11,322 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Miguéns MV, Quintela-Vilariño C, Casado S et al. · 2026 · Life sciences
Scope Global increase in obesity and metabolic syndrome has led to a marked rise in comorbidities, with liver disease emerging as a major concern. Metabolic dysfunction-associated fatty liver disease (MAFLD) affects over 30% of the…
View details →Martins DS, Demasi M, de Lima Bellan D et al. · 2025 · Biochemical and biophysical research communications
The development of resistance by tumor cells is a challenge in cancer treatment; either in chemotherapy, immunotherapy and targeted therapy. Proteasome can be considered a promising therapeutic target, as it is considered the key to the…
View details →Pavicich MA, Maldonado ML, Nguyen TN et al. · 2025 · International Journal of Food Microbiology
Apple fruit is widely consumed worldwide, but fungal contamination in the postharvest stage presents a significant food safety concern. This study evaluates the production and accumulation of Alternaria mycotoxins, including alternariol…
View details →Hoe B, Heimbürger SMN, Gasbjerg LS et al. · 2026 · Diabetes, obesity & metabolism
Aims In type 1 diabetes, glucose-dependent insulinotropic polypeptide (GIP) increases glucagon secretion during low plasma glucose and improves time in the glycaemic range during daytime. To explore the glucose-stabilising potential of GIP…
View details →Seekings AH, Billington E, Mahmood S et al. · 2026 · Virology
H7N7 low-pathogenicity avian influenza virus (H7N7-LPAIV) incursions preceded emergence of H7N7 high-pathogenicity (HP)AIV at several European layer hen outbreaks. Evidence from a UK layer H7N7-HPAIV (2008) outbreak informed in vivo…
View details →Carvalho AVS, Hoeper ES, Dúran-Carabali LE et al. · 2026 · The Journal of nutritional biochemistry
Neonatal hypoxia-ischemia (HI) is one of the main causes of perinatal death and is commonly associated with neurological damage which are usually observed on motor and cognitive domains. Plinia trunciflora or "jabuticaba" is a native…
View details →Nair-Shalliker V, Smith DP, Gebski V et al. · 2026 · British journal of cancer
Background The ProsD trial aimed to determine if oral vitamin D supplementation could prevent prostate cancer (PC) progression in men on active surveillance (AS). Methods ProsD is a phase-II double-blinded randomized trial of newly…
View details →Gu Q, Silva CS, Twaddle NC et al. · 2026 · International journal of molecular sciences
Arsenic induces apoptosis in both cancerous and non-cancerous cells. The mechanism of arsenic-induced apoptosis is complex. We previously demonstrated that the antioxidant acetyl L-carnitine prevented sodium arsenite-induced apoptosis in…
View details →Lankinen T, Leinonen S, Ikäheimo K et al. · 2025 · Neurobiology of aging
Hallmarks of sensorineural hearing loss are elevated hearing thresholds and defects in temporal auditory processing, the former being often caused by outer hair cell (OHC) damage, and the latter by the loss of synapses between inner hair…
View details →Vilela WR, Platt N, Bechara LRG et al. · 2025 · Molecular neurobiology
Microglia exhibit targeted responses to different stimuli, including lipids, which can differ depending on the environmental conditions they encounter. These responses involve inflammatory mediators and are crucial for maintaining brain…
View details →Pohoreski KT, Galante G, Pajunen K et al. · 2026 · JPGN reports
We present a novel case of gastrointestinal strictures in a young girl with Satoyoshi syndrome (SS), highlighting multi-system features of alopecia universalis, painful muscle cramps with dystonia, aberrant growth velocity, and skeletal…
View details →Oger R, Hulet C, Tripon M et al. · 2026 · Orthopaedics & traumatology, surgery & research : OTSR
Introduction Fracture of ceramic components in total hip arthroplasty (THA), although rare, remains a major concern. The optimal bearing choice in revision surgery following such fractures is still debated. Few studies have specifically…
View details →Alkhabbaz A, Alnaqeeb A, Alabduljader F et al. · 2025 · Cureus
Introduction The placenta is a transient pregnancy organ, and its development depends on proliferation and apoptosis throughout pregnancy. Abnormal placental development can result in intrauterine growth restriction (IUGR). Progesterone…
View details →Lauxen JR, Callegari-Jacques SM, Mombelli AS et al. · 2025 · The journal of contemporary dental practice
Aims To assess the effect of dental application of oral probiotics containing Streptococcus salivarius K12 and Lactobacillus brevis CD2 on preventing secondary bacterial pneumonia in patients with severe COVID-19. Materials and methods In…
View details →Biswas S, Casteels I, Bremond-Gignac D et al. · 2025 · Ophthalmology and therapy
Introduction Cystinosis is a multisystemic disease manifesting in the eyes initially as asymptomatic corneal cystine crystals and later with photophobia and serious visual impairment. Systemic effects of cystinosis arise from multiple…
