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11,309 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Gastric electrical stimulation treatment of type 2 diabetes: effects of implantation versus meal-mediated stimulation. A randomized blinded cross-over trial

Harold E. Lebovitz, Bernhard Ludvik, Jarosław Kozakowski et al. · 2015 · Physiological Reports

Gastric electrical stimulation with the implanted DIAMOND device has been shown to improve glycemic control and decrease weight and systolic blood pressure in patients with type 2 diabetes inadequately controlled with oral antidiabetic agents. The objective of this study was to determine if device implantation alone (placebo effect) contributes to the long-term metabolic benefits of DIAMOND(®) meal-mediated gastric electrical stimulation in patients with type 2 diabetes. The study was a 48 week randomized, blinded, cross-over trial in university centers comparing glycemic improvement of DIAMON

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Negative / Null Result ReportOpen accessMedicine

Serum Uric Acid Level as a Biomarker in Idiopathic and Genetic (p.A53T Alpha-Synuclein Carriers) Parkinson’s Disease: Data from the PPMI Study

Christos Koros, Athina‐Maria Simitsi, Dimitra Papadimitriou et al. · 2020 · Journal of Parkinson s Disease

BACKGROUND: Blood uric acid level represents an emerging biomarker in Parkinson's disease (PD). Whether uric acid levels change in genetic forms of PD is just beginning to be explored. OBJECTIVE: The aim of the present study was to assess differences in serum uric acid level among PD patients harboring the p.A53T mutation in the alpha-synuclein gene, idiopathic PD, and healthy controls. METHODS: Longitudinal 5-year serum uric acid measurement data of 369 de novo idiopathic PD patients and 174 age- and gender-matched healthy controls have been downloaded from the Parkinson's Progression Markers

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Negative / Null Result ReportOpen accessMedicine

Cost-effectiveness of weekly adaptive radiotherapy versus standard IMRT in head and neck cancer alongside the ARTIX trial

Lionel Perrier, Frédéric Balusson, Magali Morelle et al. · 2024 · Radiotherapy and Oncology

BACKGROUND AND PURPOSE: We performed a cost-effectiveness analysis (CEA) comparing an adaptive radiotherapy (ART) strategy, based on weekly replanning, aiming to correct the parotid gland overdose during treatment and expecting therefore…

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Negative / Null Result ReportOpen accessMedicine

Thromboelastography With Platelet Mapping is Not an Effective Measure of Platelet Inhibition in Patients With Spontaneous Intracerebral Hemorrhage on Antiplatelet Therapy

Helena Lam, Nakul Katyal, Catherine D. Parker et al. · 2018 · Cureus

Thromboelastography with platelet mapping (TEG-PM) is a modality to measure platelet function, especially in patients taking antiplatelet medications. It consists of two components: arachidonic acid (AA), which is sensitive to aspirin, and adenosine diphosphate (ADP), which is sensitive to clopidogrel. In patients with spontaneous intracerebral hemorrhages (sICH), the clinical interpretation of platelet mapping is unclear. The objective of this study was to evaluate TEG-PM in patients with sICH on aspirin and/or clopidogrel who receive platelet transfusions. This study was an IRB-approved, ret

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Negative / Null Result ReportOpen accessMedicine

Re-Sequencing of the <b><i>APOL1</i></b>-<b><i>APOL4</i></b> and <b><i>MYH9</i></b> Gene Regions in African Americans Does Not Identify Additional Risks for CKD Progression

Gregory A. Hawkins, David J. Friedman, Lingyi Lu et al. · 2015 · American Journal of Nephrology

<b><i>Background:</i></b> In African Americans (AAs), <i>APOL1</i> G1 and G2 nephropathy risk variants are associated with non-diabetic end-stage kidney disease (ESKD) in an autosomal recessive pattern.…

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Negative / Null Result ReportOpen accessMedicine

Evaluation of a DNA demethylating agent in combination with all-trans retinoic acid for IDH1-mutant gliomas

