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490 real negative results, null findings, and replication failures in Medicine · Failed Experiment Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Failed Experiment ReportOpen accessMedicine

Evaluation of quantitative polymerase chain reaction for detecting BRCA1 or BRCA2 copy number loss in high-grade serous ovarian cancer

A. J. Oswald, R. L. Hollis, M. Churchman et al. · 2026 · Scientific Reports

Abstract Copy number loss (CNL) of tumour suppressors genes, such as BRCA1/2, are frequent but under-researched tumour driver events. Accurate identification of BRCA1/2 CNL has potential therapeutic implications, particularly in high grade serous tubo-ovarian carcinoma (HGSOC), and cost-effective detection methods are desirable. This study assessed quantitative PCR (qPCR) as a method of BRCA1/2 CNL detection in HGSOC, in two patient cohorts (cohort 1 n = 355, cohort 2 n = 86) and a cell line panel (n = 10) using sequencing-based copy number (CN) assessment as a comparator (panel-based sequenci

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Failed Experiment ReportOpen accessMedicine

A multi-ingredient containing carbohydrate, proteins L-glutamine and L-carnitine attenuates fatigue perception with no effect on performance, muscle damage or immunity in soccer players.

Fernando Naclerio, Eneko Larumbe-Zabala, Robert Cooper et al. · 2015 · PLoS ONE

We investigated the effects of ingesting a multi-ingredient (53 g carbohydrate, 14.5 g whey protein, 5 g glutamine, 1.5 g L-carnitine-L-tartrate) supplement, carbohydrate only, or placebo on intermittent performance, perception of fatigue, immunity, and functional and metabolic markers of recovery. Sixteen amateur soccer players ingested their respective treatments before, during and after performing a 90-min intermittent repeated sprint test. Primary outcomes included time for a 90-min intermittent repeated sprint test (IRS) followed by eleven 15 m sprints. Measurements included creatine kina

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Failed Experiment ReportMedicine

Managing post-laminoplasty deformity after resection in of a cervical intramedullary hemangioblastoma in a 36-year-old male: a case report.

Versyck, Tollenaere, Schelfaut et al. · 2026 · Journal of spine surgery (Hong Kong)

Cervical kyphotic deformity is a recognized complication following posterior cervical spine surgery, particularly after laminectomy. However, post-laminoplasty kyphosis remains an underreported entity. We present a case of progressive…

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Failed Experiment ReportOpen accessMedicine

Clotted Apheresis Hematopoietic Stem Cell Product.

Zhuang L, Woo J, Francisco F et al. · 2024 · Journal of clinical apheresis

The majority of the time hematopoietic progenitor cells (HPC) are collected through leukapheresis, where anticoagulants are necessary to prevent clotting of the apheresis circuit and HPC product. Although clotting of the product is a…

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Failed Experiment ReportMedicine

Transposition of the right renal artery to gastroduodenal artery for management of acute, symptomatic renovascular hypertension.

Ellis, Perry, Tabbara et al. · 2026 · Journal of vascular surgery cases and innovative techniques

Renovascular hypertension can be clinically challenging to diagnose. The most common etiology remains atherosclerotic disease. When medical management fails, renal artery revascularization is considered. Since the advent of endovascular…

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Failed Experiment ReportMedicine

Role of Colchicine in Reducing Reperfusion Injury in STEMI Patients Who Undergo Primary Percutaneous Coronary Intervention: A Randomized Clinical Trial.

Karim B, Alwi I, Yamin M et al. · 2025 · Acta medica Indonesiana

Background Inflammation plays a role in ST-segment elevation myocardial infarction (STEMI), especially in reperfusion injury (RI). Colchicine, an anti-inflammatory drug, can suppress inflammation during RI. We assessed the effectiveness of…

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Failed Experiment ReportOpen accessMedicine

MMP-2 and MMP-9 as prognostic factors in ischaemic stroke

Justyna Zielińska-Turek, Grzegorz Turek, Dominika Jakubowicz-Lachowska et al. · 2016 · Aktualności Neurologiczne

Objectives: No widely available, adequately sensitive diagnostic test to establish prognosis in stroke patients has been developed thus far. The aim of this study was to analyse changes in plasma levels of MMP-9 and MMP-2 as potential prognostic factors in patients with ischaemic stroke. Methods: The study included 56 patients presenting with the signs of ischaemic stroke for less than 24 hours, and 60 healthy controls without a history of neurological and/or inflammatory disorders. Plasma concentrations of MMP-2 and MMP-9 were determined immunoenzymatically at admission (i.e. within 24 hours

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Failed Experiment ReportMedicine

Laparoscopic Hiatus Hernia Repair with BIO-A ® mesh is Safe and Effective for Patients Suffering Severe Gastro-Esophageal Reflux Disease After Sleeve Gastrectomy - A Single Surgeon Experience.

Sercombe, Frankel, Hatzifotis · 2026 · Obesity surgery

There is a complex relationship between gastroesophageal reflux disease (GORD), hiatus hernia, obesity, and metabolic bariatric surgery. We report the outcomes of laparoscopic hiatus hernia repair (HHR) with BIO-A ® mesh in the…

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Failed Experiment ReportMedicine

Establishing the Minimum Future Liver Remnant Volume for Safe Hepatectomy.

