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Browse the failure-mode index

11,317 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Surface charge engineering improves the alkaline resistance of Pseudoalteromonas tetraodonis κ-carrageenase for application in hydrolysis of κ-carrageenan industrial waste residues.

Su Y, Hu Q, Dou Z et al. · 2026 · Food research international (Ottawa, Ont.)

κ-Carrageenase with alkaline resistance can promote the resource utilization of κ-carrageenan industrial residues. In this study, a rational design strategy integrating surface charge optimization and consensus sequence analysis was…

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Negative / Null Result ReportMedicine

Help Received and Functional Decline in Older Adults: A Longitudinal Analysis of (I)ADL Difficulties Across Europe, the US, and China.

Hofbauer LM, Rodriguez FS · 2026 · Journal of applied gerontology : the official journal of the Southern Gerontological Society

PurposeThis study examined whether different types of help received influence subsequent levels of functional ability in older adults.MethodsLongitudinal data were drawn from the US Health and Retirement Study (HRS), the Survey of Health,…

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Negative / Null Result ReportMedicine

The effect of nasal patency and anatomy during asymmetrical nasal high flow.

Rees M, Vieira F, Yarragudi SB et al. · 2026 · Journal of applied physiology (Bethesda, Md. : 1985)

Nasal high flow (NHF) with the asymmetrical cannula interface (AI) is increasingly used as respiratory support across a broad range of patients. By incorporating one unilaterally oversized prong, the AI enhances dead-space clearance and…

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Negative / Null Result ReportMedicine

Mechanistic insights into the modification of peanut protein by novel radio frequency roasting: Revealing multi-scale protein conformational changes

Peng Z, Xu C, Zhang Y et al. · 2026 · Innovative Food Science and Emerging Technologies.

Radio frequency (RF) heating, as a promising alternative roasting method, could effectively improve peanut oil quality and degrade aflatoxins. However, during the peanut oil processing, the modification effect and mechanism on protein by…

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Negative / Null Result ReportMedicine

The effect of citalopram treatment on memory performance, mood state, catalase, BDNF, and MDA in REM sleep-deprived rats.

Elham Mahdavi, Ghorbani Yekta B, Fereshteh Atabi · 2026 · Cellular and molecular biology (Noisy-le-Grand, France)

Rapid-eye movement (REM) sleep is a critical stage of sleep that plays a pivotal role in memory formation, consolidation, and mood regulation. While REM sleep deprivation (REM SD) has been shown to impair cognitive and affective functions,…

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Negative / Null Result ReportMedicine

Expectations and tolerance of transcranial magnetic stimulation in patients with functional neurological disorder.

Azzopardi S, Garcin B, Mesrati F et al. · 2026 · Neurophysiologie clinique = Clinical neurophysiology

Background and objective In patients with functional neurological disorder (FND), transcranial magnetic stimulation (TMS) can be used for either diagnostic or therapeutic purpose. This study aimed to determine patients' expectations and…

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Negative / Null Result ReportMedicine

Complications of spinal fusion: comparing Medicare transforming episode accountability (TEAM) hospitals to control hospitals.

Martin BI, Mirza SK, Ko H et al. · 2026 · The spine journal : official journal of the North American Spine Society

Background context Medicare's Transforming Episode Accountability Model (TEAM) holds hospitals accountable for 30-day postoperative complications across 18 categories of spinal fusion bundles, yet baseline differences in complication rates…

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Negative / Null Result ReportMedicine

Root-secreted nicotinic acid ameliorates Mn toxicity in sugarcane

Yang S, Qin M, Wei J et al. · 2026 · Industrial Crops & Products.

Nicotinic acid (NIA) is known to function in heavy metal detoxification; however, the regulation and physiological significance of its endogenous secretion in metal tolerance remain unclear. In this study, NIA was identified as a…

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Negative / Null Result ReportMedicine

Effects of Short-Duration Cycling After Resistance Exercise on Aortic Stiffness and Next-Day Recovery in Strength-Trained Men.

Vondrasek JD, Brown JE, Grosicki GJ et al. · 2026 · Journal of strength and conditioning research

Abstract Vondrasek, JD, Brown, JE, Grosicki, GJ, and Flatt, AA. Effects of short-duration cycling after resistance exercise on aortic stiffness and next-day recovery in strength-trained men. J Strength Cond Res 40(5): 536-544, 2026-We…

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Negative / Null Result ReportMedicine

Association Between Venlafaxine Exposure And Treatment Outcomes In Older Adults With Depression: Association entre l'exposition à la venlafaxine et les résultats du traitement chez les personnes âgées atteintes de dépression.

Men X, Taylor ZL, Marshe VS et al. · 2026 · Canadian journal of psychiatry. Revue canadienne de psychiatrie

BackgroundVenlafaxine is commonly prescribed for older adults with depression, yet the relationship between venlafaxine-related exposure and treatment outcomes remains unclear. We aimed to assess the association of exposure to venlafaxine,…

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Negative / Null Result ReportMedicine

Patient reported outcomes after cheilectomy versus cheilectomy and Moberg osteotomy.

Littmann J, Steiner N, Cabrejo-Jones K et al. · 2026 · The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons

Background A Moberg osteotomy is a dorsal closing wedge osteotomy of the base of the first proximal phalanx that is thought to augment the effect of cheilectomy by increasing dorsiflexion and ultimately improve patient outcomes in Hallux…

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Negative / Null Result ReportOpen accessMedicine

Fe(II) with Tris(1-pyrazolyl)methane Complex Increases Thermal Stability In Vitro and Activity In Vivo of the Mutant 447R Form of Mouse Tryptophan Hydroxylase 2.

Terentieva EI, Komleva PD, Antonova SM et al. · 2026 · International journal of molecular sciences

Pharmacological chaperones (PCs)-small molecules that normalize the 3D structure of mutant protein molecules-are promising substances for pharmacological treatment of grave hereditary pathologies. In this study, possible chaperone-like…

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Negative / Null Result ReportMedicine

Comparison of the proteolysis and occurrence of a range of β-casomorphin peptides in commercial U.S. Cheddar cheeses manufactured from A1/A2 and A2/A2 β-casein milks.

Daniloski D, Ibáñez RA, McCarthy NA et al. · 2026 · Journal of dairy science

Bovine β-casein (β-CN) is a major milk protein that exists as multiple genetic variants, distinguished by differences in their amino acid sequences. Among these, the A1 and A2 variants are the most extensively studied. They differ at…

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Negative / Null Result ReportMedicine

PARK7 (DJ-1) indicates favorable prognosis and correlates with estrogen-receptor status and N<sup>ε</sup>-carboxymethyl-lysine (CML) accumulation in breast cancer.

Nass N, Sprung S, Ignatov A et al. · 2026 · Cancer treatment and research communications

In cancer, aerobic glycolysis predominantly used to provide energy. This high glycolytic flow results in the formation of reactive aldehydes such as glyoxal and methylglyoxal forming advanced glycation end products (AGEs) by reacting with…

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Negative / Null Result ReportMedicine

Comparative reliability of internal and vendor-derived computed tomography angiography (CTA) measurements in pretranscatheter aortic valve replacement (TAVR) assessment.

Claus L, Zhang X, Ocasio L et al. · 2026 · Clinical radiology

Aim Computed tomography angiography (CTA) is essential for preprocedural assessment in transcatheter aortic valve replacement (TAVR), particularly as TAVR becomes the preferred treatment for high-risk patients with severe aortic stenosis.…

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