11,416 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Pundi K, Frimodt-Møller EK, Soliman EZ et al. · 2025 · Open heart
Background Previous epidemiological studies demonstrated that premature atrial contractions (PACs) and premature ventricular contractions (PVCs) detected by single 12-lead ECGs can predict incident cardiovascular disease and death. The…
View details →Bokan J, Schmid JQ, Middelberg C et al. · 2026 · Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie
Purpose Large overjet increases the risk of traumatic dental injury (TDI). This study, part of the Münster Long-Term Study (MLS), aimed to investigate long-term changes in overjet with or without orthodontic treatment and to evaluate…
View details →Moreira SE, Debs AL, de Oliveira EH et al. · 2026 · Brazilian journal of physical therapy
Background Diastasis recti abdominis (DRA) is a common postpartum condition that can persist for months, impair abdominal function, and negatively affect quality of life. Despite its prevalence, there is no gold standard treatment.…
View details →Su M, Saxon-Filipe S, Ahn C et al. · 2025 · Clinical breast cancer
Background Metaplastic breast carcinoma (MpBC) is an aggressive subtype of breast cancer that is usually resistant to chemotherapy. Few studies have analyzed the role of immunotherapy and other treatments in early stage MpBC. We identified…
View details →Narayan P · 2025 · Indian journal of thoracic and cardiovascular surgery
Dual antiplatelet therapy (DAPT) is recommended after acute coronary syndrome (ACS), but evidence in coronary artery bypass graft (CABG) patients is limited. The TACSI (Dual Antiplatelet Therapy with Ticagrelor and Acetylsalicylic Acid…
View details →Marr J, Meyers DJ, Ryan AM · 2026 · Health affairs (Project Hope)
The Centers for Medicare and Medicaid Services (CMS) is increasingly experimenting with prior authorization in traditional Medicare. In 2016, CMS began using pre-claim review, a prior authorization-like system in which claims are reviewed…
View details →Liu S, Song X, Li D et al. · 2025 · Wetlands.
Constructed Wetland (CW) is a low-carbon, sustainable ecological treatment technology widely used for deep treatment of wastewater treatment plant tailwater. However, constrained by the lack of available carbon source in the tailwater, the…
View details →Martínez-Ocón J, Pérez M, Calvo A et al. · 2026 · Journal of clinical anesthesia
Background Sedation during endoscopic retrograde cholangiopancreatography procedures (ERCP) increases the risk of hypoxemia and the need for respiratory support in high-risk patients. High flow nasal cannula (HFNC) provides humidified gas…
View details →Michaan N, Michaan N, Laskov I et al. · 2026 · Journal of lower genital tract disease
Objectives Cervical conization (loop electrosurgical excision procedure) under local anesthesia is often associated with anxiety and procedural pain. Virtual reality (VR) glasses may enhance patient experience and reduce discomfort during…
View details →Butala AD, Nanayakkara S, Johnston R et al. · 2026 · The American journal of cardiology
Stroke is a serious complication following transcatheter aortic valve implantation, associated with increased disability and mortality. Despite this, there is a lack of patient-level data examining stroke in contemporary, lower-risk…
View details →Zhou Y, Dai C, Wu F et al. · 2026 · Pulmonology
Background Low-dose theophylline has anti-inflammatory effects, but its efficacy in mild to moderate COPD remains controversial. Research question Is low dose theophylline effective and safe in patients with mild to moderate COPD? Methods…
View details →Geoffrion D, Mikhail D, Rizk M et al. · 2025 · Ocular immunology and inflammation
Authors reported an 18% rate of endophthalmitis in Boston type 1 keratoprosthesis (KPro) patients, higher than previously reported rates. Most cases occurred during the COVID-19 pandemic, likely due to reduced access to care. Bandage…
View details →Pacini GS, Manfro AG, Schuchmann RA et al. · 2026 · Clinical kidney journal
Background Percutaneous kidney allograft biopsy is essential for evaluating graft dysfunction, but post-procedural bleeding remains the most frequent complication, particularly among recipients with impaired renal function. Desmopressin…
View details →Stelmashook EV, Genrikhs EE, Alexandrova OP et al. · 2025 · Biomeditsinskaia khimiia
Copper ions (Cu2+) at concentrations of 25-50 μM stimulate lipopolysaccharide (LPS)-induced nitric oxide (NO) production in glial cell cultures derived from rat cerebral cortex and containing both astrocytes and microglia. Addition of a…
View details →Hamaya R, Li S, Lau J et al. · 2026 · American journal of hypertension
Background Multivitamin-multimineral (MVM) supplements have been associated with lower blood pressure (BP) in several small trials. We investigated the effects of a MVM on incident hypertension and BP in a secondary analysis of the COcoa…
View details →Detelich J, Martin GS · 2025 · Annals of internal medicine
Clinical impact ratings Emergency Med: [Formula: see text] GIM/FP/GP: [Formula: see text] Critical Care: [Formula: see text].