Steinharter JA, Chou J, Ilagan CH et al. · 2026 · Journal of the American College of Surgeons

Background An adequate future liver remnant volume (FLRV%) reduces the risk of posthepatectomy liver failure (PHLF). This study evaluates (1) the association of FLRV% with grade 4/5 morbidity and (2) the safe FLRV% threshold for PHLF- and…

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Failed Experiment ReportOpen accessMedicine

Severe pneumococcal hemolytic uremic syndrome in an 8-month-old girl

Tahar Gargah, Majda Cherif, Rim Goucha-Louzir et al. · 2012 · Saudi Journal of Kidney Diseases and Transplantation

The hemolytic uremic syndrome (HUS), characterized by microangiopathic hemolytic anemia, thrombocytopenia and acute renal failure, represents one of the major causes of acute renal failure in infancy and childhood. The typical form occurring after an episode of diarrhea caused by Escherichia coli is the most frequent in children. Other microorganisms also may be responsible for HUS, such as Streptococcus pneumoniae, which causes more severe forms of the disease. We report an 8-month-old girl who presented with pneumonia and subsequently developed HUS. Renal biopsy showed characteristic lesion

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Failed Experiment ReportOpen accessMedicine

Efficacy assessment of a novel endolysin PlyAZ3aT for the treatment of ceftriaxone-resistant pneumococcal meningitis in an infant rat model.

Luca G Valente, Ngoc Dung Le, Melissa Pitton et al. · 2022 · PLoS ONE

Background Treatment failure in pneumococcal meningitis due to antibiotic resistance is an increasing clinical challenge and alternatives to antibiotics warrant investigation. Phage-derived endolysins efficiently kill gram-positive bacteria including multi-drug resistant strains, making them attractive therapeutic candidates. The current study assessed the therapeutic potential of the novel endolysin PlyAZ3aT in an infant rat model of ceftriaxone-resistant pneumococcal meningitis. Methods Efficacy of PlyAZ3aT was assessed in a randomized, blinded and controlled experimental study in infant Wis

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Failed Experiment ReportMedicine

Dreaming up scale invariance via inverse renormalization group.

Rançon A, Rançon U, Ivek T et al. · 2026 · Physical review. E

We explore how minimal neural networks can invert the renormalization group (RG) coarse-graining procedure in the two-dimensional Ising model, effectively dreaming up microscopic configurations from coarse-grained states. This task,…

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Failed Experiment ReportMedicine

Failed air enema reduction leading to the diagnosis of small-bowel intussusception secondary to Meckel's diverticulum with ectopic gastric mucosa in a 5-month-old infant: A case report.

Wang, Yu · 2026 · SAGE open medical case reports

A 5-month-old infant presented with paroxysmal crying and vomiting for more than 4 h. Ultrasonography confirmed intussusception in the right abdomen, but intraluminal gas limited precise classification. On the assumption of…

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Failed Experiment ReportOpen accessMedicine

Does the Fissure Last Technique Really Reduce Postoperative Airleak After Lung Resection? Results From a Prospective Randomized Controlled Trial.

Vaisitti F, Sobrero S, Rudella S et al. · 2026 · Interdisciplinary cardiovascular and thoracic surgery

Objectives The fissure last (FL) technique described in 1998 has the goal of minimizing postoperative airleak leaving the stapling of the fissure as the last step. The aim of this study was the reduction in airleak may be already evident…

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Failed Experiment ReportMedicine

Survival impact of adjuvant capecitabine in triple-negative breast cancer Latin American patients with residual disease: a real-world study.

Graciano N, López L, Rodriguez CA et al. · 2025 · Breast cancer research and treatment

Purpose Patients with triple-negative breast cancer (TNBC) who do not achieve pathological complete response (non-pCR) after neoadjuvant chemotherapy (NACT) have a high-risk of relapse. While adjuvant capecitabine (AdjCape) has…

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Failed Experiment ReportOpen accessMedicine

Effects of ischemic conditioning on head and neck free flap oxygenation: a randomized controlled trial

Se-Hee Min, Suk Hyung Choe, Won Shik Kim et al. · 2022 · Scientific Reports

Abstract Flap failure after microvascular reconstructive surgery is a rare but devastating complication caused by reperfusion injury and tissue hypoperfusion. Remote ischemic conditioning (RIC) provides protection against ischemia/reperfusion injury and reduces tissue infarction. We hypothesized that RIC would enhance flap oxygenation and exert organ-protective effects during head and neck free flap reconstructive surgery. Adult patients undergoing free flap transfer surgery for head and neck cancer were randomized to receive either RIC or sham-RIC during surgery. RIC consisted of four cycles

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Failed Experiment ReportOpen accessMedicine

A biomechanical investigation comparing a novel bone cement bridging screw system with conventional treatment methods for Kummell’s disease

Yi Zhan, Huiming Yang, Jiangtao Wang et al. · 2024 · Scientific Reports

Abstract Based on the characteristics of Kummell’s disease (KD) and related anatomical structures of the thoracolumbar spine, a novel bone cement screw system has been designed to effectively avoid the cement loosening and displacement. This experiment aimed to assess the biological effects of the novel bone cement screw system in KD on fresh cadaveric thoracolumbar spine specimens, thereby discussing its potential application value and providing a foundation for clinical implementation. This study employed a total of 50 fresh female adult cadaver specimens. Each specimen underwent extraction

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Failed Experiment ReportOpen accessMedicine

Caesarean myomectomy in Kano northern Nigeria

Omole-ohonsi A, Ashimi AO · 2008 · Ibom Medical Journal

Objective: To evaluate the feasibility and outcome of caesarean myomectomy. Patients and Methods: A retrospective study of cases of caesarean myomectomy at the Aminu Kano Teaching Hospital, Kano, Nigeria, a tertiary health facility in a developing country between January 1998 and December 2004. Outcome Measures: Age and parity of the women, number, size and location of fibroids, duration of operation, estimated blood loss, postoperative complications and duration of hospital stay. Results: Sixteen cases of caesarean myomectomy were done during the study period using the tourniquet method. It i

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