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11,300 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Calcium intake and its relationship with risk of overweight and obesity in adolescents

Tamara Beres Lederer Goldberg, Carla Cristiane da Silva, Luciana Peres et al. · 2026 · Archivos Latinoamericanos de Nutrición

Adolescents' eating habits are determined by social, psychological, economic, political, and educational influences. They tend to prefer foods with inadequate nutritional value and high fat and carbohydrate content which leads to excessive…

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Negative / Null Result ReportOpen accessMedicine

Sequential or Simultaneous Injection of Preformed Fibrils and AAV Overexpression of Alpha-Synuclein Are Equipotent in Producing Relevant Pathology and Behavioral Deficits

Matilde Negrini, Giuseppe Tomasello, Marcus Davidsson et al. · 2022 · Journal of Parkinson s Disease

BACKGROUND: Preclinical rodent models for Parkinson's disease (PD) based on viral human alpha-synuclein (h-αSyn) overexpression recapitulate some of the pathological hallmarks as it presents in humans, such as progressive cell loss and additional synucleinopathy in cortical and subcortical structures. Recent studies have combined viral vector-based overexpression of human wild-type αSyn with the sequential or simultaneous inoculation of preformed fibrils (PFFs) derived from human αSyn. OBJECTIVE: The goal of the study was to investigate whether sequential or combined delivery of the AAV vector

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Negative / Null Result ReportOpen accessMedicine

Kawasaki disease and 13-valent pneumococcal conjugate vaccination among young children: A self-controlled risk interval and cohort study with null results

Meghan A. Baker, Bethany Baer, Martin Kulldorff et al. · 2019 · PLoS Medicine

BACKGROUND: Kawasaki disease is an acute vasculitis that primarily affects children younger than 5 years of age. Its etiology is unknown. The United States Vaccine Safety Datalink conducted postlicensure safety surveillance for 13-valent pneumococcal conjugate vaccine (PCV13), comparing the risk of Kawasaki disease within 28 days of PCV13 vaccination with the historical risk after 7-valent PCV (PCV7) vaccination and using chart-validation. A relative risk (RR) of 2.38 (95% CI 0.92-6.38) was found. Concurrently, the Food and Drug Administration (FDA) conducted a postlicensure safety review that

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Negative / Null Result ReportOpen accessMedicine

Surgical Methods and Experiences of Surgeons did not Significantly Affect the Recovery in Phonation Following Reconstruction of the Recurrent Laryngeal Nerve

Kana Yoshioka, Akira Miyauchi, Mitsuhiro Fukushima et al. · 2016 · World Journal of Surgery

BACKGROUND: We reported phonatory recovery in the majority of 88 patients after recurrent laryngeal nerve (RLN) reconstruction. Here we analyzed factors that might influence the recovery, in a larger patient series. METHODS: At Kuma Hospital, 449 patients (354 females and 95 males) underwent RLN reconstruction with direct anastomosis, ansa cervicalis-to-RLN anastomosis, free nerve grafting, or vagus-to-RLN anastomosis; 47.4 % had vocal cord paralysis (VCP) preoperatively. Maximum phonation time (MPT) and mean airflow rate during phonation (MFR) were measured 1 year post surgery. Forty patients

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Negative / Null Result ReportOpen accessMedicine

Replicative Fitness Costs of Nonnucleoside Reverse Transcriptase Inhibitor Drug Resistance Mutations on HIV Subtype C

Kimberly L. Armstrong, Tun‐Hou Lee, Max Essex · 2011 · Antimicrobial Agents and Chemotherapy

Single-dose nevirapine (NVP) is quite effective in preventing transmission of the human immunodeficiency virus (HIV) from mother to child; however, many women develop resistance to NVP in this setting. Comparing outcomes of clinical studies reveals an increased amount of resistance in subtype C relative to that in other subtypes. This study investigates how nonnucleoside reverse transcriptase inhibitor (NNRTI) drug resistance mutations of subtype C affect replication capacity. The 103N, 106A, 106M, 181C, 188C, 188L, and 190A drug resistance mutations were placed in a reverse transcriptase (RT)

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Negative / Null Result ReportMedicine

The Role of IGF-I, IGF-II, and IGFBP-3 in Male Cognitive Aging and Dementia Risk: The Caerphilly Prospective Study

Christopher J. Green, Jeffrey M P Holly, Antony Bayer et al. · 2014 · Journal of Alzheimer s Disease

