Negative / Null Result ReportOpen accessMedicine
Natalia Spasova, Desislava Somleva, Bozhidar Krastev et al. · 2024 · Folia Medica
Introduction : Trimethylamine-N-oxide (TMAO) is a metabolite produced by intestinal microbiota. It is well recognized as an independent risk marker for cardiovascular and renal diseases and mortality. Aim : The aim of the present study was…
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Xiaodong Wang, Jing He, Gouping Ding et al. · 2025 · Frontiers in Immunology
Immune checkpoint inhibitors (ICIs) targeting PD-1 and CTLA-4 have achieved groundbreaking clinical success in multiple cancers; however, a large proportion of patients experience primary or acquired resistance. This review synthesizes the complex mechanisms underlying resistance to PD-1/CTLA-4 blockade and surveys emerging strategies to overcome them. Resistance arises from multifaceted interactions among tumor-intrinsic alterations (e.g., epigenetic silencing of antigen presentation machinery via EZH2/PRC2, oncogenic pathway-driven upregulation of PD-L1, genetic loss of IFNγ pathway componen
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Hidehiko Okazawa, Tetsuya Tsujikawa, Yoshifumi Higashino et al. · 2019 · EJNMMI Research
Accurate attenuation correction (AC) is one of the most important issues to be addressed in quantitative brain PET/MRI imaging. Atlas-based MRI AC (AB-MRAC), one of the representative MRAC methods, has been used to estimate the skull attenuation in brain scans. The zero echo time (ZTE) pulse sequence is also expected to provide a better MRAC estimation in brain PET scans. The difference in quantitative measurements of cerebral blood flow (CBF) using H215O-PET/MRI was compared between the two MRAC methods, AB and ZTE. Twelve patients with cerebrovascular disease (4 males, 43.2 ± 11.7 years) und
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Kushala Abeysekera, James Orr, Paul Madley‐Dowd et al. · 2021 · The Lancet Regional Health - Europe
BACKGROUND: The importance of the maternal-infant dyad in the genesis of nonalcoholic fatty liver disease (NAFLD) is of increasing interest. The Avon Longitudinal Study of Parents and Children (ALSPAC) showed that at age 24, 1 in 5 had…
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Eisaku Miyauchi, Tatsuo Matsuda, Kazuma Kiyotani et al. · 2018 · Cancer Science
Recent clinical trials of non-small cell lung cancer with immune checkpoint inhibitors revealed that patients with epidermal growth factor receptor (EGFR) mutations had more unfavorable outcomes compared with those with wild-type EGFR.…
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Anna Katri, Aneta Dąbrowska, Henrik Löfvall et al. · 2019 · Arthritis Research & Therapy
BACKGROUND: Pain is a debilitating symptom of rheumatoid arthritis (RA), caused by joint inflammation and cartilage and bone destruction. Nonsteroidal anti-inflammatory drugs (NSAIDs) are used to treat pain and inflammation in RA, but are not disease-modifying and do not prevent joint destruction when administered alone. KBPs (Key Bioscience peptides) are synthetic peptides based on salmon calcitonin and are expected to inhibit bone resorption and to be chondroprotective. In this study, we investigated if combining a standard of care NSAID (naproxen) with a KBP resulted in improvement in pain
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Yue Yang, Dominic B. Rowe, Heather McCann et al. · 2023 · Neuropathology and Applied Neurobiology
AIMS: Although the orally available brain-penetrant copper compound CuATSM has demonstrated promising effects in SOD1-linked mouse models, the impact of CuATSM on disease pathology in patients with amyotrophic lateral sclerosis (ALS) remains unknown. METHODS: The present study set out to address this deficit by performing the first pilot comparative analysis of ALS pathology in patients that had been administered CuATSM and riluzole [N = 6 cases composed of ALS-TDP (n = 5) and ALS-SOD1 (n = 1)] versus riluzole only [N = 6 cases composed of ALS-TDP (n = 4) and ALS-SOD1 (n = 2)]. RESULTS: Our re
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Stefanie G. Beesems, Jocelyn Berdowski, Michiel Hulleman et al. · 2016 · Resuscitation
BACKGROUND: Previous large retrospective analyses have found an association between duration of peri-shock pauses in cardiopulmonary resuscitation (CPR) and survival. In a randomized trial, we tested whether shortening these pauses…
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Toshiki Kuno, Takahisa Mikami, Yuki Sahashi et al. · 2022 · Scientific Reports
Acute kidney injury (AKI) after percutaneous coronary intervention (PCI) is associated with a significant risk of morbidity and mortality. The traditional risk model provided by the National Cardiovascular Data Registry (NCDR) is useful for predicting the preprocedural risk of AKI, although the scoring system requires a number of clinical contents. We sought to examine whether machine learning (ML) techniques could predict AKI with fewer NCDR-AKI risk model variables within a comparable PCI database in Japan. We evaluated 19,222 consecutive patients undergoing PCI between 2008 and 2019 in a Ja
