Negative / Null Result ReportMedicine
Saiz-Gonzalo G, Drouin G, Rao Y et al. · 2026 · Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Non-nutritive sweeteners (NNS) are increasingly consumed during pregnancy, yet their distinct metabolic fates obscure a unified mechanism for developmental programming. We tested whether maternal NNS exposure acts upstream of metabolism by…
View details →Negative / Null Result ReportMedicine
Magsi FH, Ullah A, Ma Y et al. · 2026 · Journal of chemical ecology
Fall armyworm (Spodoptera frugiperda) has emerged as a major pest of maize across the Americas, Africa and Asia. Current management relies heavily on synthetic insecticides, which are environmentally unsustainable. However, pheromone-based…
View details →Negative / Null Result ReportMedicine
Rajhansa S, Crump NT, Khoo HM et al. · 2026 · Experimental hematology
A major challenge in cancer therapeutics has been the identification of targets that are selectively toxic to cancer cells while displaying limited effects on healthy counterparts. Toxicities related to blood production from hematopoietic…
View details →Negative / Null Result ReportMedicine
Hajj-Boutros G, Faust A, Mastrandrea C et al. · 2026 · Experimental physiology
Bed rest accelerates bone loss and may exacerbate skeletal fragility. This study examined the effects of 14 days of head-down tilt bed rest (HDBR) with or without exercise, and subsequent recovery, on bone turnover, density and structure…
View details →Negative / Null Result ReportMedicine
Cuadro R, Borrajo CI, Marino MA et al. · 2026 · European Journal of Agronomy.
Nitrogen (N) and phosphorus (P) deficiencies commonly limit plant growth in agroecosystems. While critical N concentration (Nc) dilution curves are widely used to assess the N status of crops and pastures, it remains unclear whether Nc…
View details →Negative / Null Result ReportMedicine
Zhao Y, Ma Y, Fan Y et al. · 2023 · Lung cancer (Amsterdam, Netherlands)
Purpose This study aimed to evaluate the efficacy and safety of cadonilimab (anti PD-1 and CTLA-4 bispecific antibody) in patients with previously treated metastatic non-small-cell lung cancer (NSCLC). Methods In this multicenter,…
View details →Negative / Null Result ReportOpen accessMedicine
Karavia EA, Pittaras A, Andreopoulou O et al. · 2026 · Pharmaceuticals (Basel, Switzerland)
Background/Objectives: Non-alcoholic fatty liver disease (NAFLD), recently redefined as metabolic dysfunction-associated steatotic liver disease (MASLD), represents a growing global health burden closely linked to obesity, insulin…
View details →Negative / Null Result ReportOpen accessMedicine
Limon D, Bokstein F, Blumenthal DT et al. · 2026 · Neuro-oncology advances
Background Tumor-treating fields (TTFields) have demonstrated efficacy in newly diagnosed glioblastoma (ndGBM) when combined with adjuvant temozolomide (TMZ). Preclinical studies suggest that TTFields enhance the therapeutic effect of…
View details →Negative / Null Result ReportMedicine
Chen B, Wang Q, Xue X et al. · 2026 · NPJ biofilms and microbiomes
Autism spectrum disorder (ASD) is a complex neurodevelopmental condition arising from interactions between genetic and environmental factors. The interplay between the microbiota-gut-brain axis and epigenetics has been implicated in ASD,…
View details →Negative / Null Result ReportMedicine
Takeuchi H, Akiba Y, Van Quang N et al. · 2026 · Journal of prosthodontic research
Purpose Osseointegration begins at the initial blood-implant contact; however, titanium-adhesive blood proteins remain incompletely defined. We used a structure-free, nano-smooth titanium substrate (Ra ≈ 0.6 nm) to identify…
View details →Negative / Null Result ReportMedicine
Riancho-Zarrabeitia L, Barrena OI, Santos-Gomez M et al. · 2026 · Reumatologia clinica
Background/objectives Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease marked by diverse autoantibodies. While serological clusters have been associated with distinct clinical phenotypes, most existing studies rely…
View details →Negative / Null Result ReportMedicine
Bonthrone AF, Cromb D, Javed SA et al. · 2026 · Placenta
Objectives To assess if maternal stress is higher in pregnancies with congenital heart disease (CHD) compared to low-risk pregnancies and if maternal stress is associated with placental microstructure and function. To explore if CHD alters…
View details →Negative / Null Result ReportMedicine
Li J, de Vries HD, Ustyantsev K et al. · 2026 · Journal of lipid research
Farnesoid-x-receptor (FXR), a bile acid (BA)-activated nuclear receptor, is a therapeutic target for cholestatic and metabolic liver diseases. However, species differences in BA metabolism and FXR signaling hamper translation from mice to…
View details →Negative / Null Result ReportMedicine
Kirk C, Smith E, Wozniak A et al. · 2026 · Cutaneous and ocular toxicology
Purpose Emerging evidence supports a protective role of statins at preventing the progression of early-intermediate stage non-neovascular (dry) AMD. Clinical findings, however, remain equivocal as to the beneficial effects of statin use…
View details →Negative / Null Result ReportMedicine
Mattke AC, Schlapbach LJ, Takashima M et al. · 2026 · ASAIO journal (American Society for Artificial Internal Organs : 1992)
Extracorporeal membrane oxygenation (ECMO) can trigger a systemic inflammatory response syndrome (SIRS) with activation of inflammatory, endothelial, and coagulation system pathways. We assessed in a randomized trial whether a) sweep flow…
View details →Negative / Null Result ReportMedicine
