentives affects one's desire for the reward object. We hypothesized that the flexible nature of performance incentives creates an attentional fixation on the reward object (e.g.,…
View details →Jack Dempsey, Qiawen Liu, Kiel Christianson · 2020 · Journal of Experimental Psychology Learning Memory and Cognition
Previous work has ostensibly shown that readers rapidly adapt to less predictable ambiguity resolutions after repeated exposure to unbalanced statistical input (e.g., a high number of reduced relative-clause garden-path sentences), and…
View details →Sophie E. Field, Annabel J. Curle, Roger A. Barker · 2024 · Expert Opinion on Investigational Drugs
INTRODUCTION: Huntington's Disease (HD) is a genetic neurodegenerative disease for which there is currently no disease-modifying treatment. One of several underlying mechanisms proposed to be involved in HD pathogenesis is inflammation;…
View details →David R. Roalf, Martijn Figee, Desmond J. Oathes · 2024 · Translational Psychiatry
Although neuroimaging has been widely applied in psychiatry, much of the exuberance in decades past has been tempered by failed replications and a lack of definitive evidence to support the utility of imaging to inform clinical decisions. There are multiple promising ways forward to demonstrate the relevance of neuroimaging for psychiatry at the individual patient level. Ultra-high field magnetic resonance imaging is developing as a sensitive measure of neurometabolic processes of particular relevance that holds promise as a new way to characterize patient abnormalities as well as variability
View details →Sang‐Rae Lee, Hong J. Lee, Sang-Hoon Cha et al. · 2015 · Cell Transplantation
Cellular fate of human neural stem cells (hNSCs) transplanted in the brain of nonhuman primates (NHPs) with no immunosuppression was determined at 22 and 24 months posttransplantation (PTx) regarding survival, differentiation, and tumorigenesis. Survival of hNSCs labeled with magnetic nanoparticles was successfully detected around injection sites in the brain at 22 months PTx by MRI. Histological examination of brain sections with H&E and Prussian blue staining at 24 months revealed that most of the grafted hNSCs were found located along the injection tract. Grafted hNSCs were found to differe
View details →María Valdés Hernández, Lucia Ballerini, Andreas Glatz et al. · 2019 · Brain Imaging and Behavior
Brain iron deposits (IDs) are indicative of microvessel dysfunction which may predispose to small vessel disease (SVD) brain damage and worsen cognition later in life. Visible perivascular spaces in the centrum semiovale (CSO-PVS) are SVD features linked with microvessel dysfunction. We examined possible associations of CSO-PVS volume and count with brain IDs and cognitive abilities in 700 community-dwelling individuals from the Lothian Birth Cohort 1936 who underwent detailed cognitive testing and multimodal brain MRI at mean age 72.7 years. Brain IDs were assessed automatically followed by m
View details →Karam Khateeb, Zhaojie Yao, Viktor Kharazia et al. · 2019
Ischemic stroke is a major cause of disability among adults worldwide. Despite its prevalence, few effective treatment options exist to alleviate sensory and motor dysfunctions that result from stroke. In the past, rodent models of stroke…
View details →Ryan Smith, Claire A. Lavalley, S Taylor et al. · 2023 · Journal of Psychiatry and Neuroscience
BACKGROUND: Decision-making under approach-avoidance conflict (AAC; e.g., sacrificing quality of life to avoid feared outcomes) may be affected in multiple psychiatric disorders. Recently, we used a computational (active inference) model…
View details →Klára Marečková, Amy Miles, Zhijie Liao et al. · 2022 · NeuroImage Clinical
BACKGROUND: Prenatal stress influences brain development and mood disorder vulnerability. Brain structural covariance network (SCN) properties based on inter-regional volumetric correlations may reflect developmentally-mediated shared…
View details →A. V. Dyomina, Anna A. Kovalenko, Maria V. Zakharova et al. · 2022 · International Journal of Molecular Sciences
Metabotropic glutamate receptors (mGluRs) are expressed predominantly on neurons and glial cells and are involved in the modulation of a wide range of signal transduction cascades. Therefore, different subtypes of mGluRs are considered a promising target for the treatment of various brain diseases. Previous studies have demonstrated the seizure-induced upregulation of mGluR5; however, its functional significance is still unclear. In the present study, we aimed to clarify the effect of treatment with the selective mGluR5 antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]-pyridine (MTEP) on epile
View details →Sean Coulborn, Howard Bowman, R. Chris Miall et al. · 2020 · Frontiers in Human Neuroscience
