11,317 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Eser M, Yazıcı C, Kandemir Ü et al. · 2026 · Research in veterinary science
Ivermectin (IVR) is a semi-synthetic macrocyclic lactone widely used against nematodes. Under physiological conditions, its central nervous system (CNS) penetration is limited by P-glycoprotein-mediated efflux at the blood-brain barrier…
View details →Farber C, Jackson C, Renteria K et al. · 2026 · Nutrition (Burbank, Los Angeles County, Calif.)
Background Exposure to a Western diet during gestation and lactation adversely impacts offspring mood, learning, and memory. We determined if high dose maternal methyl donor nutrient (MDN) supplementation ameliorated the effects of a high…
View details →Khaliji E, Marycz K, Horna M et al. · 2025 · American journal of veterinary research
Objective To evaluate IA autologous platelet-derived mitochondrial preparation versus vehicle control in a bilateral lipopolysaccharide (LPS)-induced model of equine synovitis. Methods 2 ng of LPS was injected into bilateral intercarpal…
View details →Quan F, Ma J, Zhao Y et al. · 2025 · Aquaculture international
This study investigated the effects of supplementing high soybean meal diets with alpha-ketoglutaric acid (AKG) on the intestinal health and growth performance of spotted sea bass (Lateolabrax maculatus). A total of 270 fish (average…
View details →Zoughaib WS, Fry MJ, Singhal A et al. · 2026 · Medicine and science in sports and exercise
Purpose Increasing nitric oxide bioavailability via nitrate (NO 3- ) ingestion enhances muscle contractility, which may be due to phosphorylation of the regulatory light chain of myosin. If so, there should be an interaction between NO 3-…
View details →Wackernagel D, Gavelli V, Nydert P · 2025 · Clinical nutrition ESPEN
Background & aims In preterm and sick newborn infants, peripherally inserted central catheters (PICC) are used for the delivery of concentrated parenteral nutrition and other high risk drugs. Despite the precaution issued by the ESPGHAN…
View details →Barbosa MG, Vos DY, Verzijl CRC et al. · 2026 · Cellular and molecular gastroenterology and hepatology
Background & aims Hepatocellular carcinoma is the third leading cause of cancer-related mortality worldwide. Therapeutic options for hepatocellular carcinoma remain limited, and the mechanisms underlying hepatocellular carcinoma are not…
View details →Wooliver R, Neupane A, DeBruyn JM et al. · 2026 · Journal of environmental quality
Microplastics derived from agricultural plastic films accumulate in soils, potentially impacting ecosystem functions such as soil organic carbon (SOC) storage. Microbial degradation of biodegradable plastics, which are intentionally tilled…
View details →Zhao X, Tian Q, Michelsen A et al. · 2025 · Applied Soil Ecology.
Roots and extraradical mycelium (EMM) influence the soil carbon (C) cycle, but it remains unclear how warming alters their effects on soil organic carbon (SOC) and its composition in alpine swamp meadows. A three-year ingrowth core…
View details →Bertrand-Ndoye M, Girard H, Hakim F et al. · 2026 · Forensic science international
In forensic thanatology, post-mortem blood is often stored for long periods, leading to in vitro variations in drug concentrations. This study evaluated the use of dried blood microsampling supports dried (Dried Blood Spot - DBS and…
View details →Fukunaga N, Takanishi T, Wakami T et al. · 2026 · Circulation reports
Background The impact of emergency surgery for acute type A aortic dissection (ATAAD) on renal function in patients with autosomal dominant polycystic kidney disease (ADPKD) remains unclear. Methods and results The renal function of 4…
View details →Li T, Jiang X, Tian X et al. · 2026 · The Journal of endocrinology
Postmenopausal osteoporosis, characterized by estrogen deficiency-induced bone loss and elevated fracture risk, is commonly managed with hormone replacement therapy (HRT). This study aimed to evaluate whether passive exercise via…
View details →Chen W, Zhang C, Guo W et al. · 2026 · Journal of experimental botany
Apple is an important economic species, but it suffers from biotic stress during its growth and development. Fungi and pests are two types of biotic stress that have significant destructive effects on apple. Members of the leucine-rich…
View details →Fischer J, Seguel JM, Drole K et al. · 2026 · BMC sports science, medicine & rehabilitation
Background This study investigated the comparative acute effects of 3 × 30 s of vibration foam rolling (VFR) or percussive massage (PM) on the hamstring muscles, specifically range of motion (ROM), maximum voluntary isometric contraction…
View details →Fujii N, Katagiri A, Nakagome K et al. · 2026 · Scandinavian journal of medicine & science in sports
Continuous monitoring of core temperature is crucial for optimizing exercise performance, promoting health, and ensuring safety. Here, we evaluated the validity of a machine learning-based earbud-type core temperature sensor during…
View details →Maksymowych WP, Weiss PF, Francavilla ML et al. · 2026 · Seminars in arthritis and rheumatism
