Negative / Null Result ReportMedicine
Petr V, Tichanek F, Liu SL et al. · 2025 · American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Targeting peritransplant inflammation via tumor necrosis factor alpha blockade failed to improve kidney transplantation outcomes in the CTOT-19 trial that tested infliximab (IFX) induction. As natural antibodies (nAbs) to cardiolipin and…
View details →DOI: 10.1016/j.ajt.2025.06.003 Negative / Null Result ReportOpen accessMedicine
M.Ghasemi, Z. Hajheidari, M. Golpour · 2007 · Journal of Mazandaran University of Medical Sciences
AbstractPemphigus Erythematosus specially its localized form is a rare autoimmune blistering disease combining features of Pemphigus Foliaceus and Lupus Erythematosus. We reported a 60 years old woman with skin lesion which presented Erythemato squamo plaque with oozing in the right cheek. The chief compliant was burning and pruritus. Skin biopsy was obtained and discoid Lupus Erythemato was reported. She was prescribed with topical steroid but did not improve. All of the lab tests such as Anti DNA, ESR, RF, CRP, CH50, C3, C4, ANA were normal. The biopsy repeated and Pemphigus Erythematosus wa
Negative / Null Result ReportMedicine
Huang Y, Huang X, Ling L et al. · 2024 · Kardiologiia
Aim Elevated levels of pro-inflammatory factors in plasma have been linked to worse prognosis after on-pump cardiac surgery, yet interventions that reduce the levels in patients have failed to improve prognosis. Therefore, we explored…
View details →DOI: 10.18087/cardio.2024.9.n2682 Negative / Null Result ReportMedicine
Cornell CA, Norman KA, Griffiths TL et al. · 2024 · Psychological science
We often use cues from our environment when we get stuck searching our memories, but prior research has failed to show benefits of cuing with other, randomly selected list items during memory search. What accounts for this discrepancy? We…
View details →DOI: 10.1177/09567976231215298 Negative / Null Result ReportMedicine
Morimoto J, Satogami K, Naraoka T et al. · 2024 · International heart journal
Deficiency of vitamin B 1 (VB1), an essential micronutrient, causes heart failure (HF). A recent randomized controlled trial failed to show any improvement in HF prognosis after short-term VB1 supplementation. In the current study, we…
View details →DOI: 10.1536/ihj.23-550 Negative / Null Result ReportMedicine
Drieghe B, De Buyzere M, Bové T et al. · 2024 · Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions
Randomized clinical trials failed to show additional benefit of renal artery stenting on top of medical therapy. Instead of writing an obituary on renal artery stenting, we try to explain these disappointing results. A transstenotic…
View details →DOI: 10.1002/ccd.31117 Negative / Null Result ReportMedicine
Van Gent JM, Clements TW, Gurney JM et al. · 2025 · The journal of trauma and acute care surgery
Background Empiric cryoprecipitate administration has recently failed to show survival benefit in hemorrhaging trauma patients. However, a recent Trauma Quality Improvement Program query suggested a survival benefit in massive transfusions…
View details →DOI: 10.1097/ta.0000000000004643 Negative / Null Result ReportMedicine
Bhardwaj A, Saili A, Yadav DK et al. · 2025 · Journal of neonatal-perinatal medicine
BackgroundThe prolonged ductal patency in preterm newborns despite being associated with short- and long-term morbidities has failed to show significant improvement in the long-term outcome with routine ductal treatment. Echocardiography…
View details →DOI: 10.1177/19345798251343494 Negative / Null Result ReportMedicine
Imam R, Chastang KM, Olowojesiku R et al. · 2025 · The Pediatric infectious disease journal
Background Multiple clinical trials evaluating therapies for cerebral malaria (CM) have failed to demonstrate improved outcomes. This may derive from inclusion of children at all risk levels, including those at low risk of mortality or…
View details →DOI: 10.1097/inf.0000000000004581 Negative / Null Result ReportOpen accessSpecial aspects of education
Ning Zhang, Fan Ouyang · 2023 · International Journal of Educational Technology in Higher Education
Abstract Collaborative knowledge construction (CKC) involved students’ sharing of information, improvement of ideas, and construction of collective knowledge. In this process, knowledge extraction and analysis can provide valuable insights into students’ knowledge capacities, depths, and levels in order to improve the CKC quality. However, existing studies tended to extract and analyze knowledge from a single perspective (e.g., the number of certain knowledge types and knowledge structures), which failed to demonstrate the complexity and dynamics of knowledge construction and advancement. To f
View details →DOI: 10.1186/s41239-023-00414-5 Negative / Null Result ReportOpen accessMedicine
Hattori Y, Abe S, Kakino Y et al. · 2026 · Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
Interventional trials with high-density lipoprotein cholesterol (HDL-C)-raising drugs have generally failed to demonstrate a beneficial effect on cardiovascular outcomes, although low HDL-C levels confer the risk of cerebrocardiovascular…
