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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

741 results for "aging" · page 6 of 25

Negative / Null Result ReportOpen accessComputer Science

Comparative analysis of supervised and self-supervised learning with small and imbalanced medical imaging datasets

Andrea Espis, Chiara Marzi, Stefano Diciotti · 2025 · Scientific Reports

Self-supervised learning (SSL) in computer vision has shown its potential to reduce reliance on labeled data. However, most studies focused on balanced, large, broad-domain datasets like ImageNet, whereas, in real-world medical applications, dataset size is typically limited. This study compares the performance of SSL versus supervised learning (SL) on small, imbalanced medical imaging datasets. We experimented with four binary classification tasks: age prediction and diagnosis of Alzheimer's disease from brain magnetic resonance imaging scans, pneumonia from chest radiograms, and retinal dise

View details →DOI: 10.1038/s41598-025-99000-0Cited by 9
Negative / Null Result ReportOpen accessMedicine

Maximizing the Utility of Alzheimer's Disease Trial Data: Sharing of Baseline A4 and LEARN Data

Gustavo Jimenez‐Maggiora, Arndt‐Peter Schulz, Michael Donohue et al. · 2024 · The Journal of Prevention of Alzheimer s Disease

BACKGROUND: The Anti-Amyloid Treatment in Asymptomatic Alzheimer's Disease (A4) and Longitudinal Evaluation of Amyloid Risk and Neurodegeneration (LEARN) studies were conducted between 2014 and 2023, with enrollment completed in 2017 and final study results reported in 2023. The study screening process involved the collection of initial clinical, cognitive, neuroimaging, and genetic measures to determine eligibility. Once randomized, enrolled participants were assessed every four weeks over a 4.5-year follow-up period during which longitudinal clinical, cognitive, and neuroimaging measures wer

View details →DOI: 10.14283/jpad.2024.120Cited by 9
Negative / Null Result ReportOpen accessMedicine

The Price of Explainability in Machine Learning Models for 100-Day Readmission Prediction in Heart Failure: Retrospective, Comparative, Machine Learning Study

Amira Soliman, Björn Agvall, Kobra Etminani et al. · 2023 · Journal of Medical Internet Research

BACKGROUND: Sensitive and interpretable machine learning (ML) models can provide valuable assistance to clinicians in managing patients with heart failure (HF) at discharge by identifying individual factors associated with a high risk of readmission. In this cohort study, we delve into the factors driving the potential utility of classification models as decision support tools for predicting readmissions in patients with HF. OBJECTIVE: The primary objective of this study is to assess the trade-off between using deep learning (DL) and traditional ML models to identify the risk of 100-day readmi

View details →DOI: 10.2196/46934Cited by 9
Negative / Null Result ReportOpen accessMedicine

Prediction of Radiation-Induced Hypothyroidism Using Radiomic Data Analysis Does Not Show Superiority over Standard Normal Tissue Complication Models

Urszula Smyczyńska, Szymon Grabia, Zuzanna Nowicka et al. · 2021 · Cancers

State-of-art normal tissue complication probability (NTCP) models do not take into account more complex individual anatomical variations, which can be objectively quantitated and compared in radiomic analysis. The goal of this project was development of radiomic NTCP model for radiation-induced hypothyroidism (RIHT) using imaging biomarkers (radiomics). We gathered CT images and clinical data from 98 patients, who underwent intensity-modulated radiation therapy (IMRT) for head and neck cancers with a planned total dose of 70.0 Gy (33–35 fractions). During the 28-month (median) follow-up 27 pat

View details →DOI: 10.3390/cancers13215584Cited by 9
Negative / Null Result Report

Diagnostic Accuracy Of Global Longitudinal Strain For Detecting Significant Coronary Artery Disease In Diabetic Patients Without Regional Wall Motion Abnormality

Oumaima Alaika, Souad Jamai, Nawal Doghmi et al. · 2020 · Journal of the Saudi Heart Association

