466 results in Negative / Null Result Report for "randomized controlled trial" · page 7 of 16
Negative / Null Result ReportMedicine
Treanor M, Zbozinek TD, Rosenberg BM et al. · 2025 · Journal of consulting and clinical psychology
Objective To investigate the role of extinction learning and habituation by comparing inhibitory retrieval to habituation-focused exposure for social anxiety and panic disorder. Method In this assessor-blinded, parallel-group, two-arm…
View details →DOI: 10.1037/ccp0000970 Negative / Null Result ReportMedicine
Scott R, Sale C, James R et al. · 2026 · Bone
Exercise interventions frequently prescribe impact activities assuming that identical tasks produce similar mechanical loads, yet few studies quantify the external loads experienced during such interventions. This study examined drop-jump…
View details →DOI: 10.1016/j.bone.2026.117903 Negative / Null Result ReportMedicine
Yang, Mueller, D'Andrea et al. · 2026 · Academic psychiatry : the journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry
Resident physicians experience high rates of depression, anxiety, burnout, and loneliness, yet few evidence-based interventions have been evaluated in this population. This randomized controlled pilot trial examined the feasibility,…
View details →DOI: 10.1007/s40596-026-02384-y Negative / Null Result ReportMedicine
Kayin Y, Oztas B · 2026 · Nurse education in practice
Aim This study examined the effects of PechaKucha and Teach-Back teaching techniques on nursing students' knowledge, self-efficacy and satisfaction regarding discharge education. Background Effective discharge education requires strategies…
View details →DOI: 10.1016/j.nepr.2026.104807 Negative / Null Result ReportMedicine
Gou, He, Zhuo · 2026 · Frontiers in medicine
To investigate the effect and safety of astragalus injection at Neiguan (PC6) for chronic heart failure (CHF; HF) with qi-deficiency and blood-stasis syndrome, and its effect on the renin-angiotensin-aldosterone system (RAAS). A…
View details →DOI: 10.3389/fmed.2026.1836620 Negative / Null Result ReportMedicine
Ormsbee LT, Akhavan NS, Munoz J et al. · 2026 · Nutrients
Background/Objectives : Approximately 53.4 million U.S. adults aged 50 or older have low bone mass, yet male bone health remains under-researched. This study evaluated the effects of one year of prune supplementation on bone health in…
View details →DOI: 10.3390/nu18121854 Negative / Null Result Report
Koutsonida M, Markozannes G, Kanellopoulou A et al. · 2026 · Preprint
Background: Metabolic syndrome (MetS) has been associated with cognitive decline. Considering its increasing prevalence worldwide, the goal of this study was to evaluate the feasibility and efficacy of a short-term, self-administered…
View details →DOI: 10.64898/2026.06.22.26356249 Negative / Null Result ReportOpen accessMedicine
Mabkhot BA, Taha SEE, Kamel MH et al. · 2026 · BMC oral health
BACKGROUND: Subgingival crown margins have been linked to chronic gingival inflammation in pediatric patients. This clinical trial evaluated periodontal outcomes in first permanent molars that had undergone root canal therapy and were…
View details →DOI: 10.1186/s12903-026-08077-0 Negative / Null Result ReportMedicine
Bicici Ulusahin S, Celik C, Abut CZ et al. · 2026 · Health care for women international
Primary dysmenorrhea (PD) is a prevalent condition in young women, characterized by menstrual pain, sleep disturbances, and reduced physical activity. Yoga has been suggested as a non-pharmacological intervention. We examined the effects…
View details →DOI: 10.1080/07399332.2026.2682319 Negative / Null Result ReportMedicine
Gürsu S, Saydam BK, Kalkanlı O · 2026 · Saudi medical journal
Objectives To compare the effects of incubator and radiant heat on physiological criteria and pain-stress levels during heel prick procedures in newborns in the neonatal intensive care unit (NICU). Methods This randomized controlled…
View details →DOI: 10.15537/1658-3175.8806 Negative / Null Result ReportOpen accessInformation technology
Pang, Yan, Molton, James Steven, Ooi, Wei Tsang et al. · 2020 · JMIR mHealth and uHealth
BackgroundAs people living with HIV infection require lifelong treatment, nonadherence to medication will reduce their chance of maintaining viral suppression and increase the risk of developing drug resistance and HIV transmission. ObjectiveThis study aimed to evaluate the efficacy of a mobile app, Mobile Interactive Supervised Therapy (MIST), for improving adherence to oral HIV medications among HIV-infected adults in Singapore. MethodsWe conducted a two-group pilot randomized controlled trial (RCT) with a process evaluation, in which 40 HIV-infected participants with once-daily medication r
View details →DOI: 10.2196/15702 Negative / Null Result ReportOpen accessMedicine
Lisa Baquet, Helge Hasselmann, Stefan Patra et al. · 2018 · PeerJ
