e-ISSN: Pending
WASTE Journal

Browse the failure-mode index

11,312 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Effects of sildenafil on gas exchange, ventilatory, and sensory responses to exercise in subjects with mild-to-moderate COPD: A randomized cross-over trial.

Gass R, Plachi F, Silva FOB et al. · 2025 · Respiratory physiology & neurobiology

Excess exercise ventilation (high ventilation (V̇ E )/carbon dioxide output (V̇CO 2 )) contributes significantly to dyspnea and exercise intolerance since the earlier stages of chronic obstructive pulmonary disease (COPD). A selective…

View details →
Negative / Null Result ReportMedicine

Phase 2 trial of veliparib, local irradiation, and temozolomide in patients with newly diagnosed high-grade glioma: a Children's Oncology Group study.

Karajannis MA, Onar-Thomas A, Lin T et al. · 2025 · Neuro-oncology

Background The outcome for pediatric patients with high-grade glioma (HGG) remains poor. Veliparib, a potent oral poly(adenosine diphosphate-ribose) polymerase (PARP) 1/2 inhibitor, enhances the activity of radiotherapy and DNA-damaging…

View details →
Negative / Null Result ReportOpen accessMedicine

High-Dose Furmonertinib Management of Advanced NSCLC Harboring an EGFR Exon 14 Missense Mutation: A Case Report and Literature Review.

Luo JY, Xiang J, Hong XL et al. · 2026 · The American journal of case reports

BACKGROUND Epidermal growth factor receptor (EGFR) is a key driver gene in non-small-cell lung cancer (NSCLC), and EGFR tyrosine kinase inhibitors (TKIs) are the standard treatment for classical mutations, including exon 19 deletion and…

View details →
Negative / Null Result ReportMedicine

Influence of short bouts of stair climbing on young adults during prolonged sitting on posture, discomfort, and musculoskeletal performance outcomes: a counterbalanced pilot randomised crossover trial.

Raj AK, Pedersen SJ, Mainsbridge C et al. · 2024 · Ergonomics

Prolonged sitting is postulated to influence musculoskeletal performance (cervical flexor endurance, balance, and agility), discomfort and alter cervical spine angles during work-based computer use. Stair climbing breaks may be a great…

View details →
Negative / Null Result ReportMedicine

Factors Influencing Nursing Students' Attitudes and Career Interests in Mental Health Nursing - An Integrative Review.

Cearns K, Lazarus ER, Wahid R · 2026 · The Canadian journal of nursing research = Revue canadienne de recherche en sciences infirmieres

BackgroundMental health nurses represent only 1.03% of the global nursing workforce, contributing to persistent workforce shortages. Undergraduate nursing students demonstrate limited interest in mental health nursing (MHN), often…

View details →
Negative / Null Result ReportMedicine

An Assessment of the Impacts of Feeding Four Fungal Extracts on the Lifespan and Midgut of Newly Emerged Carniolan Honey Bees (<i>Apis mellifera carnica</i>).

Ansaloni LS, Domingues CEC, Gregori M et al. · 2026 · Insects

Given the current global agricultural system, honey bees are exposed to a complex network of stressors that can act simultaneously, making it challenging to maintain healthy colonies. Therefore, studies on natural products to improve…

View details →
Negative / Null Result ReportMedicine

Effects of walnut consumption for 2 years on older adults' bone health in the Walnuts and Healthy Aging (WAHA) trial.

Oliver-Pons C, Sala-Vila A, Cofán M et al. · 2024 · Journal of the American Geriatrics Society

Background Nutritional strategies to maintain bone health in aging individuals are of great interest. Given the beneficial nutrient composition of walnuts, rich in alpha-linolenic (the vegetable n-3 fatty acid) and polyphenols, their…

View details →
Negative / Null Result ReportOpen accessMedicine

High-fat diet-induced obesity impairs endothelium-dependent relaxation in rabbits: association with MLCK upregulation and partial <i>ex vivo</i> improvement by ML-7.

Li J, Zhou J, Ha Q et al. · 2026 · Frontiers in cardiovascular medicine

Objective Obesity is an independent risk factor for cardiovascular diseases and elevated mortality, yet the underlying mechanisms remain incompletely understood. Impaired endothelium-dependent relaxation is an early manifestation of…

View details →
Negative / Null Result ReportOpen accessMedicine

Influence of stimulus material and effector specificity on performance in the measurement of interference control in adolescent handball and soccer players compared to non-player controls.

