Negative / Null Result ReportOpen accessMedicine
Christoph Garbers, Wolfgang Thaiss, Gareth W. Jones et al. · 2011 · Journal of Biological Chemistry
IL-6 trans-signaling via the soluble IL-6 receptor (sIL-6R) plays a critical role in chronic inflammation and cancer. Soluble gp130 (sgp130) specifically inhibits IL-6 trans-signaling but was described to not interfere with classic signaling via the membrane-bound IL-6R. Physiological and most pathophysiological conditions are characterized by a molar excess of serum sIL-6R over IL-6 characterized by free IL-6 and IL-6 found in IL-6·sIL-6R complexes allowing both classic and trans-signaling. Surprisingly, under these conditions, sgp130 was able to trap all free IL-6 molecules in IL-6·sIL-6R·sg
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Joshua S. Bingham, Henry D. Clarke, Mark J. Spangehl et al. · 2014 · Clinical Orthopaedics and Related Research
BACKGROUND: Diagnosing a periprosthetic joint infection (PJI) requires a complex approach using various laboratory and clinical criteria. A novel approach to diagnosing these infections uses synovial fluid biomarkers. Alpha defensin-1…
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US Preventive Services Task Force, Susan J. Curry, Alex H. Krist et al. · 2018 · JAMA
Importance: Cardiovascular disease (CVD) is the most common cause of death among adults in the United States. Treatment to prevent CVD events by modifying risk factors is currently informed by the Framingham Risk Score, the Pooled Cohort Equations, or similar CVD risk assessment models. If current CVD risk assessment models could be improved by adding more risk factors, treatment might be better targeted, thereby maximizing the benefits and minimizing the harms. Objective: To update the 2009 US Preventive Services Task Force (USPSTF) recommendation on using nontraditional risk factors in coron
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James J. McNamee, Michael Gillies, Nicholas Barrett et al. · 2021 · JAMA
Importance: In patients who require mechanical ventilation for acute hypoxemic respiratory failure, further reduction in tidal volumes, compared with conventional low tidal volume ventilation, may improve outcomes. Objective: To determine…
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Basil T. Darras, Thomas O. Crawford, Richard S. Finkel et al. · 2019 · Annals of Clinical and Translational Neurology
Abstract Objective To evaluate plasma phosphorylated neurofilament heavy chain ( pNF ‐H) as a biomarker in spinal muscular atrophy ( SMA ). Methods Levels of pNF ‐H were measured using the ProteinSimple ® platform in plasma samples from…
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Catherine Limperopoulos, Gevorg Chilingaryan, Nancy Sullivan et al. · 2012 · Cerebral Cortex
Cerebellar injury is an important complication of preterm birth with far-reaching neuropsychiatric sequelae. We have previously shown a significant association between isolated injury to the premature cerebellum and subsequent impairment…
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Fiona Smaill, Mangalakumari Jeyanathan, Marek Smieja et al. · 2013 · Science Translational Medicine
There is an urgent need to develop new tuberculosis (TB) vaccines to safely and effectively boost Bacille Calmette-Guérin (BCG)-triggered T cell immunity in humans. AdHu5Ag85A is a recombinant human type 5 adenovirus (AdHu5)-based TB…
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Sarah Fiddyment, Bruce Holsinger, Chiara Ruzzier et al. · 2015 · Proceedings of the National Academy of Sciences
Tissue-thin parchment made it possible to produce the first pocket Bibles: Thousands were made in the 13th century. The source of this parchment, often called "uterine vellum," has been a long-standing controversy in codicology. Use of the…
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Otto Erlwein, Steve Kaye, Myra O. McClure et al. · 2010 · PLoS ONE
BACKGROUND: In October 2009 it was reported that 68 of 101 patients with chronic fatigue syndrome (CFS) in the US were infected with a novel gamma retrovirus, xenotropic murine leukaemia virus-related virus (XMRV), a virus previously linked to prostate cancer. This finding, if confirmed, would have a profound effect on the understanding and treatment of an incapacitating disease affecting millions worldwide. We have investigated CFS sufferers in the UK to determine if they are carriers of XMRV. METHODOLOGY: Patients in our CFS cohort had undergone medical screening to exclude detectable organi
