A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
243 results in Negative / Null Result Report for "replication" · page 5 of 9
Fei Ke, Renbao Wang, Zihao Wang et al. · 2022 · Viruses
As nucleocytoplasmic large DNA viruses, replication of ranaviruses (genus Ranavirus, family Iridoviridae) involves a series of viral and host proteins. We have described that the replication and transcription machinery of Andrias…
Amna Chaudari, Joel A Huberman · 2012 · F1000Research
Telomeres of the fission yeast, Schizosaccharomyces pombe , are known to replicate in late S phase, but the reasons for this late replication are not fully understood. We have identified two closely-spaced DNA replication origins, 5.5 to 8…
Sean P. Carlin, Lionel G. Standing · 2013 · Psychological Reports
Previous research has suggested that motivational processes outside an individual's conscious awareness may be primed so as to enhance or impair cognitive performance. The present study involved a conceptual replication of the 2010 study…
Pinky Dutta, Andres Lõhmus, Tero Ahola et al. · 2024 · Viruses
The trans-replication system explores the concept of separating the viral RNA involved in the translation of the replicase protein from the replication of the viral genome and has been successfully used to study the replication mechanisms…
Chris C. Martin · 2020 · Journal of Social and Political Psychology
Education exacerbates partisan gaps in scientific knowledge and attitudes. However, previous findings about the extent and symmetry of this moderation have been mixed. As a conceptual replication of previous research, this study examines…
Juraj Koči, Marta Novotová, Monika Sláviková et al. · 2022 · Pathogens
The coronavirus transforms the cytoplasm of susceptible cells to support virus replication. It also activates autophagy-like processes, the role of which is not well understood. Here, we studied SARS-CoV-2-infected Vero E6 cells using…
Nicholas P Carruth, Jairo A Ramos, Akira Miyake · 2023 · PLoS ONE
This article reports a preregistered study in which we attempted to replicate the results of an influential study on the ego-depletion effect reported by Job, Dweck, and Walton in 2010. The original Job et al. study (Study 1, N = 60) provided evidence that the ego-depletion effect-a performance decrease on a self-control task after performing another self-control task-occurs only for individuals who hold a belief that their willpower is limited. This moderation of the ego-depletion effect by one's willpower mindset (limited vs. nonlimited) has been interpreted as evidence against a prevalent l
Daniel Wiswede, Jascha Rüsseler · 2021 · Frontiers in Human Neuroscience
Introduction: The present study was conducted to verify a promising experimental setup which demonstrated an inversed Stroop-effect (much faster responses for incongruent relative to congruent Stroop trials) following a mismatching tone. In the matching condition, which was an almost exact replication of the original study, participants were required to indicate whether word color and word meaning were matching, whereas in the response conflict condition, instruction was the same as in a classical Stroop task and required the participants to respond to the word color. As in the original study,
Zhou Tao, Han Yanxing, Dang Ying et al. · 2009 · Retrovirology
Abstract Background Isolation of novel retroviral restriction factors will open new avenues for anti-HIV/AIDS treatment. Although HIV-1 replication is restricted by APOBEC3G/APOBEC3F, TRIM5α, and CD317, none defend HIV-1 infection under natural conditions. Previously, we demonstrated a host factor from the human T cell line CEM.NKR that potently restricted wild-type HIV-1 replication. Interestingly, this restriction resembled the APOBEC3G/APOBEC3F pattern in that viral replication was inhibited from the second round of replication cycle at a post-entry step. Results Here, we further characteri
Nicholas P. Carruth, Jairo A. Ramos, Akira Miyake · 2023 · PLoS ONE
This article reports a preregistered study in which we attempted to replicate the results of an influential study on the ego-depletion effect reported by Job, Dweck, and Walton in 2010. The original Job et al. study (Study 1, N = 60) provided evidence that the ego-depletion effect—a performance decrease on a self-control task after performing another self-control task—occurs only for individuals who hold a belief that their willpower is limited. This moderation of the ego-depletion effect by one’s willpower mindset (limited vs. nonlimited) has been interpreted as evidence against a prevalent l
Nikola Jajcay, David Tomeček, Iveta Fajnerová et al. · 2026 · Frontiers in Computational Neuroscience
