Negative / Null Result ReportOpen accessMedicine
Vuurberg G, Maria PA, Baalbaki R et al. · 2026 · Orthopaedic journal of sports medicine
Background Lateral ligament repair is a reliable surgical approach for the treatment of chronic ankle instability (CAI). Although the open technique has shown success over time, technological advancements have enabled the increasing use of…
View details →DOI: 10.1177/23259671261417357 Negative / Null Result ReportMedicine
Yilmaz Ü, Çalişkan BB · 2026 · Gerontology & geriatrics education
Ageism remains a global challenge that undermines the quality of care for older adults. Nursing students, as future healthcare professionals, are in a key position to prevent age-related discrimination through educational interventions.…
View details →DOI: 10.1080/02701960.2026.2672041 Negative / Null Result Report
Xie E, He Y, Cao T et al. · 2026 · Preprint
Abstract Background BOPPPS, which comprises six components—Bridge-in, Objective, Pre-assessment, Participatory Learning, Post-assessment, and Summary—is a student-centered structured teaching model widely applied in theoretical courses.…
View details →DOI: 10.21203/rs.3.rs-8477294/v1 Negative / Null Result ReportOpen accessMedicine
Gonzalez DE, Dickerson BL, Hines K et al. · 2026 · Sports (Basel, Switzerland)
There are concerns that high-dose and/or long-term creatine monohydrate supplementation (CrM) leads to greater side effects (SEs) compared to placebo. This analysis investigated whether the dose or duration of CrM was associated with SEs.…
View details →DOI: 10.3390/sports14040137 Negative / Null Result ReportMedicine
Ding L, He M, Zhu Y et al. · 2026 · Scientific reports
Pregnancy emotional states can influence postpartum colostrum delivery, and lactational capacity establishes 1-5 days postpartum. Breast milk production capacity is key to promoting breastfeeding. This study applied positive psychology…
View details →DOI: 10.1038/s41598-026-46318-y Negative / Null Result Report
Koutsonida M, Markozannes G, Kanellopoulou A et al. · 2026 · Preprint
Background: Metabolic syndrome (MetS) has been associated with cognitive decline. Considering its increasing prevalence worldwide, the goal of this study was to evaluate the feasibility and efficacy of a short-term, self-administered…
View details →DOI: 10.64898/2026.06.22.26356249 Negative / Null Result ReportMedicine
Yang, Mueller, D'Andrea et al. · 2026 · Academic psychiatry : the journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry
Resident physicians experience high rates of depression, anxiety, burnout, and loneliness, yet few evidence-based interventions have been evaluated in this population. This randomized controlled pilot trial examined the feasibility,…
View details →DOI: 10.1007/s40596-026-02384-y Negative / Null Result ReportMedicine
Gou, He, Zhuo · 2026 · Frontiers in medicine
To investigate the effect and safety of astragalus injection at Neiguan (PC6) for chronic heart failure (CHF; HF) with qi-deficiency and blood-stasis syndrome, and its effect on the renin-angiotensin-aldosterone system (RAAS). A…
View details →DOI: 10.3389/fmed.2026.1836620 Negative / Null Result ReportMedicine
Bieglecka, Kęszycka, Czerwińska et al. · 2026 · Nutrients
Patients with psoriasis, a non-contagious, chronic, systemic inflammatory skin disease, often suffer from carbohydrate metabolism disorders, which can exacerbate systemic inflammation. This randomized, double-blind, placebo-controlled…
View details →DOI: 10.3390/nu18121843 Negative / Null Result ReportOpen accessInformation technology
Pang, Yan, Molton, James Steven, Ooi, Wei Tsang et al. · 2020 · JMIR mHealth and uHealth
BackgroundAs people living with HIV infection require lifelong treatment, nonadherence to medication will reduce their chance of maintaining viral suppression and increase the risk of developing drug resistance and HIV transmission. ObjectiveThis study aimed to evaluate the efficacy of a mobile app, Mobile Interactive Supervised Therapy (MIST), for improving adherence to oral HIV medications among HIV-infected adults in Singapore. MethodsWe conducted a two-group pilot randomized controlled trial (RCT) with a process evaluation, in which 40 HIV-infected participants with once-daily medication r
View details →DOI: 10.2196/15702 Negative / Null Result ReportOpen accessMedicine
Lisa Baquet, Helge Hasselmann, Stefan Patra et al. · 2018 · PeerJ
Background Only few aerobic exercise intervention trials specifically targeting cognitive functioning have been performed in multiple sclerosis. Objective and Methods This randomized controlled trial with 34 patients in the intervention group (IG) (mean: 38.2 years (±9.6)) and 34 patients in the control group (CG) (mean: 39.6 years (±9.7)) aimed to determine the effects of aerobic exercise on cognition in relapsing-remitting multiple sclerosis (RRMS). The primary outcome was verbal learning assessed by the verbal learning and memory test (VLMT). Patients were randomized to an IG or a waitlist
View details →DOI: 10.7717/peerj.6037 Negative / Null Result ReportMedicine
Pimouguet C, Kret M, Francis-Oliviero F et al. · 2026 · Journal of Alzheimer's disease : JAD
