Negative / Null Result ReportOpen accessMedicine
Hedy L. Kindler, Donna Niedzwiecki, Donna Hollis et al. · 2010 · Journal of Clinical Oncology
PURPOSE: The combination of gemcitabine plus bevacizumab produced a 21% response rate and a median survival of 8.8 months in a multicenter phase II trial in patients with metastatic pancreatic cancer. These encouraging data led Cancer and…
View details →DOI: 10.1200/jco.2010.28.1386Cited by 842 Negative / Null Result ReportOpen accessMedicine
Aneesh B. Singhal · 2011 · Archives of Neurology
OBJECTIVES: To compare the clinical, laboratory, and imaging features of patients with reversible cerebral vasoconstriction syndromes evaluated at 2 academic centers, compare subgroups, and investigate treatment effects. DESIGN:…
View details →DOI: 10.1001/archneurol.2011.68Cited by 611 Negative / Null Result ReportOpen accessEnvironmental Science
Melinda C. Power, Marc G. Weisskopf, Stacey Alexeeff et al. · 2010 · Environmental Health Perspectives
BACKGROUND: Traffic-related particles induce oxidative stress and may exert adverse effects on central nervous system function, which could manifest as cognitive impairment. OBJECTIVE: We assessed the association between black carbon (BC), a marker of traffic-related air pollution, and cognition in older men. METHODS: A total of 680 men (mean ± SD, 71 ± 7 years of age) from the U.S. Department of Veterans Affairs Normative Aging Study completed a battery of seven cognitive tests at least once between 1996 and 2007. We assessed long-term exposure to traffic-related air pollution using a validat
View details →DOI: 10.1289/ehp.1002767Cited by 448 Negative / Null Result ReportOpen accessMedicine
Mohamad Habes, Güray Erus, Jon B. Toledo et al. · 2016 · Brain
White matter hyperintensities are associated with increased risk of dementia and cognitive decline. The current study investigates the relationship between white matter hyperintensities burden and patterns of brain atrophy associated with…
View details →DOI: 10.1093/brain/aww008Cited by 429 Negative / Null Result ReportOpen accessNeuroscience
James H. Cole · 2020 · Neurobiology of Aging
The brain-age paradigm is proving increasingly useful for exploring aging-related disease and can predict important future health outcomes. Most brain-age research uses structural neuroimaging to index brain volume. However, aging affects multiple aspects of brain structure and function, which can be examined using multimodality neuroimaging. Using UK Biobank, brain-age was modeled in n = 2205 healthy people with T1-weighted MRI, T2-FLAIR, T2∗, diffusion-MRI, task fMRI, and resting-state fMRI. In a held-out healthy validation set (n = 520), chronological age was accurately predicted (r = 0.78,
View details →DOI: 10.1016/j.neurobiolaging.2020.03.014Cited by 395 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Jonathan A. Hern, Asma Baig, Gregory I. Mashanov et al. · 2010 · Proceedings of the National Academy of Sciences
G-protein-coupled receptors (GPCRs) are the largest family of transmembrane signaling proteins in the human genome. Events in the GPCR signaling cascade have been well characterized, but the receptor composition and its membrane…
View details →DOI: 10.1073/pnas.0907915107Cited by 383 Negative / Null Result ReportBusiness, Management and Accounting
Bruno Cassiman, Giovanni Valentini · 2015 · Strategic Management Journal
One novel implication of the open innovation paradigm is that inflows and outflows of knowledge are complementary. We argue that engaging simultaneously in buying and selling knowledge should allow firms to increase innovation outcomes. At…
View details →DOI: 10.1002/smj.2375Cited by 354 Negative / Null Result ReportOpen accessMedicine
Sung Soo Ahn, Myeong‐Jin Kim, Joon Seok Lim et al. · 2010 · Radiology
PURPOSE: To determine the added value of hepatobiliary phase images in gadoxetic acid-enhanced magnetic resonance (MR) imaging in the evaluation of hepatocellular carcinoma (HCC). MATERIALS AND METHODS: Institutional review board approved…
View details →DOI: 10.1148/radiol.10091388Cited by 331 Negative / Null Result ReportOpen accessEnvironmental Science
Reid Tingley, Marcelo Vallinoto, Fernando Sequeira et al. · 2014 · Proceedings of the National Academy of Sciences
Accurate forecasts of biological invasions are crucial for managing invasion risk but are hampered by niche shifts resulting from evolved environmental tolerances (fundamental niche shifts) or the presence of novel biotic and abiotic…
View details →DOI: 10.1073/pnas.1405766111Cited by 326 Negative / Null Result ReportOpen accessNeuroscience
Tong He, Ru Kong, Avram J. Holmes et al. · 2019 · NeuroImage
There is significant interest in the development and application of deep neural networks (DNNs) to neuroimaging data. A growing literature suggests that DNNs outperform their classical counterparts in a variety of neuroimaging…
View details →DOI: 10.1016/j.neuroimage.2019.116276Cited by 312 Negative / Null Result ReportOpen accessMedicine
Luke Macyszyn, Hamed Akbari, Jared Pisapia et al. · 2015 · Neuro-Oncology