View details →Dubrovsky L, Pushkarsky T, Brichacek B et al. · 2026 · Microorganisms
Trained immunity (TRIM) enhances innate immune responses through epigenetic and metabolic reprogramming but may become maladaptive, contributing to chronic inflammation. In people living with HIV (PLWH), maladaptive TRIM has been proposed…
View details →Tamoto M, Kai S, Yoshida H et al. · 2026 · Journal of cardiothoracic and vascular anesthesia
Objectives To compare the real-world effectiveness of combined propofol and dexmedetomidine (PRODEX) sedation with propofol monotherapy on survival and postoperative delirium (POD) in a large nationwide cohort of patients undergoing…
View details →Khun Jush B, Biswas MAAJ, Lim HJJ et al. · 2026 · Pancreas
Background Routine feeding tube (FT) placement during pancreaticoduodenectomy (PD) has not reduced complication rates. Nonetheless, FTs are often selectively placed in patients with poor nutritional status such as those with significant…
View details →Bücken CA, Riesthuis P, Caon G et al. · 2026 · Memory (Hove, England)
False autobiographical memories can have serious implications in legal settings, where the case outcomes may hinge entirely on memory-based eyewitness testimony. This study investigated whether a sensitisation memory training could reduce…
View details →Inácio ML, Rusinque L, Nóbrega F et al. · 2026 · Plant disease
Aphelenchoides besseyi , the causal agent of the white-tip disease, is a quarantine nematode known to affect rice ( Oryza sativa ) by colonizing leaf tips and panicles. In January 2021, A. besseyi was detected in Portugal in imported…
View details →Goren T, Vashdi DR, Beeri I · 2026 · Social science & medicine (1982)
Political trust is considered crucial for enhancing civic compliance with government policies and instructions, particularly during a health crisis. However, evidence from the COVID-19 pandemic, a major global health crisis, suggest a more…
View details →Mohanta S, Tye KM · 2025 · Neuron
In this issue of Neuron, Biane et al. 1 used cellular-resolution recordings in ventral CA1 (vCA1) to comprehensively establish that it encodes stimulus features and identity, but not a generalized abstraction of valence. This suggests a…
View details →Zhou G, Dael N, Verweij S et al. · 2026 · Pharmaceuticals (Basel, Switzerland)
Background: The rapid emergence of immune-evasive SARS-CoV-2 variants necessitates the identification of accessible, low-cost prophylactic strategies. While drug repurposing offers a time-efficient alternative to novel drug development,…
View details →Brent DA · 2026 · Journal of the American Academy of Child and Adolescent Psychiatry
In this issue of JAACAP, Asarnow and colleagues report the results of their innovative, elegantly conducted clinical trial that assessed the added value of stratified, stepped care (SSC) for youth at risk for suicidal behavior in a health…
View details →Haroon A, Almuhaideb A, Adeleke S et al. · 2026 · Nuclear medicine communications
Objective To assess the accuracy of 18F choline PET/magnetic resonance (MR) when compared with the reference standard MRI-guided template mapping (TPM) biopsies for evaluation of biochemical relapse of prostate cancer in patients with…
View details →Goldstein EL, Marcelo KR, Harjes WR et al. · 2025 · Emergency radiology
Purpose Controversy exists regarding analgesia premedication prior to right upper quadrant ultrasound (RUQUS) in the setting of abdominal pain when evaluating for acute cholecystitis (AC). The purpose of this study was to examine the…
View details →Bafaraj SM · 2025 · Current problems in diagnostic radiology
The primary aim of this study is to assess how well ultrasonography and 99mTc-sestamibi scintigraphy perform as diagnostic tools for hyperparathyroidism (HPT) when compared to the clinical measurements of parathyroid hormone (PTH) levels.…
View details →Kwatra D, Wakeford W, Ally M et al. · 2026 · BMC endocrine disorders
BACKGROUND: To evaluate the concordance of the NBCL CONNECT Point-of-Care (POC) Intraoperative Parathyroid Hormone (IOPTH) assay with a Central Laboratory standard, with a focus on percentage drops and the usefulness of POC testing in…
View details →Saucedo M, Chamorro MF, Passler T et al. · 2026 · Journal of the American Veterinary Medical Association
Objective This study aimed to compare the most accurate sample type, test, and timing for detecting bovine viral diarrhea virus (BVDV) in persistently infected (PI) calves at different time points following birth and colostrum intake.…
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