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Jonathan Tucci, Waseem Alhushki, Ting Chen et al. · 2018 · Cancer & Metabolism
BACKGROUND: It is becoming increasingly recognized that weight and nutritional status can impact cancer survival. We have previously shown that obese mice with syngeneic acute lymphoblastic leukemia (ALL) have poorer response to chemotherapy treatment than control mice. We therefore investigated whether dietary intervention could improve outcome from the most common pediatric cancer, ALL. METHODS: Diet-induced obese (DIO) mice raised on a 60% calories from fat diet and control mice were implanted with syngeneic ALL cells. Some DIO mice were switched to the low-fat control diet. Survival from A
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Valerie A. Smith, Joan E. Cunningham, Eric J. Lentsch · 2012 · Otolaryngology
OBJECTIVE: Determine if completion lymph node dissection (CLND) is associated with improved survival in sentinel lymph node (SLN)-positive cutaneous melanoma of the head and neck (CMHN) patients. STUDY DESIGN: Retrospective analysis of…
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Michelle Beam, Angela G. Spencer, Lauralee Fernandez et al. · 2018 · American Journal of Tropical Medicine and Hygiene
larvae (neurocysticercosis) is a leading cause of preventable epilepsy worldwide. Effective and sustainable strategies to control parasite transmission in rural endemic communities are needed to prevent the disease. Surveillance and…
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Duncan G.J. Green, Jinhee Kim, Stephen J. Kish et al. · 2021 · Journal of Psychiatry and Neuroscience
Background: Upregulation of the endocannabinoid enzyme fatty acid amide hydrolase (FAAH) has been linked to abnormal activity in frontoamygdalar circuits, a hallmark of posttraumatic stress disorder. We tested the hypothesis that FAAH…
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Wanzhu Tu, Samer Gawrieh, Srinivasan Dasarathy et al. · 2023 · Contemporary Clinical Trials Communications
Background: Mortality is high for severe alcohol-associated hepatitis (AH). Corticosteroids are the standard of care for patients without contraindications. Recent data showed that interleukin-1β receptor antagonist anakinra attenuated…
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Junyi Chen, Jiao Li, Chuanliang Xu et al. · 2012 · BMC Cancer
BACKGROUND: Gamma-synuclein (SNCG) has previously been demonstrated to be significantly correlated with metastatic malignancies; however, in-depth investigation of SNCG in prostate cancer is still lacking. In the present study, we evaluated the role of SNCG in prostate cancer progression and explored the underlying mechanisms. METHODS: First, alteration of SNCG expression in LNCaP cell line to test the ability of SNCG on cellular properties in vitro and vivo whenever exposing with androgen or not. Subsequently, the Dual-luciferase reporter assays were performed to evaluate whether the role of
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Manjusha Kulkarni, Sanjay Varikuti, César Terrazas et al. · 2014 · Immunology
The control of Trypanosoma cruzi infection is related to interferon-γ (IFN-γ) activation leading to intracellular clearance of parasites. The transcription factor signal transducer and activator of transcription 1 (STAT-1) is a key…
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Axel Åkerblom, Lars Wallentin, Anders Larsson et al. · 2013 · Clinical Chemistry
BACKGROUND: The estimated glomerular filtration rate (eGFR) independently predicts cardiovascular death or myocardial infarction (MI) and can be estimated by creatinine and cystatin C concentrations. We evaluated 2 different cystatin C…
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Alexander Filatenkov, Jeanette Baker, Antonia Müller et al. · 2014 · Radiation Research
The goal of this study was to determine whether a combination of local tumor irradiation and autologous T-cell transplantation can effectively treat metastatic 4T1 breast cancer in mice. BALB/c mice were injected subcutaneously with…
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Muna Canales, Terri Blackwell, Areef Ishani et al. · 2016 · American Journal of Nephrology
<b><i>Background:</i></b> Recently, the first estimated glomerular filtration rate (eGFR) formula specifically developed for community-dwelling older adults, the Berlin Initiative Study Equation 2 (BIS2), was…
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Charlotte Lindblad Wollmann, Kyle D. Hart, Can Liu et al. · 2020 · Acta Obstetricia Et Gynecologica Scandinavica