Objectives: Speckle-tracking imaging is a novel method for assessing left ventricular (LV) function and ischemic changes. The aim of this prospective study was to assess the diagnostic accuracy of global longitudinal strain (GLS) and…

View details →DOI: 10.37616/2212-5043.1096Cited by 8
Negative / Null Result Report

Find the “best evidence” of the relationship between network embeddedness and enterprise disruptive innovation performance

Neng Shen, Jing Zhang, Yangchun Cao · 2024 · Business Process Management Journal

Purpose In the context of open innovation, more and more enterprises are leveraging innovation networks to drive disruptive innovation performance, but there is no consensus on the relationship between network embeddedness and enterprise…

View details →DOI: 10.1108/bpmj-03-2024-0191Cited by 6
Negative / Null Result Report

Micro-ultrasound for the detection of clinically significant prostate cancer in biopsy-naive men with negative MRI

Patrick Albers, Jacob Bennett, Moira Evans et al. · 2024 · Canadian Urological Association Journal

Introduction: Despite a negative magnetic resonance imaging (MRI), some patients may still harbor clinically significant prostate cancer (csPCa, Gleason grade group ≥2). High-resolution micro-ultrasound (microUS) is a novel imaging…

View details →DOI: 10.5489/cuaj.8626Cited by 6
Negative / Null Result Report

Combination pretest probability assessment and D-dimer did not reduce outpatient imaging for venous thromboembolism in a tertiary care hospital emergency department

Sarah Ingber, Rita Selby, Jacques Lee et al. · 2014 · CJEM

ABSTRACT Introduction: Venous thromboembolism (VTE) is difficult to diagnose yet potentially life threatening. A low-risk pretest probability (PTP) assessment combined with a negative Ddimer can rule out VTE in two-thirds of outpatients,…

View details →DOI: 10.2310/8000.2013.130986Cited by 6
Negative / Null Result Report

Enhanced Depth Imaging Optical Coherence Tomography Technology Reveals a Significant Association Between Optic Nerve Drusen Anterior Displacement and Retinal Nerve Fiber Layer Thinning Over Time

Sara Ortiz-Toquero, Francisco J. Muñoz-Negrete, Gema Rebolleda · 2020 · Journal of Neuro-Ophthalmology

Background: Optic disc drusen (ODD) are a dynamic phenomenon, and their appearance, size, and relative location may change. The purpose of this study is to evaluate and quantify the longitudinal changes of buried ODD with enhanced depth…

View details →DOI: 10.1097/wno.0000000000001103Cited by 5
Negative / Null Result Report

Objective Assessments of Smoking and Drinking Outperform Clinical Phenotypes in Predicting Variance in Epigenetic Aging

Robert Philibert, Man-Kit Lei, Mei Ling Ong et al. · 2024 · Genes

The reliability of the associations of the acceleration of epigenetic aging (EA) indices with clinical phenotypes other than for smoking and drinking is poorly understood. Furthermore, the majority of clinical phenotyping studies have been…

View details →DOI: 10.3390/genes15070869Cited by 5
Negative / Null Result Report

Deriving significant factors for managing change in UN

James Wan, Raafat Saade, Ling Wang · 2019 · Journal of Organizational Change Management

Purpose A consequence of the UN general assembly resolution calling for increased efficiency and better utilization of resources in all its agencies, is a mandate for change. As a response to this resolution, the purpose of this paper is…

View details →DOI: 10.1108/jocm-10-2018-0288Cited by 3
Negative / Null Result Report

Association of Diuretic Dosage With Outcomes in Patients With Hemodynamically Significant Isolated Tricuspid Valve Regurgitation

Vidhu Anand, Christopher G. Scott, Khaled Ali et al. · 2025 · Journal of the American Heart Association

Background Tricuspid valve surgery is recommended for severe isolated tricuspid regurgitation (TR) if symptoms persist despite optimal medical therapy. The definition of optimal therapy for TR is unclear beyond managing underlying…

View details →DOI: 10.1161/jaha.124.039989Cited by 2
Negative / Null Result Report

Failed Intrauterine Pregnancy: What Is a Failed Pregnancy, What Is Not?

