466 results in Negative / Null Result Report for "randomized controlled trial" · page 4 of 16
Negative / Null Result Report
Yoshihiko Saito, Sadanori Okada, Hisao Ogawa et al. · 2016 · Circulation
Introduction: It takes long time to conclude efficacy and safety of an intervention on primary prevention of cardiovascular events. Up to date, there is no study to investigate the effect of the low-dose aspirin therapy on primary…
View details →DOI: 10.1161/circ.134.suppl_1.13428 Negative / Null Result Report
Daniel I. Rhon, Tina A. Greenlee, Rachel Mayhew et al. · 2022 · Journal of the American Academy of Orthopaedic Surgeons
Introduction: After elective orthopaedic surgery, many individuals go on to become long-term opioid users. Mitigating this risk has become a priority for surgeons, other members of the medical care team, and healthcare systems. The purpose…
View details →DOI: 10.5435/jaaos-d-21-00603 Negative / Null Result ReportOpen accessComputer applications to medicine. Medical informatics
Philip J Batterham, Alison L Calear, Matthew Sunderland et al. · 2021 · Journal of Medical Internet Research
BackgroundPsychosocial, self-guided, internet-based programs are effective in treating depression and anxiety. However, the community uptake of these programs is poor. Recent approaches to increasing engagement (defined as both uptake and adherence) in internet-based programs include brief engagement facilitation interventions (EFIs). However, these programs require evaluation to assess their efficacy. ObjectiveThe aims of this hybrid implementation effectiveness trial are to examine the effects of a brief internet-based EFI presented before an internet-based cognitive behavioral therapy self-
View details →DOI: 10.2196/23029 Negative / Null Result ReportOpen accessMedicine
Anita Raj, Mohan Ghule, Julie Ritter et al. · 2016 · PLoS ONE
Background Despite ongoing recommendations to increase male engagement and gender-equity (GE) counseling in family planning (FP) services, few such programs have been implemented and rigorously evaluated. This study evaluates the impact of CHARM, a three-session GE+FP counseling intervention delivered by male health care providers to married men, alone (sessions 1&2) and with their wives (session 3) in India. Methods and findings A two-armed cluster randomized controlled trial was conducted with young married couples (N = 1081 couples) recruited from 50 geographic clusters (25 clusters randomi
View details →DOI: 10.1371/journal.pone.0153190 Negative / Null Result ReportOpen accessGeriatrics
Veronika Keppner, Sebastian Krumpoch, Robert Kob et al. · 2023 · BMC Geriatrics
Abstract Background The risk of older adults being injured or killed in a bicycle accident increases significantly due to the age-related decline of physical function. Therefore, targeted interventions for older adults to improve safe cycling competence (CC) are urgently needed. Methods The “Safer Cycling in Older Age” (SiFAr) randomized controlled trial investigated if a progressive multi-component training program related to cycling improves CC of older adults. Between June 2020 and May 2022, 127 community-dwelling persons living in the area Nürnberg-Fürth-Erlangen, Germany aged 65 years and
View details →DOI: 10.1186/s12877-023-03816-2 Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
Nicholas M. Vogt, Jack F. V. Hunt, Yue Ma et al. · 2021 · Annals of Clinical and Translational Neurology
Abstract Background The brain is the most cholesterol‐rich organ and myelin contains 70% of total brain cholesterol. Statins are potent cholesterol‐lowing medications used by millions of adults for prevention of vascular disease, yet the effect of statins on cholesterol‐rich brain white matter (WM) is largely unknown. Methods We used longitudinal neuroimaging data acquired from 73 healthy, cognitively unimpaired, statin‐naïve, middle‐aged adults during an 18‐month randomized controlled trial of simvastatin 40 mg daily (n = 35) or matching placebo (n = 38). ANCOVA models (covariates: age, sex,
View details →DOI: 10.1002/acn3.51421 Negative / Null Result ReportOpen accessMedicine (General)
Nahla Tharwat Moussa Ahmed, Hany Ezzat Obaya, Azza Abd Elaziz Abd Elhadi et al. · 2025 · Вестник восстановительной медицины
INTRODUCTION. The double chin is an excessive accumulation of fat in the pre- and post-platysma that can manifest in various forms and sizes. Thin individuals might manifest a double chin, similar to those who are afflicted by obesity. It may result in a reduction in the definition of the mandible and give the perception of obesity or aging. AIM. To evaluate any effect of High-Intensity Focused Ultrasound (HIFU) on sleep quality measures in obese women with a double chin. MATERIALS AND METHODS. Typically, 60 women aged 35–50 years were selected from AL Qasr-Alaini Hospital and were equally div