Gu C, Xu R, Yin B et al. · 2025 · Integrative zoology
Predator cues have profound impacts on the behavior and physiology of prey animals. However, the mechanisms underlying stress responses induced by chronic exposure to predator cues in mammals, particularly the role of the gut microbiota,…
View details →Negative / Null Result ReportMedicine
Luo Y, Wei K · 2026 · Experimental brain research
Motor adaptation arises from multiple learning mechanisms, including use-dependent learning (UDL) driven by repetition and implicit error-based learning (EBL) driven by motor prediction errors. Although both mechanisms contribute…
View details →Negative / Null Result ReportMedicine
Gaebel L, Gerhardt T, Khamhoung A et al. · 2026 · Journal of Alzheimer's disease : JAD
BackgroundClonal hematopoiesis (CH) increases with age and elevates the risk of numerous age-associated diseases. However, the association between CH and neurodegenerative diseases has remained unclear.ObjectiveWe tested the association…
View details →Negative / Null Result ReportMedicine
Zubareva OE, Melik-Kasumov TB, Sinyak DS et al. · 2026 · Neurochemistry international
Activation of peroxisome proliferator-activated receptor alpha (PPARα) suppresses neuroinflammation and may interrupt epileptogenesis. We tested whether early intervention with the PPARα agonist fenofibrate exerts disease-modifying effects…
View details →Negative / Null Result ReportMedicine
Prakash V, Barnes BG, Windorff CJ · 2026 · Communications chemistry
Uranium-nitrogen compounds (U x N y ) pose interesting structural and electronic questions. Understanding the formation and speciation of U x N y may provide insights in nitrogen fixation as well as the preparation of potential uranium…
View details →Negative / Null Result ReportMedicine
Lawrence AG, Murangi T, Chevalier A et al. · 2026 · Journal of thrombosis and haemostasis : JTH
Background Hemophilic arthropathy (HA) is a chronic joint disease caused by repeated joint bleeding in patients with hemophilia, leading to joint degeneration despite prophylactic treatment. The CX3CL1 (fractalkine)-CX3CR1 chemokine axis…
View details →Negative / Null Result ReportMedicine
Chiusaroli L, Chiusaroli L, Boustany M et al. · 2026 · The Pediatric infectious disease journal
Background Routine blood cultures (BCs) are frequently obtained in hospitalized children with suspected infection. Although bacterial pathogens are the primary concern, fungal infections remain a consideration in high-risk populations,…
View details →Negative / Null Result ReportMedicine
Lerma-Clavero A, Kopsida M, Arendt N et al. · 2026 · FEBS open bio
The unfolded protein response (UPR) plays an important role in tumor progression and cellular stress adaptation. In hepatocellular carcinoma (HCC), pharmacological inhibition of the protein kinase R-like endoplasmic reticulum kinase (PERK)…
View details →Negative / Null Result ReportMedicine
Dantas MCDS, Moreira SDNT, Pinto Júnior FEL · 2026 · Journal of cancer education : the official journal of the American Association for Cancer Education
Background Communication of difficult news is a core competency in oncology education. How accurately medical students self-assess their communication performance shapes formative learning and curriculum design. Purpose To examine…
View details →Negative / Null Result ReportMedicine
Butzlaff R, Christoph C, Puhl L et al. · 2026 · Journal of psychosomatic research
Background Transcutaneous auricular vagus nerve stimulation (taVNS) is a promising non-pharmacological approach for postoperative pain management, but its interaction with childhood trauma (CT) remains unclear. This three-armed randomized…
View details →Negative / Null Result ReportMedicine
Barris CT, Kress TC, Antonova G et al. · 2025 · American journal of physiology. Heart and circulatory physiology
The global rise in obesity parallels the increasing rates of hypertension and cardiovascular disease (CVD). These trends, and recent clinical and experimental data, have revealed that obesity abolishes the protection from CVD typically…
View details →Negative / Null Result ReportMedicine
Giri S, Wang X · 2026 · American journal of physiology. Heart and circulatory physiology
Neointimal hyperplasia (NH) is a prominent pathological consequence following vascular injury and is driven in part by aberrant vascular smooth muscle cell (VSMC) proliferation. COP9 signalosome (CSN) subunit 5 (CSN5/JAB1/COPS5) is the…
View details →Negative / Null Result ReportMedicine
de Sousa Fernandes MS, Kanashiro A, da Silva Fidélis DE et al. · 2026 · Scientific reports
Environmental enrichment (EE), an experimental paradigm promoting cognitive, sensory, social, and motor stimulation, has been associated with neuroprotective effects. Although EE modulates immune function, its influence on the basal redox…
View details →Negative / Null Result ReportMedicine
Ling L, Ali T, Li X et al. · 2026 · Neurochemistry international
Diabetic neuropathy (DN) is driven by neuroinflammation and oxidative stress, with c-Jun N-terminal kinase (JNK) as a key mediator; however, the effects of JNK inhibition on neuropathic pain remain unclear. Therefore, we investigated the…
View details →Negative / Null Result ReportMedicine
Wu Z, Menezes ES, Silva NMLE et al. · 2026 · Genes
Background/Objectives : MicroRNAs (miRNAs) are key regulators of skeletal muscle adaptation; however, the extent to which exercise modulates the miRNA biogenesis pathway remains poorly understood. To investigate the impact of acute and…
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