11,287 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Peter Sundström, Anders Wåhlin, Khalid Ambarki et al. · 2010 · Annals of Neurology
The prevailing view on multiple sclerosis etiopathogenesis has been challenged by the suggested new entity chronic cerebrospinal venous insufficiency. To test this hypothesis, we studied 21 relapsing-remitting multiple sclerosis cases and…
View details →Angela Kuznia, Anita K Hernandez, Lydia U Lee · 2020 · PubMed
Adolescent idiopathic scoliosis affects 1% to 3% of U.S. adolescents. It is defined by a lateral curvature of the spine (Cobb angle) of at least 10 degrees in the absence of underlying congenital or neuromuscular abnormalities. Adolescent…
View details →Myung‐Ju Ahn, Kentaro Tanaka, Luis Paz‐Ares et al. · 2024 · Journal of Clinical Oncology
PURPOSE The randomized, open-label, global phase III TROPION-Lung01 study compared the efficacy and safety of datopotamab deruxtecan (Dato-DXd) versus docetaxel in patients with pretreated advanced/metastatic non–small cell lung cancer…
View details →DK Patel, R Kumar, SK Prasad et al. · 2011 · Asian Pacific Journal of Tropical Biomedicine
OBJECTIVE: To evaluate antidiabetic and antioxidant potential of Hybanthus enneaspermus in different models. METHODS: The oral glucose tolerance test (OGTT) and normoglycemic effect of alcoholic extract of Hybanthus enneaspermus (AHE) were…
View details →Ilaria Montagni, Elie Guichard, Claire Carpenet et al. · 2015 · Cephalalgia
Objective The objective of this article is to investigate whether excessive screen time exposure is associated with non-migraine headache and migraine in young adults. Background Increased levels of television time have been associated…
View details →Ranjani R. Starr · 2015 · American Journal of Public Health
Millions of people in the United States consume dietary supplements hoping to maintain or improve their health; however, extensive research has failed to demonstrate the efficacy of numerous supplements in disease prevention. In addition,…
View details →Miriam M. Boxer, Shalini Vinod, Jesmin Shafiq et al. · 2011 · Cancer
BACKGROUND: There is limited evidence regarding the effectiveness of multidisciplinary team (MDT) meetings in lung cancer. The objective of this study was to compare the patterns of care for patients with newly diagnosed lung cancer who…
View details →J. F. Keating, Elizabeth Will · 2011 · Journal of Bone and Joint Surgery - British Volume
A total of 80 patients with an acute rupture of tendo Achillis were randomised to operative repair using an open technique (39 patients) or non-operative treatment in a cast (41 patients). Patients were followed up for one year. Outcome…
View details →Robert H. Squires, Anil Dhawan, Estella M. Alonso et al. · 2012 · Hepatology
UNLABELLED: N-acetylcysteine (NAC) was found to improve transplantation-free survival in only those adults with nonacetaminophen (non-APAP) acute liver failure (ALF) and grade 1-2 hepatic encephalopathy (HE). Because non-APAP ALF differs…
View details →Armin Zittermann, Jana B. Ernst, Sylvana Prokop et al. · 2017 · European Heart Journal
AIMS: Circulating 25-hydroxyvitamin D (25OHD) levels <75 nmol/L are associated with a nonlinear increase in mortality risk. Such 25OHD levels are common in heart failure (HF). We therefore examined whether oral vitamin D supplementation…
View details →Siaw Cheok Liew, Esha Dasgupta, Shew Fung Wong et al. · 2012 · Nutrition Journal
BACKGROUND: The methylenetetrahydrofolate reductase (MTHFR) enzyme catalyzes the reduction of 5, 10-methylenetetrahydrofolate to 5-methyltetrahydrofolate and methyl donors. The methyl donors are required for the conversion of homocysteine to methionine. Mutation of MTHFR 677 C > T disrupts its thermostability therefore leads to defective enzyme activities and dysregulation of homocysteine levels. METHODS: This case-control study (n = 367) was conducted to investigate the correlation of the MTHFR gene polymorphism [NM_005957] and psoriasis vulgaris amongst the Malaysian population. Overnight fa