BackgroundThere is increasing interest in non-pharmacological approaches to address the needs of patients with Alzheimer's disease and other dementia. However, previous research highlighted the need to adapt interventions to the healthcare…
View details →DOI: 10.1177/13872877261442233 Negative / Null Result ReportOpen accessMedicine
Alexandria Turner, Mieke L van Driel, Ben Mitchell et al. · 2025 · Family Practice
Abstract Background Inappropriate antibiotic prescription for self-limiting respiratory tract infections (RTIs) by general practitioner (GP) registrars (trainees) is less common than by established GPs but still exceeds evidence-based…
View details →DOI: 10.1093/fampra/cmaf005 Negative / Null Result ReportMedicine
Chen, Si, Chen et al. · 2026 · Frontiers in medicine
This study aimed to evaluate the long-term effects of an automated eye position fixation training device (AEPFTD) on intraoperative cooperation, surgical efficiency, complications, and recurrence rates in patients undergoing pterygium…
View details →DOI: 10.3389/fmed.2026.1764636 Replication FailureOpen accessMedicine
Karina da Silva, Cristino Carneiro Oliveira, Leandro Ferracini Cabral et al. · 2023 · PLoS ONE
Pulmonary expansion manoeuvres are therapeutic techniques used to prevent and reverse atelectasis; however, no randomized controlled trials have provided evidence supporting the use of this intervention among individuals on mechanical ventilation. Objective To evaluate the effects of chest compression-decompression and chest block manoeuvres compared to usual care among patients on mechanical ventilation. Methods The current study was a randomized clinical trial of adult subjects on mechanical ventilation for 12 to 48 hours. The control group received usual care (passive or active mobilization
View details →DOI: 10.1371/journal.pone.0295775 Negative / Null Result ReportMedicine
Kim M, Owens R, Tucker S et al. · 2026 · The Journal of nursing administration
Objective Evaluate the short-term effectiveness of interventions to address nurse leader resilience and well-being. Background Nurse leaders face unique stressors in their role. Evidence-based, feasible interventions are urgently needed.…
View details →DOI: 10.1097/nna.0000000000001749 Negative / Null Result ReportOpen accessDiseases of the endocrine glands. Clinical endocrinology
Maiko Miyamoto, Aika Miya, Akinobu Nakamura et al. · 2026 · Journal of Diabetes Investigation
ABSTRACT Aims/Introduction We aimed to explore the short‐term effects of tofogliflozin on the insulin secretory capacity of people with type 2 diabetes. Materials and Methods We performed a multicenter, prospective, randomized, active‐controlled, open‐label, parallel‐group comparison study of people with type 2 diabetes aged 20–89 years, with hemoglobin A1c (HbA1c) 6.5%–9.0%, not previously treated with antihyperglycemic agents. The participants were randomly assigned to a group that received 20 mg tofogliflozin per day or a group that received 500 mg metformin per day for 4 weeks. Fasting blo
View details →DOI: 10.1111/jdi.70245 Negative / Null Result ReportMedicine
Aziz R, Khoddami SM, Jalaie S et al. · 2026 · Journal of voice : official journal of the Voice Foundation
Objectives This study investigated the effects of four common semioccluded vocal tract exercises (SOVTEs)-tongue trill, lip trill, straw phonation, and water resistance therapy (WRT)-in primary muscle tension dysphonia (MTD). Study design…
View details →DOI: 10.1016/j.jvoice.2025.12.036 Negative / Null Result ReportOpen accessSpecial aspects of education
Maryam Amiri, Zahra Khademian, Reza Nikandish · 2018 · BMC Medical Education
Abstract Background The complexity of patients’ condition and treatment processes in intensive care units (ICUs) predisposes patients to more hazardous events. Effective patient safety culture is related to lowering the rate of patients’ complications and fewer adverse events. The present study aimed to determine the effect of empowering nurses and supervisors through an educational program on patient safety culture in adult ICUs. Methods A randomized controlled trial was conducted during April–September 2015 in 6 adult ICUs at Namazi Hospital, Shiraz, Iran. A total of 60 nurses and 20 supervi
View details →DOI: 10.1186/s12909-018-1255-6 Negative / Null Result ReportMedicine
Shah S, Kaul A, Pandey P et al. · 2026 · Indian pediatrics
Objectives To evaluate the efficacy of oral Lactobacillus rhamnosus GG (LGG) in reducing neonatal enterocolitis (NEC), sepsis and mortality in very low birth weight (VLBW) infants. Methods This open-label randomized controlled trial…
View details →DOI: 10.1007/s13312-025-00252-w Negative / Null Result ReportOpen accessMedicine (General)
Weishen WANG, Wenhui LOU, Zhiwei XU et al. · 2023 · Journal of Advanced Research
