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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

730 results in Negative / Null Result Report for "aging" · page 8 of 25

Negative / Null Result ReportMedicine

Comparative evaluation of MRI Dixon T2-weighted, T2 mapping, and T1 mapping for Graves' ophthalmopathy activity assessment.

Wu S, Yang L, Cai Y et al. · 2026 · Eye (London, England)

Objective This study aimed to compare the diagnostic performance of Dixon T2-weighted imaging (Dixon-T2WI), T2 mapping, and T1 mapping in evaluating orbital activity in Graves' orbitopathy (GO). Methods Seventy-three GO patients were…

View details →DOI: 10.1038/s41433-026-04560-8
Negative / Null Result ReportOpen accessMedicine

Novel fungicide and neonicotinoid insecticide impair flight behavior in pollen foraging honey bees, Apis mellifera

Anna Keodara, Lukas Jeker, Lars Straub et al. · 2024 · Scientific Reports

Abstract Bees are often exposed to pesticides affecting physiological functions and molecular mechanisms. Studies showed a potential link between altered expression of energy metabolism related transcripts and increased homing flight time of foragers exposed to pesticides. In this study, we investigated the effects of thiamethoxam and pyraclostrobin on longevity, flight behavior, and expression of transcripts involved in endocrine regulation (hbg-3, buffy, vitellogenin) and energy metabolism (cox5a, cox5b, cox17) using radio frequency identification (RFID) technology and quantitative polymeras

View details →DOI: 10.1038/s41598-024-73235-9
Negative / Null Result ReportOpen accessMedicine (General)

Effect of High-Intensity Focused Ultrasound on sleep quality measures in obese doubled chin women: a randomized controlled trial

Nahla Tharwat Moussa Ahmed, Hany Ezzat Obaya, Azza Abd Elaziz Abd Elhadi et al. · 2025 · Вестник восстановительной медицины

INTRODUCTION. The double chin is an excessive accumulation of fat in the pre- and post-platysma that can manifest in various forms and sizes. Thin individuals might manifest a double chin, similar to those who are afflicted by obesity. It may result in a reduction in the definition of the mandible and give the perception of obesity or aging. AIM. To evaluate any effect of High-Intensity Focused Ultrasound (HIFU) on sleep quality measures in obese women with a double chin. MATERIALS AND METHODS. Typically, 60 women aged 35–50 years were selected from AL Qasr-Alaini Hospital and were equally div

View details →DOI: 10.38025/2078-1962-2025-24-1-47-54
Negative / Null Result ReportOpen accessAnimal culture

Quality of Meat () from Male Fallow Deer () Packaged and Stored under Vacuum and Modified Atmosphere Conditions

N. Piaskowska, T. Daszkiewicz, D. Kubiak et al. · 2016 · Asian-Australasian Journal of Animal Sciences

This study evaluated the effect of vacuum and modified atmosphere (40% CO2+60% N2, MA) packaging on the chemical composition, physicochemical properties and sensory attributes of chill-stored meat from 10 fallow deer (Dama dama) bucks at 17 to 18 months of age. The animals were hunter-harvested in the forests of north-eastern Poland. During carcass dressing (48 to 54 h post mortem), both musculus longissimus muscles were cut out. Each muscle was divided into seven sections which were allocated to three groups: 0, A, and B. Samples 0 were immediately subjected to laboratory analyses. Samples A

View details →DOI: 10.5713/ajas.15.1016
Negative / Null Result ReportOpen accessZoology

Spatial movements and habitat use of an opportunistic gull species in relation to their colony sites during the breeding season

Biljana Ječmenica, Louie Taylor, Jelena Kralj et al. · 2026 · Avian Research

The Yellow-legged Gull (Larus michahellis) is a widespread and opportunistic central-place forager during the breeding season, yet its spatial behavior and habitat use in Adriatic Sea remain poorly understood. Our aim was to investigate their foraging ranges, movement patterns, and habitat selection during the breeding season. In this study, we tracked 45 adult gulls from 9 breeding colonies distributed along the Adriatic coast using high-resolution GPS devices. Most individuals foraged relatively close to their breeding sites, typically within 20–50 km. However, some gulls demonstrated the ca

View details →DOI: 10.1016/j.avrs.2026.100372
Negative / Null Result ReportOpen accessComputer applications to medicine. Medical informatics

A Survey Study on the Impact of Contextual Variables on Medical Students’ Use of Health Messenger Media

Mehrvash Moradi, Zahra Karimian, Nahid Zarifsanaiey · 2023 · Interdisciplinary Journal of Virtual Learning in Medical Sciences

