Negative / Null Result ReportMedicine
Riehm A, Senicourt L, O'Shaughnessy E et al. · 2026 · Diagnostic and interventional imaging
Purpose The purpose of this study was to develop a machine learning-based algorithm based on a combination of magnetic resonance imaging (MRI) and color-Doppler ultrasound (CDUS) to characterize lacrimal gland lesions. Materials and…
View details →DOI: 10.1016/j.diii.2026.06.001 Negative / Null Result ReportMedicine
Joy N, Soslow JH, Crum K et al. · 2026 · Cardiology in the young
Background Pulmonary valve replacement may be required for patients with pulmonary valve disease. Exertional symptoms related to cardiovascular disease are an indication for pulmonary valve replacement; however, quantification of symptom…
View details →DOI: 10.1017/s1047951126113493 Abandoned HypothesisOpen accessMedicine
Ghosh AK, Bhattacharjee A, Jayashankar U et al. · 2026 · Organic & biomolecular chemistry
We have investigated diastereoselective Ugi-multicomponent reactions (Ugi-MCR) relevant to bis-amide scaffolds related to SARS-CoV-2 main protease (Mpro) inhibitors. The studies were mainly focussed on development of diastereoselective…
View details →DOI: 10.1039/d5ob01897h Negative / Null Result ReportOpen accessMedicine
Christianson G, Howard ZM, Kenney S et al. · 2026 · mAbs
The use of animal models that can reliably predict drug performance in human patients is critical to antibody therapeutic development. Along with assessing toxicity and efficacy, determining the pharmacokinetic (PK) properties of…
View details →DOI: 10.1080/19420862.2026.2649990 Negative / Null Result ReportMedicine
Ng Fat, West, E Jackson · 2026 · BMJ public health
Stopping tobacco smoking, reducing alcohol consumption from high-risk levels, increasing physical activity and improving diet can improve mental well-being. To gain a preliminary estimate of the potential benefits of healthy lifestyle…
View details →DOI: 10.1136/bmjph-2025-004301 Negative / Null Result ReportMedicine
Jamei-Martel, Garibaldi, Castroviejo Fernández et al. · 2026 · JSES international
The optimal management of high-grade acromioclavicular (AC) joint dislocations remains controversial. While surgical treatment improves radiographic alignment, its impact on functional outcomes remains debated. This study prospectively…
View details →DOI: 10.1016/j.jseint.2026.101722 Negative / Null Result ReportMedicine
Kavakli, Bozkurt, Diri et al. · 2026 · Surgical endoscopy
Conventional abdominal wall blocks primarily target somatic afferent nerves and may therefore provide limited relief for the peritoneal component of postoperative pain. This study aimed to investigate whether a laparoscopic-guided deep…
View details →DOI: 10.1007/s00464-026-12973-5 Methods Dead-EndMedicine
Kadesch, Weiss, Hetjens et al. · 2026 · Obesity surgery
Preoperative multidisciplinary team assessment (MTA) for bariatric surgery is complex and associated with high attrition rates. Digital health applications may improve patient engagement and completion rates, but evidence remains limited.…
View details →DOI: 10.1007/s11695-026-08768-1 Negative / Null Result ReportMedicine
Coellar, Keshvani, Jain et al. · 2026 · American journal of preventive cardiology
Medication non-adherence following acute coronary syndrome (ACS) is common, especially among underserved populations. The use of fixed-dose combination pills (polypills) may improve both adherence and prescription practices. This…
View details →DOI: 10.1016/j.ajpc.2026.101499 Negative / Null Result ReportMedicine
Fukushi, Emori, Tsuchie et al. · 2026 · Cureus
Aggressive surgical resection with adequate margins is associated with improved local control and survival in selected patients with primary spinal sarcomas. However, anatomical constraints often preclude complete resection, and outcomes…