Marina da Costa Rosa, Alex Shimura Yamashita, Gregory J. Riggins · 2021 · Neuro-Oncology

BACKGROUND: Isocitrate Dehydrogenase 1/2 (IDH1/2) mutations are diagnostic for Astrocytoma or Oligodendroglioma, IDH-mutant. In these IDH-mutant gliomas, retinoic acid-related gene expression is commonly silenced by DNA hypermethylation.…

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Negative / Null Result ReportOpen accessMedicine

An Aetiology-Based Subanalysis of the Telerehabilitation in Heart Failure Patients (TELEREH-HF) Trial

Dominika Szalewska, Renata Główczyńska, Ryszard Piotrowicz et al. · 2021 · ESC Heart Failure

AIMS: The aim of our study was to analyse the benefits of a 9 week hybrid comprehensive telerehabilitation (HCTR) programme in heart failure (HF) patients according to aetiology, as a subanalysis of the Telerehabilitation in Heart Failure…

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Negative / Null Result ReportMedicine

Dyslipidemia Is a Major Factor in Stem Cell Damage Induced by Uncontrolled Long-Term Type 2 Diabetes and Obesity in the Rat, as Suggested by the Effects on Stem Cell Culture

Maryam Masouminia, R. Gelfand, Istvan Kovanecz et al. · 2018 · The Journal of Sexual Medicine

BACKGROUND: Previous work showed that muscle-derived stem cells (MDSCs) exposed long-term to the milieu of uncontrolled type 2 diabetes (UC-T2D) in male obese Zucker (OZ) rats, were unable to correct the associated erectile dysfunction and…

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Negative / Null Result ReportOpen accessMedicine

Integrating large language model-based agents into a virtual patient chatbot for clinical anamnesis training

Nicolas Laverde, Christian Grévisse, Sandra Ximena Jaramillo-Rincón et al. · 2025 · Computational and Structural Biotechnology Journal

Effective communication is crucial for trust-building, accurate information gathering, and clinical decision-making in healthcare. Despite its emphasis in medical curricula, traditional training methods, such as role-playing with…

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Negative / Null Result ReportOpen accessMedicine

Using infective mosquitoes to challenge monkeys with Plasmodium knowlesi in malaria vaccine studies

Jittawadee Murphy, Walter R. Weiss, David J. Fryauff et al. · 2014 · Malaria Journal

BACKGROUND: When rhesus monkeys (Macaca mulatta) are used to test malaria vaccines, animals are often challenged by the intravenous injection of sporozoites. However, natural exposure to malaria comes via mosquito bite, and antibodies can neutralize sporozoites as they traverse the skin. Thus, intravenous injection may not fairly assess humoral immunity from anti-sporozoite malaria vaccines. To better assess malaria vaccines in rhesus, a method to challenge large numbers of monkeys by mosquito bite was developed. METHODS: Several species and strains of mosquitoes were tested for their ability

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Negative / Null Result ReportOpen accessMedicine

Is There Significant Difference between Digital and Glass Mercury Thermometer?

Hadgu Gerensea, Rajalakshmi Murugan · 2016 · Advances in Nursing

Background . Children’s decisions concerning investigation and treatment may be based on the results of temperature alone. Although the accuracy of axillary temperature measurement is affected by a number of factors, device dwell time and device type are common. Objective . Compare body temperature between glass mercury thermometer (GMT) and digital thermometer (DT). Method . Comparative descriptive study was used. A total of 101 samples were taken with convenient sampling technique, but 98 were analyzed. Statistical significance (p<0.01) and clinical significance (MD≥0.2°C) were used in th

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Negative / Null Result ReportMedicine

Is the Short Form of the Mini-Mental State Examination (MMSE) a better screening instrument for dementia in older primary care patients than the original MMSE? Results of the German study on ageing, cognition, and dementia in primary care patients (AgeCoDe).

