459 results in Negative / Null Result Report for "randomized controlled trial" · page 6 of 16
Negative / Null Result ReportMedicine
Chen, Si, Chen et al. · 2026 · Frontiers in medicine
This study aimed to evaluate the long-term effects of an automated eye position fixation training device (AEPFTD) on intraoperative cooperation, surgical efficiency, complications, and recurrence rates in patients undergoing pterygium…
View details →DOI: 10.3389/fmed.2026.1764636 Negative / Null Result ReportOpen accessMedicine
Gonzalez DE, Dickerson BL, Hines K et al. · 2026 · Sports (Basel, Switzerland)
There are concerns that high-dose and/or long-term creatine monohydrate supplementation (CrM) leads to greater side effects (SEs) compared to placebo. This analysis investigated whether the dose or duration of CrM was associated with SEs.…
View details →DOI: 10.3390/sports14040137 Negative / Null Result ReportOpen accessDiseases of the endocrine glands. Clinical endocrinology
Maiko Miyamoto, Aika Miya, Akinobu Nakamura et al. · 2026 · Journal of Diabetes Investigation
ABSTRACT Aims/Introduction We aimed to explore the short‐term effects of tofogliflozin on the insulin secretory capacity of people with type 2 diabetes. Materials and Methods We performed a multicenter, prospective, randomized, active‐controlled, open‐label, parallel‐group comparison study of people with type 2 diabetes aged 20–89 years, with hemoglobin A1c (HbA1c) 6.5%–9.0%, not previously treated with antihyperglycemic agents. The participants were randomly assigned to a group that received 20 mg tofogliflozin per day or a group that received 500 mg metformin per day for 4 weeks. Fasting blo
View details →DOI: 10.1111/jdi.70245 Negative / Null Result Report
Xie E, He Y, Cao T et al. · 2026 · Preprint
Abstract Background BOPPPS, which comprises six components—Bridge-in, Objective, Pre-assessment, Participatory Learning, Post-assessment, and Summary—is a student-centered structured teaching model widely applied in theoretical courses.…
View details →DOI: 10.21203/rs.3.rs-8477294/v1 Negative / Null Result ReportOpen accessSpecial aspects of education
Maryam Amiri, Zahra Khademian, Reza Nikandish · 2018 · BMC Medical Education
Abstract Background The complexity of patients’ condition and treatment processes in intensive care units (ICUs) predisposes patients to more hazardous events. Effective patient safety culture is related to lowering the rate of patients’ complications and fewer adverse events. The present study aimed to determine the effect of empowering nurses and supervisors through an educational program on patient safety culture in adult ICUs. Methods A randomized controlled trial was conducted during April–September 2015 in 6 adult ICUs at Namazi Hospital, Shiraz, Iran. A total of 60 nurses and 20 supervi
View details →DOI: 10.1186/s12909-018-1255-6 Negative / Null Result ReportOpen accessMedicine
Vuurberg G, Maria PA, Baalbaki R et al. · 2026 · Orthopaedic journal of sports medicine
Background Lateral ligament repair is a reliable surgical approach for the treatment of chronic ankle instability (CAI). Although the open technique has shown success over time, technological advancements have enabled the increasing use of…
View details →DOI: 10.1177/23259671261417357 Negative / Null Result ReportMedicine
Kim M, Owens R, Tucker S et al. · 2026 · The Journal of nursing administration
Objective Evaluate the short-term effectiveness of interventions to address nurse leader resilience and well-being. Background Nurse leaders face unique stressors in their role. Evidence-based, feasible interventions are urgently needed.…
View details →DOI: 10.1097/nna.0000000000001749 Negative / Null Result ReportMedicine
Iamchaimongkol A, Sangkrai S, Alberts P et al. · 2026 · Journal of neuroengineering and rehabilitation
Objective To evaluate the effect of the Virtual Reality (VR) in upper extremities function in children with Cerebral Palsy (CP). Study design Pilot randomization study. Methods A total of 42 children with CP, aged 10 to15 years, were…
View details →DOI: 10.1186/s12984-026-02043-1 Negative / Null Result ReportOpen accessMedicine (General)
Weishen WANG, Wenhui LOU, Zhiwei XU et al. · 2023 · Journal of Advanced Research
Introduction: The value of extended lymphadenectomy in pancreatoduodenectomy (PD) has been discussed by five randomized controlled studies. However, the limitations in the studies made their conclusions not sufficiently reliable. Objectives: This multi-center randomized controlled study was designed to clarify the efficacy of extended lymphadenectomy in PD for pancreatic ductal adenocarcinoma (PDAC). Methods: From December 2016 to October 2018, 170 consecutive patients undergoing PD were enrolled and randomized to standard or extended lymphadenectomy for the treatment of PDAC from three high-v
