11,412 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Bäumges H, Jelinek S, Lange H et al. · 2025 · Cells
Fucose-containing glycoproteins and glycolipids broadly occur in humans as well as in many other species and are essential for a wide range of physiological processes, such as cell adhesion, fertilization, and tumor development. In humans,…
View details →Leslie WD, Zarzour F, Binkley N et al. · 2025 · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Statins are among the most widely prescribed medications in older individuals. Inconsistent data in humans suggest that statin medications may be associated with greater BMD and lower risk for osteoporosis. We identified 22 393 individuals…
View details →Sadiq DR, Mikhael EM · 2024 · Clinical ophthalmology (Auckland, N.Z.)
Background Glaucoma is a chronic progressive eye disorder. It is the primary cause of blindness. To prevent glaucomatous damage and blindness, the intra-ocular pressure (IOP) must be lowered to certain levels, this level is known as "IOP"…
View details →Birk JB, Møller MA, Wojtaszewski JFP et al. · 2025 · FEBS letters
It has been proposed that the regulatory Sit4-associated protein subunit 3 (SAPS3) of protein phosphatase 6 (PP6C) acts as an AMP-activated protein kinase (AMPK) inhibitor by recruiting PP6C to dephosphorylate AMPKα-T172. While we confirm…
View details →Biçengil K, Kurt A, Naralan ME et al. · 2026 · Diagnostics (Basel, Switzerland)
Objectives : To evaluate the diagnostic performance of a YOLOv8x-based deep learning model for detecting approximal, occlusal and buccal caries on paediatric panoramic radiographs and to compare its performance with human observers with…
View details →Airaksinen J, Siimes S, Hartikainen J et al. · 2024 · Pflugers Archiv : European journal of physiology
Arrhythmia detection is essential when assessing the safety of novel drugs and therapies in preclinical studies. Many short-term arrhythmia monitoring methods exist, including non-invasive ECG and Holter. However, there are no reliable,…
View details →Ura H, Hatanaka H, Togi S et al. · 2025 · International journal of molecular sciences
RNA sequencing (RNA-Seq) is a powerful technique for the quantification of transcripts and the analysis of alternative splicing. Previously, our laboratory developed the targeted RNA long-amplicon sequencing (rLAS) method, which has the…
View details →Fan Z, Kitaura H, Marahleh A et al. · 2025 · International journal of molecular sciences
Bone remodeling is maintained through the coordinated actions of osteoblasts, osteoclasts, and osteocytes, among which osteocytes serve as major regulators of osteoclast-mediated bone resorption through the receptor activator of the…
View details →Stracquadanio S, Nicolosi A, Marino A et al. · 2024 · Diagnostics (Basel, Switzerland)
Background The rise of multi-drug-resistant Gram-negative bacteria necessitates the development of new antimicrobial agents. Cefiderocol shows promising activity by exploiting bacterial iron transport systems to penetrate the outer…
View details →Bui TI, Farnsworth CW, Anderson NW · 2024 · Journal of clinical microbiology
Many emergency departments (ED) use rapid human immunodeficiency virus (HIV) antibody tests as screening tools, despite limited sensitivity for detecting acute HIV infections. In a 4-year retrospective analysis of 1,192 patients, we…
View details →Lamarre J, Wilson DR · 2025 · The Journal of experimental biology
Docosahexaenoic acid (DHA), a long-chain omega-3 fatty acid (n3-LCPUFA), is an integral component of vertebrate brains. Vertebrates maintain their DHA levels through biosynthesis using alpha-linolenic acid (ALA; omega-3 precursor) or by…
View details →Walker UA, Nettermann K, Walker S et al. · 2025 · PloS one
Objectives To evaluate if self-assessed rheumatic disease activity in patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA) or ankylosing spondyloarthritis (AS) is linked to local weather. Methods In this prospective,…
View details →Verdecchia P, Coiro S, Bartolini C et al. · 2025 · American journal of hypertension
Background Different definitions of white-coat hypertension (WCH) may explain its variable outcome across studies. Methods In an Italian study started in 1986, we followed 3,153 people with (office blood pressure (BP) >=140/90 mmHg) and…
View details →Falck RS, Cosco TD, Wister AV et al. · 2024 · Maturitas
Objectives To explore whether the association between physical activity (PA) and cognition is moderated by neighbourhood disadvantage, and whether this relationship varies with age. Study design A longitudinal analysis of the Canadian…
View details →Poyntz-Wright IP, Harrison XA, Pedersen S et al. · 2024 · The Science of the total environment
Environmental DNA (eDNA) is a technique increasingly used for monitoring organisms in the natural environment including riverine macroinvertebrates. However, the effectiveness of eDNA for monitoring riverine macroinvertebrates compared…
