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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

1934 results for "Mpro" · page 41 of 65

Methods Dead-EndOpen accessMedicine

Improving the field accuracy of a malaria diagnostic algorithm combining sequential interpretation of rapid diagnostic test detecting PfHRP2 and pLDH in febrile children in a seasonal hyperendemic malaria transmission area in Burkina Faso.

Some DY, Kiemde F, Kabore B et al. · 2026 · PloS one

Objective To evaluate the field accuracy of a malaria diagnostic algorithm combining sequential interpretation of two-step malaria RDT detecting PfHRP2 and pLDH with information on previous antimalarial treatments within the past four…

View details →DOI: 10.1371/journal.pone.0351990
Negative / Null Result ReportOpen accessMedicine

Pre-TIPS Liver and Spleen Volumetry Are Not Associated With Liver-Related Outcomes After TIPS Placement for Refractory Ascites.

Bedoya JU, Wagner M, Malézieux E et al. · 2026 · Liver international : official journal of the International Association for the Study of the Liver

Background & aims Transjugular intrahepatic portosystemic shunt (TIPS) improves survival in refractory ascites. A careful patient's selection is mandatory as TIPS can lead to complications. Liver volumetry is predictive of outcomes before…

View details →DOI: 10.1111/liv.70691
Negative / Null Result ReportMedicine

Early Endoscopic Retrograde Cholangiopancreatography is Associated With Improved Health Care Resource Utilization in Acute Biliary Pancreatitis Without Cholangitis.

Chu BK, Abdelbaki A, Nikahd M et al. · 2026 · Journal of clinical gastroenterology

Background The optimal timing for endoscopic retrograde cholangiopancreatography (ERCP) in managing uncomplicated acute biliary pancreatitis (ABP) remains unclear. This population-based study assessed the impact of ERCP timing on outcomes…

View details →DOI: 10.1097/mcg.0000000000002341
Negative / Null Result ReportMedicine

Replacing stationary time or light physical activity with moderate-to-vigorous physical activity is associated with improved metabolic health in adults with or at risk of knee osteoarthritis.

Halliwell C, Courish M, Moyer R et al. · 2026 · Clinical rheumatology

Background Individuals with knee osteoarthritis are at an increased risk of poor metabolic health. We tested if cross-sectionally replacing stationary time with light or moderate-to-vigorous physical activity would be associated with lower…

View details →DOI: 10.1007/s10067-026-08253-1
Negative / Null Result ReportMedicine

Identification of Gait Patterns Associated with Paretic Propulsion and Velocity in Community-Dwelling Individuals with Stroke: A Multicenter Retrospective Study.

Mano N, Mori K, Kuwabara T et al. · 2026 · Annals of biomedical engineering

Purpose Diverse gait patterns in individuals with stroke require personalized rehabilitation to improve paretic propulsion (Pp), which reflects gait function. However, the gait characteristics associated with Pp have not been fully…

View details →DOI: 10.1007/s10439-026-04203-9
Negative / Null Result ReportMedicine

Preoperative posterior pelvic tilt is associated with residual low back pain and inferior patient-reported outcomes after total hip arthroplasty.

Ito K, Fujii M, Oba Y et al. · 2026 · International orthopaedics

Purpose To determine changes in low back pain (LBP) after total hip arthroplasty (THA), identify preoperative factors associated with residual LBP and LBP improvement, and clarify the association between residual LBP and patient-reported…

View details →DOI: 10.1007/s00264-026-06885-1
Negative / Null Result ReportMedicine

Abdominal massage improves intestinal barrier function via the TLR4/MyD88/NF-κB signaling pathway in obesity-associated T2DM rats.

Han Y, Zhong C, Lu Z et al. · 2026 · Scientific reports

Abdominal massage (AM), a traditional Chinese medicine treatment, is gradually being recognized in clinical practice for its ability to improve the symptoms of obesity and type 2 diabetes mellitus (T2DM) in clinical practice. This study…

View details →DOI: 10.1038/s41598-026-57589-w
Negative / Null Result ReportMedicine

Cut-off values of serum homocysteine and high-sensitivity CRP for predicting early neurological improvement after intravenous thrombolysis.

