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Browse the failure-mode index

11,419 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Effects of executive function training on balance and auditory-cognitive dual-task performance in adults with and without hearing loss.

Niroshica Mohanathas, Lianna Montanari, Rachel Downey et al. · 2026 · PLoS ONE

Background Multitasking, such as listening while balancing, relies on integrated processing in the sensory, cognitive, and motor systems; systems that often decline with age. Hearing loss is linked to increased risks of both falls and cognitive decline. Improving cognitive processing through executive function (EF) training may support balance, especially in older adults with hearing loss. This randomized controlled study conducted across age groups and hearing abilities, examined the effects of a 12-week EF training program on postural outcomes (center of pressure (COP)) using an auditory-cog

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Negative / Null Result ReportMedicine

Preoperative blood spinal cord barrier biomarker levels correlate with neurological outcome in patients with degenerative cervical myelopathy one year after surgery: a prospective cohort study.

Schmidt TP, Jütten K, Bertram U et al. · 2026 · World neurosurgery

Degenerative cervical myelopathy (DCM) is the leading cause of chronic spinal cord dysfunction and can lead to severe neurological impairment if untreated. While decompressive surgery is the standard treatment, predicting postoperative…

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Negative / Null Result ReportMedicine

Statins May Not Reduce Reoperation Rates in Chronic Subdural Hematoma, Regardless of the Use of Antithrombotic Medication.

Klein J, Carl B, Schackert G · 2026 · Journal of neurological surgery. Part A, Central European neurosurgery

Objective Various studies have shown a beneficial effect of statins in patients with chronic subdural hematoma (cSDH) who do not require surgery. In surgical cohorts, however, the results of statin treatment in cSDH have been inconsistent,…

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Negative / Null Result ReportMedicine

Determination of the First Aid Knowledge Level of Teachers Working in Special Education and Rehabilitation Centers Regarding Tooth Avulsion.

Yabaş ŞM, Gümüşboğa ZŞ · 2026 · Dental traumatology : official publication of International Association for Dental Traumatology

Aim Tooth avulsion is among the traumatic dental injuries that require immediate intervention during childhood, and children are often with teachers or parents at the time of such incidents. This situation highlights the need to evaluate…

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Negative / Null Result ReportMedicine

Nociception-guided opioid administration within multimodal analgesia for laparoscopic endometriosis surgery: a randomized controlled trial.

Buis HT, Berger-Estilita J, Zirngast S et al. · 2026 · Journal of clinical monitoring and computing

Women with endometriosis are at increased risk of severe postoperative pain due to nociceptive sensitization. While multimodal analgesia reduces opioid use, the added value of objective nociception monitoring remains unclear. This study…

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Negative / Null Result ReportMedicine

Influence of Cavity Design, Bonding-Banding Sequence, and Thermomechanical Loading on the Marginal Adaptation of Class II Resin Composite Restorations.

Ismail HS, Ali AI, Soliman HAN · 2026 · Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.]

Objective To evaluate whether differences exist in marginal adaptation among beveled and non-beveled cavity designs, different bonding-banding sequences, and before and after thermomechanical loading. Methods Forty molars received…

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Negative / Null Result ReportMedicine

Causal Impact of Primary Care and Publicly Funded Health Insurance on Catastrophic Health Spending From Climate-Sensitive Diseases in India.

Chaudhary D, Mukhopadhyay I · 2026 · Applied health economics and health policy

Background Universal health coverage has become central to health policy debates, particularly as a strategy to protect households from financial hardship and impoverishment related to out-of-pocket (OOP) spending. Many low- and…

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Negative / Null Result ReportOpen accessMedicine

The mediating role of job and life satisfaction in the effect of psychological resilience on employee performance: evidence from the February 6 Kahramanmaraş (Türkiye) earthquakes.

Amırlı H, Gurbanli E · 2026 · BMC psychology

The purpose of this study is to investigate the mediating roles of job satisfaction (JS) and life satisfaction (LS) in the relationship between psychological resilience (PR) and employee performance (EP). Data for this study, which…

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Negative / Null Result ReportMedicine

The combined and independent influence of food texture and a 'mindful eating' instruction on eating rate and food intake among Dutch primary schoolchildren.