View details →DOI: 10.1016/j.jare.2022.09.011 Negative / Null Result ReportMedicine
Bieglecka, Kęszycka, Czerwińska et al. · 2026 · Nutrients
Patients with psoriasis, a non-contagious, chronic, systemic inflammatory skin disease, often suffer from carbohydrate metabolism disorders, which can exacerbate systemic inflammation. This randomized, double-blind, placebo-controlled…
View details →DOI: 10.3390/nu18121843 Negative / Null Result ReportMedicine
Wongtangman, Reddy Janga, Azimaraghi et al. · 2026 · Critical care (London, England)
Patients recovering from cardiac surgery in the intensive care unit (ICU) do not sleep well. Commonly used sedative-hypnotic medications can disrupt sleep architecture and increase the risk of delirium in critically ill patients after…
View details →DOI: 10.1186/s13054-026-06151-1 Negative / Null Result ReportMedicine
Leggett CL, Plowman RS, Surace L et al. · 2026 · Gastrointestinal endoscopy
Background and aims Computer-aided polyp detection (CADe) systems can enhance polyp detection, although their performance has largely been evaluated at academic rather than community practices. This randomized controlled trial evaluated…
View details →DOI: 10.1016/j.gie.2025.12.290 Negative / Null Result ReportMedicine
Anusuya, Balaji, Manikandan · 2026 · Journal of Indian Society of Periodontology
Periodontal regeneration aims to restore the natural structure of the periodontium, therefore improving the long-term stability and function of the affected teeth. Traditional bone graft materials such as allografts, autografts,…
View details →DOI: 10.4103/jisp.jisp_210_24 Negative / Null Result ReportMedicine
Ortiz-Gutiérrez S, Serralde-Zúñiga AE, González-Salazar LE et al. · 2026 · Scientific reports
Iron deficiency without anemia (IDNA) may be linked to obesity-related inflammation. Weight reduction and heme-iron intake from red meat are proposed to improve iron status. This randomized controlled trial (NCT06104800) assessed the…
View details →DOI: 10.1038/s41598-026-53056-8 Negative / Null Result ReportOpen accessNursing
Maryam Ahmadinezhad, Marzieh Kargar, Fatemeh Vizeshfar et al. · 2017 · Iranian Journal of Nursing and Midwifery Research
Background: Postmenopausal women experience a variety of symptoms, among which sleep disorder is one of the most common problems. Acupressure and Pilates exercise programs are effective nonpharmaceutical treatments which can improve sleep quality. In the present study, we aimed to compare the effects of acupressure and Pilates-based exercises on the sleep quality of postmenopausal women referred to medical clinics. Materials and Methods: In this single-blinded randomized controlled clinical trial, we recruited 108 women aged 40–60 years who were randomly assigned into one control and two inter
View details →DOI: 10.4103/1735-9066.205954 Negative / Null Result ReportOpen accessMedicine
Stróżyk A, Horvath A, Kozłowska-Jalowska A et al. · 2026 · Frontiers in pediatrics
Objective Evidence supporting the effectiveness of a low fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (low-FODMAP) diet in treating functional abdominal pain disorders remains limited. We aimed to assess the…
View details →DOI: 10.3389/fped.2026.1809053 Negative / Null Result ReportOpen accessMedicine
Tobias Lohaus, Sally Reckelkamm, Patrizia Thoma · 2024 · PLoS ONE
Objective Acquired brain injuries (ABIs), such as traumatic brain injuries (TBIs), often entail impairments of general cognition (e.g., memory, attention or executive functions) and social cognition (e.g. emotion recognition, theory of mind [ToM], social problem-solving). The availability of fully computerized interventions targeting sociocognitive deficits specifically in neurologically impaired patients is extremely limited. Therefore, the Treatment Program for Deficits in Social Cognition and Social Competencies of the Ruhr University Bochum (SoCoBo), a fully computerized online therapy des
View details →DOI: 10.1371/journal.pone.0294767 Negative / Null Result ReportMedicine
Ghotboddin Mohammadi S, Shafie D, Feizi A et al. · 2026 · Scientific reports
Chronic inflammation and dyslipidemia are common pathophysiological features of heart failure (HF). Astaxanthin, a potent marine-derived antioxidant, has shown anti-inflammatory and lipid-lowering properties. This study conducted to…
View details →DOI: 10.1038/s41598-026-58512-z Negative / Null Result ReportOpen accessNutrition. Foods and food supply
Ye Li Lee, Sang Yeoup Lee, Sang Yeoup Lee et al. · 2022 · Frontiers in Nutrition
IntroductionOysters possess an excellent nutritional profile containing γ-aminobutyric acid (GABA). Previous data suggest that GABA is a potent bioactive compound for improving muscle health. Lactic acid fermentation is thought to increase GABA content. However, the effect of oral supplementation of fermented oyster extracts (FO) on human muscle strength and mass is unclear. Therefore, we tested the effects and safety of consumption of FO combined with regular walking for 12 weeks on muscle strength and mass in older adults with relatively low muscle mass.Materials and methodsA randomized cont