Background: Medical students receive health information from various media sources and messages. Receiving health information can have a significant impact on the students’ dietary habits and healthy lifestyles. This study aimed to investigate the status of medical students’ use of health media and messaging, as well as the contextual variables that affect it.Methods: A survey study was conducted on 500 students of Shiraz University of Medical Sciences during September to December 2022 that were selected by simple random sampling. The research tool was a researcher-made questionnaire consistin

View details →DOI: 10.30476/ijvlms.2023.99255.1237
Negative / Null Result ReportOpen accessBusiness

Relationship of job level, burnout to job satisfaction and task performance in functional officers managing goods and services procurement in government institutions

Yuyun Sumirat, Rhian Indradewa · 2023 · Jurnal Ekonomi dan Bisnis

Emotional exhaustion, frustration or emotional or what is called burnout is the cause of bad work attitudes, unfocused concentration, and negative assessment of employees, in the world of work there are many things that affect a worker in achieving job satisfaction, factors that cause leaders and workers itself is not satisfied with the results of the work that has been completed due to fatigue, emotions, frustration. In this study, researchers used a sample of 166 employees of the Goods and Services Procurement Unit with a functional position as Goods/Services Procurement Manager for the Stat

View details →DOI: 10.24914/jeb.v26i1.4516
Negative / Null Result ReportOpen accessDairying

Application of common packaging materials in the probiotic fresh cheese production

Mirela Iličić, Spasenija Milanović, Marijana Carić et al. · 2016 · Mljekarstvo

The aim of this work was to investigate the application of common packaging materials polypropylene (PP) and polystyrene (PS) in the probiotic fresh cheese production packaging. Probiotic and traditional cheeses were produced from milk with standardized milk fat content of 2.3 g/100 g including the application of two cultures (probiotic and traditional). The samples were packed in the PP and PS cups and stored at 4 ºC for 30 days. The observed permeability of gases through the two applied packaging materials was significantly different. Cheese samples were analysed for microbiological properti

View details →DOI: 10.15567/mljekarstvo.2016.0201
Negative / Null Result ReportOpen accessZoology

Ambient Air Temperature Does Not Predict whether Small or Large Workers Forage in Bumble Bees (Bombus impatiens)

Margaret J. Couvillon, Ginny Fitzpatrick, Anna Dornhaus · 2010 · Psyche: A Journal of Entomology

Bumble bees are important pollinators of crops and other plants. However, many aspects of their basic biology remain relatively unexplored. For example, one important and unusual natural history feature in bumble bees is the massive size variation seen between workers of the same nest. This size polymorphism may be an adaptation for division of labor, colony economics, or be nonadaptive. It was also suggested that perhaps this variation allows for niche specialization in workers foraging at different temperatures: larger bees might be better suited to forage at cooler temperatures and smaller

View details →DOI: 10.1155/2010/536430
Negative / Null Result ReportOpen accessMedicine

Radiological differentiation of succinate dehydrogenase-deficient renal cell carcinoma from renal oncocytoma and chromophobe renal cell carcinoma.

Wang G, Yu Y, Han Y et al. · 2026 · BMC cancer

Purpose To characterize the imaging features of succinate dehydrogenase-deficient renal cell carcinoma (SDH-RCC) and compare them with those of renal oncocytoma (RO) and chromophobe RCC (chRCC). Methods This retrospective two-center study…

View details →DOI: 10.1186/s12885-026-16112-0
Negative / Null Result ReportOpen accessMedicine

Efficacy of insecticide-infused hydrogel baits in managing European earwig (Dermaptera: Forficulidae) in citrus.

Dhungana SK, Gautam SG · 2026 · Journal of economic entomology

European earwig (Forficula auricularia L.) is an omnivorous insect commonly found in California citrus orchards. Often considered a beneficial predator, earwigs can damage young fruit, causing rind scarring and reducing the market value.…

View details →DOI: 10.1093/jee/toag108
Negative / Null Result ReportMedicine

Diagnostic Performance of Diffusion-Weighted Imaging for Evaluation of Breast Lesions: Correlation With Prognostic Factors and Histological Phenotypes.

Konukoglu O, Kaya M, Arslan BC · 2026 · Journal of clinical ultrasound : JCU

Purpose To investigate the role of diffusion-weighted imaging (DWI) in the differential diagnosis of breast lesions and to determine whether there is an association with histological subtypes and prognostic factors. Materials & methods…

View details →DOI: 10.1002/jcu.70303
Negative / Null Result ReportOpen accessMedicine

A Botanical Mixture of Boswellia serrata, Commiphora myrrha, Propolis and Scutellaria baicalensis Reduces Expression of Inflammatory Chemokines in Canine Keratinocytes In Vitro.