View details →Li SL, Lin HL, Mi HF et al. · 2024 · Practical laboratory medicine
Objectives To evaluate the diagnostic performance of different brands of immunochromatographic test (ICT) reagents for Chlamydia trachomatis using homogenized samples to provide a reference for reagent quality control. Methods Eight…
View details →Schilter KF, Kapoor S, Smith BA et al. · 2024 · Laboratory medicine
Objective The aim of this study was to compare the performance of direct amplification of viral nucleic acid from transport medium to extracted nucleic acid for polymerase chain reaction (PCR), sequencing, and genotyping applications.…
View details →Maestrini I, Viganò A, Di Stefano G et al. · 2024 · Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
Background The association between paroxysmal hemicrania (PH) and trigeminal neuralgia-the so-called PH-tic syndrome-has rarely been described. However, a correct diagnosis is crucial since both disorders require specific treatments.…
View details →Craver R, Collier S, Anderson M · 2024 · Fetal and pediatric pathology
Background: We investigated the utilization of cell free microbial DNA (cfDNA) at a Children's Hospital. Materials and Methods: cfDNA results were assessed regarding the contribution to therapeutic decisions. Results: Of 80 tests on 59…
View details →Fruhauf F, Cibula D, Kocian R et al. · 2024 · International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
Objectives To assess the diagnostic performance of ultrasonography in pre-operative assessment of lymph nodes in patients with cervical cancer, to compare the outcomes for pelvic and para-aortic regions, and to detect macrometastases and…
View details →Xing L, Lu B, Zhu X et al. · 2026 · Inflammation and regeneration
Background Mesenchymal stromal cells (MSCs) possess therapeutic potential largely reliant on intact mitochondrial function to maintain reparative function. However, obesity compromises MSC metabolism and reparative capacity. MOTS-c, a…
View details →Zheng B · 2026 · Current molecular medicine
Background/objective Patients with renal artery stenosis (RAS) exhibit increased risk of cardiovascular death and all-cause death. Our previous finding showed that the presence of RAS is associated with poor coronary collateral development…
View details →Luda KM, Agerholm M, Sonne SB et al. · 2026 · Molecular metabolism
Background White adipose tissue (WAT) plays a central role in maintaining systemic metabolic homeostasis by buffering lipid flux throughout the body. Impairment of this lipid-buffering capacity is a hallmark of obesity and has also been…
View details →Wang H, Kang L, Mu Y et al. · 2026 · Archives of animal nutrition
Light weaning body weight (LWBW) piglets exhibit inferior growth performance, and their energy requirement vary dynamically with increasing body weight. Although high-energy diets improve growth, they risk impairing liver health.…
View details →Walsh RW, Meledeo MA, Nicolson SE et al. · 2026 · Transfusion
Background Hypocalcemia is correlated with poor outcomes in trauma patients and is considered the fourth component in the "diamond of death" alongside acidosis, coagulopathy, and hypothermia. Study design and methods We characterized the…
View details →Pelletier M, Yang J, Joshi M et al. · 2026 · Clinical cancer research : an official journal of the American Association for Cancer Research
Background Transforming Growth Factor Beta (TGFβ) plays a dual role in cancer, acting as a tumor suppressor early in disease but promoting progression and immune evasion when dysregulated. In pancreatic ductal adenocarcinoma (PDAC),…
View details →De S Ferreira JM, Rodrigues HP, Alba HDR et al. · 2026 · Animal : an international journal of animal bioscience
High-concentrate diets supplemented with rumen-protected fats are widely used in feedlot lamb systems to improve energy supply and performance; however, the metabolic efficacy of these lipid sources may depend on the availability of…
View details →· 2025 · Nephron
In the article "Immunosuppressant Agents as Add-On Therapy Failed to Improve the Outcome of Immunoglobulin A Nephropathy with Crescent Score C1" [Nephron. 2024;148:587-600; https://doi.org/10.1159/000534788] by Bi et al., the funding grant…
View details →Ngeve SM, Khoury AL, Long JM · 2026 · Journal of visualized experiments : JoVE
Vanishing Lung Syndrome (VLS) is a rare, severe form of bullous pulmonary disease characterized by giant bullae occupying more than 30% of the hemithorax, which can easily be misdiagnosed as a pneumothorax. While cigarette smoking is the…
View details →Stahl M, Zeidan AM · 2026 · Blood
Abstract Aside from allogeneic transplantation, the current standard-of-care approach for higher-risk myelodysplastic syndromes/neoplasms (HR-MDS) remains monotherapy with a hypomethylating agent (HMA), including azacitidine, decitabine,…
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