Jager G, de Wild VWT, Camps G et al. · 2026 · Appetite

Eating rate (ER), the amount of food consumed per unit of time, is a key determinant of food intake, with faster ER associated with larger meal size. Research in adults has shown that both sensory properties like texture, and instructions…

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Negative / Null Result ReportOpen accessMedicine

Intravascular Imaging for Facilitated Coronary Interventions in DES Era.

Zeren G, Bakır EO, Tufaro V et al. · 2026 · Journal of cardiovascular development and disease

Intravascular imaging (IVI) was introduced 35 years ago to assess coronary artery pathology and plaque vulnerability. However, from its first applications it became apparent that it can also be useful in percutaneous coronary intervention…

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Negative / Null Result ReportMedicine

Artificial Liver Support.

Kim HK, Huang DT, Al-Khafaji A · 2026 · Journal of intensive care medicine

Acute liver failure (ALF) and acute-on-chronic liver failure (ACLF) both have high mortality rates without liver transplantation. Artificial liver support systems may benefit patients with liver failure, serving as a bridge to…

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Negative / Null Result ReportMedicine

Employing Comics Storytelling to Promote Climate Change Mitigation: An Experimental Study Grounded on the Situational Theory of Public.

Guo Y, Wei D, Xu S et al. · 2026 · Risk analysis : an official publication of the Society for Risk Analysis

This study examines the potential of comics as an infotainment strategy for engaging the public in climate change mitigation from the perspective of the situational theory of public. A 2 × 2 × 2 factorial experiment (N = 320) was conducted…

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Negative / Null Result ReportMedicine

Mpox therapeutics in the post-STOMP/PALM era.

Promer K, Brenner SB, Ostrer L et al. · 2026 · Current opinion in HIV and AIDS

Purpose of review This article reviews the evidence behind mpox antiviral therapies which are clinically available and/or or under clinical investigation. For much of the mpox epidemic, tecovirimat has been used compassionately but there…

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Negative / Null Result ReportMedicine

Neopterin Levels in Pediatric Allogeneic Hematopoietic Stem Cell Transplantation: A Potential Biomarker for Acute Graft-Versus-Host Disease?

Kirkiz Kayalı S, Deveci TS, Gülbahar Ö et al. · 2026 · Transplantation proceedings

Introduction Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative treatment for hematologic disorders. Acute graft-versus-host disease (aGVHD) remains a major cause of nonrelapse mortality. Distinguishing aGVHD from…

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Negative / Null Result ReportMedicine

Systemic Immune-Inflammation Index (SII) as a Predictive Biomarker of Therapeutic Response in Psoriasis: A Retrospective Comparative Analysis of Anti-TNF, Anti-IL-17, and Anti-IL-23 Agents.

Trovato, La Marca, Simonini et al. · 2026 · Journal of personalized medicine

Background/Objectives: The Systemic Immune-Inflammation Index (SII), derived from routine blood counts, has emerged as a potential marker of systemic inflammation in psoriasis. However, its longitudinal behavior across different systemic…

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Negative / Null Result ReportMedicine

Outcome After Surgery for Type A Intramural Hematoma.

Biancari, Dell'Aquila, Mäkikallio et al. · 2026 · Journal of cardiovascular development and disease

Background: The nature and prognosis of type A intramural hematoma (TAIMH) are not well established. In this study, we evaluated the early and late outcome after surgery for this emergency condition. Methods: The ERTAAD registry included…

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Negative / Null Result ReportMedicine

Left Ventricular Remodeling After Total Coronary Revascularization via Anterior Thoracotomy Versus Conventional Coronary Artery Bypass Grafting.

Aslan, Sural, Özçalışkan et al. · 2026 · Journal of cardiovascular development and disease

Total coronary revascularization via anterior thoracotomy (TCRAT) enables complete anatomical revascularization without sternotomy; however, data on its impact on left ventricular function remain limited. This study compared left…

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