Failed Experiment ReportMedicine
Abukhalaf, Al-Ihribat, Sabarna et al. · 2026 · International journal of surgery case reports
Pancreaticoduodenal artery (PDA) pseudoaneurysms are rare vascular complications, accounting for approximately 2% of all visceral artery aneurysms. They are often associated with chronic pancreatitis and have a high risk of rupture, which…
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Ren, Nan, Li et al. · 2026 · Annals of medicine
To evaluate the analgesic efficacy of thoracic paravertebral block (TPVB) with different doses of liposomal bupivacaine (LB) or ropivacaine in patients undergoing single-port thoracoscopic lung surgery. A total of 105 patients scheduled…
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Harder K, Thöle M · 2026 · Tierarztliche Praxis. Ausgabe K, Kleintiere/Heimtiere
Objective The aim of this study was to evaluate the therapeutic success of a conservative treatment approach for macrodontic molars in guinea pigs. To this end, longitudinal data from conservative management were analyzed and parameters of…
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Çimen Ş, Altındağ N, Erginöz E et al. · 2026 · International journal of molecular sciences
The relationship between biochemical severity parameters and adenoma burden in primary hyperparathyroidism (PHPT) has been widely studied, although some variability across studies persists. This relationship is clinically relevant for…
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Afuh R, Ashinze P, Banerjee S et al. · 2026 · Discover oncology
Melanoma remains one of the most aggressive cutaneous malignancies, accounting for a disproportionate share of skin cancer-related mortality despite relatively lower incidence. Over the past decade, immune checkpoint inhibitors (ICIs) have…
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Lizwan, Cynthia Chia · 2026 · Journal of cardiothoracic surgery
Early chest drain removal and discharge are standard in enhanced-recovery protocols after video-assisted thoracoscopic surgery (VATS) lobectomy, but rare wound complications may arise. We report a 71-year-old man who underwent uneventful…
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Xu, Hu, Cai · 2026 · PloS one
The layout of the image and the positional distribution of the objects directly affect the audience's visual focus and the effect of the message conveyed. By setting up a specific layout structure, the viewer's attention can be more…
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Hopkins S, Banks E, Bentley SA et al. · 2026 · Optometry and vision science : official publication of the American Academy of Optometry
Purpose To evaluate whether luminance-matching of non-target elements (Study 1) and incorporating artwork (Study 2) within the newly designed turtle optotype would impact visual acuity (VA) measures. Methods Study 1 evaluated the…
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Lorenzo Porta, Sih-Shiang Huang, Chen Wei et al. · 2022 · PLoS ONE
Objectives While corticosteroids have been hypothesized to exert protective benefits in patients infected with SARS-CoV-2, data remain mixed. This study sought to investigate the outcomes of methylprednisone administration in an Italian cohort of hospitalized patients with confirmed SARS-CoV-2 infection. Methods Patients with confirmatory testing for SARS-CoV-2 were retrospectively enrolled from a tertiary university hospital in Milan, Italy from March 1st to April 30th, 2020 and divided into two groups by administration of corticosteroids. Methylprednisolone was administered to patients not r
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Artyszak A, Gozdowski D, Litwińczuk-Bis M · 2026 · Plants (Basel, Switzerland)
In 2017-2019, in a field experiment in Sahryń, Poland (50°40'42″ N, 23°47'35″ E), the effect of foliar application of various forms of silicon (calcium silicate-CS, sodium metasilicate-SM, and micronized silica-MS) and the timing of their…
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Li P, Xu S, Chen C et al. · 2026 · Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
Objectives To evaluate whether early antifungal prophylaxis reduces the incidence of influenza-associated pulmonary aspergillosis (IAPA) in critically ill adults with influenza. Methods We emulated a target trial using a multicentre cohort…
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Princiotta SD, Ostergaard E, Carroll E · 2026 · microPublication biology
Lakes often exist in two alternative stable states: clear waters dominated by submerged aquatic vegetation and turbid states with an abundance of phytoplankton. Management decisions must balance the value of primary producers with…
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Yuka Takahashi, Toshiyuki Himichi, Ayumi Masuchi et al. · 2023 · PLoS ONE
Previous studies have revealed that reading fiction is associated with dispositional empathy and theory-of-mind abilities. Earlier studies established a correlation between fiction reading habits and the two measures of social cognition: trait fantasy (i.e., the tendency to transpose oneself into fictitious characters) and performance on the Reading the Mind in the Eyes Test (RMET; a test of the ability to identify others’ mental states based on their eyes). Recently, experimental studies have shown that brief exposure to fiction enhances RMET performance. Nevertheless, these studies have been
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Yang, Han, Cui et al. · 2026 · Pharmacology research & perspectives
JKN2306 is a novel, highly selective Nav1.8 inhibitor under development for the treatment of acute pain. This first-in-human study aimed to evaluate its safety, tolerability, pharmacokinetics, and food effect (FE). This was a single…
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Nicholas J Douville, Lisa Bastarache, Emily Bertucci-Richter et al. · 2024 · PLoS ONE
