NISCAHN: a phase II trial of nivolumab in patients with salivary gland carcinoma (Unicancer ORL-08)
Christian Borel; Caroline Even; Christophe Le Tourneau; Jerome Fayette; Laurence Bozec; Joël Guigay; Sylvie Chabaud; Laurence Digue · 2023 · BMJ Oncology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Objective Salivary gland cancers (SGC) are rare cancers with currently no standard treatment for recurrent/metastatic disease. Based on checkpoint inhibitors benefit in a broad range of tumours, NIvolumab in Salivary gland CArcinoma of the Head and Neck (NISCAHN) evaluated nivolumab efficacy in SGC.Methods and analysis In this phase II single-stage Fleming design, patients with SGC with a progressive disease progression within 6 months prior to entering the study, were divided into ACC (adenoid cytic carcinoma) and non-ACC. All received nivolumab for a maximum of 12 months. The primary endpoin
Abstract by Christian Borel; Caroline Even; Christophe Le Tourneau; Jerome Fayette; Laurence Bozec; Joël Guigay; Sylvie Chabaud; Laurence Digue, BMJ Oncology (2023) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1136/bmjonc-2023-000065