Negative / Null Result ReportOpen accessEarth and Planetary Sciences
Alok Bharadwaj, R. de Bruin, Arjen J. Jakobi · 2026 · Nature Communications
Cryogenic sample electron microscopy (cryo-EM) maps often display uneven quality, with high-resolution features coexisting alongside weak or poorly ordered regions. Such variation complicates structural interpretation, especially for heterogeneous macromolecular assemblies. Here, we present LocScale-2.0, a context-aware map optimisation framework that operates without prior knowledge of molecular structure or composition. By leveraging general expectations of electron scattering by biological macromolecules, it enhances local detail and connectivity while preserving weak but biologically relev
View details →DOI: 10.1038/s41467-026-75327-8Cited by 10 Negative / Null Result ReportOpen accessMedicine
Judith Charbit, Jean‐Sébastien Vidal, Olivier Hanon · 2025 · Nutrients
Cognitive aging is a complex, multifactorial process influenced by genetic, metabolic, and environmental factors. Among modifiable risk factors, nutrition has emerged as a promising target to preserve cognitive function. This review provides a comprehensive overview of the impact of dietary interventions-including specific nutrients and dietary patterns-on cognitive domains (memory, executive function, global cognition) and mental health. Recent findings: multinutrient supplementation, particularly combinations of B vitamins and omega-3 fatty acids, appears beneficial for episodic memory, espe
View details →DOI: 10.3390/nu17121964Cited by 10 Negative / Null Result ReportOpen accessBusiness, Management and Accounting
Abdulalem Mohammed, Abdullah Kaid Al‐Swidi, Mohammed A. Al-Hakimi et al. · 2025 · Discover Sustainability
The relationship between Corporate Social Responsibility (CSR) and competitive advantage (CA) has become more critical than ever for firms, particularly in the hospitality and other service industries, during times of crisis. This study…
View details →DOI: 10.1007/s43621-025-00824-7Cited by 10 Negative / Null Result ReportOpen accessPhysics and Astronomy
Matthias Klein, J. J. Mohr, C. T. Davies · 2024 · Astronomy and Astrophysics
Galaxy clusters are useful cosmological probes and interesting astrophysical laboratories. As the cluster samples continue to grow in size, a deeper understanding of the sample characteristics and improved control of systematics becomes more crucial. For this analysis we created a new and larger ACT-DR5-based thermal Sunyaev–Zel’dovich Effect- (tSZE-) selected galaxy cluster catalog with improved control over sample purity and completeness. We employed the red sequence based cluster redshift and confirmation tool MCMF together with optical imaging data from the Legacy Survey DR-10 and infrared
View details →DOI: 10.1051/0004-6361/202451203Cited by 10 Negative / Null Result ReportOpen accessNeuroscience
Chao Jiang, Yingying Dai, Yunheng Ding et al. · 2024 · Brain Sciences
Electroencephalography (EEG)-based emotion recognition is increasingly pivotal in the realm of affective brain-computer interfaces. In this paper, we propose TSANN-TG (temporal-spatial attention neural network with a task-specific graph), a novel neural network architecture tailored for enhancing feature extraction and effectively integrating temporal-spatial features. TSANN-TG comprises three primary components: a node-feature-encoding-and-adjacency-matrices-construction block, a graph-aggregation block, and a graph-feature-fusion-and-classification block. Leveraging the distinct temporal sca
View details →DOI: 10.3390/brainsci14050516Cited by 10 Negative / Null Result ReportOpen accessMedicine
Amira Soliman, Björn Agvall, Kobra Etminani et al. · 2023 · Journal of Medical Internet Research
BACKGROUND: Sensitive and interpretable machine learning (ML) models can provide valuable assistance to clinicians in managing patients with heart failure (HF) at discharge by identifying individual factors associated with a high risk of readmission. In this cohort study, we delve into the factors driving the potential utility of classification models as decision support tools for predicting readmissions in patients with HF. OBJECTIVE: The primary objective of this study is to assess the trade-off between using deep learning (DL) and traditional ML models to identify the risk of 100-day readmi
