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Browse the failure-mode index

46 real negative results, null findings, and replication failures in Medicine · Abandoned Hypothesis. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Abandoned HypothesisMedicine

Descriptive oxidative and lipid-related fluorescence observations associated with Esketamine treatment in a high-concentration NMDA-exposed HT-22/C8-D1A co-culture model.

Ni X, Zhou S, He X et al. · 2026 · Toxicology in vitro : an international journal published in association with BIBRA

Background In HT-22 cells, 500 μM NMDA was used as a high-concentration oxidative stressor rather than a classical NMDA receptor-mediated excitotoxic stimulus. Because HT-22 cells lack functional ionotropic NMDA receptors, this model…

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Abandoned HypothesisMedicine

Is active surveillance of CIN2 always appropriate? Clinical outcomes and factors associated with progression and regression over 48 months in an HPV-positive cohort.

Bruno MT, Pagana A, Aiello T et al. · 2026 · BMC cancer

Background Active surveillance of cervical intraepithelial neoplasia grade 2 (CIN2) is increasingly adopted to reduce the risk of overtreatment, particularly in young women. However, the appropriateness of this approach remains debated,…

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Abandoned HypothesisOpen accessMedicine

Use Treadmills with Caution: Walking Energy Expenditure and Metabolic Cost Are Elevated Compared to Overground Across Multiple Speeds in Healthy Young Adults.

Das Gupta S, Kamishita K, Kondo M et al. · 2026 · Journal of functional morphology and kinesiology

Objectives : Treadmill walking is often employed for tightly controlled gait and energetics research, but growing evidence suggests that treadmill-based metabolic and biomechanical measurements may not directly reflect the ecologically…

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Abandoned HypothesisMedicine

Iridology: Biological plausibility, clinical evidence, and implications for ophthalmic practice : A position paper of the Associazione Pazienti Malattie Oculari (APMO).

Iuliano L, Veritti D, Lanzetta P · 2026 · Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

Iridology is an alternative diagnostic practice that claims to identify systemic diseases and organ dysfunction through visual inspection of iris features, including pigmentation patterns, crypts, furrows, and discolorations. Despite its…

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Abandoned HypothesisOpen accessMedicine

Intrawound vancomycin powder in orthopaedic surgery after the VPIP trial: a critical reappraisal of efficacy, dosing, application plane, and antimicrobial stewardship.

Werneburg F, Zeh A, Gutteck N et al. · 2026 · Journal of bone and joint infection

Topical intrawound vancomycin powder has been widely adopted in orthopaedic surgery as an adjunct for the prevention of surgical site infection (SSI) and periprosthetic joint infection (PJI). Retrospective cohorts and derived meta-analyses…

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Abandoned HypothesisMedicine

Hermann J. Muller's research swan song: His long-term radiation dose-rate mutation investigations yielded no research publications, leaving questions of scientific misconduct.

Calabrese EJ · 2026 · Chemico-biological interactions

This paper evaluates the final major research effort of Hermann J. Muller, Nobel Laureate, to assess whether radiation displays a dose-rate process for radiation-induced germ cell mutation. Muller tried to extend the dose-rate findings of…

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Abandoned HypothesisOpen accessMedicine

Ugi multicomponent reactions of optically active aldehydes and chiral aminoindanols: diastereoselective synthesis of bisamides relevant to SARS-CoV-2 Mpro inhibitors.

Ghosh AK, Bhattacharjee A, Jayashankar U et al. · 2026 · Organic & biomolecular chemistry

We have investigated diastereoselective Ugi-multicomponent reactions (Ugi-MCR) relevant to bis-amide scaffolds related to SARS-CoV-2 main protease (Mpro) inhibitors. The studies were mainly focussed on development of diastereoselective…

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Abandoned HypothesisMedicine

Two New Pyrrole Alkaloids From Lanmaoa asiatica.

Li, Hou, Li et al. · 2026 · Chemistry & biodiversity

Two new pyrrole alkaloids, asiaticain A (1) and asiaticain B (2), two aromatic compounds 3-4, and one steroid 5 were isolated from Lanmaoa asiatica. The structural elucidation of the isolated compounds was determined by using NMR, MS, IR,…

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