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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

713 results in Negative / Null Result Report for "aging" · page 8 of 24

Negative / Null Result ReportMedicine

Magnetic resonance imaging of dogs with cervical disease revealed a higher proportion of intervertebral disk disease in small dogs and neoplasia in large dogs.

Darrah, Spence · 2026 · American journal of veterinary research

To compare the proportion of lesions identified on cervical MRI in dogs based on weight. Medical records from a tertiary referral hospital were reviewed for dogs that underwent cervical MRI to investigate clinical signs consistent with…

View details →DOI: 10.2460/ajvr.25.12.0450
Negative / Null Result ReportMedicine

An Observational Study on Impact of Interim Obturators in COVID-19-Associated Mucormycosis.

Chittamuru, Vengamma, Priya et al. · 2026 · Journal of maxillofacial and oral surgery

During the second wave of COVID-19 pandemic, there was surge in reporting of COVID-19-associated mucormycosis cases. Government of India declared rhino-orbito-cerebral mucormycosis as a notifiable disease. Managing this condition posed a…

View details →DOI: 10.1007/s12663-024-02120-9
Negative / Null Result ReportMedicine

Association of Race and Ethnicity With Computed Tomography Head Utilization in Children Presenting to the Emergency Department With an Unprovoked Seizure.

Kannikeswaran, Sivaswamy, Przyklenk et al. · 2026 · Pediatric neurology

Although not routinely recommended, computed tomography (CT) head are frequently performed in children presenting to emergency department (ED) with seizures. Racial and ethnic disparities have been reported in pediatric ED imaging. Our…

View details →DOI: 10.1016/j.pediatrneurol.2026.05.005
Negative / Null Result ReportOpen accessMedicine

Age-Dependent Alterations of Chromosomal Passenger Complex Members During Implantation and Decidualization in the Mouse Uterus.

Golal E, Balci CN, Acar N · 2026 · Aging cell

Successful embryo development, acquisition of uterine receptivity, implantation, and decidualization during the peri-implantation window are essential events that ensure a healthy pregnancy. While ovarian aging has long been considered the…

View details →DOI: 10.1111/acel.70506
Negative / Null Result ReportMedicine

Plaque phenotypes across remodeling patterns in vertebrobasilar atherosclerosis: a high-resolution magnetic resonance vessel wall imaging study.

Liu, Xu, Zhong et al. · 2026 · Quantitative imaging in medicine and surgery

Intracranial atherosclerosis is the predominant etiology of ischemic stroke in East Asian populations. Atherosclerotic progression frequently involves concomitant vascular remodeling, and stroke risk profiles may vary across distinct…

View details →DOI: 10.21037/qims-2025-1812
Negative / Null Result ReportMedicine

Clinical Implications of Stroke Progressor Phenotypes defined based on ASPECTS decay and perfusion estimated infarct growth rate: insights from a large national thrombectomy registry.

Ciacciarelli, Nicolini, Saia et al. · 2026 · Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

Infarct growth rate (IGR) is highly heterogeneous among ischemic stroke patients, reflecting a spectrum of progressor phenotypes with clinical implications. We aim to compare different imaging approaches to investigate stroke progressors…

View details →DOI: 10.1007/s10072-026-09148-4
Negative / Null Result ReportOpen accessMedicine

Efficacy of insecticide-infused hydrogel baits in managing European earwig (Dermaptera: Forficulidae) in citrus.

Dhungana SK, Gautam SG · 2026 · Journal of economic entomology

European earwig (Forficula auricularia L.) is an omnivorous insect commonly found in California citrus orchards. Often considered a beneficial predator, earwigs can damage young fruit, causing rind scarring and reducing the market value.…

View details →DOI: 10.1093/jee/toag108
Negative / Null Result ReportMedicine

[The health insurers' perspective on defining and managing healthcare needs].

