e-ISSN: Pending
WASTE Journal

Browse the failure-mode index

11,317 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Short-Chain Fatty Acids May Promote Regulatory T Cell Induction to Enhance Maternal Immune Tolerance in Early Pregnancy.

Takahashi K, Kawagoe J, Takehara I et al. · 2026 · Reproductive sciences (Thousand Oaks, Calif.)

This study examined whether oral administration of individual short-chain fatty acids (SCFAs) alters Treg- and Th17-related immune parameters during the peri-implantation period in pregnant mice. Using a mouse model, the effects of SCFAs…

View details →
Negative / Null Result ReportMedicine

Operative management of supination-external rotation type trimalleolar equivalent ankle fractures: reassessing the role of deltoid ligament repair and impact of posterior malleolar fixation on postoperative syndesmotic widening.

Choi JY, Yu OJ, Yun JY et al. · 2026 · European journal of orthopaedic surgery & traumatology : orthopedie traumatologie

Purpose The role of deltoid ligament (DL) repair in supination-external rotation (SER)-type trimalleolar equivalent ankle fractures (TEAFs) remains controversial. Additionally, it remains unclear whether posterior malleolar fixation alone…

View details →
Negative / Null Result ReportMedicine

Cytotoxicity assessment of Tera Harz TC-85DAC direct-printed clear aligners and effects of post curing time.

Peanchitlertkajorn S, Makkasaman K, Neoh SP et al. · 2026 · Journal of the World federation of orthodontists

Background To evaluate the cytotoxicity of direct 3D-printed aligners fabricated from Tera Harz TC-85DAC resin (TC) compared with conventional thermoformed aligners, and to investigate the effect of different post curing durations on TC…

View details →
Negative / Null Result ReportMedicine

Safety of insulin eye drops in the tratment of open angle glaucoma: a randomized phase I clinical trial.

Liu J, Nassrallah W, Quan-Nguyen C et al. · 2026 · Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

Objective The progression of glaucoma despite adequate intraocular pressure (IOP) control highlights the need for neuroprotective and neuroregenerative therapies. Preclinical studies suggest insulin promotes retinal ganglion cell survival…

View details →
Negative / Null Result ReportMedicine

S. aureus colonization and clinical symptoms remain stable upon topical XZ.700 treatment: Results of a double-blind randomized clinical trial in patients with mild to moderate atopic dermatitis.

van der Meulen LWJ, Bergmans ME, Assil S et al. · 2026 · British journal of clinical pharmacology

Aim Recovering dysbiosis may improve atopic dermatitis (AD) symptoms. XZ.700 is a recombinant chimeric endolysin that specifically targets Staphylococcus aureus and could be a new treatment option for patients with AD. The aim of this…

View details →
Negative / Null Result ReportMedicine

Impact of ultrahypofractionated adjuvant regional nodal radiotherapy on patient-reported quality of life: the HYPORT adjuvant trial (NCT03788213).

Chakraborty S, Chatterjee S, S P et al. · 2026 · Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

Introduction The HYPORT Adjuvant trial is comparing a one-week (26 Gy) course of adjuvant breast radiotherapy (RT) to a three-week (40 Gy) course. We report the interaction of regional nodal irradiation (RNI) and the dose fractionation…

View details →
Negative / Null Result ReportMedicine

Evaluating Joint Position Sense With 3D Motion Capture System: The Effect of Muscle Activation Without a Reference Angle in Shoulder Movements.

Lim W · 2026 · Physiotherapy research international : the journal for researchers and clinicians in physical therapy

Background and purpose Joint position sense (JPS) is frequently assessed using joint position reproduction (JPR); however, JPR has limitations, where reference angles are typically unavailable. This study aimed to examine the accuracy of…

View details →
Negative / Null Result ReportMedicine

No difference in patella mobility between conventional mechanically aligned and robotic-assisted functionally aligned total knee arthroplasty.

Lachowski K, Naja KM, Prill R et al. · 2026 · Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA

Purpose Robotic-assisted (RA) surgery allows for higher accuracy in total knee arthroplasty (TKA) and for better standardization of alignment concepts. It was hypothesized that the more personalized component placement in functional…

View details →
Negative / Null Result ReportMedicine

Identifying Candidate Mediators Linking ADHD Symptoms and Internalising Problems in Adolescence: An Exploratory Longitudinal Mediation Analysis.