View details →DOI: 10.38025/2078-1962-2025-24-1-47-54 Negative / Null Result ReportOpen accessMedicine
Patel DM, Wilson RF, Gharibani T et al. · 2026 · Journal of patient-reported outcomes
BACKGROUND: Patient-reported outcomes (PROs) are key outcomes of importance for people with chronic kidney disease (CKD), and may be of even higher relevance for patients with concomitant anemia which can often be symptomatic. Thus, PROs…
View details →DOI: 10.1186/s41687-026-01007-2 Negative / Null Result ReportMedicine
Moranne O, Gerbal M, Chkair S et al. · 2026 · Blood purification
Introduction This single center randomized controlled trial (NCT03562754) compared pre-diluted IHDF (PIHDF) without systemic anticoagulation and the Prometheus system with regional citrate anticoagulation (IHD-RCA) in high-bleeding-risk…
View details →DOI: 10.1159/000552412 Negative / Null Result ReportMedicine
Kacaroglu Vicdan A, Gibyeli Genek D · 2026 · BMC complementary medicine and therapies
Background Hemodialysis often leads to various physiological, psychological, and social challenges for individuals receiving this treatment. This study was conducted to determine the effects of stress ball use on stress, sleep quality, and…
View details →DOI: 10.1186/s12906-026-05429-9 Negative / Null Result ReportOpen accessMedicine
Alsaid HM, Khadour YA, Zakaria HM et al. · 2026 · Journal of musculoskeletal & neuronal interactions
Objectives This study evaluated the effect of sensory re-education on quality of life and sensation in patients with post-COVID-19 polyneuropathy. Methods Forty patients with post-COVID-19 polyneuropathy were randomly assigned to a study…
Negative / Null Result ReportMedicine
Haidar M, Raslan N · 2026 · Scientific reports
The use of local anesthesia is essential for pain control during the treatment of MIH-affected molars. This study aimed to compare injection-related pain and anesthetic efficacy between 2% lidocaine with epinephrine (LE) and 4% articaine…
View details →DOI: 10.1038/s41598-026-54698-4 Negative / Null Result ReportOpen accessMedicine
Gao J, Hu CC, Wang XY et al. · 2026 · Frontiers in medicine
Background Perinatal sleep disturbance is highly prevalent among women undergoing elective cesarean section. Dexmedetomidine has been proven effective in improving sleep quality in patients undergoing general surgery, and this study aimed…
View details →DOI: 10.3389/fmed.2026.1823100 Negative / Null Result ReportOpen accessMedicine
Gonultas D, Kulcu DG, Kaymaz EP et al. · 2026 · Turkish journal of physical medicine and rehabilitation
Objectives This study aims to investigate the effectiveness of mesotherapy in patients with acute or subacute neck pain compared to oral medications with the same active ingredients. Patients and methods In this randomized, single-blind…
View details →DOI: 10.5606/tftrd.2025.16956 Negative / Null Result ReportOpen accessMedicine
Abjar R, NasiriFormi E, Kazemi AH et al. · 2026 · Health science reports
Background and aims High-quality sleep, calmness, and lack of fatigue are vital for the health of critical hospital staff. Operating room personnel experience significant mental and physical stress, including anxiety and sleep…
View details →DOI: 10.1002/hsr2.72680 Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
Suwang Zheng, Tianli Fu, Jinlong Yan et al. · 2024 · Journal of NeuroEngineering and Rehabilitation
Abstract Background Temporal interference (TI) stimulation, an innovative non-invasive brain stimulation technique, has the potential to activate neurons in deep brain regions. The objective of this study was to evaluate the effects of repetitive TI stimulation targeting the lower limb motor control area (i.e., the M1 leg area) on lower limb motor function in healthy individuals, which could provide evidence for further translational application of non-invasive deep brain stimulation. Methods In this randomized, double-blinded, parallel-controlled trial, 46 healthy male adults were randomly di
View details →DOI: 10.1186/s12984-024-01336-7 Negative / Null Result ReportOpen accessMedicine
Ruengsiriphakakul S, Bumrerraj S, Thaenkham T · 2026 · Journal of education and health promotion
Background Iodine deficiency remains a global public health problem. Urinary iodine concentration (UIC) in pregnant women is a key indicator of iodine status in the population. Knowledge (K), attitude (A), and practice (P) levels of…