Malzahn, Höft Budde, Kneißl et al. · 2026 · Innere Medizin (Heidelberg, Germany)

The German healthcare system, despite its high performance, fails to achieve the goal of needs-based service provision. Supply-induced demand, regional disparities and misaligned financial incentives lead to overuse, underuse and misuse of…

View details →DOI: 10.1007/s00108-026-02117-1
Negative / Null Result ReportMedicine

Posterior circulation stroke secondary to atlantoaxial instability-induced vertebral artery dissection and pseudoaneurysm in a paediatric patient.

Bedia Cadelo, García Feijoo, Zamorano-Fernandez et al. · 2026 · BMJ case reports

A boy in his early teens presented with transient visual disturbances and headache. Brain imaging revealed bilateral occipital infarctions, while vascular studies demonstrated bilateral V3 vertebral artery wall abnormalities with…

View details →DOI: 10.1136/bcr-2026-272989
Negative / Null Result ReportOpen accessBusiness

Relationship of job level, burnout to job satisfaction and task performance in functional officers managing goods and services procurement in government institutions

Yuyun Sumirat, Rhian Indradewa · 2023 · Jurnal Ekonomi dan Bisnis

Emotional exhaustion, frustration or emotional or what is called burnout is the cause of bad work attitudes, unfocused concentration, and negative assessment of employees, in the world of work there are many things that affect a worker in achieving job satisfaction, factors that cause leaders and workers itself is not satisfied with the results of the work that has been completed due to fatigue, emotions, frustration. In this study, researchers used a sample of 166 employees of the Goods and Services Procurement Unit with a functional position as Goods/Services Procurement Manager for the Stat

View details →DOI: 10.24914/jeb.v26i1.4516
Negative / Null Result ReportMedicine

Bedside transcranial Doppler as a diagnostic bridge for suspected intracranial hypertension after traumatic brain injury surgery: A case report.

Prandani, Fuadi, Halimi et al. · 2026 · Surgical neurology international

Early recognition of postoperative neurologic deterioration in patients with traumatic brain injury (TBI) is essential but remains challenging, as clinical assessment may lack sensitivity and computed tomography (CT) imaging is not always…

View details →DOI: 10.25259/sni_1424_2025
Negative / Null Result ReportMedicine

MD-DGNN: A Metadata-Driven Dual Graph Neural Network based on Brain Functional Connectivity for ASD Classification.

Li, Zhang, Leng et al. · 2026 · IEEE journal of biomedical and health informatics

Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder that requires early and efficient diagnosis. Functional magnetic resonance imaging (fMRI), with high temporal and spatial resolution, is a powerful tool for…

View details →DOI: 10.1109/jbhi.2026.3702096
Negative / Null Result ReportMedicine

Leveraging Synchrosqueezing Transform (SST)-based representations in a dual-stream attention framework to enhance sleep apnea detection and subtyping.

Zhao, Fu, Li et al. · 2026 · Frontiers in neuroscience

Sleep apnea and hypopnea syndrome (SAHS) is a prevalent disorder with profound adverse effects on health and overall quality of life, thereby necessitating the development of accurate and accessible screening tools. Electrocardiogram…

View details →DOI: 10.3389/fnins.2026.1853573
Negative / Null Result ReportMedicine

A web-based prognostic nomogram incorporating VETC-associated imaging markers for predicting postoperative recurrence in hepatocellular carcinoma.

Zhao, Xie, Yu et al. · 2026 · BMC cancer

BACKGROUND: Vessels that encapsulate tumor clusters (VETC) is a powerful predictor of aggressive hepatocellular carcinoma (HCC) and associated with poor outcomes of HCC. Imaging surrogates of VETC potentially help predict postsurgical…

View details →DOI: 10.1186/s12885-026-15895-6
Negative / Null Result ReportMedicine

Effects of Hydrogen Water Gargling on Oral Mucositis and Pain in Head and Neck Cancer Patients: A Randomized Controlled Pilot Study.