Heilmann F, Langsdorf LE, Schubert T · 2026 · Psychological research

This study investigated how stimulus material and effector specificity influence interference control (a form of inhibitory control) in adolescent players. Ninety-one males aged 15-18 years (28 handball players, 34 soccer players, 29…

View details →
Negative / Null Result ReportMedicine

Evaluating the addition of real-time continuous glucose monitors to pharmacist intervention on glycated hemoglobin.

DeBoest A, Holley C, Hickey M et al. · 2026 · American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists

Purpose To determine the impact of pharmacist intervention with real-time continuous glucose monitors (rtCGMs) on glycated hemoglobin (HbA1c) levels and the number of pharmacist touchpoints compared to standard of care (SOC). Methods…

View details →
Negative / Null Result ReportMedicine

Comparative Safety of Long-Acting Versus Short-Acting Erythropoiesis-Stimulating Agents (ESA): Disproportionality Analysis Using the FDA Adverse Event Reporting System.

Park M, Park H, Baek IH et al. · 2026 · Journal of patient safety

Objectives Erythropoiesis-stimulating agents (ESAs), classified as long-acting or short-acting, is a primary treatment for anemia in chronic kidney disease and chemotherapy. Given ongoing safety concerns regarding cardiovascular events and…

View details →
Negative / Null Result ReportMedicine

Mastic gum as an adjunct therapy to standard bismuth quadruple therapy for Helicobacter pylori eradication: A randomized single-blind pilot study.

Tulsian V, Kant R, Patnaik I et al. · 2026 · Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology

Background and objectives Helicobacter pylori infection is highly prevalent globally. Standard bismuth quadruple therapy is commonly used in India, but there are growing concerns regarding the emergence of anti-microbial resistance and…

View details →
Negative / Null Result ReportMedicine

Increasing Facial Attractiveness by Lateralizing the Auricle-Analyzing the Pan-Facial Effects of the Postauricular Injection Technique in Chinese Patient Populations.

Hong WJ, Huang JM, Liu YH et al. · 2025 · Aesthetic plastic surgery

Background The postauricular injection technique is a needle-based technique that places soft tissue fillers behind the ears into the supra-periosteal plane of the mastoid process of the temporal bone. The resulting clinical effect pushes…

View details →
Negative / Null Result ReportMedicine

The impact of total laparoscopic excision of deep endometriosis (DE) on bladder and bowel dysfunction: a prospective longitudinal study.

Morris JS, Rajshekhar S, Gremmo G et al. · 2026 · European journal of obstetrics, gynecology, and reproductive biology

Deep endometriosis (DE) is established to cause chronic pelvic pain (CPP), lower urinary tract symptoms (LUTS) and altered bowel function. Although the aim of surgical excision is often to relieve CPP, evidence suggests it could also…

View details →
Negative / Null Result ReportOpen accessMedicine

Molecular imaging of lymphatic organs provides prognostic value after acute myocardial infarction.

Reiter T, Dörrler AL, Hasenauer N et al. · 2026 · European journal of nuclear medicine and molecular imaging

Introduction Acute myocardial infarction (AMI) triggers local inflammation in the injured myocardium, followed by a systemic inflammatory response of lymphatic organs. This prospective trial (NCT05519735) focused on molecular imaging of…

View details →
Negative / Null Result ReportMedicine

Effects of heat stress on human health and physio-biochemical attributes of quinoa growing in arsenic contaminated soil.

Shabbir A, Abbas G, Alharby HF et al. · 2026 · International journal of phytoremediation

Heat stress and soil arsenic (As) contamination are resulting in severe decline in crop production around the world. The present experiment aimed to assess physiological and biochemical changes induced by the combination of As and heat…

View details →
Negative / Null Result ReportMedicine

Evaluation of incisional negative pressure wound therapy with anterior approach total ankle arthroplasty.

Cottom JM, Verdoni TJ · 2026 · The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons

Background Total ankle replacement continues to find significantly increased utilization as the technology advances. While there are different systems on the market, most are implanted through an anterior incisional approach just lateral…

View details →
Negative / Null Result ReportMedicine

Exposure levels and target attainment of meropenem in adult patients admitted to the intensive care unit: a prospective observational study.

El-Haffaf I, Marsot A, Paillault A et al. · 2025 · Canadian journal of physiology and pharmacology

In this study, we evaluate the exposure and pharmacokinetic/pharmacodynamic target attainment of meropenem in critically ill patients. We conducted a prospective observational study in two Canadian intensive care units (ICUs) from January…

View details →