Negative / Null Result ReportOpen accessMedicine
Marie Fallon, Maciej Sopata, Erika Dragon et al. · 2023 · The Oncologist
BACKGROUND: This phase III, randomized, double-blind, placebo-controlled, parallel-group study assessed the efficacy and safety of tanezumab in subjects with cancer pain predominantly due to bone metastasis receiving background opioid…
View details →Negative / Null Result ReportOpen accessMedicine
Akiyoshi Hagiwara, Noriko Tanaka, Tatsuki Uemura et al. · 2016 · BMJ Open
OBJECTIVE: To determine whether treatment with recombinant human thrombomodulin (rhTM) increases survival among patients with severe septic-induced disseminated intravascular coagulation (DIC). DESIGN: Single-centre, open-label, randomised…
View details →Negative / Null Result ReportOpen accessMedicine
Charles Sharp, Huzaifa Adamali, Ann Millar · 2017 · ERJ Open Research
Idiopathic pulmonary fibrosis (IPF) has an unpredictable course and prognostic factors are incompletely understood. We aimed to identify prognostic factors, including multidimensional indices from a significant IPF cohort at the Bristol…
View details →Negative / Null Result ReportOpen accessMedicine
Agatha Lenartowicz, Holly Truong, Giulia C. Salgari et al. · 2019 · Journal of Child Psychology and Psychiatry
BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is associated with working memory (WM) deficits. However, WM is a multiprocess construct that can be impaired through several pathways, leaving the source of WM impairments in…
View details →Negative / Null Result ReportOpen accessMedicine
Christoph Rochlitz, Martin Bigler, Roger von Moos et al. · 2016 · BMC Cancer
BACKGROUND: Adding bevacizumab to chemotherapy improves response rates and progression-free survival (PFS) in metastatic breast cancer (mBC). We aimed to demonstrate decreased toxicity with metronomic chemotherapy/bevacizumab compared with paclitaxel/bevacizumab. METHODS: This multicenter, randomized phase III trial compared bevacizumab with either paclitaxel (arm A) or daily oral capecitabine-cyclophosphamide (arm B) as first-line treatment in patients with HER2-negative advanced breast cancer. The primary endpoint was the incidence of selected grade 3-5 adverse events (AE) including: febrile
View details →Negative / Null Result ReportMedicine
Larisa I. Labzin, Keng Yih Chew, Kathrin Eschke et al. · 2023 · Science Signaling
Macrophages are key cellular contributors to the pathogenesis of COVID-19, the disease caused by the virus SARS-CoV-2. The SARS-CoV-2 entry receptor ACE2 is present only on a subset of macrophages at sites of SARS-CoV-2 infection in…
View details →Negative / Null Result ReportOpen accessMedicine
Jessica J. Harrison, David Warrilow, Breeanna J. McLean et al. · 2016 · Viruses
The discovery and characterisation of new mosquito-borne viruses provides valuable information on the biodiversity of vector-borne viruses and important insights into their evolution. In this study, a broad-spectrum virus screening system, based on the detection of long double-stranded RNA in inoculated cell cultures, was used to investigate the presence of novel viruses in mosquito populations of northern Australia. We detected and isolated a new virus (tentatively named Parry's Lagoon virus, PLV) from Culex annulirostris, Culex pullus, Mansonia uniformis and Aedes normanensis mosquitoes that
View details →Negative / Null Result ReportOpen accessMedicine
Florence T.H. Wu, Ping Xu, Annabelle Chow et al. · 2018 · British Journal of Cancer
There are phase 3 clinical trials underway evaluating anti-PD-L1 antibodies as adjuvant (postoperative) monotherapies for resectable renal cell carcinoma (RCC) and triple-negative breast cancer (TNBC); in combination with antiangiogenic VEGF/VEGFR2 inhibitors (e.g., bevacizumab and sunitinib) for metastatic RCC; and in combination with chemotherapeutics as neoadjuvant (preoperative) therapies for resectable TNBC. This study investigated these and similar clinically relevant drug combinations in highly translational preclinical models of micro- and macro-metastatic disease that spontaneously de