Oh MS, Park KY, Jeong HB et al. · 2026 · BMC neurology

Background We aimed to determine cut-off values of factors affecting early neurological improvement in patients after recombinant tissue plasminogen activator therapy for acute ischemic stroke. Methods A total of 135 patients with acute…

View details →DOI: 10.1186/s12883-026-05064-4
Failed Experiment ReportMedicine

Improved Iron Status, but Not Protein Source, Is Related to Appetite, Satiety, and Mood in Women of Reproductive Age With Iron Deficiency: A Randomized Controlled Trial.

Hennigar SR, Miller KM, Murphy RD et al. · 2026 · The Journal of nutrition

Background Iron deficiency (ID) is associated with decreased appetite and altered mood, which can contribute to feelings of early satiety and reduced overall well-being. Few studies have examined differences in appetite, satiety, and mood…

View details →DOI: 10.1016/j.tjnut.2026.101559
Negative / Null Result ReportOpen accessMedicine

Impact of tumor budding on recurrence risk prediction in stage I-III colorectal cancer: a Swedish cohort study.

Barot S, Andersson-Franko M, Ghazi S et al. · 2026 · American journal of clinical pathology

Objectives Tumor budding is an emerging micromorphologic predictor of recurrence in localized colorectal cancer (CRC). Whether its addition to established CRC recurrence risk factors routinely assessed in clinical practice improves…

View details →DOI: 10.1093/ajcp/aqag057
Negative / Null Result ReportMedicine

Integrating ankle weights into Nordic walking to improve muscle strength and functional outcomes in community-dwelling older adults: A randomized controlled trial.

Soenarti S, Sitorus S, Nugroho MB et al. · 2026 · Rehabilitacion

Sarcopenia represents a leading cause of functional decline in older adults. This randomized controlled trial examined whether the addition of ankle weights to a Nordic walking protocol yields superior outcomes compared with standard…

View details →DOI: 10.1016/j.rh.2026.100998
Negative / Null Result ReportOpen accessMedicine

Cerebral glycerol during haemorrhagic shock in normal and raised intracranial pressure resuscitated with total REBOA: an experimental porcine study.

Bader S, Magnuson A, Brorsson C et al. · 2026 · European journal of trauma and emergency surgery : official publication of the European Trauma Society

Background Haemorrhagic shock (HS) is frequently associated with secondary cerebral injury due to compromised cerebral perfusion. Resuscitative endovascular balloon occlusion of the aorta (REBOA) is an effective haemorrhage control…

View details →DOI: 10.1007/s00068-026-03236-y
Failed Experiment ReportMedicine

Automated tools for evidence quality assessment: a scoping review.

Huang J, Deng X, Zhou L et al. · 2026 · BMC medical research methodology

Background Evidence quality assessment is critical for informed public health decision-making, but manual approaches are time-consuming and subject to variability. Automated support tools have been proposed to improve efficiency and…

View details →DOI: 10.1186/s12874-026-02868-3
Failed Experiment ReportMedicine

NICU Nurses' Attitudes Toward Adopting an Evidence-Based Practice Intervention to Improve Bone Mineralization in Preterm Infants.

Melendez Vassall I, Mannino JE, Watters P et al. · 2026 · Advances in neonatal care : official journal of the National Association of Neonatal Nurses

Metabolic bone disease (MBD) is a disorder affecting bone mineralization that leads to short and long-term consequences. A daily exercise regimen consisting of passive range of motion (ROM) and gentle compression of upper and lower…

View details →DOI: 10.1097/anc.0000000000001397
Negative / Null Result ReportMedicine

Herbal Products and Dietary Supplements in Radiation Oncology: Evidence, Safety, and Practical Patient Counseling.

Hou YN, Gubili J, Mao JJ · 2026 · Seminars in radiation oncology

Studies show that patients with cancer use herbal products more often than the general population. Lowering the risk of disease recurrence, symptom control, and improving quality of life are often the reasons cited for such use. However, a…

View details →DOI: 10.1016/j.semradonc.2026.151035
Negative / Null Result ReportMedicine

Blue versus white light for transurethral resection of non-muscle invasive bladder cancer.