Tsai, Huang, Wang et al. · 2026 · Integrative cancer therapies

BackgroundTraditional, complementary, and integrative medicine (TCIM) is an evolving field in oncology focused on managing cancer symptoms. Hydrogen water (HW) has gained attention for its antioxidant and anti-inflammatory properties, yet…

View details →DOI: 10.1177/15347354261463550
Negative / Null Result ReportOpen accessNutrition. Foods and food supply

Effects of N-acetylcysteine on aging cell and obesity complications in obese adults: a randomized, double-blind clinical trial

Mohammad Hassan Sohouli, Ghazaleh Eslamian, Nasser Malekpour Alamdari et al. · 2023 · Frontiers in Nutrition

BackgroundWe decided to conduct this study with the aim of investigating the effects of N-Acetylcysteine (NAC) on obesity complications and senescence of visceral adipose tissue in obese adults.Methods and analysisThe present study was conducted as a randomized clinical trial (RCT) (Clinical trial registry number: IRCT20220727055563N1) on 40 obese adults candidates for bariatric surgery, who were randomly assigned to receive 600 mg of NAC (n = 20) or placebo as a control (n = 20) for 4 weeks. During bariatric surgery, visceral adipose tissue was used to examine gene expression and senescence c

View details →DOI: 10.3389/fnut.2023.1237869
Negative / Null Result ReportMedicine

Sentinel Lymph Node Mapping Compared with Selective Lymph Node Sampling in the Surgical Staging of Endometrial Cancer: A Prospective Observational Study.

Gâta, Ilieș, Mureșan-Bădescu et al. · 2026 · Diagnostics (Basel, Switzerland)

Background/Objectives : Nowadays, lymph node assessment represents a key component in the surgical staging of endometrial cancer, as sentinel lymph node (SLN) mapping increased in adoption as an alternative to lymphadenectomy. This study…

View details →DOI: 10.3390/diagnostics16121904
Negative / Null Result ReportOpen accessComputer Science

Understanding and Analyzing Model Robustness and Knowledge-Transfer in Multilingual Neural Machine Translation using TX-Ray

Vageesh Saxena, Sharid Loáiciga, Nils Rethmeier · 2024 · arXiv

Neural networks have demonstrated significant advancements in Neural Machine Translation (NMT) compared to conventional phrase-based approaches. However, Multilingual Neural Machine Translation (MNMT) in extremely low-resource settings remains underexplored. This research investigates how knowledge transfer across languages can enhance MNMT in such scenarios. Using the Tatoeba translation challenge dataset from Helsinki NLP, we perform English-German, English-French, and English-Spanish translations, leveraging minimal parallel data to establish cross-lingual mappings. Unlike conventional meth

Negative / Null Result Report

“Football Did Not Make Me a World Champion, but It Did Help My Wellbeing”: A Qualitative Study of Study-sport Balance Based on Fung Ka Ki

Bill Cheuk Long Chan, Billy Lee · 2024 · Studia sportiva

Managing the balance of academic and athletic responsibilities at university is a serious challenge for student athletes. This phenomenological case study illuminates how one individual successfully managed his study-sport balance at…

View details →DOI: 10.5817/sts2023-2-6
Negative / Null Result ReportOpen accessPediatrics

The Relationship of Gonadotropin-releasing Hormone Agonists and Anthropometric Indices of Girls with Premature Idiopathic Central Precocious Puberty: A Cohort Study

Mohaddeseh Badpeyma, Roghayeh Molani-Gol, Fatemeh Sistanian et al. · 2024 · Iranian Journal of Neonatology

Background: This study aims to determine the effect of different GnRH agonist brands on body mass index (BMI), weight, and height in patients referred to the pediatric endocrinology clinic of Akbar Hospital.Methods: In this cohort study, 80 girls aged 5-8 years diagnosed with precocious puberty cases were included according to the Tanner staging and at the second puberty stage. The patients were classified into three groups of GnRH agonists, A, B, and C, receiving Diphereline, Microrelin, and Variopeptyl, respectively. Height, weight, and BMI were calculated every three months.Results: In grou

View details →DOI: 10.22038/ijn.2024.74125.2433
Negative / Null Result Report

Engaging Education About Risks of Opioid Use With Patients Before Elective Surgery of the Lower Extremity Did Not Reduce Postoperative Opioid Utilization: A Randomized Controlled Trial

