11,319 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Kasanmonadi RYN, Kamperman AM, Koch BCP et al. · 2026 · Journal of clinical psychopharmacology
Purpose/background Although combined plasma levels of imipramine and its metabolite desipramine are routinely assessed during therapeutic drug monitoring (TDM) of imipramine treatment, individual plasma levels are often overlooked.…
View details →Altan E, Küçüktağ Z, Arslankoz S et al. · 2026 · European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
OBJECTIVE: Sinonasal inverted papillomas (IPs) and nasal polyps (NPs) represent distinct benign lesions with different biological behaviors. P-glycoprotein (P-gp), a multidrug resistance transporter, has been implicated in inflammatory and…
View details →Kano T, Kawaguchi Y, Nishioka Y et al. · 2026 · Surgery today
PURPOSE: To address our hypothesis that increased surgical costs for robotic liver resection would be compensated by reduced postoperative care expenses, we compared the economic outcomes of robotic, laparoscopic, and open liver resection…
View details →Kaya G, Oskay PÖ, Mert NK et al. · 2026 · BMC infectious diseases
Background Coronavirus disease 2019 (COVID-19), first identified in Wuhan, China, in December 2019, rapidly evolved into a global pandemic with substantial morbidity and mortality. Severe COVID-19 cases, particularly those with pneumonia…
View details →Üstün Y, Yanık S, Uçar F et al. · 2026 · BMC gastroenterology
Background Inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), are chronic disorders with relapsing and remitting disease courses. Several clinical indicators and biomarkers have been evaluated…
View details →Oloruntoba AI, Rodrigues M · 2026 · Journal of cosmetic dermatology
Background Fractional CO 2 laser is an effective treatment for skin rejuvenation, although pigmentary complications remain a clinical consideration. Newer generation fractional CO 2 laser systems include pulse modes such as HighPulse (HP),…
View details →Çarikçi F, Girgin BA, Harmanci NF et al. · 2026 · Child abuse & neglect
Aim To examine and compare the proficiency of pediatric physicians and nurses in recognizing the signs of and risk factors for child maltreatment, as well as to determine the relationship between this proficiency and their reporting…
View details →Inokuchi T, Hiraoka S, Oshima N et al. · 2026 · Gerontology
Introduction We previously reported the findings of a multicenter retrospective cohort study investigating the efficacy of oral tacrolimus induction therapy in patients with ulcerative colitis (UC). In this subanalysis, we specifically…
View details →Nishino S, Asada Y, Nishino C et al. · 2026 · Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography
Background Isolated atrial amyloidosis is characterized by atrial natriuretic peptide- (ANP-) amyloid deposition confined to the atria and has been primarily linked to atrial fibrillation. However, its relationship with atrial mechanical…
View details →Hegde P, Acharya SR, Mayya A et al. · 2026 · International journal of dentistry
Background White spot lesions (WSLs) represent the earliest clinical manifestations of enamel demineralization. Resin infiltration (RI) is a minimally invasive method used to mask WSLs for esthetic improvement; however, infiltrated enamel…
View details →Li H · 2026 · Archives of sexual behavior
Previous research has shown that people tend to associate higher vertical spatial positions with male and lower positions with female. In this study, we document an understudied vertical representation of gender within Azhaliism, a…
View details →Fentahun M · 2026 · Scientific reports
Traditionally fermented beverages are potential sources of industrially relevant microorganisms. Among alternative energy sources, biofuels have gained increasing attention as replacements for fossil fuels. This study aimed to investigate…
View details →Lee J, Hwang HS, Li Y et al. · 2026 · Archives of insect biochemistry and physiology
Nesidiocoris tenuis is an important natural enemy widely used for the biological control of small pests in vegetable crop systems. Its successful implementation in commercial programs depends on reliable and cost-effective mass rearing,…
View details →Park SJ, Kim JY, Yun S et al. · 2026 · Journal of clinical medicine
Background/Objectives : Trauma triggers complex early immune responses. However, the relationship among trauma severity, changes in immune cell survival, and circulating inflammatory mediators remains unclear. This study compared early…
View details →Gülegen HÇ, Temelli G, Ucuz İ et al. · 2026 · Epilepsy & behavior : E&B
Objective Cognitive and behavioral difficulties in pediatric epilepsy extend beyond seizures. Although executive dysfunction is well recognized, Cognitive Disengagement Syndrome (CDS) remains understudied. We examined CDS-related symptoms…
View details →Sasaki M, Aoki T, Uchibori M et al. · 2026 · Oral diseases