Introduction: The value of extended lymphadenectomy in pancreatoduodenectomy (PD) has been discussed by five randomized controlled studies. However, the limitations in the studies made their conclusions not sufficiently reliable. Objectives: This multi-center randomized controlled study was designed to clarify the efficacy of extended lymphadenectomy in PD for pancreatic ductal adenocarcinoma (PDAC). Methods: From December 2016 to October 2018, 170 consecutive patients undergoing PD were enrolled and randomized to standard or extended lymphadenectomy for the treatment of PDAC from three high-v
View details →DOI: 10.1016/j.jare.2022.09.011 Negative / Null Result ReportMedicine
Yang X, Zhu L, Chen R et al. · 2026 · Human reproduction open
Study question Does adding vaginal estradiol to standard progesterone luteal phase support improve ongoing pregnancy rates in normal-responder IVF/ICSI patients undergoing GnRH antagonist cycles? Summary answer The addition of vaginal…
View details →DOI: 10.1093/hropen/hoag042 Negative / Null Result ReportMedicine
Ortiz-Gutiérrez S, Serralde-Zúñiga AE, González-Salazar LE et al. · 2026 · Scientific reports
Iron deficiency without anemia (IDNA) may be linked to obesity-related inflammation. Weight reduction and heme-iron intake from red meat are proposed to improve iron status. This randomized controlled trial (NCT06104800) assessed the…
View details →DOI: 10.1038/s41598-026-53056-8 Negative / Null Result ReportMedicine
Wu BY, Hsu CY, Cheng YH · 2026 · Archives of physical medicine and rehabilitation
Objective To evaluate the efficacy of ultrasound-guided dextrose injection (DI) therapy for chronic anterior talofibular ligament sprain. Design A randomized, single-blinded controlled trial. Setting Participants were recruited from the…
View details →DOI: 10.1016/j.apmr.2025.09.004 Negative / Null Result ReportMedicine
Wongtangman, Reddy Janga, Azimaraghi et al. · 2026 · Critical care (London, England)
Patients recovering from cardiac surgery in the intensive care unit (ICU) do not sleep well. Commonly used sedative-hypnotic medications can disrupt sleep architecture and increase the risk of delirium in critically ill patients after…
View details →DOI: 10.1186/s13054-026-06151-1 Failed Experiment ReportOpen accessMedicine
Se-Hee Min, Suk Hyung Choe, Won Shik Kim et al. · 2022 · Scientific Reports
Abstract Flap failure after microvascular reconstructive surgery is a rare but devastating complication caused by reperfusion injury and tissue hypoperfusion. Remote ischemic conditioning (RIC) provides protection against ischemia/reperfusion injury and reduces tissue infarction. We hypothesized that RIC would enhance flap oxygenation and exert organ-protective effects during head and neck free flap reconstructive surgery. Adult patients undergoing free flap transfer surgery for head and neck cancer were randomized to receive either RIC or sham-RIC during surgery. RIC consisted of four cycles
View details →DOI: 10.1038/s41598-022-12374-3 Negative / Null Result ReportMedicine
Anusuya, Balaji, Manikandan · 2026 · Journal of Indian Society of Periodontology
Periodontal regeneration aims to restore the natural structure of the periodontium, therefore improving the long-term stability and function of the affected teeth. Traditional bone graft materials such as allografts, autografts,…
View details →DOI: 10.4103/jisp.jisp_210_24 Replication FailureMedicine
Minkhorst K, Munn A, MacDermid J et al. · 2025 · Archives of physical medicine and rehabilitation
Objective To evaluate whether the addition of an orthosis improved the efficacy of cortisone injection for the nonoperative management of trigger finger. Design Block randomized controlled trial. Setting Outpatient hand clinic.…
View details →DOI: 10.1016/j.apmr.2025.05.015 Negative / Null Result ReportOpen accessNursing
Maryam Ahmadinezhad, Marzieh Kargar, Fatemeh Vizeshfar et al. · 2017 · Iranian Journal of Nursing and Midwifery Research
Background: Postmenopausal women experience a variety of symptoms, among which sleep disorder is one of the most common problems. Acupressure and Pilates exercise programs are effective nonpharmaceutical treatments which can improve sleep quality. In the present study, we aimed to compare the effects of acupressure and Pilates-based exercises on the sleep quality of postmenopausal women referred to medical clinics. Materials and Methods: In this single-blinded randomized controlled clinical trial, we recruited 108 women aged 40–60 years who were randomly assigned into one control and two inter
View details →DOI: 10.4103/1735-9066.205954 Replication FailureOpen accessDiseases of the digestive system. Gastroenterology
Ben-Gang Zhou, Ming-Wen Guo, Li-Juan Zhang et al. · 2024 · Therapeutic Advances in Gastroenterology
Background: The efficacy of the 14-day esomeprazole–amoxicillin (EA) dual therapy in eradicating Helicobacter pylori ( H. pylori ) has been widely discussed previously. Vonoprazan, a novel potassium-competitive acid blocker, presents rapid, potent, and long-lasting acid inhibitory effects compared to esomeprazole. However, there is currently a scarcity of direct comparisons between the 10-day vonoprazan–amoxicillin (VA) and the 14-day EA dual therapy for H. pylori eradication. Objectives: This study aimed to compare the efficacy and safety of the 10-day VA and the 14-day EA dual therapy for H.
View details →DOI: 10.1177/17562848241309870 