View details →DOI: 10.1016/j.neurot.2026.e00849 Negative / Null Result ReportOpen accessMedicine
Liu S, Chen B, Zhu Y et al. · 2025 · The oncologist
Background Previous results of our trial demonstrated that the addition of induction chemotherapy (IC) prior to definitive chemoradiotherapy (CRT) failed to significantly improve the response rate or 3-year survival in patients with…
View details →DOI: 10.1093/oncolo/oyae295 Negative / Null Result ReportOpen accessMedicine
Xavier Jannot, Alpha Oumar Diallo, Judicaelle Didierjean et al. · 2025 · European Journal of Case Reports in Internal Medicine
We report the case of a 75-year-old woman admitted to the emergency department for confusion, gait disturbances and mutism associated with an inflammatory syndrome occurring 3 weeks after acute carbon monoxide intoxication. The main hypothesis upon arrival was infectious meningoencephalitis, and the patient was put on acyclovir and antibiotics in meningeal doses. After a short stay in intensive care, the patient’s condition did not improve, and the revaluation of her case history and imaging studies led to the diagnosis of post-interval syndrome secondary to carbon monoxide intoxication after
View details →DOI: 10.12890/2025_005235 Negative / Null Result ReportOpen accessDiseases of the blood and blood-forming organs
Daniel A. Ermann, Victoria A. Vardell, Lindsey Fitzgerald et al. · 2026 · eJHaem
ABSTRACT Introduction B‐cell prolymphocytic leukemia (B‐PLL) is a rare, aggressive leukemic B‐cell malignancy historically associated with poor outcomes and recently reclassified in the WHO Fifth Edition but retained as a distinct entity in the ICC. Methods We analyzed 950 patients labeled as B‐PLL in the National Cancer Database (2004–2019), identified using ICD‐O‐3 morphology code 9833/3. Results Median age was 72 years, and 72% received systemic therapy at diagnosis. Median overall survival (OS) was poor (2.8 years) and did not improve over time. Patients initially managed with active surve
View details →DOI: 10.1002/jha2.70299 Negative / Null Result ReportOpen accessComputer Science
CLEO Collaboration, K. Edwards et al · 1997 · arXiv
We have searched for the decay of the tau lepton into seven charged particles and zero or one pi0. The data used in the search were collected with the CLEO II detector at the Cornell Electron Storage Ring (CESR) and correspond to an integrated luminosity of 4.61 fb^(-1). No evidence for a signal is found. Assuming all the charged particles are pions, we set an upper limit on the branching fraction, B(tau- -> 4pi- 3pi+ (pi0) nu_tau) < 2.4 x 10^(-6) at the 90% confidence level. This limit represents a significant improvement over the previous limit.
Negative / Null Result ReportMedicine
Choi, Gutman, Iglesia et al. · 2026 · Urogynecology (Philadelphia, Pa.)
Studies have shown that sexual function improves after surgical correction for stress urinary incontinence and pelvic organ prolapse. Current data suggest no significant difference in sexual function between transobturator and retropubic…
View details →DOI: 10.1097/spv.0000000000001888 Negative / Null Result ReportMedicine
Park K, Özgüroğlu M, Vansteenkiste J et al. · 2021 · Lung cancer (Amsterdam, Netherlands)
Objectives The JAVELIN Lung 200 phase 3 trial did not meet its primary endpoint of improving overall survival (OS) with avelumab vs docetaxel in patients with platinum-treated PD-L1+ NSCLC. We report post hoc analyses assessing the effects…
View details →DOI: 10.1016/j.lungcan.2021.01.026 Negative / Null Result ReportOpen accessMedicine
Sameed M, Meng Z, Marciniak ET · 2019 · Breathe (Sheffield, England)
In the EOLIA trial, early use of ECMO did not significantly improve mortality at 60 days in patients with severe ARDS, but when used as a rescue modality ECMO might help improve survival http://bit.ly/2XOjwSE.
View details →DOI: 10.1183/20734735.0363-2018 Negative / Null Result ReportMedicine
Finkelstein A, Cantor JC, Gubb J et al. · 2024 · Health affairs (Project Hope)
When a randomized evaluation finds null results, it is important to understand why. We investigated two very different explanations for the finding from a randomized evaluation that the Camden Coalition's influential care management…
View details →DOI: 10.1377/hlthaff.2023.01151 Negative / Null Result ReportMedicine
Adams MS, Mensink RP, Plat J et al. · 2026 · European journal of clinical nutrition
Background Previous almond intervention studies involving relatively healthy populations did not demonstrate improvements in cognitive performance. However, a long-term study with participants at risk of cognitive decline, such as those…
View details →DOI: 10.1038/s41430-026-01705-6 Negative / Null Result ReportMedicine
Diz-Lopes M, Rovetta CF, Pollastri F et al. · 2026 · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
We evaluated how romosozumab affects bone structure, density, and strength at the wrist over 12 months. Volumetric bone mineral density did not increase, but high-resolution quantitative computed tomography imaging showed modest…
View details →DOI: 10.1007/s00198-026-08113-3 