View details →DOI: 10.2196/46934Cited by 9 Negative / Null Result ReportOpen accessMedicine
Urszula Smyczyńska, Szymon Grabia, Zuzanna Nowicka et al. · 2021 · Cancers
State-of-art normal tissue complication probability (NTCP) models do not take into account more complex individual anatomical variations, which can be objectively quantitated and compared in radiomic analysis. The goal of this project was development of radiomic NTCP model for radiation-induced hypothyroidism (RIHT) using imaging biomarkers (radiomics). We gathered CT images and clinical data from 98 patients, who underwent intensity-modulated radiation therapy (IMRT) for head and neck cancers with a planned total dose of 70.0 Gy (33–35 fractions). During the 28-month (median) follow-up 27 pat
View details →DOI: 10.3390/cancers13215584Cited by 9 Negative / Null Result ReportOpen accessMedicine
Akhilesh Mishra, Ajay Sharma, Kuldeep Gupta et al. · 2026 · Science Advances
Optimizing dosing strategies is critical to balance effectiveness and toxicity, especially for drugs with narrow therapeutic windows such as antibody-drug conjugates (ADCs). This study evaluates whether positron emission tomography (PET) imaging targeting Nectin-4 can noninvasively quantify the real-time interaction of the ADC enfortumab vedotin (EV) with tumors in urothelial carcinoma. Using the imaging agent [ 68 Ga]AJ647, dynamic changes in the interaction of EV with Nectin-4 were measured across preclinical models and correlated with therapeutic responses. PET imaging identified dose-depen
View details →DOI: 10.1126/sciadv.ady1111Cited by 9 Negative / Null Result ReportOpen accessMedicine
Shanshan Zhang, Tingyu Wang, Ye Peng et al. · 2026 · Molecular Biomedicine
Parkinson's disease (PD) is a neurodegenerative disorder primarily characterized by motor impairments such as bradykinesia, tremor, and rigidity. Its neuropathological hallmarks include the progressive loss of dopaminergic neurons in the substantia nigra pars compacta (SNc) and the aggregation of α-synuclein (α-syn) into Lewy bodies (LBs), which gradually spread to other central nervous system regions and peripheral tissues. The etiology of PD is multifactorial, involving a complex interplay of genetic predisposition, aging, environmental exposures, and lifestyle factors. Disease pathogenesis
View details →DOI: 10.1186/s43556-026-00445-0Cited by 9 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Zhenghao Sun, Qian Gong, Zi-lai Wang et al. · 2026 · International Journal of Biological Sciences
The gut microbiota, as a source of profound genetic and metabolic capacity, affects every aspect of human biology including health, development and aging, as well as disease. Studies have demonstrated the crosstalk between the gut…
View details →DOI: 10.7150/ijbs.124499Cited by 9 Negative / Null Result ReportOpen accessMedicine
Émilie Le Rhun, Lakshmi Nayak, Mary Jane Lim-Fat et al. · 2024 · Neuro-Oncology
BACKGROUND: There are no validated tools for the clinical neurological assessment of patients with leptomeningeal metastases (LM). However, clinical examination during the course of the disease guides medical management and is part of response assessment in clinical trials. Because neuroimaging may not always be obtained owing to rapid clinical deterioration, clinical neurological assessment of LM is essential, and standardization is important to minimize rater disagreement. METHODS: The Response Assessment in Neuro-oncology-LM group launched a 2-step process, aiming at improving and standardi
View details →DOI: 10.1093/neuonc/noae171Cited by 9 Negative / Null Result ReportOpen accessEnvironmental Science
Moritz Mager, Lukas Zeilerbauer, Alexander Felgel-Farnholz et al. · 2026 · Waste Management
European legislation, particularly the Packaging and Packaging Waste Regulation (PPWR), is rapidly increasing the demand for high-quality recycled polypropylene (PP) in packaging applications. Achieving such qualities through mechanical recycling remains challenging due to the heterogeneity of post-consumer waste, while the role of intensified washing in the overall decontamination remains debated. This study evaluates the influence of additional sorting and washing intensity on material properties, product performance, and environmental impacts in mechanical recycling of Dutch post-consumer r