Maisch P, Hamidi Madani M, Koziarz A et al. · 2026 · The Cochrane database of systematic reviews

Rationale Disease recurrence and progression remain major challenges in the treatment of non-muscle invasive bladder cancer (NMIBC). Blue light-enhanced transurethral resection of bladder cancer (TURBT) is an approach to improve staging…

View details →DOI: 10.1002/14651858.cd013776.pub3
Negative / Null Result ReportOpen accessMedicine

Benefits of Incretin Therapy on Ovarian Function: A Scientific Literature Review.

La Vignera S, Condorelli RA · 2026 · International journal of molecular sciences

Incretin-based therapies, particularly glucagon-like peptide-1 receptor agonists (GLP-1 RAs), have emerged as potentially promising therapeutic agents for improving ovarian function, especially in women with polycystic ovary syndrome…

View details →DOI: 10.3390/ijms27114752
Negative / Null Result ReportMedicine

Crude protein oscillation in diets adequate and deficient in metabolizable protein: Effects on nutrient digestibility, nitrogen balance, plasma amino acids, and greenhouse gas emissions.

Erickson MG, Reinhardt LA, Svaren L et al. · 2024 · Journal of dairy science

Reducing dietary CP is a well-established means to improve N use efficiency. Yet, few studies have considered if transient restrictions in dietary CP could reduce the environmental footprint of late-lactation cows. We hypothesized that the…

View details →DOI: 10.3168/jds.2023-24150
Negative / Null Result ReportMedicine

Limits of verbal labels in cognition: Category labels do not improve visual working memory performance for obfuscated objects.

Chung YH, Williams LH, Brady TF et al. · 2025 · Journal of experimental psychology. General

Across many studies, verbal labels have been shown to significantly affect perceptual and cognitive processes. Here, we ask whether verbal labels can also improve visual working memory performance by making objects more recognizable. In a…

View details →DOI: 10.1037/xge0001801
Negative / Null Result Report

Short Naps Improve Subsequent Learning in a High School Setting

Vidal V, Pretel MR, Capurro L et al. · 2024 · Preprint

Abstract The application of neuroscience findings in educational settings offers promising opportunities to enhance academic performance. Adolescents, particularly affected by delayed sleep patterns due to early school start times, often…

View details →DOI: 10.21203/rs.3.rs-5485881/v1
Negative / Null Result ReportOpen accessMedicine

Patients undergoing thyroid surgery suffer preoperatively from poor quality of life.

Honkanen J, Molnár K, Karhumaa T et al. · 2025 · Journal of endocrinological investigation

Purpose Thyroid surgery is performed for various indications, including goiter, suspected or diagnosed malignancy, and hyperthyroidism. While previous studies have focused on postoperative quality of life (QoL) improvements, limited data…

View details →DOI: 10.1007/s40618-025-02661-x
Negative / Null Result ReportMedicine

Aerobic Cycling Exercise Training Does Not Improve Impaired Vagal Reactivation in Patients with Chronic Kidney Disease.

Sabino-Carvalho JL, Li S, Mekonnen E et al. · 2025 · Medicine and science in sports and exercise

Purpose Parasympathetic reactivation is essential for the rapid decrease in heart rate following exercise and delayed heart rate recovery (HRR) post-exercise is linked to poor clinical outcomes. Chronic kidney disease (CKD) is associated…

View details →DOI: 10.1249/mss.0000000000003824
Negative / Null Result ReportMedicine

Objective Changes in Pelvic Floor Muscle Strength and Length in Women With High-Tone Pelvic Floor Dysfunction After Pelvic Floor Physical Therapy (RELAX Trial).

Volpe LJ, Zugelder M, Kotarinos R et al. · 2023 · Urogynecology (Philadelphia, Pa.)

Importance Although pelvic floor physical therapy (PFPT) is effective in treating high-tone pelvic floor dysfunction (HTPFD), data on the mechanism of improvement are limited. Objectives This study aimed to compare squeeze intravaginal…

View details →DOI: 10.1097/spv.0000000000001355