View details →Negative / Null Result ReportOpen accessMedicine
Phitsinee Thipubon, Chairat Uthaipibull, Sumalee Kamchonwongpaisan et al. · 2015 · Malaria Journal
BACKGROUND: Iron is an essential micronutrient required by all living organisms including malaria parasites (Plasmodium spp.) for many biochemical reactions, especially growth and multiplication processes. Therefore, malaria parasite needs to take up the iron from outside or/and inside the parasitized red blood cells (PRBC). Iron chelators are widely used for the treatment of thalassaemia-related iron overload and also inhibit parasite growth at levels that are non-toxic to mammalian cells. METHODS: Inhibitory effect of 1-(N-acetyl-6-aminohexyl)-3-hydroxy-2-methylpyridin-4-one (CM1) and green
View details →Negative / Null Result ReportOpen accessMedicine
Qinfeng Huang, Junjie Shao, Shuiyun Lan et al. · 2015 · Journal of Virology
UNLABELLED: Arenaviruses cause severe hemorrhagic fever diseases in humans, and there are limited preventative and therapeutic measures against these diseases. Previous structural and functional analyses of arenavirus nucleoproteins (NPs)…
View details →Negative / Null Result ReportOpen accessMedicine
L. Kavalieris, P.J. O’Sullivan, James M. Suttie et al. · 2015 · BMC Urology
BACKGROUND: Hematuria can be symptomatic of urothelial carcinoma (UC) and ruling out patients with benign causes during primary evaluation is challenging. Patients with hematuria undergoing urological work-ups place significant clinical and financial burdens on healthcare systems. Current clinical evaluation involves processes that individually lack the sensitivity for accurate determination of UC. Algorithms and nomograms combining genotypic and phenotypic variables have largely focused on cancer detection and failed to improve performance. This study aimed to develop and validate a model inc
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Michael Mullerad, Jonatan R. A. Aguinaga, Tareq Aro et al. · 2017 · Rambam Maimonides Medical Journal
OBJECTIVE: High-power Holmium Laser (120H) has a unique modulated pulse mode, Moses™ technology. Moses technology modulates the laser pulse to separate the water (vapor bubble), then deliver the remaining energy through the bubble. Proprietary laser fibers were designed for the Moses technology. Our aim was to compare stone lithotripsy with and without the Moses technology. METHODS: We designed a questionnaire for the urologist to fill immediately after each ureteroscopy in which the Lumenis 120H was used. We compared procedures with (n=23) and without (n=11) the use of Moses technology. Surge
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Huajun Zhang, Shawn Todd, Mary Tachedjian et al. · 2012 · Journal of Virology
Herpesviruses or herpesviral sequences have been identified in various bat species. Here, we report the isolation, cell tropism, and complete genome sequence of a novel betaherpesvirus from the bat Miniopterus schreibersii (MsHV). In…
View details →Negative / Null Result ReportOpen accessMedicine
Mauro Giovanni Carta, Maria Efisia Lecca, Luca Saba et al. · 2015 · BMC Psychiatry
BACKGROUND: To compare the six-month outcome on mood, cognition and quality of life (QoL) in patients with severe carotid atherosclerosis (CA) who underwent carotid endarterectomy (CEA) with subjects who refused treatment. METHODS: Cohort study on consecutive inpatients with CA (stenosis ≥ 50 %) (N = 46; age 72.56 ± 7.26; male 65.2 %). Intervention cohort: subjects who decided to undergo CEA (N = 35); Control cohort patients who refused CEA (N = 11). DSM-IV-Psychiatric diagnosis made by clinicians using interviews, QoL measured by Short Form Health Survey (SF-12); cognitive performance by WAIS
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Tracy L. Diamond, Winnie Ngo, Min Xu et al. · 2022 · Antimicrobial Agents and Chemotherapy
Islatravir (ISL) is a nucleoside reverse transcriptase translocation inhibitor (NRTTI) that inhibits human immunodeficiency virus (HIV) reverse transcription by blocking reverse transcriptase (RT) translocation on the primer:template. ISL…
