11,322 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Deng SM, Chen YJ, Hung WC et al. · 2026 · Translational psychiatry
Anxiety is a common mental health disorder marked by heightened stress responses and impaired emotional regulation. While the hippocampus and the hypothalamic-pituitary-adrenal (HPA) axis play key roles in regulating anxiety, the molecular…
View details →Najafi A, Nosaka K, Javidi M et al. · 2026 · Journal of strength and conditioning research
Abstract Najafi, A, Nosaka, K, Javidi, M, Naddafha, S, Kumagawa, D, Bertochi, GFA, and Latella, C. Acute effects of accentuated eccentric loading in comparison to traditional resistance loading on velocity and other parameters in…
View details →Goonasekera MA, Malijan GB, Sardell RJ et al. · 2026 · American journal of nephrology
Introduction Sacubitril/valsartan shows benefits in heart failure and may have kidney protective effects. Its impact on kidney tubular health in chronic kidney disease (CKD) remains unclear. We evaluated the effects of sacubitril/valsartan…
View details →Asnicar D, Jonah L, Kingsbury M et al. · 2026 · The Science of the total environment
Salmon farming represents a significant economic sector on both Canada's Atlantic and Pacific coasts. To manage sea lice outbreaks, medicated feeds containing emamectin benzoate (EMB) are commonly applied. Because EMB is poorly soluble and…
View details →Hauptmann E MD, Whitlock R MD, Yeganeh S MD et al. · 2026 · The Journal of surgical research
Introduction Sternal-sparing left ventricular assist device (ssLVAD) insertion avoids the morbidity of median sternotomy for patients with heart failure. Obesity may present challenges in this minimal access operation. We present our…
View details →Yegin Katran Z, Argın Ö, Bulut İ · 2026 · The Journal of asthma : official journal of the Association for the Care of Asthma
Background Severe asthma is frequently associated with recurrent exacerbations and prolonged systemic corticosteroid use, which may lead to secondary immunodeficiency (SID). In addition, unrecognized primary immunodeficiencies (PIDs) may…
View details →Mourikes VE, Lee C, Oladosu JI et al. · 2025 · Reproductive toxicology (Elmsford, N.Y.)
Imidacloprid (IMI) is an insect-selective synthetic nicotine derivative used in commercial agricultural systems, home gardening, and veterinary pharmaceuticals. People are exposed to IMI through consumption of contaminated food and water…
View details →Fujita E, Hadano J, Hashimoto J et al. · 2026 · Behavioural brain research
Neural circuit formation through synaptogenesis plays a crucial role in learning, memory, and the recovery of neural function following brain dysfunction. We previously reported that administering the low-dose cardiac glycoside digoxin,…
View details →Lin CJ, Bosco AA, Alves LI et al. · 2026 · Scientific reports
Long-COVID-19 presentation has not been evaluated with proper depth in patients with diabetes (DM). This retrospective study evaluated 870 patients (320 DM, 550 non-DM) followed for up to 7.1 months post-hospitalization. Acute myocardial…
View details →Vincová A, Šantová K, Jaššo M et al. · 2026 · Journal of dairy science
The objective of this study was to evaluate the effect of citrus fiber (1% wt/wt) on the physicochemical, rheological, textural, tribological, and sensory properties of quark cheese spreads with different fat content (10%, 15%, and 20%…
View details →Meisinger BD, Coufal CD, Olson EG et al. · 2026 · Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes
Reducing microbial contamination during late-stage incubation is important for hatchery sanitation and early chick microbial exposure. Formaldehyde is commonly applied in commercial hatchers to reduce airborne and eggshell-associated…
View details →Urbaniec J, Anagnostopoulos A, Davies P et al. · 2026 · Journal of dairy science
Bovine coronavirus (BCV) is a common calf pathogen and has been proposed as a potential contributor to bovine respiratory disease (BRD); however, little is known about its epidemiology and genetic diversity on UK farms. The aim of this…
View details →Jamnick NA, Livingston PD, Gammon CJ et al. · 2026 · Frontiers in medicine
Background Cancer cachexia is a multifactorial metabolic syndrome marked by progressive skeletal muscle loss, reduced function, and increased mortality. Mitochondrial dysfunction is a key driver of this phenotype. MOTS-c, a…
View details →Coelho JA, Gomes KS, Cerchiaro G · 2026 · International journal of molecular sciences
Endometriosis is associated with oxidative stress and debilitating symptoms, yet its pathophysiology remains incompletely understood, and current treatments are still limited. In this study, oxidative stress responses were compared in 2D…
View details →Pottorf TS, Lane EL, Haley-Johnson Z et al. · 2026 · The Journal of neuroscience : the official journal of the Society for Neuroscience
Spinal cord ventral horn microglia proliferate after nerve injuries and migrate toward cell bodies of injured motoneurons (MNs) enwrapping them. The significance of this microglia reaction has remained unclear. Moreover, some injured MNs…