TIMOTHY P. CANAVAN · 2017 · Clinical Obstetrics & Gynecology

Pregnancy failure is defined as a lack of sonographic evidence of current or expected viability. Technologic advances in ultrasound imaging continue to redefine diagnostic criteria of pregnancy failure or success. When evaluating a…

View details →DOI: 10.1097/grf.0000000000000301Cited by 2
Negative / Null Result Report

Detection of clinically significant prostate cancer by micro-ultrasound-informed systematic biopsy during MRI/micro-ultrasound fusion biopsy

Betty Wang, Stacey Broomfield, Anaïs Medina Martín et al. · 2022 · Canadian Urological Association Journal

Introduction: High-resolution micro-ultrasound (microUS) is a novel imaging technique that may visualize clinically significant prostate cancer (csPCa), including those missed by magnetic resonance imaging (MRI), in real-time during…

View details →DOI: 10.5489/cuaj.8094Cited by 1
Negative / Null Result Report

Patient leaflets on respiratory tract infections did not improve shared decision making and antibiotic prescriptions in a low-prescriber setting

Andreas Plate, Stefania Di Gangi, Christian Garzoni et al. · 2024 · Scientific Reports

Abstract Patient information leaflets can reduce antibiotic prescription rates by improving knowledge and encouraging shared decision making (SDM) in patients with respiratory tract infections (RTI). The effect of these interventions in…

View details →DOI: 10.1038/s41598-024-55166-7Cited by 1
Negative / Null Result Report

Did the Staging of Renal Neoplasm Improve with Time? Retrospective Study on a Cohort of 2000 Patients

Nicola Arrighi, Alessandro Antonelli, Tiziano Zanotelli et al. · 2011 · Urologia Journal

Objectives During the last 3 decades ultrasonographic and cross-sectional imaging techniques have been widely adopted in the pre-operative staging of renal masses with a progressive technological refinement. The aim of this study is to…

View details →DOI: 10.5301/ru.2011.8521Cited by 1
Negative / Null Result Report

Exploring the Effects of Brain Stimulation on Musical Taste: tDCS on the Left Dorso-Lateral Prefrontal Cortex—A Null Result

Gemma Massetti, Carlotta Lega, Zaira Cattaneo et al. · 2022 · Brain Sciences

Humans are the only species capable of experiencing pleasure from esthetic stimuli, such as art and music. Neuroimaging evidence suggests that the left dorsolateral prefrontal cortex (DLPFC) plays a critical role in esthetic judgments,…

View details →DOI: 10.3390/brainsci12040467Cited by 1
Negative / Null Result Report

Detection of recurrent brain tumors in children: No significant difference in sensitivity between unenhanced and contrast-enhanced MRI

Yasmina Bouzidi, Emmanuel Barteau, Julien Lejeune et al. · 2019 · The Neuroradiology Journal

Background Magnetic resonance imaging (MRI) with a gadolinium injection is currently used in the follow-up of children in remission of cerebral tumors (CTs). Intracerebral gadolinium deposition has been recently reported with unknown…

View details →DOI: 10.1177/1971400919845619Cited by 1
Negative / Null Result Report

#4204 MULTIPARAMETRIC MAGNETIC RESONANCE IMAGING BIOMARKERS OUTPERFORM LAB BIOMARKERS FOR PREDICTING PROGRESSION OF DIABETIC KIDNEY DISEASE

Paul Hockings, Kianoush Makvandi, Johannes Hulthe et al. · 2023 · Nephrology Dialysis Transplantation

Abstract Background and Aims We recently showed that comprehensive non-contrast multiparametric Magnetic Resonance Imaging (mpMRI) allowed functional and structural assessment of diabetic kidney disease (DKD) and that an imaging endpoint,…

View details →DOI: 10.1093/ndt/gfad063c_4204Cited by 1
Negative / Null Result Report