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Chung-Young Lee, Se-Hee An, Il Hwan Kim et al. · 2017 · Scientific Reports
The polymerase of avian influenza A virus (AIV) is a heterotrimer composed of PB2, PB1, and PA. PB2 plays a role in overcoming the host barrier; however, the genetic prerequisites for avian PB2 to acquire mammalian pathogenic mutations have not been well elucidated. Previously, we identified a prototypic avian PB2 that conferred non-replicative and non-pathogenic traits to a PR8-derived recombinant virus when it was used to infect mice. Here, we demonstrated that key amino acid mutations (I66M, I109V, and I133V, collectively referred to as MVV) of this prototypic avian PB2 increase the replica
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Raffaele Di Fenza, Naman S. Shetty, Stefano Gianni et al. · 2023 · American Journal of Respiratory and Critical Care Medicine
Abstract Rationale The effects of high-dose inhaled nitric oxide on hypoxemia in coronavirus disease (COVID-19) acute respiratory failure are unknown. Objectives The primary outcome was the change in arterial oxygenation (PaO2/Fi O2) at 48…
View details →Negative / Null Result ReportOpen accessMedicine
Abigail T. Berman, Leslie A. Litzky, Virginia A. LiVolsi et al. · 2011 · Cancer
BACKGROUND: The clinical benefit of postoperative mediastinal radiation for completely resected Masaoka stage 2 thymoma remains controversial. Due to its indolent nature and infrequent recurrences, no study has definitively determined the…
View details →Negative / Null Result ReportMedicine
Andrée-Anne Houde, Stéphanie-May Ruchat, Catherine Allard et al. · 2015 · Epigenomics
AIM: To assess the associations between gestational diabetes mellitus (GDM) and DNA methylation levels at genes related to energy metabolism. PATIENTS & METHODS: Ten loci were selected from our recent epigenome-wide association study on…
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Arthur Caye, Jessica Agnew‐Blais, Louise Arseneault et al. · 2019 · Epidemiology and Psychiatric Sciences
AIM: Few personalised medicine investigations have been conducted for mental health. We aimed to generate and validate a risk tool that predicts adult attention-deficit/hyperactivity disorder (ADHD). METHODS: Using logistic regression models, we generated a risk tool in a representative population cohort (ALSPAC - UK, 5113 participants, followed from birth to age 17) using childhood clinical and sociodemographic data with internal validation. Predictors included sex, socioeconomic status, single-parent family, ADHD symptoms, comorbid disruptive disorders, childhood maltreatment, ADHD symptoms,
View details →Negative / Null Result ReportMedicine
Douglas K. Rex, Indira Bhavsar-Burke, Daniel Buckles et al. · 2024 · Annals of Internal Medicine
BACKGROUND: Real-time prediction of histologic features of small colorectal polyps may prevent resection and/or pathologic evaluation and therefore decrease colonoscopy costs. Previous studies showed that computer-aided diagnosis (CADx)…
View details →Negative / Null Result ReportOpen accessMedicine
Meisam Yousefi, Wai Suet Lee, Biaoguo Yan et al. · 2022 · PLoS Pathogens
Transmembrane Protein 41B (TMEM41B) and Vacuole Membrane Protein 1 (VMP1) are two ER-associated lipid scramblases that play a role in autophagosome formation and cellular lipid metabolism. TMEM41B is also a recently validated host factor required by flaviviruses and coronaviruses. However, the exact underlying mechanism of TMEM41B in promoting viral infections remains an open question. Here, we validated that both TMEM41B and VMP1 are essential host dependency factors for all four serotypes of dengue virus (DENV) and human coronavirus OC43 (HCoV-OC43), but not chikungunya virus (CHIKV). While
View details →Negative / Null Result ReportOpen accessMedicine
Hao Chen, Donghang Zheng, Jeff Abbott et al. · 2013 · Antimicrobial Agents and Chemotherapy
Lethal viral infections produce widespread inflammation with vascular leak, clotting, and bleeding (disseminated intravascular coagulation [DIC]), organ failure, and high mortality. Serine proteases in clot-forming (thrombotic) and…