View details →Scioli MV, Sosa E, Barale J et al. · 2026 · Veterinary immunology and immunopathology
Bovine genital campylobacteriosis (BGC) remains a major cause of reproductive failure in beef cattle systems. This study evaluated the persistence of Campylobacter fetus subsp. venerealis (Cfv) and associated lesions in the reproductive…
View details →Ormes JA, Smrcka AV, Jutkiewicz EM · 2026 · Molecular pharmacology
The clinical utility of μ-opioid receptor (MOR) agonists is limited by side effects and tolerance. G protein βγ subunits (Gβγ) are critical mediators of MOR signaling that not only drive anticonception but also regulate phospholipase C and…
View details →Sigaard JVA, Spindler H, Joensen EDR et al. · 2026 · Journal of palliative medicine
Background An estimated 4.4 million people in Europe require palliative care annually, a number expected to rise with population aging. Telepalliative care (TPC) has been practiced in various settings over the past two decades. The Telepal…
View details →AhmadQaderi F, Pazouki A, Pishgahroudsari M et al. · 2026 · Obesity surgery
BACKGROUND: Metabolic-bariatric surgery (MBS) is recognized as the most effective long-term intervention for obesity and its associated conditions, including type 2 diabetes mellitus (T2DM) One-anastomosis gastric bypass (OAGB), the third…
View details →Del-Ángel-Monroy S, Rodríguez-Márquez A, Orozco-Suárez S et al. · 2026 · Basic & clinical pharmacology & toxicology
Vascular relaxation induced by 5-HT 2B receptor is thought to be mediated by stimulation of endothelial nitric oxide synthase (eNOS), but this assumption still requires investigation. To investigate potential mechanisms, BW723C86 (5-HT 2B…
View details →Torres-Huerta A, Ruley-Haase K, Boger-May A et al. · 2026 · Journal of immunology (Baltimore, Md. : 1950)
The cause of inflammatory bowel disease (IBD) is not known, but both innate and adaptive immunity contribute to IBD pathogenesis. To better understand the contributions of innate immunity to IBD, we have generated a mouse model of IBD that…
View details →Aragone L, Burbano P, Cameron A et al. · 2026 · Annals of surgical treatment and research
Purpose A Suffocating Neck Hematoma (Snh) Is A Rare But Potentially Fatal Surgical Complication Of Thyroidectomy. In An Effort To Reduce Its Incidence, Many Surgeons Opt For The Selective Use Of Drains. However, There Are No Studies…
View details →Szlufik S, Duszyńska-Wąs K, Koźmińska A et al. · 2026 · Neurologia i neurochirurgia polska
Introduction Bilateral subthalamic nucleus deep brain stimulation (DBS STN) is a very effective surgical method of treating motor symptoms in Parkinson's disease (PD) patients. The long-term cognitive outcome after the surgery is still…
View details →Piślewska-Bednarek M, Czerniawski P, Kuczewska S et al. · 2026 · Phytochemistry
Glucosinolates (GLs) are sulfur-containing specialized metabolites from plants representing the Brassicales order. They can be derived from several amino acids through a complex biosynthetic pathway. The majority of steps on this pathway…
View details →Wang X, Xi Q, Zhuang Q et al. · 2026 · Clinical nutrition ESPEN
Background & aims Malnutrition complicates recovery in gastrectomy patients, worsened by adjuvant chemotherapy and linked to poorer outcomes. However, evidence regarding the influence of Oral Nutritional Supplements (ONS) on skeletal…
View details →Barney DE Jr, Panik KN, Michalak J et al. · 2026 · The Journal of nutrition
Background When glucose (GLU) is consumed during endurance exercise in an energy deficit state (DEF), exogenous carbohydrate oxidation is lower than in energy balance (BAL). Whether consuming multiple transportable carbohydrates, such as…
View details →Agarwal A, Iqbal MZ, Bhalla S · 2026 · Journal of clinical orthopaedics and trauma
Background Prophylactic trochanteric epiphyseodesis is commonly performed with proximal femoral varus osteotomy in Perthes disease to reduce relative trochanteric overgrowth. However, its effectiveness, particularly in children at the…
View details →Thomou Z, Dovas CI, Poutahidis T et al. · 2026 · Viral immunology
Maternal antibodies protect mink kits early in life, but their duration and impact on subsequent SARS-CoV-2 exposure remain unclear. We longitudinally characterized passive immunity in kits born to mothers previously infected with lineage…
View details →Suárez F, Couso-Queiruga E, Osorio J et al. · 2026 · Clinical implant dentistry and related research
Objectives The objective of this ex vivo investigation was to study the significance of barrier membrane application on graft stability across different peri-implantitis-related bone defect configurations. Materials and methods Fresh pig…
View details →Zhu C, Zhu Y, Gao H et al. · 2026 · Current microbiology
This study evaluates the long-term conservation of humid earthen archaeological sites using protective shelters and plant essential oil treatments at the Laohuling Dam (Liangzhu, China), a UNESCO World Heritage site. Over seven years…
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