View details →Mengyue Niu, Yang Li, Gerald Li et al. · 2020 · European Journal of Neurology
BACKGROUND AND PURPOSE: The identification of reliable diagnostic and prognostic biomarkers for Parkinson's disease (PD) is urgently needed. Here, we explored the potential use of α-synuclein (α-syn) in plasma neuronal exosomes as a…
View details →US Preventive Services Task Force, David C. Grossman, Susan J. Curry et al. · 2018 · JAMA
Importance: Skin cancer is the most common type of cancer in the United States. Although invasive melanoma accounts for only 2% of all skin cancer cases, it is responsible for 80% of skin cancer deaths. Basal and squamous cell carcinoma,…
View details →Charles Pilgrim, Richard McIntyre, Michael Bailey · 2010 · Diseases of the Colon & Rectum
PURPOSE: There is little evidence regarding the prevalence or incidence of parastomal hernia, but it is thought to be common. Repair of parastomal hernia can be troublesome, and methods of repair need to be validated based on reduced…
View details →Farzana Saleh, Shirin Jahan Mumu, Ferdous Ara et al. · 2014 · BMC Public Health
BACKGROUND: Non-adherence to lifestyle modification among diabetic patients develops the short-term risks and the long-term complications as well as declines the quality of life. This study aimed to find out the association between non-adherence to self-care practices, medication and health related quality of life (HR-QoL) among type 2 diabetic patients. METHODS: At least 1 year diagnosed patients with type 2 diabetes (N = 500), age>25 years were conveniently selected from the Out-Patient Department of Bangladesh Institute of Health Sciences Hospital. Patients' self-care practices were assesse
View details →Maximilian Christopeit, Oliver Kuß, Jürgen Finke et al. · 2013 · Journal of Clinical Oncology
PURPOSE: To evaluate the role of a second allogeneic hematopoietic stem-cell transplantation (HSCT2) given for relapsed acute leukemia (AL) after related or unrelated first hematopoietic stem-cell transplantation (HSCT1) and to analyze the…
View details →Ulf Neumann, Mike Ufer, Laura H. Jacobson et al. · 2018 · EMBO Molecular Medicine
The beta‐site amyloid precursor protein cleaving enzyme‐1 (BACE‐1) initiates the generation of amyloid‐β (Aβ), and the amyloid cascade leading to amyloid plaque deposition, neurodegeneration, and dementia in Alzheimer's disease (AD). Clinical failures of anti‐Aβ therapies in dementia stages suggest that treatment has to start in the early, asymptomatic disease states. The BACE‐1 inhibitor CNP520 has a selectivity, pharmacodynamics, and distribution profile suitable for AD prevention studies. CNP520 reduced brain and cerebrospinal fluid (CSF) Aβ in rats and dogs, and Aβ plaque deposition in APP
View details →Stefan Hagel, Friedhelm Bach, Thorsten Brenner et al. · 2022 · Intensive Care Medicine
PURPOSE: Insufficient antimicrobial exposure is associated with worse outcomes in sepsis. We evaluated whether therapeutic drug monitoring (TDM)-guided antibiotic therapy improves outcomes. METHODS: Randomized, multicenter, controlled…
View details →RBC Kavia, Dirk De Ridder, Cris S. Constantinescu et al. · 2010 · Multiple Sclerosis Journal
BACKGROUND: Bladder dysfunction is a common feature of multiple sclerosis (MS). OBJECTIVE: In this study we aimed to assess the efficacy, tolerability and safety of Sativex(®) (nabiximols) as an add-on therapy in alleviating bladder…
View details →Rebecca Erwin Wells, Rebecca Burch, Randall H. Paulsen et al. · 2014 · Headache The Journal of Head and Face Pain
OBJECTIVE: Our objective was to assess the safety, feasibility, and effects of the standardized 8-week mindfulness-based stress reduction (MBSR) course in adults with migraines. BACKGROUND: Stress is a well-known trigger for headaches.…
View details →Jessica Lieffers, Vickie E. Baracos, Marcy Winget et al. · 2010 · Cancer
