11,417 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Yang H, Dai T, Wolf RM · 2026 · NPJ digital medicine
Artificial intelligence (AI) is increasingly used for diagnostic screening. In diabetic retinopathy screening, autonomous AI systems can identify disease without a specialist. However, patient trust in AI remains a challenge, and it…
View details →Roy C, Ouellet DR, Pellerin D et al. · 2026 · Journal of dairy science
The current experiment studied 2 situations proposed to lead to decreased milk protein yield (MPY). First, NRC (2001) predicts that substitution of soybean meal (SBM) by canola meal (CM) decreases MP supply, thereby negatively affecting…
View details →Jing S, Wang J, Cheng S et al. · 2026 · Toxicon : official journal of the International Society on Toxinology
Voltage-gated sodium channels (VGSCs) are emerging therapeutic targets for cancers including neural tumors such as neuroblastomas and gliomas. BmK IT2, a neurotoxic polypeptide from the scorpion Buthus martensii Karsch, is a known…
View details →Onu CJ, Adu M, Jabbar D et al. · 2026 · Biochimica et biophysica acta. Molecular and cell biology of lipids
Inositol is an essential metabolite required for membrane biogenesis, cell signaling and trafficking, and gene expression. Its importance is underscored by the fact that inositol depletion leads to death in eukaryotic cells ranging from…
View details →Tiburcio MA, Cali MP, Pereira LMB et al. · 2026 · Dalton transactions (Cambridge, England : 2003)
Amyloid deposits of amyloid-β (Aβ) and hyperphosphorylated tau are pathological hallmarks of Alzheimer's disease (AD), which accounts for most dementia cases worldwide. This study investigates the effect of the complex [Ru(phen) 2 (pNDIp)]…
View details →Sevim B · 2026 · Tropical animal health and production
This study investigated the effects of dietary supplementation with fermented black garlic powder on performance, carcass characteristics, serum parameters, immunological responses and antioxidant status in male Japanese quail. A total of…
View details →Silva ACD, Varela Junior AS, França RT et al. · 2026 · Cell biochemistry and function
Lectins are carbohydrate-binding proteins that recognize specific glycan patterns on cell surfaces and have been increasingly explored as analytical tools in reproductive biology. This study characterized the interaction of a lectin…
View details →Wang NN, Luo CJ, Liu LG et al. · 2026 · Ying yong sheng tai xue bao = The journal of applied ecology
Litter decomposition is a core process regulating the formation and stability of soil organic carbon. Under the background of climate warming, the intrinsic mechanisms by which the expansion of alpine shrubs affects carbon balance of…
View details →Gokdemir MT, Gokdemir GS · 2026 · BMC infectious diseases
Background Studies have reported that the Coronavirus Disease 2019 (COVID-19) vaccine causes other serious health problems, including myocarditis, pericarditis, neurological problems, and problems resulting from the reactivation of chronic…
View details →Shehata MA, Khirallah MG, Al Nafesa A et al. · 2026 · Pediatric surgery international
Purpose To evaluate whether routine omentectomy improves outcomes during laparoscopic placement of peritoneal dialysis (PD) catheters in children. Methods This multicenter retrospective study included children ≤ 5 years who underwent…
View details →Matsuoka C, Takatama N, Muraoka T et al. · 2026 · Genes and environment : the official journal of the Japanese Environmental Mutagen Society
Background Previous research using the Ames assay showed that licoricidin (LCD) and isoliquiritigenin (ILTG) can block mutations caused by N-methyl-N-nitrosourea (MNU) in Salmonella typhimurium (S. typhimurium) TA1535. With the aim to…
View details →Loayza J, Taylor CJL, Renstrom JG et al. · 2026 · eNeuro
Tourette syndrome (TS) has been linked to reduced GABAergic inhibition, the so-called neural disinhibition, in the dorsal striatum. Dorsal striatal neural disinhibition in animal models, caused by local microinfusion of GABA-A receptor…
View details →Caenepeel C, Deleu S, Vazquez Castellanos JF et al. · 2025 · Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
Background & aims Rigorous donor preselection on microbiota level, strict anaerobic processing, and repeated fecal microbiota transplantation (FMT) administration were hypothesized to improve FMT induction of remission in ulcerative…
View details →Gathirua-Mwangi W, Martin H, He D et al. · 2025 · The oncologist
Background Real-world data are limited for patients with brain metastases secondary to metastatic breast cancer (MBC) and treated with cyclin-dependent kinase 4/6 inhibitors (CDK4/6i). This study describes real-world outcomes in patients…
View details →Ogasawara F, Minami Y, Chi S et al. · 2026 · International journal of hematology
Mutant TP53 (mTP53) variants are diverse, and residual wild-type p53 function (functional, non-functional), gain-of-function (GOF) mTP53, and the number of mTP53 (single-hit, multi-hit) can affect prognosis. We used next-generation…