Murray AL, Dryburgh K, Sonuga-Barke EJS · 2026 · Journal of attention disorders

Objective ADHD and internalising symptoms such as anxiety and depression are known to be associated in adolescence and understanding the mechanisms linking them is important for improving mental health outcomes for adolescents with ADHD…

View details →
Negative / Null Result ReportMedicine

Biodegradable plastic mulches: Distinct effects on microbial communities but no impact on soil multifunctionality during cabbage production.

Liang R, Mei L, Ding J et al. · 2026 · Journal of hazardous materials

Biodegradable plastic mulches (BDMs) are increasingly promoted as environmentally friendly alternatives to conventional mulches. However, the ecological impacts of different BDMs on soil remains incompletely understood. A field experiment…

View details →
Negative / Null Result ReportMedicine

Prospective Trial of Radiofrequency Catheter Ablation of High Dominant Frequencies After Pulmonary Vein Isolation in Non-Paroxysmal Atrial Fibrillation (PAD-AF Trial): A Multicenter, Randomized Clinical Trial.

Kumagai K, Hasegawa T, Kutsuzawa D et al. · 2026 · Journal of cardiovascular electrophysiology

Background The role of dominant frequency (DF)-guided ablation after pulmonary vein isolation (PVI) in persistent atrial fibrillation (AF) remains uncertain. We evaluated the clinical and mechanistic impact of DF mapping in a multicenter…

View details →
Negative / Null Result ReportMedicine

The impact of clinical presentation on one-year major adverse cardiac events in patients with angiographically defined moderate to severe calcified coronary artery disease.

Mkrtchjan A, Ntantou E, Siskos AA et al. · 2026 · The Journal of invasive cardiology

Objectives The authors aimed to investigate the impact of clinical presentation on 1-year major adverse cardiac events (MACE) in patients with angiographically defined moderate or severe calcified coronary artery disease. Methods The…

View details →
Negative / Null Result ReportMedicine

In neonates, how effective is lung ultrasonography in directing chest physiotherapy intervention when compared to the combination of chest x-ray and auscultation?

Hough J, Gouveia M, Steele M et al. · 2026 · Physiotherapy

Objective Evaluate the impact of lung ultrasound (LUS) compared to current chest physiotherapy (CPT) outcome measures on clinical decision-making in the Neonatal Intensive Care Unit (NICU). Design and setting Single-centre prospective…

View details →
Negative / Null Result ReportOpen accessMedicine

Effect of cold atmospheric pressure plasma on wettability of implant prosthetic materials: an in-vitro study.

Bayadse M, Grander L, Steiner L et al. · 2026 · International journal of implant dentistry

Purpose Surface wettability is a key factor in bonding of dental materials. The aim of the present study was to investigate the influence of different exposure times of cold atmospheric pressure plasma at constant power on the surface…

View details →
Negative / Null Result ReportMedicine

Peri-Implant Reconstruction With Autogenous Bone and Electrolytic Therapy: A Randomized Controlled Clinical Trial.

Puisys A, Akhondi S, Vindasiute-Narbute E et al. · 2026 · Clinical implant dentistry and related research

Objectives To evaluate the efficacy of peri-implant reconstructive therapy using autogenous tuberosity bone grafts, with or without adjunctive electrolytic therapy, as part of surgical treatment for peri-implantitis. Methods This…

View details →
Negative / Null Result ReportMedicine

How changes to frequency of treatment and mode of treatment improved paediatric speech-language pathology services: A pragmatic clinical trial.

Van Epps VM, Daur-Schierholz M, Dortenzio M et al. · 2026 · International journal of speech-language pathology

Purpose This pragmatic clinical trial examined the functional impact of a modified speech-language pathology intervention delivery model (including telepractice, reduced therapy frequency, and emphasised home programmes with parent…

View details →
Negative / Null Result ReportMedicine

Evaluation of Short-Term Stall Size Housing on the Behavior and Welfare of Domestic Horses (Equus caballus).

Outouil M, Daugherity EK, Warnick LD et al. · 2026 · Journal of the American Association for Laboratory Animal Science : JAALAS

Single-stall housing is a common system used for horses in various settings, including racing stables, riding schools, teaching and research facilities. Adequate stall space is necessary for horses to lie down and make postural…

View details →
Negative / Null Result ReportMedicine

Is multimodal monitoring effective in detecting neurological changes in cases of severe idiopathic scoliosis after halo gravity traction?: a series of 70 patients.

Richard L, Vermersch AI, Saghbini E et al. · 2026 · Neurophysiologie clinique = Clinical neurophysiology

Objective Severe scoliosis, defined by a Cobb angle exceeding 80°, requires surgical correction and is associated with a high risk of postoperative neurological complications. These complications may be reduced by halo gravity traction…

View details →