e-ISSN: Pending
WASTE Journal

Browse the failure-mode index

11,317 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Determining the Minimal Number of Passive Hip and Knee Joint Movement Repetitions Recommended for the Stiff Rectus Femoris Muscle Due to Osgood-Schlatter Disease.

Ikeda N, Yoshikawa A, Yamaguchi S et al. · 2026 · Children (Basel, Switzerland)

Background/objectives Osgood-Schlatter disease (OSD) is a common overuse condition in adolescents characterized by increased stiffness of the rectus femoris muscle, which contributes to pain and functional limitations around the knee. We…

View details →
Negative / Null Result ReportMedicine

Vilobelimab to improve clinical outcomes in moderate-to-severe hidradenitis suppurativa through an adjunctive effect on draining tunnels: results of the SHINE double-blind placebo-controlled randomized trial.

Giamarellos-Bourboulis EJ, Jemec GBE, Prens EP et al. · 2026 · The British journal of dermatology

Background The results of a previous phase IIa trial suggested efficacy of the anti-C5a compound vilobelimab in a small number of patients with severe hidradenitis suppurativa (HS) refractory to adalimumab treatment. Objectives To study…

View details →
Negative / Null Result ReportOpen accessMedicine

Cost-Effectiveness of an Antibacterial Envelope in Patients at High Risk of Cardiac Implantable Electronic Device Infection in the Australian Public Healthcare System.

Hill M, Khalaj BH, Shawon MSR et al. · 2026 · Journal of arrhythmia

Background The Worldwide Randomized Antibiotic Envelope Infection Prevention Trial (WRAP-IT) demonstrated a 40% reduction of major cardiac implantable electronic device (CIED) infection with the use of an absorbable antibacterial envelope…

View details →
Negative / Null Result ReportOpen accessMedicine

The impact paradox: mixed-methods evaluation of National Institute of Health and Care Research funding for intellectual disability research in the UK.

Goddard N, Dale M, Bishop R et al. · 2026 · BJPsych open

Background People with intellectual disability experience substantial health inequities, including higher multimorbidity, increased healthcare utilisation and markedly reduced life expectancy. High-quality research is essential to address…

View details →
Negative / Null Result ReportMedicine

Exploitation of Saccharomyces cerevisiae as an alternative microencapsulation strategy of thymol via β-glucan based matrix for the development of multilayer LDPE active packaging films - comparison with zeolite- and activated carbon-based carriers.

Giotopoulou I, Stamatis H, Barkoula NM · 2025 · International journal of biological macromolecules

In the current study Saccharomyces cerevisiae (S. cerevisiae) was exploited as an alternative carrier of thymol with the aim of developing multilayer low-density polyethylene (LDPE) films with advanced bioactivity over time. The results…

View details →
Negative / Null Result ReportMedicine

Experimental and clinical evidence on radiofrequency electromagnetic field effects on the blood-brain barrier: a scoping review.

Simsek ET, Sumser K, Mansourinezhad P et al. · 2026 · Physics in medicine and biology

Objective. This scoping review evaluates evidence on whether radiofrequency electromagnetic field (RF-EMF) exposure influences blood-brain barrier (BBB) permeability. Given inconsistent findings across decades of research and expanding…

View details →
Negative / Null Result ReportMedicine

Spectroscopic analysis of the N<sub>2</sub> B<sup>3</sup>Π<sub>g</sub>-A<sup>3</sup>Σ+u in radiation-induced air ionization.

Murzyn CM, Jans ER, Marshall GJ · 2026 · Physical chemistry chemical physics : PCCP

This article presents experimental results from probing atmospheric air irradiated by a Polonium-210 alpha particle source using both optical emission spectroscopy and continuous wave cavity ring down absorption spectroscopy to study the…

View details →
Negative / Null Result ReportOpen accessMedicine

Gender Differences in Preoperative Anxiety and the Association with Early Maladaptive Schemas: A Cross-Sectional Correlational Study.

Abdelrazek MN, Mohamed HMM, El-Monshed AH et al. · 2026 · Healthcare (Basel, Switzerland)

Background : Preoperative anxiety is a common and clinically significant response among surgical patients, with prevalence estimates ranging from 30% to over 80% depending on measurement method and surgical context. Early maladaptive…

View details →
Negative / Null Result ReportOpen accessMedicine

Safety of hepatitis E vaccine in pregnancy.

Zhang F, Yang G, Chen Y et al. · 2026 · Virology journal

This comment discusses the critical public health challenge of hepatitis E in pregnancy and highlights the significant safety evidence gap for the HEV239 vaccine in this vulnerable group. Focusing on a landmark study from South Sudan by…

View details →
Negative / Null Result ReportMedicine

Overnight residues of sensorimotor aftereffects and lack of visuospatial aftereffects following a single prism exposure in healthy subjects.