INTRODUCTION: Predicting a woman's probability of vaginal birth after cesarean could facilitate the antenatal decision-making process. Having a previous vaginal birth strongly predicts vaginal birth after cesarean. Delivery outcome in…
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Herbert S. B. Baraf, Puja Khanna, Alan Kivitz et al. · 2023 · Lara D. Veeken
OBJECTIVES: Serum urate (SU) lowering with PEGylated uricases in gout can reduce flares and tophi. However, treatment-emergent anti-drug antibodies adversely affect safety and efficacy and the currently approved PEGylated uricase…
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Gabriëlle J. M. Tuijthof, M. M. de Vaal, I. N. Sierevelt et al. · 2011 · Knee Surgery Sports Traumatology Arthroscopy
PURPOSE: During arthroscopies, bleeding episodes occur as a result of tissue damage. Irrigation systems assist in minimizing these disturbances. The performance of three arthroscopic irrigation systems in clearing bleeding episodes was…
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Tomoaki Natsukawa, Norikazu Maeda, Shiro Fukuda et al. · 2017 · Journal of Atherosclerosis and Thrombosis
AIMS: Adiponectin, an adipocyte-specific secretory protein, abundantly exists in the blood stream while its concentration paradoxically decreases in obesity. Hypoadiponectinemia is one of risks of cardiovascular diseases. However, impact…
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Leah Wetherill, Dongbing Lai, Emma C. Johnson et al. · 2019 · Genes Brain & Behavior
Abstract Genetic influences on alcohol and drug dependence partially overlap, however, specific loci underlying this overlap remain unclear. We conducted a genome‐wide association study (GWAS) of a phenotype representing alcohol or illicit…
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Steven J. Kiddle, Nicola Voyle, Richard J.B. Dobson · 2018 · Journal of Alzheimer s Disease
Ever since the discovery of APOEɛ4 around 25 years ago, researchers have been excited about the potential of a blood test for Alzheimer's disease (AD). Since then researchers have looked for genetic, protein, metabolite, and/or gene…
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Sorena Keihani, Douglas Rogers, Bryn Putbrese et al. · 2019 · The Journal of Trauma: Injury, Infection, and Critical Care
BACKGROUND: In 2018, the American Association for the Surgery of Trauma (AAST) published revisions to the renal injury grading system to reflect the increased reliance on computed tomography scans and non-operative management of high-grade…
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Sebastian Richards-Taylor, Charles Tilley, Eleanor Jaynes et al. · 2017 · Pancreas
OBJECTIVE: Pancreatic neuroendocrine tumors (NETs) (pNETs) have a varied prognosis according to their grade. The European Neuroendocrine Tumor Society grading system uses assessment of the proliferation index via Ki-67 immunohistochemistry…
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Thiago Pereira Diniz, Wilson Luiz da Costa, Victor Hugo Fonseca de Jesus et al. · 2019 · Journal of Surgical Oncology
BACKGROUND: Hyperthermic intraperitoneal chemotherapy (HIPEC) has been associated with improved survival when compared with surgery alone for non-metastatic gastric cancer patients in randomized trials and meta-analyses. However, little evidence is available regarding the use of HIPEC in nonmetastatic patients who are treated with perioperative chemotherapy and radical surgery. The aim of this study was to investigate the putative survival benefit of HIPEC in the subgroup of gastric cancer patients treated with perioperative chemotherapy and surgery. PATIENTS AND METHODS: This was a retrospect
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Geovani de Oliveira Ribeiro, Antônio Charlys da Costa, Danielle Elise Gill et al. · 2021 · Scientific Reports
Classical insect-flaviviruses (cISFVs) and dual host-related insect-specific flavivirus (dISFV) are within the major group of insect-specific flavivirus. Remarkably dISFV are evolutionarily related to some of the pathogenic flavivirus, such as Zika and dengue viruses. The Evolutionary relatedness of dISFV to flavivirus allowed us to investigate the evolutionary principle of host adaptation. Additionally, dISFV can be used for the development of flavivirus vaccines and to explore underlying principles of mammalian pathogenicity. Here we describe the genetic characterization of a novel putative
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Amy K. Sheaffer, Min S. Lee, Dennis Hernandez et al. · 2011 · Antiviral Therapy
BACKGROUND: To support clinical development of HCV non-structural protein (NS) 3 protease inhibitors (PIs), phenotypic monitoring of patient isolates is a prerequisite for understanding the emergence of resistance. HCV isolates typically…
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