BACKGROUND: The increasing incidence of cognitive impairment and dementia in an aging population poses a significant burden on healthcare. Consequently, identifying modifiable physiological factors which may influence the onset of…

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Negative / Null Result ReportOpen accessMedicine

Development of Three-Dimensional Human Intestinal Organoids as a Physiologically Relevant Model for Characterizing the Viral Replication Kinetics and Antiviral Susceptibility of Enteroviruses

Jessica Oi‐Ling Tsang, Jie Zhou, Xiaoyu Zhao et al. · 2021 · Biomedicines

Enteroviruses are important causes of hand, foot, and mouth disease, respiratory infections, and neurological infections in human. A major hurdle for the development of anti-enterovirus agents is the lack of physiologically relevant evaluation platforms that closely correlate with the in vivo state. We established the human small intestinal organoids as a novel platform for characterizing the viral replication kinetics and evaluating candidate antivirals for enteroviruses. The organoids supported productive replication of enterovirus (EV)-A71, coxsackievirus B2, and poliovirus type 3, as evide

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Negative / Null Result ReportMedicine

The UK Experience of a Treatment Strategy for Pediatric Metastatic Medulloblastoma Comprising Intensive Induction Chemotherapy, Hyperfractionated Accelerated Radiotherapy and Response Directed High Dose Myeloablative Chemotherapy or Maintenance Chemothera

Sindu Vivekanandan, Richard Breene, Ramya Ramanujachar et al. · 2015 · Pediatric Blood & Cancer

BACKGROUND: Historically, the 5-year overall survival (OS) for metastatic medulloblastoma (MMB) was less than 40%. The strategy of post-operative induction chemotherapy (IC) followed by hyperfractionated accelerated radiotherapy (HART) and…

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Negative / Null Result ReportOpen accessMedicine

Comorbidity of Glucose-6-Phosphate Dehydrogenase Deficiency and Sickle Cell Disease Exert Significant Effect on RBC Indices

Samuel Antwi‐Baffour, Jonathan Kofi Adjei, Peter Owadee Forson et al. · 2019 · Anemia

BACKGROUND: Glucose-6-phosphate dehydrogenase (G6PD) converts glucose-6-phosphate into 6-phosphogluconate in the pentose phosphate pathway and protects red blood cells (RBCs) from oxidative damage. Their deficiency therefore makes RBCs prone to haemolysis. Sickle cell disease (SCD) on the other hand is a hereditary blood disorder in which there is a single nucleotide substitution in the codon for amino acid 6 substituting glutamic acid with valine. SCD patients are prone to haemolysis due to the shape of their red blood cells and if they are deficient in G6PD, the haemolysis may escalate. Repo

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Negative / Null Result ReportMedicine

No significant effect of uridine or pravastatin treatment for HIV lipoatrophy in men who have ceased thymidine analogue nucleoside reverse transcriptase inhibitor therapy: a randomized trial*

Alexandra Calmy, Mark Bloch, Handan Wand et al. · 2010 · HIV Medicine

BACKGROUND: Lipoatrophy can complicate thymidine analogue nucleoside reverse transcriptase inhibitor (tNRTI)-based antiretroviral therapy (ART). Lipoatrophy may be less likely with ART including ritonavir-boosted lopinavir (LPV/r). Small,…

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Negative / Null Result ReportOpen accessMedicine

Ten-Year Results of Laparoscopic Sleeve Gastrectomy: Retrospective Matched Comparison with Laparoscopic Adjustable Gastric Banding—Is There a Significant Difference in Long Term?

Mario Musella, Giovanna Berardi, Nunzio Velotti et al. · 2021 · Obesity Surgery

BACKGROUND: The laparoscopic sleeve gastrectomy (LSG) is the most common bariatric procedure performed worldwide while the laparoscopic adjustable gastric banding (LAGB) has been almost abandoned. Aim of this study was to retrospectively assess 10-year outcomes of LSG through a matched comparison with LAGB. MATERIALS AND METHODS: Retrospective search of prospectively maintained database of our university was carried out to find all patients that underwent LSG before December 2010. Each subject with LSG was matched one-to-one with a patient that had undergone LAGB in the same period with corres

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Negative / Null Result ReportOpen accessMedicine

No Significant Differences in Clinical and Radiographic Outcomes between PCL Retained or Sacrificed Kinematic Aligned Medial Pivot Total Knee Arthroplasty in Varus Knee

Fortunato Giustra, Francesco Bosco, Giorgio Cacciola et al. · 2022 · Journal of Clinical Medicine