Ha D, Jung K, Choi H et al. · 2026 · Veterinary medicine and science

Background Botanical ingredients can function as adjunctive therapies for managing inflammatory skin diseases. Objectives This study aimed to investigate the anti-inflammatory effects of a mixture of Boswellia serrata, Commiphora myrrha,…

View details →DOI: 10.1002/vms3.70963
Negative / Null Result ReportMedicine

Homemade Ultrasound Stand-Off Gel Pads: A Multi-Parameter Performance Study.

William MFGBMF, Jamil NAB, Leong SS et al. · 2026 · Australasian journal of ultrasound in medicine

Aim Stand-off gel pads made of natural ingredients may provide a low-cost option in clinical ultrasound imaging. This study investigated the performance and safety of homemade pads. Methods Thirty stand-off gel pads were made of aloe vera,…

View details →DOI: 10.1002/ajum.70044
Negative / Null Result ReportOpen accessMedicine

Age-Dependent Alterations of Chromosomal Passenger Complex Members During Implantation and Decidualization in the Mouse Uterus.

Golal E, Balci CN, Acar N · 2026 · Aging cell

Successful embryo development, acquisition of uterine receptivity, implantation, and decidualization during the peri-implantation window are essential events that ensure a healthy pregnancy. While ovarian aging has long been considered the…

View details →DOI: 10.1111/acel.70506
Negative / Null Result Report

Lower urinary tract symptoms are elevated with depression in Japanese male

Yamazaki M, Ninomiya S, Hashizume A et al. · 2026 · Preprint

Abstract Background About half of both men and women have lower urinary tract symptoms, and aging is reported to have a significant impact on these symptoms. Lifestyle-related diseases such as diabetes, hypertension, and metabolic syndrome…

View details →DOI: 10.21203/rs.3.rs-9310496/v1
Negative / Null Result ReportMedicine

Can Knowledge and Motivation for Lymphedema Self-Management Be Improved with the Use of ICG Lymphography? A Prospective Observational Repeated Measures Study.

Trevethan, Doig, Patterson et al. · 2026 · Lymphology

ICG lymphography is a lymphatic imaging tool that can inform lymphedema treatment, including self-management. Self-management requires patient engagement in a multimodal treatment program. However, lack of knowledge about lymphedema,…

Negative / Null Result ReportMedicine

The effectiveness of vitrified zygote banking for managing the severe diminished ovarian reserve in infertile women: A retrospective cohort study.

Huang, Tsai, Lin et al. · 2026 · Taiwanese journal of obstetrics & gynecology

A higher oocyte yield is generally associated with improved outcomes in assisted reproductive technology (ART). Vitrification enables the accumulation of oocytes, zygotes, or embryos across multiple cycles, offering a potential strategy to…

View details →DOI: 10.1016/j.tjog.2025.06.010
Negative / Null Result ReportOpen accessNutrition. Foods and food supply

Effects of N-acetylcysteine on aging cell and obesity complications in obese adults: a randomized, double-blind clinical trial

Mohammad Hassan Sohouli, Ghazaleh Eslamian, Nasser Malekpour Alamdari et al. · 2023 · Frontiers in Nutrition

BackgroundWe decided to conduct this study with the aim of investigating the effects of N-Acetylcysteine (NAC) on obesity complications and senescence of visceral adipose tissue in obese adults.Methods and analysisThe present study was conducted as a randomized clinical trial (RCT) (Clinical trial registry number: IRCT20220727055563N1) on 40 obese adults candidates for bariatric surgery, who were randomly assigned to receive 600 mg of NAC (n = 20) or placebo as a control (n = 20) for 4 weeks. During bariatric surgery, visceral adipose tissue was used to examine gene expression and senescence c

View details →DOI: 10.3389/fnut.2023.1237869
Negative / Null Result ReportMedicine

Associations Between Apparent Diffusion Coefficient Values and Histopathologic Prognostic Factors in Breast Cancer: A Retrospective Study.

Mahdavi Sabet, Zeinalkhani, Forghani et al. · 2026 · International journal of breast cancer

This study is aimed at investigating the correlation between apparent diffusion coefficient (ADC) values obtained from diffusion-weighted imaging (DWI) and prognostic factors in breast cancer. We hypothesized that lower ADC values would be…

View details →DOI: 10.1155/ijbc/5114852
Negative / Null Result ReportMedicine

Magnetic resonance imaging of dogs with cervical disease revealed a higher proportion of intervertebral disk disease in small dogs and neoplasia in large dogs.