View details →Negative / Null Result ReportOpen accessMedicine
Yan Sun, Ying Cheng, Xuezhi Hao et al. · 2016 · BMC Cancer
BACKGROUND: Extensive-disease small-cell lung cancer (ED-SCLC) is characterized by rapid progression and relapse, despite high initial response rates to chemotherapy. The primary objective of this trial was to demonstrate the non-inferiority of amrubicin and cisplatin (AP) combination therapy compared with the standard first-line regimen of etoposide and cisplatin (EP) for previously untreated ED-SCLC in a Chinese population. When non-inferiority was verified, the objective was switched from non-inferiority to superiority. METHODS: From June 2008 to July 2010, 300 patients were enrolled and ra
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Shuang-Jie Cao, Yue Zhang, Yuxiu Zhang et al. · 2023 · British Journal of Anaesthesia
BACKGROUND: Experimental evidence indicates that i.v. anaesthesia might reduce cancer recurrence compared with volatile anaesthesia, but clinical information is observational only. We therefore tested the primary hypothesis that…
View details →Negative / Null Result ReportMedicine
Robert A. Comley, Simon Červenka, Sven Pålhagen et al. · 2010 · Journal of Neuroimaging
BACKGROUND: Restless legs syndrome (RLS) is a common neurological disorder the pathophysiology of which is incompletely understood. Four studies have examined structural differences between the brains of RLS patients and healthy controls,…
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Joshua T. Kantrowitz, Christoph U. Correll, Rakesh Jain et al. · 2023 · The International Journal of Neuropsychopharmacology
BACKGROUND: Schizophrenia is a disabling disorder that profoundly affects functioning and quality of life. While available antipsychotics have improved outcomes for patients with schizophrenia, they are relatively ineffective for negative and cognitive symptoms and are associated with a range of troublesome side effects. A significant unmet medical need for more effective and better-tolerated therapies remains. METHODS: A roundtable consisting of 4 experts in the treatment of patients with schizophrenia convened to discuss the current treatment landscape, unmet needs from patient and societal
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Shigeki Nanjo, Tadaaki Yamada, Hiroshi Nishihara et al. · 2013 · PLoS ONE
PURPOSE: Although EGF receptor tyrosine kinase inhibitors (EGFR-TKI) have shown dramatic effects against EGFR mutant lung cancer, patients ultimately develop resistance by multiple mechanisms. We therefore assessed the ability of combined treatment with the Met inhibitor crizotinib and new generation EGFR-TKIs to overcome resistance to first-generation EGFR-TKIs. EXPERIMENTAL DESIGN: Lung cancer cell lines made resistant to EGFR-TKIs by the gatekeeper EGFR-T790M mutation, Met amplification, and HGF overexpression and mice with tumors induced by these cells were treated with crizotinib and a ne
View details →Negative / Null Result ReportOpen accessMedicine
Daniel V.T. Catenacci, Agnes Ang, Wei‐Li Liao et al. · 2016 · Cancer
BACKGROUND: MET gene amplification and Met protein overexpression may be associated with a poor prognosis. The MET/Met status is typically determined with fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC),…
View details →Negative / Null Result ReportOpen accessMedicine
Xiaoyan Zhang, Sufang Shi, Yan Ouyang et al. · 2018 · Journal of Translational Medicine
BACKGROUND: A working group on the Oxford classification of IgA nephropathy (IgAN) recently reported that crescents detected in kidney tissue predicted a worse renal outcome. However, this finding must be validated in independent cohorts before it can be widely applied to clinical practice. METHODS: Biopsy-proven IgAN patients were continuously recruited from two large renal centers in China from 1989 to 2014. All patients were followed for more than 1 year unless end stage renal disease (ESRD) occurred within 12 months. Crescents were defined as focal cellular or fibrocellular crescent format
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