Daniel I. Rhon, Tina A. Greenlee, Rachel Mayhew et al. · 2022 · Journal of the American Academy of Orthopaedic Surgeons

Introduction: After elective orthopaedic surgery, many individuals go on to become long-term opioid users. Mitigating this risk has become a priority for surgeons, other members of the medical care team, and healthcare systems. The purpose…

View details →DOI: 10.5435/jaaos-d-21-00603
Negative / Null Result Report

This is Going to Sound Crazy, But What If We Used Large Language Models to Boost Automatic Database Tuning Algorithms By Leveraging Prior History? We Will Find Better Configurations More Quickly Than Retraining From Scratch!

William Zhang, Wan Shen Lim, Andrew Pavlo · 2026 · Proceedings of the ACM on Management of Data

Tuning database management systems (DBMSs) is challenging due to trillions of possible configurations and evolving workloads. Recent advances in tuning have led to breakthroughs in optimizing over the possible configurations. However, due…

View details →DOI: 10.1145/3786704
Negative / Null Result ReportOpen accessComputer Science

CMAX++ : Leveraging Experience in Planning and Execution using Inaccurate Models

Anirudh Vemula, J. Andrew Bagnell, Maxim Likhachev · 2020 · arXiv

Given access to accurate dynamical models, modern planning approaches are effective in computing feasible and optimal plans for repetitive robotic tasks. However, it is difficult to model the true dynamics of the real world before execution, especially for tasks requiring interactions with objects whose parameters are unknown. A recent planning approach, CMAX, tackles this problem by adapting the planner online during execution to bias the resulting plans away from inaccurately modeled regions. CMAX, while being provably guaranteed to reach the goal, requires strong assumptions on the accuracy

Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system

Efficacy analysis of mechanical thrombectomy combined with prolonged mild hypothermia in the treatment of acute middle cerebral artery occlusion: a single-center retrospective cohort study

Anqi Wang, Anqi Wang, Xuan Meng et al. · 2024 · Frontiers in Neurology

ObjectiveTo determine the efficacy of mechanical thrombectomy combined with prolonged mild hypothermia compared with conventional treatment in managing acute middle cerebral artery occlusion, and to explore whether extending the duration of hypothermia can improve neurological function.MethodFrom 2018 to June 2023, a retrospective analysis was conducted on 45 patients with acute middle cerebral artery occlusion treated at the NICU of Suzhou Kowloon Hospital, affiliated with Shanghai Jiao Tong University School of Medicine. After thrombectomy, patients were admitted to the neurological intensiv

View details →DOI: 10.3389/fneur.2024.1406293
Negative / Null Result ReportOpen accessEngineering

Audio-Conditioned Diffusion LLMs for ASR and Deliberation Processing

Mengqi Wang, Zhan Liu, Zengrui Jin et al. · 2025 · arXiv

Diffusion-based large language models (DLLMs) have recently attracted growing interest as an alternative to autoregressive decoders. In this work, we present an empirical study on using the diffusion-based large language model LLaDA for automatic speech recognition (ASR). We first investigate its use as an external deliberation-based processing module for Whisper-LLaMA transcripts. By leveraging the bidirectional attention and denoising capabilities of LLaDA, we explore random masking, low-confidence masking, and semi-autoregressive strategies, showing that Whisper-LLaDA substantially reduces

Negative / Null Result ReportOpen accessComputer Science

Towards the Design of Effective Freehand Gestural Interaction for Interactive TV

Gang Ren, Wenbin Li, Eamonn O'Neill · 2016 · arXiv

As interactive devices become pervasive, people are beginning to looking for more advanced interaction with televisions in the living room. Interactive television has the potential to offer a very engaging experience. But most common user tasks are still challenging with such systems, such as menu selection or text input. And little work has been done on understanding and sup-porting the effective design of freehand interaction with an TV in the living room. In this paper, we perform two studies investi-gating freehand gestural interaction with a consumer level sensor, which is suitable for TV