Mizrahi O, Wilf M, Ovadia-Caro S · 2025 · Cortex; a journal devoted to the study of the nervous system and behavior

Prism adaptation (PA) is a visuomotor adaptation paradigm resulting in transient sensorimotor shifts. Previous work shows PA can cause additional changes in higher-level visuospatial representations in healthy subjects. In patients with…

View details →
Negative / Null Result ReportOpen accessMedicine

Biological Therapy Leads to a Reduction in Systemic Inflammation but Leaves Serum Uric Acid Unmodified in Moderate-to-Severe Plaque Psoriasis: A Prospective Longitudinal Cohort Study.

Suiu LI, Vreju FA, Turcu-Stiolica A et al. · 2026 · Journal of clinical medicine

Background/Objective: Psoriasis is a systemic inflammatory disease often associated with metabolic comorbidities, including hyperuricemia. While biological therapies effectively target inflammatory pathways, their specific impact on serum…

View details →
Negative / Null Result ReportOpen accessMedicine

Are Atrial Fibrillation Risk Loci Universally Applicable? Insights from Whole-Genome Sequencing in a Polish Population.

Wasiak M, Sypniewski M, Dobosz P et al. · 2026 · Medical sciences (Basel, Switzerland)

Background: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia worldwide and has a substantial genetic component. Genome-wide association studies (GWASs) have identified more than 100 susceptibility loci; however,…

View details →
Negative / Null Result ReportOpen accessMedicine

Does Provider Identity at Triage Improve Machine Learning Prediction of Hospital Admission? A Comparative Analysis of Ten Supervised Classifiers with SHAP Explainability.

Brown AE, Marostica CW, Martini WA · 2026 · Journal of personalized medicine

Background/Objectives: Machine learning (ML) models can predict hospital admission from emergency department (ED) triage data with areas under the receiver operating characteristic curve (AUC) exceeding 0.85. Whether incorporating the…

View details →
Negative / Null Result ReportOpen accessMedicine

The Question of Violent Video Games and Aggression: Testing Statistical and Methodological Issues of Null Effects Using Data From an Open-Access Case Study.

Miles-Novelo A, Anderson CA · 2025 · Aggressive behavior

While numerous meta-analyses, reviews, and task forces from various scientific bodies have linked violent media use to aggression, some studies report null effects and claim that such a relationship is non-existent. Several scholars have…

View details →
Negative / Null Result ReportOpen accessMedicine

FreeSurfer-Based MRI Volumetry Reveals Thalamic and Hippocampal Atrophy as Significant Correlates of Disability in Multiple Sclerosis.

Juković M, Stošić S, Kostić D et al. · 2026 · Medicina (Kaunas, Lithuania)

Background and Objectives : Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disease that progressively leads to brain atrophy and the accumulation of disability over time. In this study, we used FreeSurfer to…

View details →
Negative / Null Result ReportOpen accessMedicine

Economic incentives contribute little to reducing agricultural damage from invasive non-native species: evidence from raccoon management in Hokkaido, Japan.

Mameno K, Suzuki T, Yamaguchi S et al. · 2026 · Pest management science

Background An economic incentive scheme is utilized to enhance citizens' support for managing invasive non-native species. However, the effectiveness of the incentive scheme in the outcomes of the management remains unclear. This study…

View details →
Negative / Null Result ReportOpen accessMedicine

The effect of performance-based financing interventions on health worker motivation and job satisfaction: experimental evidence from six national pilots.

Lamba S, Friedman J, Kandpal E · 2025 · Health policy and planning

A long-standing concern suggests that performance-based financing (PBF) may undermine the intrinsic motivation of health workers by heightening extrinsic motivation concerns via the novel introduction of financial incentives. However, the…

View details →
Negative / Null Result ReportOpen accessMedicine

Prospective association between the triglyceride-glucose index and frailty in middle-aged and older adults: insights from a nationwide cohort study.

Hou J, Zhao S, Shi J et al. · 2026 · European journal of medical research

Background Frailty is notably prevalent in individuals aged 50 and older and has been associated with metabolic dysfunction. The triglyceride-glucose (TyG) index is a reliable surrogate marker for insulin resistance. This study aimed to…

View details →
Negative / Null Result ReportMedicine

Does perceptual disfluency affect the illusion of causality?

Bona SD, Vicovaro M · 2024 · Quarterly journal of experimental psychology (2006)

When a subjective experience of difficulty is associated with a mental task, people tend to engage in systematic and deliberative reasoning, which can reduce the usage of intuitive and effortless thinking that gives rise to cognitive…

View details →