Browse the failure-mode index

32 real negative results, null findings, and replication failures in Neurology. Diseases of the nervous system · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system

The m.3243A > G mutation load in hair follicles from different scalp regions of patients with MELAS

Yuan-yuan LU, Xu-tong ZHAO, Qing-qing WANG et al. · 2018 · Chinese Journal of Contemporary Neurology and Neurosurgery

Objective To investigate the mitochondrial DNA (mtDNA) mutation load in hair follicles from different scalp regions of patients with mitochondrial, encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS), compare the mutation load in different scalp regions, and analyze the difference in mutation load between scalp regions with lesion site in the brain and scalp regions without lesion site in the brain. Methods Seven MELAS patients with m.3243A > G mutations were studied. Hair follicles were obtained from 8 scalp regions (bilateral frontal, temporal, parietal and occipital lobe

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Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system

Exploring EEG resting state differences in autism: sparse findings from a large cohort

Adam J.O. Dede, Wenyi Xiao, Nemanja Vaci et al. · 2025 · Molecular Autism

Abstract Background Autism is a complex neurodevelopmental condition, the precise neurobiological underpinnings of which remain elusive. Here, we focus on group differences in resting state EEG (rsEEG). Although many previous reports have pointed to differences between autistic and neurotypical participants in rsEEG, results have failed to replicate, sample sizes have typically been small, and only a small number of variables are reported in each study. Methods Here, we combined five datasets to create a large sample of autistic and neurotypical individuals (n = 776) and extracted 726 variable

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