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Pedram Gerami, Richard A. Scolyer, Xiaowei Xu et al. · 2013 · The American Journal of Surgical Pathology
Risk assessment for atypical Spitz tumors remains an enigma for physicians. Many prognosticators including sentinel lymph node biopsy fail to show the same prognostic significance in these tumors as seen in conventional melanoma. We…
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Henrik Sillesen, Samantha Sartori, Benjamin Sandholt et al. · 2017 · European Heart Journal - Cardiovascular Imaging
Introduction: Prediction of cardiovascular events improves using imaging, i.e. coronary calcium score and ultrasound assessment of carotid plaque. This study analysed the predictive value of two ultrasound measures of carotid plaque size:…
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Yasmine T. Asi, Julie E. Simpson, Paul R. Heath et al. · 2014 · Glia
Multiple system atrophy (MSA) is a progressive neurodegenerative disease presenting clinically with parkinsonian, cerebellar, and autonomic features. α-Synuclein (αsyn), encoded by the gene SNCA, is the main constituent of glial cytoplasmic inclusion (GCI) found in oligodendrocytes in MSA, but the methods of its accumulation have not been established. The aim of this study is to investigate alterations in regional and cellular SNCA mRNA expression in MSA as a possible substrate for GCI formation. Quantitative reverse transcription polymerase chain reaction (qPCR) was performed on postmortem br
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Steven M. Opal, R. Phillip Dellinger, Jean‐Louis Vincent et al. · 2014 · Critical Care Medicine
OBJECTIVE: The developmental pipeline for novel therapeutics to treat sepsis has diminished to a trickle compared to previous years of sepsis research. While enormous strides have been made in understanding the basic molecular mechanisms…
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US Preventive Services Task Force, David C. Grossman, Susan J. Curry et al. · 2018 · JAMA
Importance: Because of the aging population, osteoporotic fractures are an increasingly important cause of morbidity and mortality in the United States. Approximately 2 million osteoporotic fractures occurred in the United States in 2005,…
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Liselotte van Asten, Cees van den Wijngaard, Wilfrid van Pelt et al. · 2012 · The Journal of Infectious Diseases
BACKGROUND: Because there may be substantial hidden mortality caused by common seasonal pathogens, we estimated the number of deaths in elderly persons attributable to viruses and bacteria for which robust weekly laboratory surveillance…
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Frank W. Roemer, C. Kent Kwoh, Michael J. Hannon et al. · 2015 · Arthritis & Rheumatology
OBJECTIVE: To assess whether the presence of structural osteoarthritis (OA) features over as many as 4 years prior to incident radiographic OA increases the risk of radiographic OA in a nested, case-control design. METHODS: We studied 355…
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Meeta Prasad Kerlin, Dylan S. Small, Elizabeth Cooney et al. · 2013 · New England Journal of Medicine
BACKGROUND: Increasing numbers of intensive care units (ICUs) are adopting the practice of nighttime intensivist staffing despite the lack of experimental evidence of its effectiveness. METHODS: We conducted a 1-year randomized trial in an…
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Nevert Badreldin, William A. Grobman, Lynn M. Yee · 2019 · Obstetrics and Gynecology
OBJECTIVE: To evaluate racial and ethnic differences in women's postpartum pain scores, inpatient opioid administration, and discharge opioid prescriptions. METHODS: We conducted a retrospective cohort study of all deliveries at a single…
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Alisa J. Prager, Nina Martinez, Kathryn Beal et al. · 2015 · American Journal of Neuroradiology
BACKGROUND AND PURPOSE: Treatment-related changes and recurrent tumors often have overlapping features on conventional MR imaging. The purpose of this study was to assess the utility of DWI and DSC perfusion imaging alone and in combination to differentiate treatment-related effects and recurrent high-grade gliomas. MATERIALS AND METHODS: We retrospectively identified 68 consecutive patients with high-grade gliomas treated by surgical resection followed by radiation therapy and temozolomide, who then developed increasing enhancing mass lesions indeterminate for treatment-related changes versus