In the last decades, several surgical techniques, such as medial pivot (MP) philosophy and kinematic alignment (KA), have been introduced in total knee arthroplasty (TKA) to improve patients’ outcomes. This retrospective study aims to evaluate the clinical, radiographic, and functional results of PCL preservation or sacrifice in KA MP-TKA. A consecutive series of 147 patients older than 60, with a minimum follow-up of two years, were treated with TKA for severe primary knee osteoarthritis (OA) at the Department of Orthopedics and Traumatology between 1 January 2019, and 1 July 2020. After excl

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Negative / Null Result ReportOpen accessMedicine

Bronchiectasis: Phenotyping a Complex Disease

James D. Chalmers · 2017 · COPD Journal of Chronic Obstructive Pulmonary Disease

Bronchiectasis is a long-neglected disease currently experiencing a surge in interest. It is a highly complex condition with numerous aetiologies, co-morbidities and a heterogeneous disease presentation and clinical course. The past few…

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Negative / Null Result ReportOpen accessMedicine

Targeting TREM-1 Signaling in the Presence of Antibiotics is Effective Against Streptococcal Toxic-Shock-Like Syndrome (STSLS) Caused by Streptococcus suis

Chao Yang, Jianqing Zhao, Lan Lin et al. · 2015 · Frontiers in Cellular and Infection Microbiology

Streptococcus suis (S.suis), a major swine pathogen, is also a severe threat to human health. Infection with highly virulent strains of S. suis can cause human Streptococcal toxic-shock-like syndrome (STSLS), which is associated with high serum pro-inflammatory cytokine levels and a high mortality rate. Our previous study indicated that highly virulent S. suis infection could activate the TREM-1 signaling pathway, which promotes host clearance of S. suis during early infection. However, it remained to be elicited whether TREM-1 signaling could be a target against STSLS in the presence of antib

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Negative / Null Result ReportMedicine

Initiating acute dialysis at earlier Acute Kidney Injury Network stage in critically ill patients without traditional indications does not improve outcome: A prospective cohort study

Cynthia Ciwei Lim, Chieh Suai Tan, Manish Kaushik et al. · 2014 · Nephrology

AIM: Optimal timing for acute renal replacement therapy (ARRT) initiation in critically ill patients with acute kidney injury (AKI) is unclear. We aimed to evaluate outcomes in patients who initiated ARRT for traditional indications versus…

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Negative / Null Result ReportOpen accessMedicine

Positron Emission Tomography Scan for a Hepatic Mass

Boris Blechacz, Gregory J. Gores · 2010 · Hepatology

A 66-year-old male patient who is hepatitis C RNA–positive without cirrhosis has been found to have a mass on ultrasound examination of the liver. The physical examination is unremarkable. The hemoglobin, white cell count, and platelet…

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Negative / Null Result ReportOpen accessMedicine

Measured GFR: not a gold, but a gold-plated standard

Elise Boele-Schutte, Ron T. Gansevoort · 2016 · Nephrology Dialysis Transplantation

Because of the circadian rhythm in kidney function the true glomerular filtration rate (GFR) is historically considered to be the average GFR measured by urinary inulin clearance over a 24-h period [1]. In clinical practice, it is…

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Negative / Null Result ReportOpen accessMedicine

Mobile Money Use and Healthcare Utilization: Evidence from Rural Uganda

Hiroyuki Egami, Tomoya Matsumoto · 2020 · Sustainability

Lack of cash on hand is a significant obstacle in accessing healthcare services in developing countries. Many expectant mothers in the least developed countries do not receive sufficient care during pregnancy due to financial constraints. If such hurdles in accessing healthcare can be overcome, it will contribute to reduction in maternal and newborn mortality, which is a key target of Sustainable Development Goal 3. This study reports the first assessment of the impact of mobile money services on maternal care utilization. We hypothesize that mobile money adoption would motivate rural Ugandan

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Negative / Null Result ReportOpen accessMedicine

Comparisons between Murine Polyomavirus and Simian Virus 40 Show Significant Differences in Small T Antigen Function

Shaida Andrabi, Justin H. Hwang, Jennifer Kean Choe et al. · 2011 · Journal of Virology

Although members of a virus family produce similar gene products, those products may have quite different functions. Simian virus 40 (SV40) large T antigen (LT), for example, targets p53 directly, but murine polyomavirus LT does not. SV40…