Janine Stein, Melanie Luppa, Hanna Kaduszkiewicz et al. · 2015 · Psychological Assessment

The aim of the study was to investigate the psychometric properties of a Short Form of the Mini-Mental State Examination (SMMSE) for the screening of dementia in older primary care patients. Data were obtained from a large longitudinal…

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Negative / Null Result ReportOpen accessMedicine

Excision margins and sentinel lymph node status as prognostic factors in thick melanoma of the head and neck: A retrospective analysis

Olivia Ruskin, Alexandra Sanelli, Alan Herschtal et al. · 2016 · Head & Neck

BACKGROUND: Recommended margins for thick cutaneous melanoma (Breslow thickness >4 mm; T4) have decreased over recent decades. Optimal margins and the role of sentinel node biopsy (SNB) in thick head and neck melanoma remain controversial.…

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Negative / Null Result ReportOpen accessMedicine

Aβ plaques do not protect against HSV‐1 infection in a mouse model of familial Alzheimer's disease, and HSV‐1 does not induce Aβ pathology in a model of late onset Alzheimer's disease

Olga V. Bocharova, Aidan Fisher, Narayan Pandit et al. · 2022 · Brain Pathology

The possibility that the etiology of late onset Alzheimer's disease is linked to viral infections of the CNS has been actively debated in recent years. According to the antiviral protection hypothesis, viral pathogens trigger aggregation…

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Negative / Null Result ReportOpen accessMedicine

Practice of oxygen use in anesthesiology – a survey of the European Society of Anaesthesiology and Intensive Care

Martin Scharffenberg, Thomas G. Weiss, Jakob Wittenstein et al. · 2022 · BMC Anesthesiology

Abstract Background Oxygen is one of the most commonly used drugs by anesthesiologists. The World Health Organization (WHO) gave recommendations regarding perioperative oxygen administration, but the practice of oxygen use in anesthesia, critical emergency, and intensive care medicine remains unclear. Methods We conducted an online survey among members of the European Society of Anaesthesiology and Intensive Care (ESAIC). The questionnaire consisted of 46 queries appraising the perioperative period, emergency medicine and in the intensive care, knowledge about current recommendations by the WH

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Negative / Null Result ReportOpen accessMedicine

Combination of Hydrogen Inhalation and Hypothermic Temperature Control After Out-of-Hospital Cardiac Arrest: A Post hoc Analysis of the Efficacy of Inhaled Hydrogen on Neurologic Outcome Following Brain Ischemia During PostCardiac Arrest Care II Trial

Tomoyoshi Tamura, Hiromichi Narumiya, Koichiro Homma et al. · 2024 · Critical Care Medicine

OBJECTIVE: The Efficacy of Inhaled Hydrogen on Neurologic Outcome Following Brain Ischemia During Post-Cardiac Arrest Care (HYBRID) II trial (jRCTs031180352) suggested that hydrogen inhalation may reduce post-cardiac arrest brain injury…

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Negative / Null Result ReportOpen accessMedicine

Antiviral activity of Chongkukjang extracts against influenza A virus in vitro and in vivo

Bai Wei, Se-Yeoun Cha, Min Kang et al. · 2015 · Journal of Ethnic Foods

Chongkukjang is a traditional Korean fermented product prepared from soybeans and reported to have multiple biological functions, including antidiabetic, antiinflammatory, and neuroprotective effects. Influenza is a respiratory disease caused by influenza viruses and continues to be a worldwide threat with a high potential to cause pandemics. Besides vaccination, only two classes of drugs are available for antiviral treatment against these pathogens. We tested the inhibitory activity of an ethyl acetate extract from Chongkukjang toward influenza A virus neuraminidase. All 10 compounds extracte

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Negative / Null Result ReportOpen accessMedicine

Emerging biologic frontiers for Sjogren’s syndrome: Unveiling novel approaches with emphasis on extra glandular pathology