View details →DOI: 10.7759/cureus.108569 Negative / Null Result ReportMedicine
Merluzzi, Lepri, Lidano et al. · 2026 · Animals : an open access journal from MDPI
The Anatomage Table Vet (ATV) is a digital tool that may facilitate the understanding of complex structures and improve visuospatial skills. This study evaluated the effectiveness of the ATV as a review method prior to cadaveric dissection…
View details →DOI: 10.3390/ani16111695 Negative / Null Result ReportMedicine
Chen, Yi, Cao et al. · 2026 · Neurology
The efficacy of endovascular treatment for acute large vessel occlusion strokes has been demonstrated, but whether it can improve functional outcomes in patients with acute ischemic stroke (AIS) who only present with severe large vessel…
View details →DOI: 10.1212/wnl.0000000000218157 Negative / Null Result ReportMedicine
Zhang, Chen, Chen et al. · 2026 · Chinese medical journal
This is a multicenter, randomized, double-blind, placebo-controlled interventional clinical study to evaluate the efficacy and safety of pronase in improving visibility in colonoscopy and to evaluate whether pronase can increase the…
View details →DOI: 10.1097/cm9.0000000000004114 Negative / Null Result ReportMedicine
Budak, Yıldırım · 2026 · Psychiatria Danubina
Treatment adherence improves the quality of life and functional outcomes in patients with bipolar disorder (BD) by supporting effective disease management and fostering the development of self-esteem and self-efficacy. This study aimed to…
View details →DOI: 10.24869/psyd.2026.68 Negative / Null Result ReportMedicine
Bagdonas, Schäfer, Wolf et al. · 2026 · BMC complementary medicine and therapies
Complementary and alternative medicine (CAM) is widely used by oncology patients to manage symptoms, reduce stress, and improve quality of life. Unlike conventional treatments, CAM is rarely reimbursed in Germany, resulting in significant…
View details →DOI: 10.1186/s12906-026-05417-z Negative / Null Result ReportMedicine
Ran, Wei, Huang et al. · 2025 · Frontiers in psychology
To investigate the effectiveness of a VR preoperative education program with sensory information support in reducing perioperative anxiety and improving the delivery experience among primiparas undergoing cesarean section (CS). A total of…
View details →DOI: 10.3389/fpsyg.2025.1648706 Negative / Null Result ReportMedicine
Sumi, Yasutaka, Ogata et al. · 2026 · Gan to kagaku ryoho. Cancer & chemotherapy
Hematologic malignancies have shown improved prognosis in some diseases owing to advanced treatment. Cytarabine (Ara-C) is widely used for treatment; however, ocular symptoms frequently occur as a side effect. In this retrospective study,…
Negative / Null Result ReportMedicine
Yang, Dong, Cheng et al. · 2026 · Clinical oral investigations
To evaluate whether early orthodontic traction of inversely impacted maxillary central incisors with curved roots affects subsequent root development and labial/palatal alveolar bone support. A retrospective cone-beam computed tomography…
View details →DOI: 10.1007/s00784-026-06962-0 Negative / Null Result ReportMedicine
Lee, Mak, Leong et al. · 2026 · European journal of clinical nutrition
Okara is a protein-rich food by-product that can be biovalorised with Rhizopus oligosporus to improve its protein digestibility and quality. This study investigated postprandial circulating amino acid changes following okara and…
View details →DOI: 10.1038/s41430-026-01769-4 Negative / Null Result ReportMedicine
Hamadani, Banu, Wieczorek et al. · 2026 · Scientific reports
A soft-anchored titanium (Ti-6Al-4V) mesh implantable device was designed and morphologically characterised in an in vitro study. The mesh implant consists of a titanium mesh aimed at preserving continence and improving the quality of life…
View details →DOI: 10.1038/s41598-026-46836-9 Negative / Null Result ReportMedicine