Darrah, Spence · 2026 · American journal of veterinary research

To compare the proportion of lesions identified on cervical MRI in dogs based on weight. Medical records from a tertiary referral hospital were reviewed for dogs that underwent cervical MRI to investigate clinical signs consistent with…

View details →DOI: 10.2460/ajvr.25.12.0450
Negative / Null Result ReportMedicine

An Observational Study on Impact of Interim Obturators in COVID-19-Associated Mucormycosis.

Chittamuru, Vengamma, Priya et al. · 2026 · Journal of maxillofacial and oral surgery

During the second wave of COVID-19 pandemic, there was surge in reporting of COVID-19-associated mucormycosis cases. Government of India declared rhino-orbito-cerebral mucormycosis as a notifiable disease. Managing this condition posed a…

View details →DOI: 10.1007/s12663-024-02120-9
Negative / Null Result ReportOpen accessPediatrics

The Relationship of Gonadotropin-releasing Hormone Agonists and Anthropometric Indices of Girls with Premature Idiopathic Central Precocious Puberty: A Cohort Study

Mohaddeseh Badpeyma, Roghayeh Molani-Gol, Fatemeh Sistanian et al. · 2024 · Iranian Journal of Neonatology

Background: This study aims to determine the effect of different GnRH agonist brands on body mass index (BMI), weight, and height in patients referred to the pediatric endocrinology clinic of Akbar Hospital.Methods: In this cohort study, 80 girls aged 5-8 years diagnosed with precocious puberty cases were included according to the Tanner staging and at the second puberty stage. The patients were classified into three groups of GnRH agonists, A, B, and C, receiving Diphereline, Microrelin, and Variopeptyl, respectively. Height, weight, and BMI were calculated every three months.Results: In grou

View details →DOI: 10.22038/ijn.2024.74125.2433
Negative / Null Result ReportMedicine

Association of Race and Ethnicity With Computed Tomography Head Utilization in Children Presenting to the Emergency Department With an Unprovoked Seizure.

Kannikeswaran, Sivaswamy, Przyklenk et al. · 2026 · Pediatric neurology

Although not routinely recommended, computed tomography (CT) head are frequently performed in children presenting to emergency department (ED) with seizures. Racial and ethnic disparities have been reported in pediatric ED imaging. Our…

View details →DOI: 10.1016/j.pediatrneurol.2026.05.005
Negative / Null Result ReportMedicine

Plaque phenotypes across remodeling patterns in vertebrobasilar atherosclerosis: a high-resolution magnetic resonance vessel wall imaging study.

Liu, Xu, Zhong et al. · 2026 · Quantitative imaging in medicine and surgery

Intracranial atherosclerosis is the predominant etiology of ischemic stroke in East Asian populations. Atherosclerotic progression frequently involves concomitant vascular remodeling, and stroke risk profiles may vary across distinct…

View details →DOI: 10.21037/qims-2025-1812
Negative / Null Result ReportMedicine

Clinical Implications of Stroke Progressor Phenotypes defined based on ASPECTS decay and perfusion estimated infarct growth rate: insights from a large national thrombectomy registry.

Ciacciarelli, Nicolini, Saia et al. · 2026 · Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

Infarct growth rate (IGR) is highly heterogeneous among ischemic stroke patients, reflecting a spectrum of progressor phenotypes with clinical implications. We aim to compare different imaging approaches to investigate stroke progressors…

View details →DOI: 10.1007/s10072-026-09148-4
Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system

Efficacy analysis of mechanical thrombectomy combined with prolonged mild hypothermia in the treatment of acute middle cerebral artery occlusion: a single-center retrospective cohort study

Anqi Wang, Anqi Wang, Xuan Meng et al. · 2024 · Frontiers in Neurology

ObjectiveTo determine the efficacy of mechanical thrombectomy combined with prolonged mild hypothermia compared with conventional treatment in managing acute middle cerebral artery occlusion, and to explore whether extending the duration of hypothermia can improve neurological function.MethodFrom 2018 to June 2023, a retrospective analysis was conducted on 45 patients with acute middle cerebral artery occlusion treated at the NICU of Suzhou Kowloon Hospital, affiliated with Shanghai Jiao Tong University School of Medicine. After thrombectomy, patients were admitted to the neurological intensiv

View details →DOI: 10.3389/fneur.2024.1406293