An increasing number of studies are currently focusing on “personality neuroscience,” a term denoting the research aimed at neuroimaging correlates of inter-individual temperament and character variability. Among other methods, a graph theoretical analysis of the functional connectivity in resting-state functional magnetic resonance imaging data was applied in a study by, reporting novel functional connectivity correlates of personality traits. The current paper presents a conceptual replication of the results of this study and discusses the related challenges, including an extension of the or
Jonas Weijers, Jonas Weijers, Wolfgang Viechtbauer et al. · 2018 · Frontiers in Psychiatry
A previous study observed that reported childhood abuse moderated psychotic and emotional reactivity to stress among patients with non-affective psychotic disorder. However, that study used a type of analysis unsuited for skewed data. This study aimed (1) to replicate the study and (2) to examine whether we would obtain similar results using a statistical approach better suited to skewed data. Fifty-nine patients with non-affective psychotic disorder were examined for up to 6 days using an intensive diary method to assess levels of negative affect, psychosis, and daily-life stress. A mixed-lin
Sahaana Chandran, Jan Vinjé, Kimberly Huynh et al. · 2026 · Applied and Environmental Microbiology
ABSTRACT Human intestinal enteroid (HIE) and zebrafish larva (ZF) models support the replication of certain strains of human norovirus (HuNoV), the leading cause of viral gastroenteritis worldwide. The replication of 17 HuNoV-positive stool specimens (nine genotypes) from patients ranging from 5 months to 83 years old was evaluated in both HIE and ZF models. The yolk of 3-day post-fertilization ZF larvae was microinjected with 3 nL 10% clarified stool suspension. Each day post-infection (dpi), 10 larvae were pooled as one sample, and two specimens were collected daily until 5 dpi. Viral RNA wa
Andrew M. Colman, Briony D. Pulford, Caren A. Frosch et al. · 2022 · Royal Society Open Science
In this preregistered study, we attempted to replicate and substantially extend a frequently cited experiment by Schurr and Ritov, published in 2016, suggesting that winners of pairwise competitions are more likely than others to steal money in subsequent games of chance against different opponents, possibly because of an enhanced sense of entitlement among competition winners. A replication seemed desirable because of the relevance of the effect to dishonesty in everyday life, the apparent counterintuitivity of the effect, possible problems and anomalies in the original study, and above all t
Selvaraj Pavulraj, Rhett W. Stout, Daniel B. Paulsen et al. · 2023 · Viruses
Like other alpha herpesviruses, pseudorabies virus (PRV) establishes lifelong latency in trigeminal ganglionic (TG) neurons. Upon stress, the latent viruses in the TG neurons reactivate and are transported anterograde from the neuron cell bodies to the nerve endings in the nasal mucosa, where they replicate and are discharged in the nasal and oral secretions. Consequently, the virus is transmitted to other naïve animals. This cycle of latency and reactivation continues until the animal dies or is slaughtered. We have constructed a PRV triple mutant virus (PRVtmv) and used it as a live subunit
Yuka Takahashi, Toshiyuki Himichi, Ayumi Masuchi et al. · 2023 · PLoS ONE
Previous studies have revealed that reading fiction is associated with dispositional empathy and theory-of-mind abilities. Earlier studies established a correlation between fiction reading habits and the two measures of social cognition: trait fantasy (i.e., the tendency to transpose oneself into fictitious characters) and performance on the Reading the Mind in the Eyes Test (RMET; a test of the ability to identify others' mental states based on their eyes). Recently, experimental studies have shown that brief exposure to fiction enhances RMET performance. Nevertheless, these studies have been
Fernando Caravaggio, Pontus Plavén-Sigray, Granville James Matheson et al. · 2018 · PLoS ONE
High levels of trait impulsivity are considered a risk factor for substance abuse and drug addiction. We recently found that non-planning trait impulsivity was negatively correlated with post-commissural putamen volumes in men, but not women, using the Karolinska Scales of Personality (KSP). Here, we attempted to replicate this finding in an independent sample using an updated version of the KSP: the Swedish Universities Scales of Personality (SSP). Data from 88 healthy male participants (Mean Age: 28.16±3.34), who provided structural T1-weighted magnetic resonance images (MRIs) and self-repor