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Negative / Null Result ReportOpen accessMedicine

Adjuvant Therapeutic Modalities in Primary Small Cell Carcinoma of Esophagus Patients

Bingwen Zou, Tao Li, Qiang Zhou et al. · 2016 · Medicine

To evaluate the treatment pattern and survival of patients receiving radical resection for primary small cell carcinoma of the esophagus (PSCCE).This retrospective study included 150 patients who received radical resection of PSCCE. Data were retrieved from 4 centers in Western China. Thirty-nine of 150 patients received postoperative chemo-radiotherapy, 62 received postoperative chemotherapy, and 49 received radical resection only. The median radiation dosage was 50 Gy. The chemotherapeutic regimen was platinum-based and lasted for 2 to 6 cycles (median, 3).Median disease-free survival (mDFS)

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Negative / Null Result ReportOpen accessMedicine

A Novel SARS-CoV-2 Viral Sequence Bioinformatic Pipeline Has Found Genetic Evidence That the Viral 3′ Untranslated Region (UTR) Is Evolving and Generating Increased Viral Diversity

Carlos Farkas, Andy Mella, Maxime Turgeon et al. · 2021 · Frontiers in Microbiology

An unprecedented amount of SARS-CoV-2 sequencing has been performed, however, novel bioinformatic tools to cope with and process these large datasets is needed. Here, we have devised a bioinformatic pipeline that inputs SARS-CoV-2 genome sequencing in FASTA/FASTQ format and outputs a single Variant Calling Format file that can be processed to obtain variant annotations and perform downstream population genetic testing. As proof of concept, we have analyzed over 229,000 SARS-CoV-2 viral sequences up until November 30, 2020. We have identified over 39,000 variants worldwide with increased polymo

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Negative / Null Result ReportOpen accessMedicine

Cross-species transcriptome analysis for early detection and specific therapeutic targeting of human lupus nephritis

Eleni Frangou, Panagiotis Garantziotis, Maria Grigoriou et al. · 2022 · Annals of the Rheumatic Diseases

OBJECTIVES: Patients with lupus nephritis (LN) are in urgent need for early diagnosis and therapeutic interventions targeting aberrant molecular pathways enriched in affected kidneys. METHODS: We used mRNA-sequencing in effector (spleen) and target (kidneys, brain) tissues from lupus and control mice at sequential time points, and in the blood from 367 individuals (261 systemic lupus erythematosus (SLE) patients and 106 healthy individuals). Comparative cross-tissue and cross-species analyses were performed. The human dataset was split into training and validation sets and machine learning was

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Negative / Null Result ReportMedicine

Complete Atrioventricular Block does not Reduce Long-Term Mortality in Patients with Permanent Atrial Fibrillation Treated with Cardiac Resynchronization Therapy

José Marı́a Tolosana, Emilce Trucco, Malek Khatib et al. · 2013 · European Journal of Heart Failure

AIMS: A maximum percentage of ventricular pacing is mandatory to obtain a good response to CRT. Atrioventricular junction (AVJ) ablation has been recommended to attain this objective in patients with AF. THE AIMS OF OUR STUDY WERE: (i) to…

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Negative / Null Result ReportOpen accessMedicine

Natural killer cell functional genetics and donor-specific antibody-triggered microvascular inflammation

Matthias Diebold, Hannes Vietzen, Andreas Heinzel et al. · 2023 · American Journal of Transplantation

Antibody-mediated rejection (ABMR) is a leading cause of graft failure. Emerging evidence suggests a significant contribution of natural killer (NK) cells to microvascular inflammation (MVI). We investigated the influence of genetically determined NK cell functionality on ABMR development and activity. The study included 86 kidney transplant recipients subjected to systematic biopsies triggered by donor-specific antibody detection. We performed killer immunoglobulin-like receptor typing to predict missing self and genotyped polymorphisms determining NK cell functionality (FCGR3AV/F158 [rs39699

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Negative / Null Result ReportOpen accessMedicine

Inhibition of Protein Kinase Cβ Does Not Improve Endothelial Function in Type 2 Diabetes

Joshua A. Beckman, Allison B. Goldfine, Alison Goldin et al. · 2010 · The Journal of Clinical Endocrinology & Metabolism

CONTEXT: Antagonism of protein kinase Cbeta (PKCbeta) restores endothelial function in experimental models of diabetes and prevents vascular dysfunction in response to hyperglycemia in healthy humans. OBJECTIVE: We tested the hypothesis…

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