Do Female Fund Managers outperform their Male Counterparts? A Quantitative Analysis of UK Retail Funds

Jacob H Schmidt, Bianca Hutton Chimes · 2023 · Journal of Applied Finance & Banking

Abstract Why are there so few women in finance and even fewer managing funds? There is a major discrepancy between the number of female and male fund managers worldwide. The aim of this paper is to ascertain if gender is a contributing…

View details →DOI: 10.47260/jafb/1352Cited by 1
Negative / Null Result Report

“Football Did Not Make Me a World Champion, but It Did Help My Wellbeing”: A Qualitative Study of Study-sport Balance Based on Fung Ka Ki

Bill Cheuk Long Chan, Billy Lee · 2024 · Studia sportiva

Managing the balance of academic and athletic responsibilities at university is a serious challenge for student athletes. This phenomenological case study illuminates how one individual successfully managed his study-sport balance at…

View details →DOI: 10.5817/sts2023-2-6
Negative / Null Result Report

Engaging Education About Risks of Opioid Use With Patients Before Elective Surgery of the Lower Extremity Did Not Reduce Postoperative Opioid Utilization: A Randomized Controlled Trial

Daniel I. Rhon, Tina A. Greenlee, Rachel Mayhew et al. · 2022 · Journal of the American Academy of Orthopaedic Surgeons

Introduction: After elective orthopaedic surgery, many individuals go on to become long-term opioid users. Mitigating this risk has become a priority for surgeons, other members of the medical care team, and healthcare systems. The purpose…

View details →DOI: 10.5435/jaaos-d-21-00603
Negative / Null Result Report

Inflation Management In The Eu: Does The Eurozone Outperform Non-Euro States?

Anna Prucnal · 2025 · International Journal of Business & Management Studies

This study examines the effectiveness of the monetary policy of the European Central Bank (ECB) in managing inflation in the Euro Area compared to the independent monetary policy of seven European Union Member States outside the Economic…

View details →DOI: 10.56734/ijbms.v6n1a7
Negative / Null Result Report

Downstream Imaging Studies Do Not Significantly Improve Outcome in Most Patients with Chest Pain Who Did Not Reach Their Target Heart Rate on a Stress ECHO Study

Nativ Henkin, Ifat Karilker, Sergio L. Kobal et al. · 2023 · Journal of Clinical Medicine

Echocardiographic stress tests are often used to evaluate patients who complain of chest pain. However, some patients fail to reach the target heart rate required for the test to be conclusive (usually defined as 85% of the predicted…

View details →DOI: 10.3390/jcm12144832
Negative / Null Result Report

Citrulline ingestion did not improve the age‐associated reduction in nitric oxide synthesis (698.6)

Il‐Young Kim, Scott Schutzler, Nicolaas Deutz et al. · 2014 · The FASEB Journal

A reduction in nitric oxide (NO) bioavailability that impairs peripheral blood flow regulation is a natural consequence of aging. Therefore , we investigated the effect of ingestion of citrulline, the precursor of arginine, on de novo…

View details →DOI: 10.1096/fasebj.28.1_supplement.698.6
Negative / Null Result Report

Double Stigma: The Influence of Race & Mental Health

Bobbie Call, null null, null null et al. · 2020 · John Heinrichs Scholarly & Creative Activities Day

Mental health stigma is prevalent and many people are affected all around the world (Watson, 2002). Stigma often prevents individuals with a mental illness from engaging in typical life routines (Corrigan, 2004). Individuals of ethnic…

View details →DOI: 10.58809/ccrp9120
Negative / Null Result Report

The Effects of Bisphenol A on Plant A

Michelle Storey, null null, null null et al. · 2020 · John Heinrichs Scholarly & Creative Activities Day

Bisphenol A (BPA) is a ubiquitous raw material used in the production of many everyday things such as food packaging and baby bottles. While there have been many studies about the effect that this can have on water and animals, there are…

View details →DOI: 10.58809/vacy9619