View details →DOI: 10.1016/j.wasman.2026.115356Cited by 9 Negative / Null Result ReportOpen accessMedicine
F Visalli, Matteo Capobianco, F. Cappellani et al. · 2026 · International Journal of Molecular Sciences
Mitochondrial dysfunction represents a central hallmark of aging and a broad spectrum of chronic diseases, ranging from metabolic to neurodegenerative and ocular disorders. Nicotinamide riboside (NR), a vitamin B3 derivative and efficient precursor of NAD+ (nicotinamide adenine dinucleotide), and berberine (BBR), an isoquinoline alkaloid widely investigated in metabolic regulation, have independently emerged as promising mitochondrial modulators. NR enhances cellular NAD+ pools, thereby activating sirtuin-dependent pathways, stimulating PGC-1α–mediated mitochondrial biogenesis, and triggering
View details →DOI: 10.3390/ijms27010485Cited by 9 Negative / Null Result ReportOpen accessMedicine
T. Nguyen, Tam Dao, Ha Thu Nguyen et al. · 2026 · Endocrinology and Metabolism
Sarcopenia is a progressive, age-related condition characterized by the loss of skeletal muscle mass, strength, and function, which increases the risk of falls, frailty, and loss of independence. Despite growing recognition and its…
View details →DOI: 10.3803/enm.2025.2656Cited by 9 Negative / Null Result ReportOpen accessMedicine
Gustavo Jimenez‐Maggiora, Arndt‐Peter Schulz, Michael Donohue et al. · 2024 · The Journal of Prevention of Alzheimer s Disease
BACKGROUND: The Anti-Amyloid Treatment in Asymptomatic Alzheimer's Disease (A4) and Longitudinal Evaluation of Amyloid Risk and Neurodegeneration (LEARN) studies were conducted between 2014 and 2023, with enrollment completed in 2017 and final study results reported in 2023. The study screening process involved the collection of initial clinical, cognitive, neuroimaging, and genetic measures to determine eligibility. Once randomized, enrolled participants were assessed every four weeks over a 4.5-year follow-up period during which longitudinal clinical, cognitive, and neuroimaging measures wer
View details →DOI: 10.14283/jpad.2024.120Cited by 9 Negative / Null Result ReportOpen accessComputer Science
Andrea Espis, Chiara Marzi, Stefano Diciotti · 2025 · Scientific Reports
Self-supervised learning (SSL) in computer vision has shown its potential to reduce reliance on labeled data. However, most studies focused on balanced, large, broad-domain datasets like ImageNet, whereas, in real-world medical applications, dataset size is typically limited. This study compares the performance of SSL versus supervised learning (SL) on small, imbalanced medical imaging datasets. We experimented with four binary classification tasks: age prediction and diagnosis of Alzheimer's disease from brain magnetic resonance imaging scans, pneumonia from chest radiograms, and retinal dise
View details →DOI: 10.1038/s41598-025-99000-0Cited by 9 Negative / Null Result Report
Oumaima Alaika, Souad Jamai, Nawal Doghmi et al. · 2020 · Journal of the Saudi Heart Association
Objectives: Speckle-tracking imaging is a novel method for assessing left ventricular (LV) function and ischemic changes. The aim of this prospective study was to assess the diagnostic accuracy of global longitudinal strain (GLS) and…
View details →DOI: 10.37616/2212-5043.1096Cited by 8 Negative / Null Result Report
Richard Lu, Vu Tran Hoang, Wing-Keung Wong · 2020 · Studies in Economics and Finance
Purpose The literature has demonstrated that lump-sum (LS) outperforms dollar-cost averaging (DCA) in uptrend markets while DCA outperforms LS only when the asset price is mean-reverted or downtrend. To bridge the gap in the literature,…
View details →DOI: 10.1108/sef-04-2018-0107Cited by 7 Negative / Null Result Report
Neng Shen, Jing Zhang, Yangchun Cao · 2024 · Business Process Management Journal
Purpose In the context of open innovation, more and more enterprises are leveraging innovation networks to drive disruptive innovation performance, but there is no consensus on the relationship between network embeddedness and enterprise…
View details →DOI: 10.1108/bpmj-03-2024-0191Cited by 6 Negative / Null Result Report
Patrick Albers, Jacob Bennett, Moira Evans et al. · 2024 · Canadian Urological Association Journal
