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11,287 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Efficacy and Safety of a Once‐Yearly Intravenous Zoledronic Acid 5 mg for Fracture Prevention in Elderly Postmenopausal Women with Osteoporosis Aged 75 and Older

Steven Boonen, Dennis M. Black, Cathleen Colón‐Emeric et al. · 2010 · Journal of the American Geriatrics Society

OBJECTIVES: To determine the efficacy of once-yearly intravenous zoledronic acid (ZOL) 5 mg in reducing risk of clinical vertebral, nonvertebral, and any clinical fractures in elderly osteoporotic postmenopausal women. DESIGN: A post hoc…

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Negative / Null Result ReportOpen accessMedicine

Neuronal complex I deficiency occurs throughout the Parkinson’s disease brain, but is not associated with neurodegeneration or mitochondrial DNA damage

Irene H. Flønes, Erika Fernández‐Vizarra, Maria Lykouri et al. · 2017 · Acta Neuropathologica

Mitochondrial complex I deficiency occurs in the substantia nigra of individuals with Parkinson's disease. It is generally believed that this phenomenon is caused by accumulating mitochondrial DNA damage in neurons and that it contributes to the process of neurodegeneration. We hypothesized that if these theories are correct, complex I deficiency should extend beyond the substantia nigra to other affected brain regions in Parkinson's disease and correlate tightly with neuronal mitochondrial DNA damage. To test our hypothesis, we employed a combination of semiquantitative immunohistochemical an

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Negative / Null Result ReportOpen accessMedicine

RNA Interference Therapy With ARC‐520 Results in Prolonged Hepatitis B Surface Antigen Response in Patients With Chronic Hepatitis B Infection

Man‐Fung Yuen, Ingolf Schiefke, Jung‐Hwan Yoon et al. · 2019 · Hepatology

BACKGROUND AND AIMS: ARC-520, the first an RNA interference (RNAi) therapeutic, was designed to reduce all RNA transcripts derived from covalently closed circular DNA, leading to a reduction in viral antigens and hepatitis B virus (HBV)…

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Negative / Null Result ReportOpen accessMedicine

Clinical Utility of the Cryptococcal Antigen Lateral Flow Assay in a Diagnostic Mycology Laboratory

Brendan McMullan, Catriona Halliday, Tania C. Sorrell et al. · 2012 · PLoS ONE

BACKGROUND: Cryptococcus neoformans causes life-threatening meningitis. A recently introduced lateral flow immunoassay (LFA) to detect cryptococcal antigen (CRAG) is reportedly more rapid and convenient than standard latex agglutination (LA), but has not yet been evaluated in a diagnostic laboratory setting. METHODS: One hundred and six serum, 42 cerebrospinal fluid (CSF), and 20 urine samples from 92 patients with known or suspected cryptococcosis were tested by LA and LFA, and titres were compared. Results were correlated with laboratory-confirmed cryptococcosis. Serial samples were tested i

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Negative / Null Result ReportOpen accessMedicine

Serum Sclerostin Increases in Healthy Adult Men during Bed Rest

Jordan Spatz, E. E. Fields, Elaine W Yu et al. · 2012 · The Journal of Clinical Endocrinology & Metabolism

CONTEXT: Animal models and human studies suggest that osteocytes regulate the skeleton's response to mechanical unloading in part by an increase in sclerostin. However, few studies have reported changes in serum sclerostin in humans…

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Negative / Null Result ReportMedicine

Etiologic Factors in Sialolithiasis

Kevin C. Huoh, David W. Eisele · 2011 · Otolaryngology

OBJECTIVES: The purpose of this study was to investigate etiologic factors for sialolithiasis in a population of patients from the United States. STUDY DESIGN: Retrospective, cohort study. SETTING: Tertiary university. MATERIALS AND…

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Negative / Null Result ReportOpen accessMedicine

Perioperative risk of major non-cardiac surgery in patients with severe aortic stenosis: a reappraisal in contemporary practice

Teruko Tashiro, Sorin V. Pislaru, Jodi M Blustin et al. · 2014 · European Heart Journal

AIMS: Severe aortic stenosis (SAS) is a major risk factor for death after non-cardiac surgery, but most supporting data are from studies over a decade old. We evaluated the risk of non-cardiac surgery in patients with SAS in contemporary…