Lasmanovich, Chepeliuk, Fihman et al. · 2026 · World journal of surgical oncology
Segmental ureterectomy (SU) is an established kidney-sparing strategy for upper tract urothelial carcinoma (UTUC), yet few studies have compared the standard open approach to the emerging robotic modality. We performed a clinical outcome…
View details →DOI: 10.1186/s12957-026-04422-3 Negative / Null Result ReportMedicine
Berthelot, Audureau, Bouleti et al. · 2026 · Archives of cardiovascular diseases
The MonCœur smartphone application (app) was developed to meet the specific needs of individuals living with heart failure (HF). To evaluate whether the MonCœur smartphone app improves self-care at 6months in patients with HF,…
View details →DOI: 10.1016/j.acvd.2026.04.007 Negative / Null Result ReportMedicine
Wilcox, Campbell, Gill et al. · 2026 · The bone & joint journal
Computer navigation is capable of improving the accuracy of glenoid baseplate and screw positioning in shoulder arthroplasty, but there is very limited evidence of its effect on clinical outcomes. In Australia, there is one commonly used…
View details →DOI: 10.1302/0301-620x.108b6.bjj-2025-1772.r1 Negative / Null Result ReportMedicine
Sood, Turnbull, De Silva et al. · 2026 · Heart, lung & circulation
Improved patient outcomes after ventricular arrhythmia (VA) ablation procedure have been found to correlate with procedures being performed in high volume centres. Whether the concentration of expertise in experienced, urban centres…
View details →DOI: 10.1016/j.hlc.2025.12.026 Negative / Null Result ReportMedicine
Esmer, Hafızoğlu, Bardakçı et al. · 2026 · Journal of ovarian research
Advanced epithelial ovarian cancer (EOC) is commonly diagnosed at late stages, and despite improvements with neoadjuvant chemotherapy (NACT) followed by interval debulking surgery (IDS), prognosis remains poor. Body composition has emerged…
View details →DOI: 10.1186/s13048-025-01960-4 Negative / Null Result ReportMedicine
Li, Zhan, Zhang et al. · 2026 · Molecules (Basel, Switzerland)
The present study investigates the effect of 1,8-cineole on improving lipid metabolism disorder by regulating oxidative stress and inflammation via the TLR4/MyD88/NF-κB pathway. 1,8-Cineole is a monoterpene compound widely found in…
View details →DOI: 10.3390/molecules31111933 Negative / Null Result ReportMedicine
Rovira-Lastra, ElOtmani-Sabiri, Ustrell-Barral et al. · 2026 · Diagnostics (Basel, Switzerland)
Background/Objectives : This clinical study assessed the validity of articulating paper for detecting occlusal contacts points, including examining the effects of clinical technique, paper thickness, and the arch. Methods : This…
View details →DOI: 10.3390/diagnostics16101450 Negative / Null Result ReportMedicine
Chen, Ma, Zhang · 2026 · Accident; analysis and prevention
Automated vehicles (AVs) are designed to improve traffic safety, mobility, and driver comfort; however, their benefits depend on the widespread adoption of AVs. As full market penetration remains unlikely in the near term, AVs will…
View details →DOI: 10.1016/j.aap.2026.108516 Negative / Null Result ReportMedicine
Pujol, Minguell, Pijoan et al. · 2025 · Journal of orthopaedics
To determine if maintaining the preoperative CPAK class influences on clinical outcomes when performing a functional aligned robotic assisted TKA (RATKA). This prospective cohort study compared patients who maintained their preoperative…
View details →DOI: 10.1016/j.jor.2025.06.030 Methods Dead-EndMedicine
Vrinzen, Stadhouders, Bloemendal et al. · 2026 · BMJ open
Concentration of care and collaborations between hospitals increasingly reorganise oncological care into Comprehensive Cancer Networks (CCNs), aiming to improve care outcomes and reduce costs. This study aims to evaluate the effect of four…
View details →DOI: 10.1136/bmjopen-2025-100070 