Xiao Li, Maierhaba Maitiyaer, Qing Tan et al. · 2024 · Frontiers in Pharmacology

Primary Sjögren's Syndrome (pSS) is a complex autoimmune disorder characterized by exocrine gland dysfunction, leading to dry eyes and mouth. Despite growing interest in biologic therapies for pSS, FDA approval has proven challenging due to trial complications. This review addresses the absence of a molecular-target-based approach to biologic therapy development and highlights novel research on drug targets and clinical trials. A literature search identified potential pSS treatment targets and recent advances in molecular understanding. Overlooking extraglandular symptoms like fatigue and depr

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Negative / Null Result ReportOpen accessMedicine

Deep brain stimulation for psychiatric disorders: role of imaging in identifying/confirming DBS targets, predicting, and optimizing outcome and unravelling mechanisms of action

Dejan Georgiev, Harith Akram, Marjan Jahanshahi · 2021 · Psychoradiology

Following the established application of deep brain stimulation (DBS) in the treatment of movement disorders, new non-neurological indications have emerged, such as for obsessive-compulsive disorders, major depressive disorder, dementia, Gilles de la Tourette Syndrome, anorexia nervosa, and addictions. As DBS is a network modulation surgical treatment, the development of DBS for both neurological and psychiatric disorders has been partly driven by advances in neuroimaging, which has helped explain the brain networks implicated. Advances in magnetic resonance imaging connectivity and electrophy

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Negative / Null Result ReportMedicine

A Combination of Impulsivity Subdomains Predict Alcohol Intoxication Frequency

Laura O’Halloran, Brian Pennie, Lee Jollans et al. · 2018 · Alcoholism Clinical and Experimental Research

BACKGROUND: Impulsivity, broadly characterized as the tendency to act prematurely without foresight, is linked to alcohol misuse in college students. However, impulsivity is a multidimensional construct and different subdomains likely…

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Negative / Null Result ReportMedicine

Factors and consequences of hypertension

Alberto Zanchetti · 2016 · Journal of Hypertension

The articles published in the current issue of the Journal of Hypertension focus on risk factors for the development of hypertension and on the relationship of hypertension with cardiovascular disease. Two articles illustrate the role of…

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Negative / Null Result ReportOpen accessMedicine

Opportunistic pathology-based screening for diabetes

Aaron Simpson, Renata Krowka, Jennifer Kerrigan et al. · 2013 · BMJ Open

OBJECTIVE: To determine the potential of opportunistic glycated haemoglobin (HbA1c) testing of pathology samples to detect previously unknown diabetes. DESIGN: Pathology samples from participants collected for other reasons and suitable…

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Negative / Null Result ReportMedicine

SAKK 24/09: Safety and tolerability of bevacizumab plus paclitaxel versus bevacizumab plus metronomic cyclophosphamide and capecitabine as first-line therapy in patients with HER2-negative advanced stage breast cancer—A multicenter, randomized phase III trial.

Christoph Rochlitz, Roger von Moos, Martin Bigler et al. · 2014 · Journal of Clinical Oncology

518 Background: Bevacizumab combined with chemotherapy has been shown to improve response rate and PFS in metastatic breast cancer. The aim of our study was to demonstrate decreased toxicity of metronomic chemotherapy/bevacizumab when…

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Negative / Null Result ReportOpen accessMedicine

Rescue of Infectious Rotavirus Reassortants by a Reverse Genetics System Is Restricted by the Receptor-Binding Region of VP4

Alexander Falkenhagen, Marno Huyzers, Alberdina A. van Dijk et al. · 2021 · Viruses

The rotavirus species A (RVA) capsid contains the spike protein VP4, which interacts with VP6 and VP7 and is involved in cellular receptor binding. The capsid encloses the genome consisting of eleven dsRNA segments. Reassortment events can result in novel strains with changed properties. Using a plasmid-based reverse genetics system based on simian RVA strain SA11, we previously showed that the rescue of viable reassortants containing a heterologous VP4-encoding genome segment was strain-dependent. In order to unravel the reasons for the reassortment restrictions, we designed here a series of

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