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Negative / Null Result ReportMedicine

Robotic Resection is a Good Prognostic Factor in Rectal Cancer Compared with Laparoscopic Resection: Long-term Survival Analysis Using Propensity Score Matching

Jin Kim, Se Jin Baek, Dong-Woo Kang et al. · 2017 · Diseases of the Colon & Rectum

BACKGROUND: Robotic total mesorectal excision for rectal cancer has rapidly increased and has shown short-term outcomes comparable to conventional laparoscopic total mesorectal excision. However, data for long-term oncologic outcomes are…

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Negative / Null Result ReportOpen accessMedicine

Impact of COVID‐19 pandemic on ST‐elevation myocardial infarction in a non‐COVID‐19 epicenter

Tarek A. Hammad, Melanie Parikh, Nour Tashtish et al. · 2020 · Catheterization and Cardiovascular Interventions

OBJECTIVES: We sought to study the impact of COVID-19 pandemic on the presentation delay, severity, patterns of care, and reasons for delay among patients with ST-elevation myocardial infarction (STEMI) in a non-hot-spot region.…

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Negative / Null Result ReportOpen accessMedicine

Reduction of inflammation after administration of interleukin-1 receptor antagonist following aneurysmal subarachnoid hemorrhage: results of the Subcutaneous Interleukin-1Ra in SAH (SCIL-SAH) study

James Galea, Kayode Ogungbenro, Sharon Hulme et al. · 2017 · Journal of neurosurgery

OBJECTIVE Aneurysmal subarachnoid hemorrhage (aSAH) is a devastating cerebrovascular event with long-term morbidity and mortality. Patients who survive the initial bleeding are likely to suffer further early brain injury arising from a…

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Negative / Null Result ReportOpen accessMedicine

Mortality due to cardiovascular disease, respiratory disease, and cancer in adults with cerebral palsy

Jennifer Ryan, Mark D. Peterson, Nicola Ryan et al. · 2019 · Developmental Medicine & Child Neurology

AIM: To compare mortality rates for cardiovascular disease, cancer, and respiratory disease between adults with cerebral palsy (CP) and the general population. METHOD: A cohort study was conducted using data from adults with CP in England,…

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Negative / Null Result ReportOpen accessMedicine

Traditional landmark versus ultrasound guided tracheal puncture during percutaneous dilatational tracheostomy in adult intensive care patients: a randomised controlled trial

Máté Rudas, Ian Seppelt, Robert Herkes et al. · 2014 · Critical Care

INTRODUCTION: Long-term ventilated intensive care patients frequently require tracheostomy. Although overall risks are low, serious immediate and late complications still arise. Real-time ultrasound guidance has been proposed to decrease complications and improve the accuracy of the tracheal puncture. We aimed to compare the procedural safety and efficacy of real-time ultrasound guidance with the traditional landmark approach during percutaneous dilatational tracheostomy (PDT). METHODS: A total of 50 patients undergoing PDT for clinical indications were randomly assigned, after obtaining infor

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Negative / Null Result ReportOpen accessMedicine

Markers of Celiac Disease and Gluten Sensitivity in Children with Autism

Nga M. Lau, Peter H.R. Green, Annette K. Taylor et al. · 2013 · PLoS ONE

OBJECTIVE: Gastrointestinal symptoms are a common feature in children with autism, drawing attention to a potential association with celiac disease or gluten sensitivity. However, studies to date regarding the immune response to gluten in autism and its association with celiac disease have been inconsistent. The aim of this study was to assess immune reactivity to gluten in pediatric patients diagnosed with autism according to strict criteria and to evaluate the potential link between autism and celiac disease. METHODS: Study participants included children (with or without gastrointestinal sym

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Negative / Null Result ReportOpen accessMedicine

Solitary plasmacytoma: population-based analysis of survival trends and effect of various treatment modalities in the USA

Nishitha Thumallapally, Ahmed Meshref, Mohammed Mousa et al. · 2017 · BMC Cancer

BACKGROUND: Solitary plasmacytoma (SP) is a localized neoplastic plasma cell disorder with an annual incidence of less than 450 cases. Given the rarity of this disorder, it is difficult to conduct large-scale population studies. Consequently, very limited information on the disorder is available, making it difficult to estimate the incidence and survival rates. Furthermore, limited information is available on the efficacy of various treatment modalities in relation to primary tumor sites. METHODS: The data for this retrospective study were drawn from the Surveillance, Epidemiology and End Resu