View details →DOI: 10.3389/fnut.2022.935395 Negative / Null Result ReportOpen accessMedicine
Odeleye V, Singh N, Gautam S et al. · 2026 · Current cardiology reports
PURPOSE OF REVIEW: This article reviews the evidence for cardiovascular and renal risk reduction with glucagon-like peptide-1 receptor agonists (GLP-1 RAs) in type 2 diabetes mellitus (T2DM), based on randomized controlled trials,…
View details →DOI: 10.1007/s11886-026-02357-5 Negative / Null Result ReportOpen accessMedicine
Michael R Gionfriddo, Yirui Hu, Bhumika Maddineni et al. · 2022 · JMIR Formative Research
BackgroundDespite routine review of medication lists during patient encounters, patients’ medication lists are often incomplete and not reflective of actual medication use. Contributing to this situation is the challenge of reconciling medication information from existing health records, along with external locations (eg, pharmacies, other provider/hospital records, and care facilities) and patient-reported use. Advances in the interoperability and digital collection of information provides a foundation for integration of these once disparate information sources. ObjectiveWe aim to evaluate th
View details →DOI: 10.2196/33488 Negative / Null Result ReportMedicine
Sun G, Lin W, Peng Y et al. · 2026 · BMC anesthesiology
Postoperative fatigue is a prevalent complication delaying early recovery after gynecological laparoscopic surgery, with no proven effective interventions. To investigate the effect of continuous intraoperative low-dose esketamine on…
View details →DOI: 10.1186/s12871-026-04051-z Negative / Null Result ReportMedicine
Haflidadottir S, Helgadottir FD, Sighvatsson MB · 2026 · Scandinavian journal of psychology
The global burden of infertility and its associated psychological distress is substantial, yet many individuals face barriers to accessing psychological support. A scalable, low-cost online intervention presents a promising solution. A…
View details →DOI: 10.1111/sjop.70126 Negative / Null Result ReportMedicine
Shah M, Burshtein J, Zakria D et al. · 2026 · Journal of drugs in dermatology : JDD
Background Mineral sunscreens are increasingly favorable among consumers. However, mineral sunscreens typically cause a white cast that can impact consumer selection and application. Objective This study measured the whitening effect of…
View details →DOI: 10.36849/jdd.9941 Negative / Null Result ReportMedicine
Liu, Yu, Gao et al. · 2026 · Drug design, development and therapy
To compare the analgesic efficacy and safety of deep, superficial and combined deep-superficial erector spinae plane block (ESPB) combined with subanesthetic-dose esketamine in patients undergoing percutaneous kyphoplasty (PKP). A total of…
View details →DOI: 10.2147/dddt.s601168 Negative / Null Result ReportMedicine
Zheng, Chen, Sui et al. · 2026 · Drug design, development and therapy
Laparoscopic sleeve gastrectomy (LSG) is associated with substantial postoperative pain and a high rate of postoperative nausea and vomiting. Tegileridine fumarate, a biased µ-opioid receptor agonist, may offer effective analgesia…
View details →DOI: 10.2147/dddt.s611241 Negative / Null Result ReportMedicine
Rawal, Asawa, Das et al. · 2026 · Cureus
Background Gingivitis, a reversible inflammatory condition of the gingiva, is primarily caused by plaque accumulation. Chlorhexidine is the gold standard for plaque control, but it is associated with side effects on prolonged use.…
View details →DOI: 10.7759/cureus.109382 Negative / Null Result Report
Balachandran A, Elliot JLN, Curtis S et al. · 2026 · Preprint
Abstract Background: Adolescents and young adults (AYAs) with congenital heart disease (CHD) are frequently lost to follow-up during transition to adult congenital heart disease (ACHD) care. Successful transition requires navigating…
View details →DOI: 10.21203/rs.3.rs-9900638/v1 Negative / Null Result ReportMedicine
Katheria, Lakshminrusimha, Morales et al. · 2026 · Pediatric research
We sought to evaluate oxidative changes in premature infants receiving 100% oxygen compared with 30% during deferred cord clamping (DCC). Premature infants born at 22 0/7 to 28 6/7 weeks received DCC in conjunction with either 30% (LO…
View details →DOI: 10.1038/s41390-026-05199-7 Negative / Null Result ReportMedicine
Chen, Wen, Zheng · 2026 · Shock (Augusta, Ga.)
Sepsis is a clinical syndrome marked by a dysregulated host response to infection, impairing oxygen delivery and utilization and causing organ dysfunction. Hypoxemia, which can cause significant tissue and organ damage, commonly occurs in…
View details →DOI: 10.1097/shk.0000000000002865 