Mind-wandering is associated with switching our attention to internally directed thoughts and is by definition an intrinsic, self-generated cognitive function. Interestingly, previous research showed that it may be possible to modulate its propensity externally, with transcranial direct current stimulation (tDCS) targeting different regions in the default mode and executive control networks. However, these studies used highly heterogeneous montages (targeting the dorsolateral prefrontal cortex (DLPFC), the right inferior parietal lobule (IPL), or both concurrently), often showed contradicting
View details →Adrienne L. Romer, Diego A. Pizzagalli · 2021 · Biological Psychiatry Global Open Science
A general psychopathology factor (p factor) captures shared variance across mental disorders in diverse samples and may partly reflect executive dysfunction. Higher p factor scores have been related to structural alterations within the…
View details →Marina Terkourafi, Benjamin Weissman, Joseph Roy · 2020 · International Review of Pragmatics
Abstract Research on the effect of face-orientation on scalar implicatures has claimed that face-threatening contexts are one type of context in which scalar implicatures are not warranted. However, that research has been based on the two…
View details →Lloyd Christopher Smith · 2026 · Zenodo (CERN European Organization for Nuclear Research)
This paper forms part of Mirror Programme, Volume I: Observerhood. Mirror Mathematics II develops the formal threshold layer of the Mirror Mathematics arc. Building on Mirror Mathematics I, it asks when a self-model becomes observer-relevant rather than merely predictive, self-referential or descriptive. The paper introduces a minimal Mirror observer predicate grounded in self-model reliability, action-guidance, cost-sensitive repair and positive viability coupling under perturbation. The central condition is expressed through a salience functional measuring whether the expected viability bene
View details →Adam Maxwell Sparks, Pat Barclay · 2015 · Letters on Evolutionary Behavioral Science
The effect of exposure to eye images on various behaviors has been explained as a response to an invalid cue of observation. This interpretation has been supported by an experiment showing that a short exposure to eye images increased…
View details →Shan-Chuan Teng, Yunn-Wen Lien · 2022 · PLoS ONE
Mind wandering has been argued to be beneficial for breaking through mental impasses, which leads to better creative performance upon a second attempt (i.e., the incubation effect). However, the evidence is inconsistent. Different from the propensity for mind wandering that has been the focus of past studies, in this study we further examined the role of diversity (i.e., non-repetitiveness of mind wandering respective to its content) and types of mind wandering along the dimensions of intentionality and awareness during incubation when engaging in a 0-back task (a mind wandering-prone conditio
View details →Megan Willis, Andrea I. Costantino, Michael A. Nitsche et al. · 2019 · Frontiers in Neuroscience
There has been increasing interest in the utility of transcranial electrical stimulation as a tool to enhance cognitive abilities. In the domain of face perception, enhancements have been reported for both transcranial direct current stimulation (tDCS) and high-frequency transcranial random noise stimulation (tRNS) targeting the occipitotemporal cortex. In a series of two experiments, we attempted to replicate these findings for face identity perception, and extend on previous studies, to determine if similar enhancements are also observed for object and facial expression perception. In Experi
View details →Jedidiah Siev, Shelby E. Zuckerman, Joseph J. Siev · 2018 · Social Psychology
Abstract. In a widely publicized set of studies, participants who were primed to consider unethical events preferred cleansing products more than did those primed with ethical events ( Zhong & Liljenquist, 2006 ). This tendency to…
View details →Ellen Bialystok · 2020 · Journal of Multilingual Theories and Practices
The controversy over whether bilingualism has consequences for mind and brain shows no sign of abating. A steady stream of research reporting both positive results supporting the claim for beneficial effects of bilingualism and null…
View details →Amit Walia, Matthew Shew, Jordan Varghese et al. · 2023 · JAMA Otolaryngology–Head & Neck Surgery
Importance: Cochlear implantation produces remarkable results in postlingual deafness, although auditory outcomes vary. Electrocochleography (ECochG) has emerged as a valuable tool for assessing the cochlear-neural substrate and evaluating…
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