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Negative / Null Result ReportOpen accessMedicine

Randomized clinical trial: rikkunshito in the treatment of functional dyspepsia—a multicenter, double‐blind, randomized, placebo‐controlled study

Hidekazu Suzuki, Juntaro Matsuzaki, Yasushi Fukushima et al. · 2014 · Neurogastroenterology & Motility

BACKGROUND: Rikkunshito, a standardized Japanese herbal medicine, is thought to accelerate gastric emptying and relieve dyspepsia, although no large-scale, randomized, placebo-controlled trials of rikkunshito have been conducted. This…

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Negative / Null Result ReportOpen accessMedicine

A phase 2 trial of dasatinib in patients with locally advanced or stage IV mucosal, acral, or vulvovaginal melanoma: A trial of the ECOG‐ACRIN Cancer Research Group (E2607)

Kevin Kalinsky, Sandra Lee, Krista M. Rubin et al. · 2017 · Cancer

BACKGROUND KIT‐directed tyrosine kinase inhibitors such as imatinib have demonstrated benefits in KIT‐mutant (KIT+) mucosal, acral, vulvovaginal, and chronically sun‐damaged (CSD) melanoma. Dasatinib has superior preclinical activity in…

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Negative / Null Result ReportOpen accessMedicine

The value of ultrasonography in predicting arthritis in auto-antibody positive arthralgia patients: a prospective cohort study

Lotte A van de Stadt, Wouter H Bos, Marlies Meursinge Reynders et al. · 2010 · Arthritis Research & Therapy

INTRODUCTION: Ultrasonography (US) has better sensitivity than clinical evaluation for the detection of synovitis in early rheumatoid arthritis (RA). Patients presenting with arthralgia and a positive anti-citrullinated protein antibodies (ACPA) and/or Rheumatoid Factor (IgM-RF) status are at risk for developing RA. In the present study, US utility and predictive properties in arthralgia patients at risk for the development of arthritis were studied. METHODS: 192 arthralgia patients with ACPA and/or IgM-RF were included. Absence of clinical arthritis was confirmed by two physicians. US was per

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Negative / Null Result ReportMedicine

Analysis of Gut Microbiome Reveals Significant Differences between Men with Chronic Prostatitis/Chronic Pelvic Pain Syndrome and Controls

Daniel A. Shoskes, Hannah Wang, A. Scott Polackwich et al. · 2016 · The Journal of Urology

PURPOSE: Chronic prostatitis/chronic pelvic pain syndrome is a common disorder with heterogeneous etiologies and clinical features. The gut microbiome is a metabolically active ecosystem linked to systemic conditions (gut-brain axis). We…

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Negative / Null Result ReportOpen accessMedicine

Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH

Jinrui Dong, Sivakumar Viswanathan, Eleonora Adami et al. · 2021 · Nature Communications

IL11 is important for fibrosis in non-alcoholic steatohepatitis (NASH) but its role beyond the stroma in liver disease is unclear. Here, we investigate the role of IL11 in hepatocyte lipotoxicity. Hepatocytes highly express IL11RA and secrete IL11 in response to lipid loading. Autocrine IL11 activity causes hepatocyte death through NOX4-derived ROS, activation of ERK, JNK and caspase-3, impaired mitochondrial function and reduced fatty acid oxidation. Paracrine IL11 activity stimulates hepatic stellate cells and causes fibrosis. In mouse models of NASH, hepatocyte-specific deletion of Il11ra1

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Negative / Null Result ReportOpen accessMedicine

Young Mania Rating Scale: how to interpret the numbers? Determination of a severity threshold and of the minimal clinically significant difference in the EMBLEM cohort

M. Lukasiewicz, Stéphanie Gerard, Adeline Besnard et al. · 2013 · International Journal of Methods in Psychiatric Research

The aim of this analysis was to identify Young Mania Rating Scale (YMRS) meaningful benchmarks for clinicians (severity threshold, minimal clinically significant difference [MCSD]) using the Clinical Global Impressions Bipolar (CGI-BP)…

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