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Browse the failure-mode index

11,417 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Hemolysis and Acute Kidney Injury Following Cardiac Surgery With Cardiopulmonary Bypass in Patients With Preexisting Renal Dysfunction.

Volleman C, Phelp PG, Dubelaar DPC et al. · 2026 · Journal of cardiothoracic and vascular anesthesia

Objectives Acute kidney injury (AKI) is a common complication following cardiac surgery with cardiopulmonary bypass (CPB). This study investigated whether cell-free hemoglobin (CFHb) levels after CPB are associated with endothelial damage…

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Negative / Null Result ReportMedicine

How Do Sex and Family SES Influence the Relation Between School Well-Being and Academic Domains? A Multi-Group Cross-Lagged Panel Analysis from Fifth To Eighth Grade.

Rémeau M, Raffy G, Borst G · 2026 · Journal of youth and adolescence

Although the association between academic achievement and well-being has been widely studied in cross-sectional and correlational studies, prior research has rarely clarified the directionality of these links by adopting a longitudinal…

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Negative / Null Result ReportMedicine

Relative influence of paraspinal muscularity and underlying bone quality on proximal junctional kyphosis and failure mode in patients undergoing thoracolumbar instrumented fusion.

Pennington Z, Mikula AL, Hamouda A et al. · 2026 · Clinical neurology and neurosurgery

Objective To assess paraspinal muscularity and bone quality contribution to PJK risk. Methods Defining PJK as ≥ 10° increase in proximal junctional angle from first upright radiograph, thoracolumbopelvic fusion patients experiencing PJK…

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Negative / Null Result ReportMedicine

Baseline electrophysiological markers of reward and error processing are associated with improved outcomes in prize-based contingency management.

Forster SE, Forman SD, Dickey MW et al. · 2026 · Drug and alcohol dependence

Background Veterans are disproportionately affected by cocaine use disorder (CUD), a condition without approved pharmacotherapies, marked by high return to use rates. Prize-Based Contingency Management (PBCM) is an effective behavioral…

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Negative / Null Result ReportMedicine

Longitudinal Associations between Mattering Dimensions and Loneliness in Adolescents: Bidirectional Effects at between- and Within-Person Levels.

Li HM, Flett GL, Cao CH et al. · 2026 · Journal of youth and adolescence

Although cross-sectional research links mattering to reduced adolescent loneliness, longitudinal studies examining temporal dynamics and distinctions between analytical levels or mattering dimensions are scarce. Without understanding…

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Negative / Null Result ReportMedicine

Harnessing Fear and Promoting Self-Efficacy in Response to Mass Casualty Scenarios: Evaluating Stop the Bleed at an Urban University.

Tong ST, Phillips K, Gomez J et al. · 2026 · Journal of prevention (2022)

Emergency situations range from everyday traffic accidents to incidents of mass gun violence and require individuals to be prepared and willing to act in times of crisis. To encourage people to help one another during such emergencies, the…

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Negative / Null Result ReportMedicine

Persistence of pulmonary hypertension in patients with ventricular septal defect after intracardiac repair: insights from a long-term follow-up study.

Wakisaka Y, Inai K, Harada G et al. · 2025 · Cardiology in the young

Background Ventricular septal defect is the most common CHD and is complicated by pulmonary hypertension in about 5% of cases. Although long-term outcomes after repair are generally good, persistent pulmonary hypertension has been…

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Negative / Null Result ReportMedicine

Subjective well-being mediates the longitudinal effect of insomnia symptoms on internalizing symptoms in community-dwelling older adults.

Ying Y, Meng R, Xu J et al. · 2026 · The journals of gerontology. Series B, Psychological sciences and social sciences

Objectives The associations between insomnia symptoms and internalizing symptoms are well-established, particularly in older adults; however, the mediating factors remain inconsistent. This study seeks to explore the longitudinal…

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Negative / Null Result ReportMedicine

Clinical impact of TP53 classifications in previously treated advanced driver-negative non-small cell lung cancer: A biomarker analysis of the OAK and POPLAR randomized clinical trials.

Zhou DD, Lord SJ, Lin FP et al. · 2026 · Lung cancer (Amsterdam, Netherlands)

Background In NSCLC, TP53 mutations are heterogeneous with varied effects on protein synthesis, function and clinical outcomes. We hypothesize that a refined classification of TP53 mutations, beyond binary categorization, could improve…

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Negative / Null Result ReportMedicine

Computed Tomography Measurement of Optic Nerve Sheath Diameter in Thrombolysis-Treated Ischemic Stroke: Association with Post-Thrombolytic Intracranial Hemorrhage.

Coşkun Yaş S, Üçöz Kocaşaban D, Güler S et al. · 2026 · Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

Optic nerve sheath diameter (ONSD) measurement is a non-invasive marker of intracranial pressure. Its role in predicting post-thrombolytic intracranial hemorrhage in acute ischemic stroke patients remains unclear. This study aimed to…

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Negative / Null Result ReportMedicine

Survival implications of computed tomography-derived muscle mass changes in patients with epithelial ovarian cancer undergoing bowel surgery.

Kim J, Lee YY, Kim TJ et al. · 2026 · International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

Objective Sarcopenia is a known adverse prognostic factor in gastrointestinal cancers undergoing bowel resection; however, its prognostic relevance in epithelial ovarian cancer remains unclear. This study aimed to evaluate the prognostic…

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Negative / Null Result ReportMedicine

Cranioplasty after surgical site infection in brain tumor patients: insights from a 15-year Swedish multicenter study.

Holmgren K, Fletcher-Sandersjöö A, Sæmundsson B et al. · 2026 · Journal of neurosurgery

Objective Postoperative surgical site infections (SSIs) following brain tumor surgery frequently necessitate wound revision and bone flap removal. However, data on subsequent cranial reconstruction in this context remain limited. The aim…

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Negative / Null Result ReportMedicine

When the Lights Go Out: Studying Sex Differences in Sleep Latency, Sleep Quality, and Social Behavior in Captive Rhesus Macaques (Macaca mulatta) Over a 24-h Period.

Roach A, Furman S, Hadeed J et al. · 2025 · American journal of primatology

Assessments of nonhuman primate (NHP) affiliation are typically restricted to daytime behavior. There is, however, a growing interest in understanding NHP behavior and welfare over the 24-h period. To assess the sleep quality and sociality…

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Negative / Null Result ReportMedicine

The MEniscal TeaR Outcome (METRO) study : a prospective cohort study exploring the factors that affect outcomes in patients undergoing treatment for a meniscal tear.

Ahmed I, Dhaif F, Bowes MA et al. · 2025 · The bone & joint journal

Aims The aim of this study was to describe the baseline characteristics of patients with a meniscal tear and explore associations with 12-month outcomes. Methods This prospective, national multicentre cohort study recruited patients aged…

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Negative / Null Result ReportMedicine

Longitudinal associations between maternal depression, problematic media use, and parenting efficacy as a time-varying mediator.

Holmgren HG, Densley RL, Coyne SM et al. · 2026 · Journal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (Division 43)

Prior research suggests a link between maternal depression and mothers' problematic media use (PMU), defined as compulsive or dysregulated media use that interferes with daily functioning. This study examined whether parenting…

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Negative / Null Result ReportMedicine

Associations between physical literacy and physical activity in adults. A cross-sectional study with self-report and device-based physical activity assessments.

Naylor A, Keegan R, Martin K et al. · 2025 · Journal of sports sciences

Physical literacy has been shown to relate to children's engagement in physical activity. However, it is unclear whether this relationship extends to adults. A two-phase cross-sectional study was conducted to examine whether physical…

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