BACKGROUND: MRI characteristics of brain gliomas have been used to predict clinical outcome and molecular tumor characteristics. However, previously reported imaging biomarkers have not been sufficiently accurate or reproducible to enter…
View details →DOI: 10.1093/neuonc/nov127Cited by 310 Negative / Null Result ReportBiochemistry, Genetics and Molecular Biology
Claudette E. Loo, Marieke E. Straver, Sjoerd Rodenhuis et al. · 2011 · Journal of Clinical Oncology
PURPOSE: To evaluate the relevance of breast cancer subtypes for magnetic resonance imaging (MRI) markers for monitoring of therapy response during neoadjuvant chemotherapy (NAC). PATIENTS AND METHODS: MRI examinations were performed in…
View details →DOI: 10.1200/jco.2010.31.1258Cited by 306 Negative / Null Result ReportBiochemistry, Genetics and Molecular Biology
Ali Alqerban, Reinhilde Jacobs, Steffen Fieuws et al. · 2011 · European Journal of Orthodontics
The diagnostic accuracy for the localization of impacted canines and the detection of canine-induced root resorption of maxillary incisors were compared between conventional radiographic procedures using one two-dimensional (2D) panoramic…
View details →DOI: 10.1093/ejo/cjq034Cited by 282 Negative / Null Result ReportOpen accessNeuroscience
Kyle S. Honegger, Robert A. A. Campbell, Glenn Turner · 2011 · Journal of Neuroscience
Sensory stimuli are represented in the brain by the activity of populations of neurons. In most biological systems, studying population coding is challenging since only a tiny proportion of cells can be recorded simultaneously. Here we…
View details →DOI: 10.1523/jneurosci.1099-11.2011Cited by 281 Negative / Null Result ReportOpen accessEnvironmental Science
Kate Osborne, Andrew M. Dolman, Scott C. Burgess et al. · 2011 · PLoS ONE
Coral reef ecosystems worldwide are under pressure from chronic and acute stressors that threaten their continued existence. Most obvious among changes to reefs is loss of hard coral cover, but a precise multi-scale estimate of coral cover dynamics for the Great Barrier Reef (GBR) is currently lacking. Monitoring data collected annually from fixed sites at 47 reefs across 1300 km of the GBR indicate that overall regional coral cover was stable (averaging 29% and ranging from 23% to 33% cover across years) with no net decline between 1995 and 2009. Subregional trends (10-100 km) in hard coral w
View details →DOI: 10.1371/journal.pone.0017516Cited by 255 Negative / Null Result ReportOpen accessMedicine
Michael A. Yassa, L. Tugan Muftuler, Craig E.L. Stark · 2010 · Proceedings of the National Academy of Sciences
The perforant path (PP) undergoes synaptic changes in the course of aging and dementia. Previous studies attempting to assess the integrity of the PP in humans using diffusion tensor imaging (DTI) were limited by low resolution and the…
View details →DOI: 10.1073/pnas.1002113107Cited by 246 Negative / Null Result ReportOpen accessMedicine
Katherine M.W. Pisters, Eric Vallières, John J. Crowley et al. · 2010 · Journal of Clinical Oncology
PURPOSE Patients with early-stage non-small-cell lung cancer (NSCLC) have a poor prognosis even after complete resection. Earlier studies of preoperative (induction) chemotherapy in resectable NSCLC demonstrated feasibility and encouraging…
View details →DOI: 10.1200/jco.2009.26.1685Cited by 246 Negative / Null Result ReportOpen accessPsychology
Nicholas Bloom, Ruobing Han, James Liang · 2024 · Nature
Abstract Working from home has become standard for employees with a university degree. The most common scheme, which has been adopted by around 100 million employees in Europe and North America, is a hybrid schedule, in which individuals spend a mix of days at home and at work each week 1,2 . However, the effects of hybrid working on employees and firms have been debated, and some executives argue that it damages productivity, innovation and career development 3–5 . Here we ran a six-month randomized control trial investigating the effects of hybrid working from home on 1,612 employees in a Ch
View details →DOI: 10.1038/s41586-024-07500-2Cited by 225 Negative / Null Result ReportOpen accessMedicine
Henrik Sillesen, Samantha Sartori, Benjamin Sandholt et al. · 2017 · European Heart Journal - Cardiovascular Imaging
Introduction: Prediction of cardiovascular events improves using imaging, i.e. coronary calcium score and ultrasound assessment of carotid plaque. This study analysed the predictive value of two ultrasound measures of carotid plaque size:…
View details →DOI: 10.1093/ehjci/jex239Cited by 199 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
R. Grace Walton, Cory M. Dungan, Douglas E. Long et al. · 2019 · Aging Cell
Progressive resistance exercise training (PRT) is the most effective known intervention for combating aging skeletal muscle atrophy. However, the hypertrophic response to PRT is variable, and this may be due to muscle inflammation susceptibility. Metformin reduces inflammation, so we hypothesized that metformin would augment the muscle response to PRT in healthy women and men aged 65 and older. In a randomized, double-blind trial, participants received 1,700 mg/day metformin (N = 46) or placebo (N = 48) throughout the study, and all subjects performed 14 weeks of supervised PRT. Although respo