BACKGROUND: Cancer survival is related to features of the primary malignancy and concurrent presence of nonmalignant diseases (comorbidities), including weight-related conditions (obesity, weight loss). The Charlson and Elixhauser methods…
View details →Benjamin W. Chaffee, Shannon Lea Watkins, Stanton A. Glantz · 2018 · PEDIATRICS
BACKGROUND: It has been shown that never-smoking adolescents who try electronic cigarettes (e-cigarettes) are at increased risk of subsequent conventional cigarette smoking. We evaluated associations between e-cigarette use and progression…
View details →Alexandra Philipsen, Thomas Jans, Erika Graf et al. · 2015 · JAMA Psychiatry
IMPORTANCE: Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder with high prevalence in adulthood. There is a recognized need to assess the efficacy of psychotherapy in adult ADHD. OBJECTIVE: To evaluate the…
View details →Richard Aplenc, Soheil Meshinchi, Lillian Sung et al. · 2020 · Haematologica
New therapeutic strategies are needed for pediatric acute myeloid leukemia (AML) to reduce disease recurrence and treatment-related morbidity. The Children’s Oncology Group Phase III AAML1031 trial tested whether the addition of bortezomib…
View details →Silvia Fernández-Serrano, Jordi Dorca, Carolina García‐Vidal et al. · 2011 · Critical Care
INTRODUCTION: The benefit of corticosteroids as adjunctive treatment in patients with severe community-acquired pneumonia (CAP) requiring hospital admission remains unclear. This study aimed to evaluate the impact of corticosteroid treatment on outcomes in patients with CAP. METHODS: This was a prospective, double-blind and randomized study. All patients received treatment with ceftriaxone plus levofloxacin and methyl-prednisolone (MPDN) administered randomly and blindly as an initial bolus, followed by a tapering regimen, or placebo. RESULTS: Of the 56 patients included in the study, 28 (50%)
View details →Peter K. Kaiser, René El Attal, Mark Kammerer et al. · 2016 · Archives of Orthopaedic and Trauma Surgery
INTRODUCTION: This study compared the feasibility of six different CT-based measurement techniques for establishing an indication for derotational osteotomy in the cases of patellar instability or femoral fracture. MATERIALS AND METHODS: CT scans of 52 single human cadaver femora were measured using six different torsion measurement techniques (described by Waidelich, Murphy, and Yoshioka on transverse images and Hernandez, Jarrett, and Yoshioka on oblique images). All measurements were performed by four observers twice to assess intraobserver and interobserver agreement. The intraclass correl
View details →US Preventive Services Task Force, David C. Grossman, Susan J. Curry et al. · 2018 · JAMA
Importance: Adolescent idiopathic scoliosis, a lateral curvature of the spine of unknown cause with a Cobb angle of at least 10°, occurs in children and adolescents aged 10 to 18 years. Idiopathic scoliosis is the most common form and…
View details →Joachim Feldkamp, Andréa Becker, Otto W. Witte et al. · 2012 · Experimental and Clinical Endocrinology & Diabetes
Anticonvulsant therapy causes changes in calcium and bone metabolism and may lead to decreased bone mass with the risk of osteoporotic fractures. The two widely used antiepileptic drugs phenytoin and carbamazepine are recognized to have…
View details →Naama Barnea‐Goraly, Mira M. Raman, Paul K. Mazaika et al. · 2013 · Diabetes Care
OBJECTIVE: To investigate whether type 1 diabetes affects white matter (WM) structure in a large sample of young children. RESEARCH DESIGN AND METHODS: Children (ages 4 to <10 years) with type 1 diabetes (n = 127) and age-matched…
View details →Carol A. Langford, David Cuthbertson, Steven R. Ytterberg et al. · 2017 · Arthritis & Rheumatology
Objective To compare the efficacy of abatacept to that of placebo for the treatment of Takayasu arteritis (TAK). Methods In this multicenter trial, patients with newly diagnosed or relapsing TAK were treated with abatacept 10 mg/kg…
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