Background Only few aerobic exercise intervention trials specifically targeting cognitive functioning have been performed in multiple sclerosis. Objective and Methods This randomized controlled trial with 34 patients in the intervention group (IG) (mean: 38.2 years (±9.6)) and 34 patients in the control group (CG) (mean: 39.6 years (±9.7)) aimed to determine the effects of aerobic exercise on cognition in relapsing-remitting multiple sclerosis (RRMS). The primary outcome was verbal learning assessed by the verbal learning and memory test (VLMT). Patients were randomized to an IG or a waitlist
View details →DOI: 10.7717/peerj.6037 Negative / Null Result ReportOpen accessMedicine
Alexandria Turner, Mieke L van Driel, Ben Mitchell et al. · 2025 · Family Practice
Abstract Background Inappropriate antibiotic prescription for self-limiting respiratory tract infections (RTIs) by general practitioner (GP) registrars (trainees) is less common than by established GPs but still exceeds evidence-based…
View details →DOI: 10.1093/fampra/cmaf005 Negative / Null Result ReportMedicine
Tavasoli H, Rajabi MM, Sadat Hoseini AS · 2026 · Journal of pediatric nursing
Purpose To determine the effect of harmonica-based breathing and airway clearance exercises on pulmonary function in children with cystic fibrosis (CF). Methods This randomized controlled trial included 70 children with CF aged 8-18 years.…
View details →DOI: 10.1016/j.pedn.2026.05.012 Negative / Null Result ReportMedicine
Chen, Si, Chen et al. · 2026 · Frontiers in medicine
This study aimed to evaluate the long-term effects of an automated eye position fixation training device (AEPFTD) on intraoperative cooperation, surgical efficiency, complications, and recurrence rates in patients undergoing pterygium…
View details →DOI: 10.3389/fmed.2026.1764636 Negative / Null Result ReportMedicine
Wang Y, Xu X, Shen WJ et al. · 2026 · Zhonghua yi xue za zhi
Objective: To investigate the effects of oliceridine versus sufentanil for anesthesia induction and postoperative patient-controlled intravenous analgesia (PCIA) on postoperative nausea and vomiting (PONV) in patients undergoing…
View details →DOI: 10.3760/cma.j.cn112137-20260205-00404 Negative / Null Result ReportOpen accessDiseases of the endocrine glands. Clinical endocrinology
Maiko Miyamoto, Aika Miya, Akinobu Nakamura et al. · 2026 · Journal of Diabetes Investigation
ABSTRACT Aims/Introduction We aimed to explore the short‐term effects of tofogliflozin on the insulin secretory capacity of people with type 2 diabetes. Materials and Methods We performed a multicenter, prospective, randomized, active‐controlled, open‐label, parallel‐group comparison study of people with type 2 diabetes aged 20–89 years, with hemoglobin A1c (HbA1c) 6.5%–9.0%, not previously treated with antihyperglycemic agents. The participants were randomly assigned to a group that received 20 mg tofogliflozin per day or a group that received 500 mg metformin per day for 4 weeks. Fasting blo
View details →DOI: 10.1111/jdi.70245 Negative / Null Result ReportOpen accessMedicine
Einfeldt AK, Tücking L, Savov P et al. · 2026 · Scientific reports
The current literature remains inconclusive about whether kinematic alignment (KA) is superior to mechanical alignment (MA) in total knee arthroplasty (TKA). Therefore, this randomized controlled trial sought to provide further…
View details →DOI: 10.1038/s41598-026-52076-8 Negative / Null Result ReportOpen accessSpecial aspects of education
Maryam Amiri, Zahra Khademian, Reza Nikandish · 2018 · BMC Medical Education
Abstract Background The complexity of patients’ condition and treatment processes in intensive care units (ICUs) predisposes patients to more hazardous events. Effective patient safety culture is related to lowering the rate of patients’ complications and fewer adverse events. The present study aimed to determine the effect of empowering nurses and supervisors through an educational program on patient safety culture in adult ICUs. Methods A randomized controlled trial was conducted during April–September 2015 in 6 adult ICUs at Namazi Hospital, Shiraz, Iran. A total of 60 nurses and 20 supervi
View details →DOI: 10.1186/s12909-018-1255-6 Negative / Null Result ReportMedicine
Çakır E, Ciğerci Y, Yılmaz S · 2026 · Scientific reports
This study aimed to evaluate the effects of a music intervention on anxiety, pain, and vital signs in patients undergoing Endoscopic Retrograde Cholangiopancreatography (ERCP). This randomized controlled trial included 70 patients who…
View details →DOI: 10.1038/s41598-026-50809-3 Negative / Null Result ReportOpen accessMedicine (General)
Weishen WANG, Wenhui LOU, Zhiwei XU et al. · 2023 · Journal of Advanced Research