Background Kidney dysfunction is a common complication in septic patients. Studies have identified numerous risk factors for sepsis-associated acute kidney injury (S-AKI), yet there is wide variability in the incidence even among patients with similar risk factors, suggesting the presence of additional uncharacterized risk factors, including genetic differences. The expansion of biobanks, advances in genotyping, and standardized diagnostic criteria have enabled large-scale, hypothesis-generating studies into the genetic mechanisms underlying S-AKI. We hypothesize that the genetic pathway behin
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Zhang T, Xiang J, Yu N et al. · 2026 · Frontiers in microbiology
Mastitis in dairy cows is one of the most prevalent infectious diseases in the dairy industry, leading to reduced milk production, increased production costs, and substantial economic losses. Antibiotics are commonly used to prevent and…
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White AB, Reid R, Graham GD et al. · 2026 · Journal of pediatric orthopedics
Background This prospective observational cohort study evaluates the clinical, radiographic, and functional differences between pins and screw fixation for displaced pediatric lateral condyle fractures of the elbow. Methods Skeletally…
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Baier, Miao, Schirrmacher et al. · 2026 · Pharmaceuticals (Basel, Switzerland)
Background : Zirconium-89 ( 89 Zr) is a key PET radionuclide and the limited in vivo stability of its clinically used 89 Zr-DFO complexes has driven the pursuit of improved chelator architectures. Among these, DFO* has attracted particular…
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Hengirmen Acu, Erbaş · 2026 · Pharmaceuticals (Basel, Switzerland)
Background: Methotrexate-induced oxidative stress is mechanistically linked not only to hepatocellular injury but also to DNA damage, indicating that oxidative stress, hepatotoxicity, and genotoxicity represent interconnected…
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Pavlasová K, Bizovská L, Rupčík L et al. · 2026 · European journal of sport science
The aim of this study was to assess the effect of gaze direction instruction on postural stabilisation and muscle activity during landings after various motor tasks in artistic gymnastics. Eighteen female gymnasts (aged 14.0 ± 2.7 years)…
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Feroze-Bakht, Espinoza, Sosa et al. · 2026 · Pharmaceutics
Background/Objectives: Carprofen (CP) is a potent non-steroidal anti-inflammatory drug whose clinical use is limited by systemic adverse effects associated with oral administration. The aim of this study was to develop and evaluate a…
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Cho, Lionakis, Khillan · 2026 · Laboratory animal research
Gene targeting via CRISPR/Cas9 has become a powerful tool to create animal models for human genetic disorders. Although CRISPR/Cas9 mediated gene editing is relatively simple, factors such as mouse strain, breeding performance, and quality…
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Versyck, Tollenaere, Schelfaut et al. · 2026 · Journal of spine surgery (Hong Kong)
Cervical kyphotic deformity is a recognized complication following posterior cervical spine surgery, particularly after laminectomy. However, post-laminoplasty kyphosis remains an underreported entity. We present a case of progressive…
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Day M, Kearney S · 2026 · Optometry and vision science : official publication of the American Academy of Optometry
Purpose To explore methods of evaluating success of optical myopia control interventions, and to apply these methods retrospectively to a clinical population. Methods A retrospective cohort study was conducted on pediatric patients…
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Krida, Tang, Mangalath et al. · 2026 · Nature communications
Thin-shell structures, found in biological systems such as beetle carapaces and widely used in aerospace and civil engineering, achieve remarkable strength-to-mass ratios given their slenderness and curved geometries. However, their…
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Mourtzos MA, Patoulias D, Keklikoglou NM et al. · 2026 · Diabetes research and clinical practice
Neurodegenerative diseases (NDs) are increasingly recognized as multifactorial disorders in which neurometabolic dysfunction intersects with classic pathological processes, including protein misfolding, neuroinflammation, synaptic failure…
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LaRue-Nolan, Flores, Vera et al. · 2026 · Molecular and cellular biology
Nuclear envelope (NE) proteins are essential for maintaining nuclear morphology, a central process controlling cellular phenotypes. While these proteins and structures are largely characterized in developmental biology, their function and…
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Knapper, Thomas, Hills et al. · 2026 · Blood
We assessed the addition of the tyrosine kinase inhibitor Quizartinib, following intensive chemotherapy and as maintenance, in patients aged >60 years with AML or high-risk MDS, regardless of FLT3 mutation status. 463 patients (median age…
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Connacher, Hu, Roden et al. · 2026 · RNA biology
Brain tumor (Brat) is a Drosophila TRIM-NHL protein required for embryogenesis and neural stem cell differentiation. Although structural and biochemical studies established that the Brat NHL domain specifically binds RNA, the in vivo…
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Ellis, Perry, Tabbara et al. · 2026 · Journal of vascular surgery cases and innovative techniques
Renovascular hypertension can be clinically challenging to diagnose. The most common etiology remains atherosclerotic disease. When medical management fails, renal artery revascularization is considered. Since the advent of endovascular…
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