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F. Perry Wilson, Melissa Martin, Yu Yamamoto et al. · 2021 · BMJ
Abstract Objective To determine whether electronic health record alerts for acute kidney injury would improve patient outcomes of mortality, dialysis, and progression of acute kidney injury. Design Double blinded, multicenter, parallel,…
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Lee Fong Ling, Thomas H. Marwick, Demetrio Roland Flores et al. · 2013 · Circulation Cardiovascular Imaging
BACKGROUND: Although the recent surgical treatment of ischemic heart failure substudy reported that revascularization of viable myocardium did not improve survival, these results were limited by the viability imaging technique used and the…
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US Preventive Services Task Force, Douglas K Owens, Karina W. Davidson et al. · 2019 · JAMA
Importance: Breast cancer is the most common nonskin cancer among women in the United States and the second leading cause of cancer death. The median age at diagnosis is 62 years, and an estimated 1 in 8 women will develop breast cancer at…
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Tony Mok, Sang‐We Kim, Yi‐Long Wu et al. · 2017 · Journal of Clinical Oncology
Purpose The Iressa Mutation-Positive Multicentre Treatment Beyond ProgRESsion Study (IMPRESS) compared the continuation of gefitinib plus chemotherapy with placebo plus chemotherapy in patients with epidermal growth factor receptor ( EGFR)…
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Elena Myasoedova, Cynthia S. Crowson, Carl Turesson et al. · 2011 · The Journal of Rheumatology
OBJECTIVE: To assess incidence and mortality effects of extraarticular rheumatoid arthritis (ExRA) in patients with incident RA in 1995-2007 compared to 1985-1994, in Olmsted County, Minnesota, USA. METHODS: Data on incident ExRA were…
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Benjamin Gravesteijn, Daan Nieboer, Ari Ercole et al. · 2020 · Journal of Clinical Epidemiology
OBJECTIVE: We aimed to explore the added value of common machine learning (ML) algorithms for prediction of outcome for moderate and severe traumatic brain injury. STUDY DESIGN AND SETTING: We performed logistic regression (LR), lasso…
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Stephan Willems, Roland Richard Tilz, Daniel Steven et al. · 2020 · Circulation
Background: Catheter ablation for ventricular tachycardia (VT) reduces the recurrence of VT in patients with implantable cardioverter-defibrillators (ICDs). The appropriate timing of VT ablation and its effects on mortality and heart…
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Adam M. Lee, Qian Shi, Emily S. Pavey et al. · 2014 · JNCI Journal of the National Cancer Institute
BACKGROUND: Previous studies have suggested the potential importance of three DPYD variants (DPYD*2A, D949V, and I560S) with increased 5-FU toxicity. Their individual associations, however, in 5-FU-based combination therapies, remain…
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Nina Johnston, Johan Bodegård, Susanna Jerström et al. · 2016 · American Heart Journal
BACKGROUND: Patients with myocardial infarction (MI) seldom reach recommended targets for secondary prevention. This study evaluated a smartphone application ("app") aimed at improving treatment adherence and cardiovascular lifestyle in MI…
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Shannon Fraser, Paul A. Gardner, Maria Koutourousiou et al. · 2017 · Journal of neurosurgery
OBJECTIVE The aim in this paper was to determine risk factors for the development of a postoperative CSF leak after an endoscopic endonasal approach (EEA) for resection of skull base tumors. METHODS A retrospective review of patients who…
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Angela Kuznia, Anita K Hernandez, Lydia U Lee · 2020 · PubMed
Adolescent idiopathic scoliosis affects 1% to 3% of U.S. adolescents. It is defined by a lateral curvature of the spine (Cobb angle) of at least 10 degrees in the absence of underlying congenital or neuromuscular abnormalities. Adolescent…
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