View details →Fattahi Z, Talakesh T, Kheiri S et al. · 2026 · Recent advances in inflammation & allergy drug discovery
Introduction/objective In children affected by allergic proctocolitis, impaired weight gain and developmental failure to thrive can be a prominent manifestation. However, it remains unclear whether the association between White Blood Cell…
View details →Baillon A, Bleichrodt H, Granic GD · 2026 · Medical decision making : an international journal of the Society for Medical Decision Making
BackgroundHealth state utility measurements are central in health policy and medical decision making. Common methods are the standard gamble (SG) and the time tradeoff (TTO). They typically use hypothetical questions. It is unknown whether…
View details →Kim DI, Lagravère MO, Almeida F et al. · 2026 · The Angle orthodontist
Objectives To characterize functional changes of the airway while wearing an appliance simulating severe arch constriction using level 3 polysomnography. Materials and methods For this pilot, single-blinded prospective randomized…
View details →Nakamura M, Nishioka Y, Akamatsu N et al. · 2026 · Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Biliary cast syndrome (BCS) remains a significant concern that can lead to graft failure and mortality. Data on the etiology and outcomes are limited, particularly with regard to the differences in the risk of occurrence of BCS between…
View details →Bottura RM, Fassone M, Avanzino L et al. · 2026 · Neuroscience
Previous studies on motor imagery (MI) suggest that the more similar the imagined and actual movement contexts are, the better the imagery quality. Thus, one might hypothesize that for movements performed within a medium, MI is more…
View details →Ganeyan A, Ganesh CB · 2026 · Neuropeptides
Galanin (GAL), a neuropeptide produced in both the central and peripheral nervous systems, is implicated in various physiological processes, including reproduction in vertebrates. Yet, the role of GAL is not understood in reptilian…
View details →Alencar TS, Santos MO, Schneider VMM et al. · 2026 · Brain research
Systemic inflammation triggers a set of physiological and behavioral changes known as sickness behavior, including fever and hypolocomotion. Previous studies demonstrated that lipopolysaccharide (LPS) induces these responses in both sexes,…
View details →Fonseca AJM, Cabrita ARJ · 2026 · JDS communications
This study evaluated the effects of replacing soybean hulls with exhausted olive pomace (EOP) on feed intake, milk production and composition, and rumen fermentation parameters. A cyclical changeover design experiment was used with 4…
View details →Muroi M, Fukuda S, Takahashi M et al. · 2026 · The Journal of reproduction and development
Our previous study in hamsters indicated that progesterone (P) induces enhancement of spermatozoal hyperactivation, while 17β-estradiol (Eβ) and γ-aminobutyric acid (GABA) suppress this enhancement. Since P has also been shown to enhance…
View details →De Bruyn L, Van Beek F, Vander Perre S et al. · 2026 · Molecular and cellular endocrinology
Background Sepsis HDL- and LDL-hypocholesterolemia associate with adverse outcomes, but whether this necessitates supplementation or merely reflects disease severity remains unclear. We hypothesize that sustained hypocholesterolemia can…
View details →Gao J, Savegnago CG, Marins TN et al. · 2026 · Journal of dairy science
This study evaluated the effects of different vaccination schedule and oral administrating a nonsteroidal anti-inflammatory drug (NSAID) around dry-off on systemic inflammation, immune responses, behaviors during the early dry period, and…
View details →Gackowska K, Krejmer-Rabalska M, Drazkowska K et al. · 2025 · Virology
Virus-like particles (VLPs) have long been utilized as immunogens to prevent infectious diseases. Particles derived from the small surface proteins of the hepatitis B virus (sHBsAg) can self-assemble into small, highly immunogenic…
View details →Hashimoto N, Wakimoto Y, Kusama T et al. · 2026 · Therapeutic drug monitoring
Background Pycsim, a dosing software for linezolid (LZD) based on Bayesian estimation, predicts dosing in the therapeutic drug monitoring (TDM) of LZD. However, its predictive performance, examined using an independent data set with a…
View details →Lou Y, Yang T, Xia C et al. · 2026 · Molecular and cellular endocrinology
Steroid hormone synthesis in granulosa cells (GCs) is crucial for normal follicular development and ovulation. Emerging evidence suggests that copper (Cu), a trace element, influences hormone secretion in yak granulosa cells (YGCs);…
View details →Alipour A, Ganjkhanlou M, Zali A et al. · 2026 · Scientific reports
The pre-weaning period is critical because early-life nutrition and management influence growth, metabolic function and Rumen development, thereby affecting subsequent productivity in dairy calves. Zinc (Zn) supplementation plays a key…
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