Sara Havrlišan, Martina Tokić, Štefanija Klarić et al. · 2026 · Tehnički Glasnik
This research analyses the impact of infill density and layer thickness on the tensile strength of test samples fabricated using FDM 3D printing, with a particular focus on comparing samples produced with and without an adhesion layer. A two-factor factorial experimental design was employed, consisting of two levels and three replications. The infill density (20% and 50%) and layer thickness (0.1 mm and 0.2 mm) were defined as input variables, while tensile strength served as the output variable. Statistical methods, such as ANOVA, were used to analyse the experimental data and evaluate the si
Julie Van, Sam E. Nielsen, C. Brock Kirwan · 2022 · NeuroImage: Reports
Common research practices in neuroimaging studies using functional magnetic resonance imaging may produce outcomes that are difficult to replicate. Results that cannot be replicated have contributed to a replication crisis in psychology, neuroscience, and other disciplines over the years. Here we replicate two previous papers in which the authors present two analysis paths for a dataset in which participants underwent fMRI while performing a recognition memory test for old and new words. Both studies found activation in the medial temporal lobe including the hippocampus, with the first demonst
Kyriakidis I, Katsarou SD, Zervou MI et al. · 2026 · Genes
Background/objectives Inherited variants in IKZF1 and CDKN2A/2B are among the most consistently reported germline susceptibility markers for childhood acute lymphoblastic leukemia (ALL). Nonetheless, effect sizes differ across ancestry…
Sudhakar S, Mishra VK, Harikrishna S et al. · 2026 · Physical chemistry chemical physics : PCCP
Human PrimPol (hPrimPol) is the primase and polymerase enzyme involved in reinitiating DNA replication at stalled replication forks. The hPrimPol mutants are linked to multiple ophthalmoplegic conditions and mitochondriopathies. The WFYY…
Lu S, Efendić E, Feldman G · 2025 · Journal of personality and social psychology
The appraisal-tendency framework proposed that specific emotions predispose individuals to appraise future events corresponding to the core appraisal themes of the emotions. In a registered report with a U.S. American online Amazon…
Gladstone JJ, Lehman M, Decker M · 2025 · Journal of experimental psychology. Applied
We investigated the influence of childhood poverty on financial decision making under threat by replicating the findings of Griskevicius et al. (2011b), which found that individuals from lower socioeconomic backgrounds tend to make riskier…
Guo J, Pratt J, Walther DB · 2025 · Attention, perception & psychophysics
The nature of visual processes underlying scene perception remains a hotly debated topic. According to one view, scene and object perception rely on similar neural mechanisms, and their processing pathways are tightly interlinked.…
Prowten S, Walker E, London B et al. · 2024 · Psychological science
People share information for many reasons. For example, Berger (2011, N = 40) found that undergraduate participants manipulated to have higher physiological arousal were more likely to share a news article with others via email than people…
Løhre E, Chandrashekar SP, Mayiwar L et al. · 2024 · Preprint
If you are trying to persuade someone, expressing your opinion with certainty intuitively seems like a good strategy to maximize your influence. However, Karmarkar and Tormala (2010) found that the effectiveness of this tactic depends on…
Vezirian K, IJzerman H, begue l et al. · 2021 · Preprint
Do colored backgrounds lead to polarized judgments? Zarkadi and Schnall (2013) found in their Study 1 that, indeed, exposing participants to a black-and-white (versus other colored) background polarized participants’ judgments in a moral…
Zhu Z, Feldman G · 2025 · Royal Society open science
Arkes (Arkes 1996 J. Behav. Decis. Mak. 9 , 213-224. (doi:10.1002/(SICI)1099-0771(199609)9:3 3.0.CO;2-1) demonstrated a phenomenon of wastefulness avoidance, showing that people's decisions are impacted by wastefulness, making decisions…
Kaicher C, Markman E, Gwilliams L · 2026 · Preprint
Labels are often advantageous for category learning. However, this may not be true for children as they learn subordinate, fine-grained object categories. In preparation for future research on subordinate category learning in children, we…
Tenney ER, Rochford K, Stillwell A et al. · 2026 · Psychological science
This is a registered report to directly replicate the primary finding in Hecht and Proffitt (1995). Hecht and Proffitt found that those with occupational experience handling liquid in containers performed worse at solving a water-level…