View details →DOI: 10.1111/acel.13039Cited by 198 Negative / Null Result ReportOpen accessMedicine
US Preventive Services Task Force, David C. Grossman, Susan J. Curry et al. · 2018 · JAMA
Importance: Because of the aging population, osteoporotic fractures are an increasingly important cause of morbidity and mortality in the United States. Approximately 2 million osteoporotic fractures occurred in the United States in 2005,…
View details →DOI: 10.1001/jama.2018.3185Cited by 195 Negative / Null Result ReportNeuroscience
Long Sha, James V. Haxby, Hervé Abdi et al. · 2014 · Journal of Cognitive Neuroscience
Major theories for explaining the organization of semantic memory in the human brain are premised on the often-observed dichotomous dissociation between living and nonliving objects. Evidence from neuroimaging has been interpreted to…
View details →DOI: 10.1162/jocn_a_00733Cited by 193 Negative / Null Result ReportOpen accessMedicine
Frank W. Roemer, C. Kent Kwoh, Michael J. Hannon et al. · 2015 · Arthritis & Rheumatology
OBJECTIVE: To assess whether the presence of structural osteoarthritis (OA) features over as many as 4 years prior to incident radiographic OA increases the risk of radiographic OA in a nested, case-control design. METHODS: We studied 355…
View details →DOI: 10.1002/art.39176Cited by 193 Negative / Null Result ReportOpen accessMedicine
Alisa J. Prager, Nina Martinez, Kathryn Beal et al. · 2015 · American Journal of Neuroradiology
BACKGROUND AND PURPOSE: Treatment-related changes and recurrent tumors often have overlapping features on conventional MR imaging. The purpose of this study was to assess the utility of DWI and DSC perfusion imaging alone and in combination to differentiate treatment-related effects and recurrent high-grade gliomas. MATERIALS AND METHODS: We retrospectively identified 68 consecutive patients with high-grade gliomas treated by surgical resection followed by radiation therapy and temozolomide, who then developed increasing enhancing mass lesions indeterminate for treatment-related changes versus
View details →DOI: 10.3174/ajnr.a4218Cited by 189 Negative / Null Result ReportMedicine
Lee Fong Ling, Thomas H. Marwick, Demetrio Roland Flores et al. · 2013 · Circulation Cardiovascular Imaging
BACKGROUND: Although the recent surgical treatment of ischemic heart failure substudy reported that revascularization of viable myocardium did not improve survival, these results were limited by the viability imaging technique used and the…
View details →DOI: 10.1161/circimaging.112.000138Cited by 188 Negative / Null Result ReportOpen accessEnvironmental Science
Jennifer Stowell, Guannan Geng, Eri Saikawa et al. · 2019 · Environment International
BACKGROUND: exposure. OBJECTIVES: levels. METHODS: for overall and age-stratified outcomes using 2-day averaging windows for cardiovascular disease and 3-day windows for respiratory disease. RESULTS: were observed for asthma and combined respiratory disease in children, and for asthma, bronchitis, COPD, and combined respiratory disease in adults. No significant associations were found in older adults. DISCUSSION: exposure in a changing climate.
View details →DOI: 10.1016/j.envint.2019.105151Cited by 179 Negative / Null Result ReportOpen accessNeuroscience
Ryan K. Shahidehpour, Rebecca E. Higdon, Nicole G. Crawford et al. · 2021 · Neurobiology of Aging
Loss of physiological microglial function may increase the propagation of neurodegenerative diseases. Cellular senescence is a hallmark of aging; thus, we hypothesized age could be a cause of dystrophic microglia. Stereological counts were…
View details →DOI: 10.1016/j.neurobiolaging.2020.12.003Cited by 174 Negative / Null Result ReportAgricultural and Biological Sciences
Julie Morand‐Ferron, Ella F. Cole, James E.C. Rawles et al. · 2011 · Behavioral Ecology
Ecological and evolutionary drivers of innovativeness among species are relatively well studied, but the significance of similar variation within species is much less well understood. Using automated foraging devices, we conducted the…
View details →DOI: 10.1093/beheco/arr120Cited by 169 Negative / Null Result ReportHealth Professions
Arne Petersson · 2010 · Journal of Oral Rehabilitation
In the current version (I) of the Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD), imaging of the temporomandibular joint (TMJ) is not required for a diagnosis. Research has shown that radiological findings of the…
View details →DOI: 10.1111/j.1365-2842.2010.02108.xCited by 168 Negative / Null Result ReportOpen accessSocial Sciences
Homa Hosseinmardi, Amir Ghasemian, Aaron Clauset et al. · 2021 · Proceedings of the National Academy of Sciences
Although it is under-studied relative to other social media platforms, YouTube is arguably the largest and most engaging online media consumption platform in the world. Recently, YouTube's scale has fueled concerns that YouTube users are…
View details →DOI: 10.1073/pnas.2101967118Cited by 163 