Negative / Null Result ReportOpen accessDermatology
Gi-Wook Lee, Keunyoung Kim, Seong-Jang Kim et al. · 2023 · Acta Dermato-Venereologica
Atopic dermatitis (AD) is an inflammatory skin disease associated with increased systemic and vascular inflammation. Although dupilumab has been proven to be effective against severe AD, imaging studies analysing its inflammation-reducing effect have rarely been reported. The aim of this study was to evaluate the effect of dupilumab on systemic and vascular inflammation in adult patients with severe AD, using 18F-fluorodeoxyglucose positron emission tomography-computed tomography (18F-FDG PET/CT). A total of 33 adult patients with severe AD and 25 healthy controls underwent 18F-FDG PET/CT at b
View details →Negative / Null Result ReportOpen accessDermatology
Fadime Mutlu İçduygu, Isil Deniz Oguz, Egemen Akgun et al. · 2026 · Dermatology Practical & Conceptual
Introduction: Psoriasis, a widespread inflammatory cutaneous disease, is driven by an interplay of genetic and environmental risk factors. miR-155 and miR-146a have been implicated in the regulation of inflammatory pathways. Objectives: In the current study, we examined the association between miR-155 rs767649 and miR-146a rs2910164 variants and the predisposition to psoriasis and psoriatic arthritis. Methods: A total of 544 individuals, including 284 psoriasis cases (68 with psoriatic arthritis) and 260 controls, were enrolled in the present study. Real-time polymerase chain reaction (qPCR) m
View details →Negative / Null Result ReportOpen accessDermatology
JI Liyue, QIU Xiaonan, WANG Xijuan et al. · 2025 · Pifu-xingbing zhenliaoxue zazhi
[Objective] To evaluate the clinical efficacy and safety of intralesional injection of heparin sodium versus carbon dioxide (CO2) laser ablation in the treatment of xanthelasma palpebrarum. [Methods] A total of 38 patients with Grade Ⅰ-Ⅲ xanthelasma and normal blood lipid levels were retrospectively enrolled, and divided into two groups based on the treatment modality: the heparin sodium group (n=20) treated with intralesional injection of heparin sodium and the CO2 laser group (n=18) treated with CO2 laser ablation. The primary and secondary outcomes were compared between the two groups, incl
View details →Negative / Null Result ReportOpen accessDermatology
Imran Majid, Gousia Sheikh, Farhath Kanth et al. · 2016 · Indian Journal of Dermatology
Background: The incidence of recurrent tinea infections after oral terbinafine therapy is on the rise. Aim: This study aims to identify the appearance of incomplete cure and relapse after 2-week oral terbinafine therapy in tinea corporis and/or tinea cruris. Materials and Methods: A total of 100 consecutive patients clinically and mycologically diagnosed to have tinea corporis and/or tinea cruris were included in the study. The enrolled patients were administered oral terbinafine 250 mg once daily for 2 weeks. All clinically cured patients were then followed up for 12 weeks to look for any rel
View details →Negative / Null Result ReportOpen accessDermatology
Anne Sofie Frølunde, Jan Brink Valentin, Lise Kristensen et al. · 2026 · Acta Dermato-Venereologica
Dermatophyte infections are common in general practice and occur more often in individuals with type 2 diabetes (T2D), but whether they signal undiagnosed T2D remains unclear. We conducted a register-based cohort study including positive PCR tests for dermatophyte infection from the feet or nails, matched 1:3 to individuals from the same geographic area in Denmark. Those with known diabetes, type 1 diabetes or aged under 20 were excluded. Incidence rates (IRs) and incidence rate ratios (IRRs) for new-onset T2D were estimated using Poisson regression. The final cohort comprised 78,140 individua
View details →Negative / Null Result ReportOpen accessDermatology
Das Nilay, Ghosh Pramit, Das Suchibrata et al. · 2008 · Indian Journal of Dermatology
Background: Onychomycosis manifests itself in various forms, notably onychodystrophy, onycholysis, subungual hyperkeratosis, or nail-plate discoloration. Not necessarily nail changes mentioned here should always be of fungal origin. Objective: The present study is planned to get an idea about etiological agent and clinical correlation in fingernail onychomycosis. Materials and Methods: Nail-clipping and subungual debris of patients with above mentioned nail changes were subjected to KOH preparation. Culture was done on SDA and SDCCA media. Species identification was done by colony character, p
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Jie Gao, Linting Wei, Xinghan Liu et al. · 2017 · Kidney & Blood Pressure Research
Background/Aims: IFN-γ was reported to be involved in the development and progression of Immunoglobulin A nephropathy (IgAN), however, few studies have investigated the association between IFN-γ polymorphisms and IgAN. Therefore, we performed a case-control study to assess the association between IFN-γ polymorphisms and the risk of IgAN. Methods: Sequenom MassARRAY was used to genotype two SNPs (rs1861494 and rs2430561) in 351 patients with IgAN and 310 healthy controls. Associations were evaluated as odd ratios (OR) with 95% confidence intervals (CI). Results: No association was found between
View details →Negative / Null Result ReportOpen accessDermatology
Souvik Sardar, Somenath Sarkar, Indrashis Podder et al. · 2022 · Indian Journal of Dermatology
Background: Primary scarring alopecias (PSAs) are a rare group of dermatological disorders with overlapping clinical features. They result in permanent hair loss and significant psychological morbidity. Aims: To analyze the clinico-epidemiology of PSAs of the scalp, along with clinico-pathological correlation. Methods: We conducted a cross sectional, observational study including 53 histopathologically confirmed cases of PSA. Clinico-demographic parameters, hair care practices, and histologic characteristics were noted and statistically analyzed. Results: Among 53 patients (mean age 30.9 ± 8.1
View details →Negative / Null Result ReportOpen accessDermatology
Raissa Massaia Londero Chemello, Elsa Regina Justo Giugliani, Renan Rangel Bonamigo et al. · 2011 · Anais Brasileiros de Dermatologia
FUNDAMENTOS: Não há consenso quanto ao efeito do aleitamento materno no desenvolvimento da dermatite atópica. É necessário aprofundar conhecimentos sobre possíveis fatores envolvidos nessa relação, como a influência do aleitamento materno na colonização do paciente atópico pelo Staphylococcus aureus (S. aureus). OBJETIVO: Avaliar uma potencial associação entre aleitamento materno e colonização pelo S. aureus nas crianças atópicas. MÉTODOS: Estudo transversal envolvendo 79 crianças atópicas de 4-24 meses, de ambos os sexos, em acompanhamento no Ambulatório de Dermatologia Sanitária de Porto Ale
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