Introduction: Despite a negative magnetic resonance imaging (MRI), some patients may still harbor clinically significant prostate cancer (csPCa, Gleason grade group ≥2). High-resolution micro-ultrasound (microUS) is a novel imaging…
View details →DOI: 10.5489/cuaj.8626Cited by 6 Negative / Null Result Report
Fei Ke, Renbao Wang, Zihao Wang et al. · 2022 · Viruses
As nucleocytoplasmic large DNA viruses, replication of ranaviruses (genus Ranavirus, family Iridoviridae) involves a series of viral and host proteins. We have described that the replication and transcription machinery of Andrias…
View details →DOI: 10.3390/v14050952Cited by 6 Negative / Null Result Report
Sarah Ingber, Rita Selby, Jacques Lee et al. · 2014 · CJEM
ABSTRACT Introduction: Venous thromboembolism (VTE) is difficult to diagnose yet potentially life threatening. A low-risk pretest probability (PTP) assessment combined with a negative Ddimer can rule out VTE in two-thirds of outpatients,…
View details →DOI: 10.2310/8000.2013.130986Cited by 6 Negative / Null Result Report
Sara Ortiz-Toquero, Francisco J. Muñoz-Negrete, Gema Rebolleda · 2020 · Journal of Neuro-Ophthalmology
Background: Optic disc drusen (ODD) are a dynamic phenomenon, and their appearance, size, and relative location may change. The purpose of this study is to evaluate and quantify the longitudinal changes of buried ODD with enhanced depth…
View details →DOI: 10.1097/wno.0000000000001103Cited by 5 Negative / Null Result Report
Robert Philibert, Man-Kit Lei, Mei Ling Ong et al. · 2024 · Genes
The reliability of the associations of the acceleration of epigenetic aging (EA) indices with clinical phenotypes other than for smoking and drinking is poorly understood. Furthermore, the majority of clinical phenotyping studies have been…
View details →DOI: 10.3390/genes15070869Cited by 5 Negative / Null Result Report
Taisaku Ogawa, Koji Ochiai, Tomoharu Iwata et al. · 2022 · PLOS ONE
Developments in high-throughput microscopy have made it possible to collect huge amounts of cell image data that are difficult to analyse manually. Machine learning (e.g., deep learning) is often employed to automate the extraction of…
View details →DOI: 10.1371/journal.pone.0262397Cited by 4 Negative / Null Result Report
James Wan, Raafat Saade, Ling Wang · 2019 · Journal of Organizational Change Management
Purpose A consequence of the UN general assembly resolution calling for increased efficiency and better utilization of resources in all its agencies, is a mandate for change. As a response to this resolution, the purpose of this paper is…
View details →DOI: 10.1108/jocm-10-2018-0288Cited by 3 Negative / Null Result Report
Vidhu Anand, Christopher G. Scott, Khaled Ali et al. · 2025 · Journal of the American Heart Association
Background Tricuspid valve surgery is recommended for severe isolated tricuspid regurgitation (TR) if symptoms persist despite optimal medical therapy. The definition of optimal therapy for TR is unclear beyond managing underlying…
View details →DOI: 10.1161/jaha.124.039989Cited by 2 Negative / Null Result Report
TIMOTHY P. CANAVAN · 2017 · Clinical Obstetrics & Gynecology
Pregnancy failure is defined as a lack of sonographic evidence of current or expected viability. Technologic advances in ultrasound imaging continue to redefine diagnostic criteria of pregnancy failure or success. When evaluating a…
View details →DOI: 10.1097/grf.0000000000000301Cited by 2 Negative / Null Result Report
Paul Hockings, Kianoush Makvandi, Johannes Hulthe et al. · 2023 · Nephrology Dialysis Transplantation
Abstract Background and Aims We recently showed that comprehensive non-contrast multiparametric Magnetic Resonance Imaging (mpMRI) allowed functional and structural assessment of diabetic kidney disease (DKD) and that an imaging endpoint,…
View details →DOI: 10.1093/ndt/gfad063c_4204Cited by 1 Negative / Null Result Report
Jacob H Schmidt, Bianca Hutton Chimes · 2023 · Journal of Applied Finance & Banking
Abstract Why are there so few women in finance and even fewer managing funds? There is a major discrepancy between the number of female and male fund managers worldwide. The aim of this paper is to ascertain if gender is a contributing…
View details →DOI: 10.47260/jafb/1352Cited by 1 