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Browse the failure-mode index

11,417 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Exercise preconditioning attenuates ischemic neurological deficits without modulating motor learning in a rodent model of focal cortical ischemia.

Silva-García J, Eurolo I, Fuentes-Flores R et al. · 2026 · Brain research

Ischemic stroke is a leading cause of death and disability worldwide. Among survivors, one-third live with permanent impairments, and two-thirds experience upper limb dysfunction. Despite advances in acute care, no universally effective…

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Negative / Null Result ReportMedicine

Does air abrasion improve the retention of restorations in non-carious cervical lesions? An 18-month split-mouth randomized controlled trial.

Forville H, Coppla FM, Naupari-Villasante R et al. · 2026 · Journal of dentistry

Objective To evaluate whether dentin airborne-particle abrasion (APA) with aluminum oxide affects the retention and clinical performance of composite resin restorations in non-carious cervical lesions (NCCLs). Methods This prospective,…

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Negative / Null Result ReportMedicine

Efficacy of a short multimodal workshop including stress management and communication skills training on objective structured clinical examination performance and exam-related anxiety in French medical students: a randomized controlled study.

Vedrenne-Cloquet M, de Montmollin E, Gaudemer A et al. · 2026 · Journal of educational evaluation for health professions

Purpose To assess the effectiveness of a short multimodal workshop, including stress-management and communication-skills training, on objective structured clinical examination (OSCE) performance and exam-related anxiety among medical…

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Negative / Null Result ReportMedicine

Modified FOLFIRINOX with or Without Stereotactic Body Radiation in Locally Advanced Unresectable Pancreatic Cancer (SABER): A Randomized Open-Label Phase 2 Trial.

Yoo C, Jeong H, Park I et al. · 2026 · Annals of surgical oncology

Background Prospective data on stereotactic body radiation therapy (SBRT) combined with modified 5-fluorouracil, leucovorin, irinotecan, and oxaliplatin (mFOLFIRINOX) in patients with locally advanced unresectable pancreatic adenocarcinoma…

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Negative / Null Result ReportMedicine

Perinatal outcomes in normotensive versus hypertensive HELLP syndrome.

Anteby M, Wertheimer KO, Dominsky O et al. · 2026 · International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

Objective To compare maternal and neonatal outcomes between women with hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome with and without associated hypertension. Methods This was a retrospective cohort study at a…

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Negative / Null Result ReportMedicine

Feasibility of a Noninvasive Core Temperature Sensor and the Effects of Combined Cooling on Thermal Strain and Performance in Beach Volleyball.

Hu X, Murakami G, Hasegawa H · 2026 · International journal of sports physiology and performance

Purpose This study evaluated the practical feasibility of the CORE sensor for noninvasive tracking of changes in estimated core body temperature (Est-Tcore) during simulated beach volleyball match-play in the heat and examined the effects…

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Negative / Null Result ReportMedicine

Randomized controlled trial investigating the efficacy of oral azithromycin in preventing perinatal infections in pregnant women undergoing labor induction.

Cao H, Zhou Y, Gu N et al. · 2026 · International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

Objectives This study evaluates oral azithromycin's effectiveness in reducing intrapartum and puerperal infection rates in term pregnant women undergoing labor induction to guide antibiotic prophylaxis. Methods This single-center…

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Negative / Null Result ReportMedicine

Utility of Very High Output Pace-Capture Testing for Posterior Wall Isolation in Patients With Persistent Atrial Fibrillation.

Hsia B, Liebman J, Garber L et al. · 2026 · Journal of cardiovascular electrophysiology

Background Pulmonary vein isolation (PVI) and posterior wall isolation (PWI) are frequently used in the treatment of persistent atrial fibrillation (AF). Minimal data support adjunct PWI, possibly due to lack of durability via epicardial…

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Negative / Null Result ReportMedicine

Size and Macroscopic Type of Type B2 Vessel Areas in JES Classification for Predicting Invasion Depth: A Multicenter Prospective Study.

Yoshida M, Urabe Y, Kadota T et al. · 2026 · Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society

Objectives To investigate whether considering the B2 vessel area (B2VA) size and macroscopic type improves diagnostic performance. Methods In total, 136 esophageal squamous cell carcinoma (ESCCs) with B2 but not B3 vessels were…

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Negative / Null Result ReportMedicine

Effects of (poly)phenol-rich cranberry on mental health in university students: The CRANMOOD randomised controlled trial.

Kamarunzaman NNZ, Le Sayec M, Li Y et al. · 2026 · Clinical nutrition (Edinburgh, Scotland)

Background and aims Increasing evidence indicate that (poly)phenol-rich foods can have beneficial effects on human brain function. This study investigated whether daily (poly)phenol-rich cranberry supplementation for 12 weeks influences…

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Negative / Null Result ReportMedicine

Prenatal representations of women with minor depressive symptoms: a randomised controlled trial of an interactive ultrasound intervention.

Lindstedt J, Ekholm E, Pulliainen H et al. · 2026 · Journal of reproductive and infant psychology

Background Maternal depressive symptoms are common during pregnancy and may negatively impact the mother-infant relationship, particularly the development of maternal prenatal representations. This study used a randomised controlled trial…

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Negative / Null Result ReportMedicine

Nivolumab plus chemoradiotherapy followed by nivolumab with or without ipilimumab for untreated locally advanced stage III NSCLC: a randomized phase 3 trial.

Peters S, Tan DSW, Gerber DE et al. · 2026 · Nature cancer

Over 50% of persons with unresectable stage III non-small cell lung cancer (NSCLC) treated with standard-of-care concurrent chemoradiotherapy (CCRT) and durvalumab consolidation progress or die within 18 months. Here adults with untreated,…

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Negative / Null Result ReportMedicine

Predicting parents' HPV vaccination intentions and behaviors across countries and time.

Schulz JV, Doerflinger JT, Behm C et al. · 2026 · Health psychology : official journal of the Division of Health Psychology, American Psychological Association

Objective This study compares three models of parental human papillomavirus (HPV) vaccination intentions across United States, United Kingdom, and Germany: A model based on the theory of planned behavior (TPB), a model incorporating…

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Negative / Null Result ReportOpen accessMedicine

Combined Detection of Preoperative Serum Calcitonin and Carcinoembryonic Antigen in Medullary Thyroid Carcinoma: A Retrospective Multicenter Cohort Study.

Yang Y, He Y, Lin B et al. · 2026 · Health care science

Background The aim of this study was to investigate the clinical value of combined detection of preoperative serum calcitonin (Ctn) and carcinoembryonic antigen (CEA) for diagnosing medullary thyroid carcinoma (MTC), as well as predicting…

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Negative / Null Result ReportMedicine

A novel approach to the clinical assessment of juvenile fibromyalgia syndrome: the Juvenile Fibromyalgia Multidimensional Assessment Report.

Drago E, Lavarello C, Alongi A et al. · 2026 · Clinical and experimental rheumatology

Objectives Development and psychometric evaluation of a disease-specific, paediatric-targeted multidimensional questionnaire for the assessment of juvenile fibromyalgia syndrome (JFS) in routine clinical practice. Methods The Juvenile…

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