View details →Diedrich CR, Rutledge T, Gleim JL et al. · 2026 · JCI insight
Coinfection with both HIV and M. tuberculosis (Mtb) results in disseminated tuberculosis (TB) and accelerated HIV progression. Despite greater access to antiretroviral treatment (ART), it remains unclear whether suppression of HIV…
View details →Anderson P, Zhou H, Patton V et al. · 2025 · International journal of orthopaedic and trauma nursing
Background Pressure injuries are a worldwide concern for patients in the acute hospital setting. They are a common hospital-acquired complication and Australian national standards, state policies, and local procedures have been developed…
View details →Mori K, Asahi T, Kataoka K et al. · 2025 · Biochemical and biophysical research communications
Mechanical stretch critically influences skeletal muscle physiology, yet its role in myoblast differentiation and the associated molecular mechanisms have not been fully clarified. This study investigated the effects of uniaxial cyclic…
View details →Khajehzadehshoushtar S, Delfinis LJ, Rahman FA et al. · 2025 · The Journal of physiology
The degree to which mitochondrial-linked programmed cell death pathways contribute to skeletal muscle atrophy during cancer remains unknown. Here we combined a novel and robust mouse model of metastatic ovarian cancer with chronic…
View details →Yin R, Fredenburgh JC, Weitz JI · 2025 · Journal of thrombosis and haemostasis : JTH
Background Milvexian, an oral factor (F)XIa inhibitor, is undergoing phase 3 evaluation for acute coronary syndrome. Such patients often require percutaneous coronary intervention (PCI). The PCI catheters trigger clotting by inducing…
View details →Drumeva GO, Plane AF, Petrenyov DR et al. · 2026 · Cardio-oncology (London, England)
BACKGROUND: Ivabradine (IVAB) is an effective drug in patients with heart failure (HF). However, data in the context of chemotherapy-induced cardiomyopathy are limited. This study investigated the cardioprotective potential of IVAB in a…
View details →Romanelli MA, Nogueira-Souza PD, Gomes DS et al. · 2026 · ACS omega
Snakebite-induced acute kidney injury (sAKI) is a severe clinical complication associated with Bothrops envenomation that can lead to kidney failure. Alternative therapies are needed due to the limitations of antivenom, including variable…
View details →Vercalsteren E, Karampatsi D, Buizza C et al. · 2025 · Nutrients
Background/objectives : Being overweight increases the predisposition to obesity and type 2 diabetes (T2D), which significantly elevate stroke risk and the likelihood of severe post-stroke disability. Dietary nitrate (NO 3 - )…
View details →Gutfreund N, Tuppi M, Schäfer B et al. · 2025 · Reproduction (Cambridge, England)
In brief Induction of DNA double-strand breaks results in oocyte death caused by the activation of TAp63α. This study investigates which chemotherapeutic drugs activate p63 and which cause oocyte death without p63 activation. Abstract…
View details →Guzzo I, Becilli M, Cappoli A et al. · 2025 · Pediatric nephrology (Berlin, Germany)
Background High panel reactive antibody (PRA) titers are a significant challenge for patients undergoing kidney transplantation. Currently, no desensitization protocol has proven effective in preventing mid- and long-term graft loss. In…
View details →Hinks A, Vlemmix E, Power GA · 2025 · The journals of gerontology. Series A, Biological sciences and medical sciences
The age-related loss of muscle mass is partly driven by a reduction in serial sarcomere number (SSN), and further SSN loss occurs during immobilization. Serial sarcomere number is associated with optimal force and power production and…
View details →Matienzo ME, Lee J, Lim S et al. · 2025 · American journal of physiology. Cell physiology
Glucocorticoids (GCs) are potent regulators of energy balance and adipose tissue function, making them attractive targets for obesity treatments. The local activation and inactivation of GCs are mediated by two key enzymes:…
View details →Czarnota P, Gromowski T, Golda A et al. · 2026 · Cell communication and signaling : CCS
Liver cancer often arises in the setting of chronic liver disease and remains a major global health challenge with limited effective treatments. Isoprenylcysteine Carboxyl Methyltransferase (ICMT) is an enzyme that catalyzes the…
View details →Ricalde A, Chen JW, Lim LJ et al. · 2025 · Pediatric dentistry
Purpose: To investigate the color difference between groups and changes over time of resin-modified glass ionomer (RMGI) restorations placed immediately after silver diammine fluoride (SDF) treatment. Methods: Thirty-six specimens were…
View details →Berger L, Mulder E, Zange J et al. · 2025 · Medicine and science in sports and exercise
Purpose During spaceflight, countermeasures are crucial to counteract cardiorespiratory and musculoskeletal deconditioning, similar to effects seen after prolonged immobilization. Within a bed rest study simulating the effects of…
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