Objective The OMERACT JAMRIS working group has defined a spectrum of MRI lesions in the sacroiliac joint (SIJ) in pediatric cases with spondyloarthritis (SpA) that match domains for inflammation and structural damage. We aimed to assess…
View details →Brandon AS, Murphy BS, Nam Y et al. · 2026 · The American journal of cardiology
Peripheral arterial disease (PAD) has many established risk factors, but social determinants of health (SDoH) are increasingly recognized as a cardiovascular disease risk factor. The multi-ethnic study of atherosclerosis (MESA) cohort was…
View details →Arnaoutis G, Vallas G, Toubekis AG et al. · 2026 · International journal of sport nutrition and exercise metabolism
Beetroot juice (BRJ) has been proposed as an ergogenic aid due to its high nitrate content, yet evidence from field-based studies in elite swimmers remains limited. This study investigated the acute effects of concentrated BRJ ingestion on…
View details →Ayaz SN, Kucuk M, Yanık Nalbantoğlu D et al. · 2025 · Odontology
We evaluated the effect of supplementary instrumentation on the removal of gutta-percha and compared the efficacy of three file systems with different metallurgical properties via micro-computed tomography (micro-CT). Forty-two moderately…
View details →Moghadam H, Sourinejad I, Kalbassi MR et al. · 2026 · Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology
Widely recognized for its translational relevance, the zebrafish (Danio rerio) is a validated model for evaluating antihyperglycemic agents. Nanocapsulation technologies have been proposed to enhance the bioefficacy of natural compounds…
View details →Mayer S, Wegehaupt FJ, Hamza B · 2026 · BMC oral health
Objectives This in-vitro study compared the protective effects of a 5000-ppm fluoride dentifrice with an anti-erosive 1450-ppm formulation containing stannous chloride and chitosan under erosive, abrasive, and erosive/abrasive conditions.…
View details →Yang Y, Lan C, Jiang Z · 2026 · Tissue engineering and regenerative medicine
Background This study evaluates the impact of Bacillus subtilis dual-strain enteric-coated capsules combined with vonoprazan-amoxicillin (VA) therapy on Helicobacter pylori (Hp) eradication rates, gastrointestinal symptoms, adverse events…
View details →Pinheiro-Machado E, Kuiper T, Huurman RH et al. · 2026 · Journal of biomedical materials research. Part B, Applied biomaterials
Polymer scaffolds are a promising platform for the transplantation of insulin-producing cells in Type 1 Diabetes. While vascularization has been a primary focus due to its role in oxygen and nutrient delivery, the interplay between blood…
View details →Ten Berg S, Beske RP, Grand J et al. · 2026 · European heart journal. Acute cardiovascular care
Background Noradrenaline is frequently used to increase mean arterial pressure (MAP) in patients with cardiogenic shock caused by infarction-related out-of-hospital cardiac arrest (OHCA-AMICS). This Blood pressure and Oxygenation-Targets…
View details →Dong M, Niimi T, Maturana AD · 2026 · Journal of cellular physiology
Intracellular calcium (Ca 2+ ) signaling controls myoblast proliferation, fusion, and myofiber formation. In myoblasts, Transient Receptor Potential Canonical (TRPC) channels, with TRPC1 as a predominant isoform, mediate store-operated…
View details →Wongwachira C, Suwajanakorn D, Kongwattananon W et al. · 2026 · Eye (London, England)
Purpose To compare the SITA Standard 24-2 and SITA Faster 24-2 C tests in patients with chloroquine/hydroxychloroquine (CQ/HCQ) retinopathy and those at high risk. Methods A prospective, cross-sectional study of 75 participants who…
View details →Morales Ruiz S, Wang Z, Miura T et al. · 2026 · Virology
We constructed two novel LC16-derived vaccinia viruses as candidate mpox vaccines to clarify the contribution of B5 to vaccine-induced protection. LC16m8Δ2 is a B5R-null mutant derived from LC16mO that contains no artificial sequences.…
View details →Sinha P, Chatterjee P, Kathiresan P et al. · 2026 · Journal of the American Geriatrics Society
Objective To evaluate the efficacy of adjunct probiotic supplementation (Lactobacillus helveticus and Bifidobacterium longum) alongside standard care compared to placebo in older adults with moderate unipolar depression. Methods A…
View details →Pontet Y, Aguirrezábal P, Pintos J et al. · 2026 · Journal of clinical gastroenterology
Background In adults, the diagnosis of celiac disease (CeD) relies on the presence of disease-specific antibodies and the confirmation of duodenal atrophy. This study aimed to develop a diagnostic model to predict duodenal atrophy in…
View details →Tanabe H, Watanabe D, Agawa M et al. · 2026 · Biochemical and biophysical research communications
Objectives Intestinal fibrosis is a severe complication of Crohn's disease (CD). While ADAMDEC1 has been identified as a marker for specific fibroblast subsets, its functional role in fibrogenesis remains unclear. This study aimed to…
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