Objective Many countries have implemented health technology assessment of their public medical insurance programs owing to rising social security costs from ageing populations and expensive emerging medical technologies. Clarifying factors…
View details →Osiak-Wicha C, Kras K, Tomaszewska E et al. · 2026 · Poultry science
This study evaluated black soldier fly (Hermetia illucens) products as alternatives to soybean meal protein in broiler pheasants, focusing on growth performance and skeletal traits in both sexes. Birds were assigned to five dietary…
View details →Kim TW, Ji SH, Park JB et al. · 2026 · Paediatric anaesthesia
Background Intravenous dexmedetomidine is a safe and effective adjunct in propofol-based sedation. Dexmedetomidine is typically administered as a loading dose, followed by continuous infusion or not. Whether the addition of a maintenance…
View details →Raj R, Nabi J, Gidwani S et al. · 2026 · East Asian archives of psychiatry : official journal of the Hong Kong College of Psychiatrists = Dong Ya jing shen ke xue zhi : Xianggang jing shen ke yi xue yuan qi kan
Objectives To determine associations between impulsivity and peripheral inflammatory ratios in patients with borderline personality disorder (BPD). Methods Consecutive patients aged ≥18 years with a diagnosis of BPD who presented to the…
View details →Jufresa-Michavila B, Bayés-Ricart C, Grillo S et al. · 2026 · Scientific reports
Despite advances in diagnosis and management, infective endocarditis (IE) remains a life-threatening condition with a high mortality rate. Most data originate from cardiac surgery centres, limiting our understanding of outcomes in…
View details →Lee S, Kim W, Moon WK · 2026 · Cyberpsychology, behavior and social networking
Artificial intelligence (AI) is increasingly encroaching on domains traditionally reserved for humans, including moral judgment. This trend has sparked heated debates, with both strong concerns and optimism about its implications. To…
View details →Chawanpaiboon S, Pooliam J · 2026 · International journal of women's health
Objective Preterm prelabor rupture of membranes (PPROM) is a major contributor to preterm birth and neonatal morbidity. Although azithromycin is increasingly used as an alternative to erythromycin for latency antibiotic therapy,…
View details →Spada E, Castelli G, Bruno F et al. · 2026 · Animals : an open access journal from MDPI
Feline leishmaniosis (FeL) caused by Leishmania infantum is increasingly recognized in endemic areas, but the inflammatory profile during infection remains poorly defined. This case-control study evaluated the acute phase proteins (APPs)…
View details →Sajedi Nia M, Khaleghi Tazji M, Abbasi A · 2026 · BMC musculoskeletal disorders
Purpose To investigate the effects of pyramidal and reverse pyramidal loading on spine and pelvis coordination patterns and their variability during deadlift. Methods Twelve trained male powerlifters performed deadlifts under two loading…
View details →Wassermann C, Rosenberger N, Gerhardt M et al. · 2026 · Scientific reports
In this in vitro study, a CAD-based test workflow was established to evaluate the dimensional accuracy of conventional dental impression materials under standardized laboratory conditions. Ninety double-mix impressions were made from a…
View details →Mguidich H, Ben Chikha H, Khacharem A · 2026 · Perceptual and motor skills
The acquisition of tactical knowledge from static diagrams is common in coaching, yet players may struggle to integrate information when it is processed passively. To address this problem, encouraging mental imagery of unfolding tactical…
View details →Park JO, Park YB, Yoon JH et al. · 2026 · The Journal of prosthetic dentistry
Statement of problem Comparative studies assessing monolithic zirconia and metal-ceramic for implant-supported fixed prostheses remain limited. Purpose This retrospective study aimed to compare the survival and success of metal-ceramic and…
View details →Uchimoto T, Hirosuna K, Niigawa H et al. · 2026 · Japanese journal of clinical oncology
Background Triplet therapy with darolutamide, androgen deprivation therapy, and docetaxel (DOC) has emerged as an intensified treatment option for metastatic castration-sensitive prostate cancer (mCSPC). This study evaluated real-world…
View details →Büğüşan Oruç S, Akdağ Mirzaoğlu N, Yakut Y · 2026 · International journal of occupational safety and ergonomics : JOSE
Objectives . This study aimed to investigate pinch strength and manual dexterity in different postures among young adults. Methods . A total of 200 individuals aged 18-45 years participated. Key, tip and palmar pinch strengths were…
View details →Karaca O, Torlak MS, Tekin AN · 2026 · Revista da Associacao Medica Brasileira (1992)
Objective The use of large language models is increasing in healthcare. The aim of this study was to evaluate and compare the responses provided by ChatGPT (OpenAI) and Gemini (Google) to frequently asked questions about stroke and its…
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