Introduction: The value of extended lymphadenectomy in pancreatoduodenectomy (PD) has been discussed by five randomized controlled studies. However, the limitations in the studies made their conclusions not sufficiently reliable. Objectives: This multi-center randomized controlled study was designed to clarify the efficacy of extended lymphadenectomy in PD for pancreatic ductal adenocarcinoma (PDAC). Methods: From December 2016 to October 2018, 170 consecutive patients undergoing PD were enrolled and randomized to standard or extended lymphadenectomy for the treatment of PDAC from three high-v
View details →DOI: 10.1016/j.jare.2022.09.011 Negative / Null Result ReportOpen accessMedicine
Roy S, Gupta N, Bharti SJ et al. · 2026 · Journal of anaesthesiology, clinical pharmacology
Background and aims Managing acute postsurgical pain following midline exploratory laparotomy in colorectal cancer patients involves various approaches, such as central neuraxial blockade, patient-controlled intravenous analgesia with…
View details →DOI: 10.4103/joacp.joacp_293_25 Negative / Null Result ReportMedicine
Bieglecka, Kęszycka, Czerwińska et al. · 2026 · Nutrients
Patients with psoriasis, a non-contagious, chronic, systemic inflammatory skin disease, often suffer from carbohydrate metabolism disorders, which can exacerbate systemic inflammation. This randomized, double-blind, placebo-controlled…
View details →DOI: 10.3390/nu18121843 Negative / Null Result ReportOpen accessMedicine
Aziz YN, Aragon Garcia R, Plummer P et al. · 2026 · Stroke (Hoboken, N.J.)
Background Recent randomized trials showed no benefit of mechanical thrombectomy (MT) for ischemic stroke due to distal medium vessel occlusion (DMVO). We sought to understand the use of MT for DMVO stroke treatment before and after the…
View details →DOI: 10.1161/svin.125.001965 Negative / Null Result ReportMedicine
Struys T, Christiaens V, De Bruyckere T et al. · 2025 · Clinical implant dentistry and related research
Aim To assess the impact of the timing of soft tissue augmentation on soft tissue changes and esthetic outcome following single immediate implant placement (IIP) in the anterior maxilla. Materials and methods Patients with a failing tooth…
View details →DOI: 10.1111/cid.70013 Negative / Null Result ReportOpen accessMedicine
De Pascale G, Cutuli SL, Vargas M et al. · 2026 · Intensive care medicine
Purpose The MICROINHALO trial investigated whether personalized management of endotracheal tube cuff pressure (Pcuff) based on exhaled CO 2 measurement combined with automatic subglottic space drainage (SSD) may prevent tracheal…
View details →DOI: 10.1007/s00134-026-08459-6 Negative / Null Result ReportMedicine
Wongtangman, Reddy Janga, Azimaraghi et al. · 2026 · Critical care (London, England)
Patients recovering from cardiac surgery in the intensive care unit (ICU) do not sleep well. Commonly used sedative-hypnotic medications can disrupt sleep architecture and increase the risk of delirium in critically ill patients after…
View details →DOI: 10.1186/s13054-026-06151-1 Negative / Null Result ReportMedicine
Anusuya, Balaji, Manikandan · 2026 · Journal of Indian Society of Periodontology
Periodontal regeneration aims to restore the natural structure of the periodontium, therefore improving the long-term stability and function of the affected teeth. Traditional bone graft materials such as allografts, autografts,…
View details →DOI: 10.4103/jisp.jisp_210_24 Negative / Null Result ReportOpen accessNursing
Maryam Ahmadinezhad, Marzieh Kargar, Fatemeh Vizeshfar et al. · 2017 · Iranian Journal of Nursing and Midwifery Research
Background: Postmenopausal women experience a variety of symptoms, among which sleep disorder is one of the most common problems. Acupressure and Pilates exercise programs are effective nonpharmaceutical treatments which can improve sleep quality. In the present study, we aimed to compare the effects of acupressure and Pilates-based exercises on the sleep quality of postmenopausal women referred to medical clinics. Materials and Methods: In this single-blinded randomized controlled clinical trial, we recruited 108 women aged 40–60 years who were randomly assigned into one control and two inter
View details →DOI: 10.4103/1735-9066.205954 Negative / Null Result ReportOpen accessMedicine
Tobias Lohaus, Sally Reckelkamm, Patrizia Thoma · 2024 · PLoS ONE
Objective Acquired brain injuries (ABIs), such as traumatic brain injuries (TBIs), often entail impairments of general cognition (e.g., memory, attention or executive functions) and social cognition (e.g. emotion recognition, theory of mind [ToM], social problem-solving). The availability of fully computerized interventions targeting sociocognitive deficits specifically in neurologically impaired patients is extremely limited. Therefore, the Treatment Program for Deficits in Social Cognition and Social Competencies of the Ruhr University Bochum (SoCoBo), a fully computerized online therapy des
View details →DOI: 10.1371/journal.pone.0294767 