View details →DOI: 10.4103/jehp.jehp_815_25 Negative / Null Result Report
Claire M. Douglas, Marnie Newell, Susan Goruk et al. · 2025 · PLOS One
Supplementation of omega-3 (n-3) polyunsaturated fatty acids has been associated with reduced side effects and improved quality of life (QoL) in breast cancer patients receiving chemotherapy. The current study reports secondary outcomes…
View details →DOI: 10.1371/journal.pone.0322178 Negative / Null Result ReportMedicine
Çi̇men HN, Uğur S, Çıralı A et al. · 2026 · Nurse education in practice
Aim The aim of this study was to evaluate the effect of podcast-based educational content delivered to students on their knowledge, awareness and anxiety levels regarding Human Papillomavirus (HPV). Method This randomized controlled…
View details →DOI: 10.1016/j.nepr.2026.104902 Negative / Null Result ReportOpen accessDiseases of the genitourinary system. Urology
Akash Bihari Pati, Pritinanada Mishra, Santosh K Mahalik et al. · 2023 · Indian Journal of Urology
Introduction: Proximal hypospadias repair has many postoperative complications such as urethrocutaneous fistulae, wound dehiscence, and urethral stricture. The beneficial effect of estrogen to promote wound healing has been known. We designed a study to determine whether preoperative stimulation of tissue with estrogen can reduce the postoperative complications associated with wound healing in patients undergoing hypospadias repair. Methods: Patients with proximal hypospadias requiring two-stage repairs (chordee correction followed by urethral tubularization) were randomized to estrogen and co
View details →DOI: 10.4103/iju.iju_387_22 Negative / Null Result ReportOpen accessMedicine
Abdelkader AM, Osama H, Hassan ES et al. · 2026 · European journal of clinical pharmacology
Purpose Gliflozins (SGLT2 inhibitors) and statins are key treatments commonly used in patients with ischemic heart failure. Although both are well known for diminishing cardiovascular risk and heart failure-related mortality, the possible…
View details →DOI: 10.1007/s00228-026-04050-6 Negative / Null Result ReportMedicine
de Azevedo Ferreira, Fitz, Gimenez et al. · 2026 · International urogynecology journal
Seventy percent of women with pelvic floor muscle (PFM) dysfunction are unable to contract these muscles correctly. Instruction to contract properly is essential for effective PFM training (PFMT). The study aimed to compare two…
View details →DOI: 10.1007/s00192-026-06775-5 Negative / Null Result ReportMedicine
Peng, Wang, Gong et al. · 2026 · International ophthalmology
To compare the outcomes of conjunctival graft (CAG) versus limbal-conjunctival autograft (LCAG) in preventing recurrence after surgery for recurrent pterygium with intraoperative application of 0.02% mitomycin C(MMC). This prospective…
View details →DOI: 10.1007/s10792-026-04121-8 Negative / Null Result ReportOpen accessSports medicine
Alison Bulow, Judith E Anderson, Jeff R S Leiter et al. · 2021 · International Journal of Sports Physical Therapy
# Background Adolescent females are at much greater risk for ACL injury than their male counterparts when participating in the same sports. Preventative and pre-operative rehabilitation neuromuscular (NM) exercise programs are often recommended to improve knee function and reduce injury rates. The effectiveness of perturbation-based NM training program has been established in an adult population but has yet to be investigated in the at-risk adolescent female population. # Purpose To determine the effectiveness of a perturbation-based NM exercise program in a group of physically active adolesce
View details →DOI: 10.26603/001c.25685 Negative / Null Result ReportMedicine
Serttas, Uysal, Deği̇rmenci̇ et al. · 2026 · Injury
Urinary tract infection(UTI) is a common complication following hip fracture surgery in elderly patients. Urinary catheterization is frequently used to improve patient comfort during prolonged preoperative immobilization; however, its…
View details →DOI: 10.1016/j.injury.2026.113449 Negative / Null Result ReportMedicine
Erdoğan, Ayaz-Alkaya · 2026 · Nurse education in practice
To evaluate the effect of crossword puzzle activities on nursing students' willingness to work with older adults and their competence in gerontological nursing. Although crossword puzzles are widely used learning tools, their effects in…
View details →DOI: 10.1016/j.nepr.2026.104844 Negative / Null Result ReportMedicine
Wang, Li, Zhang et al. · 2026 · Child development
This study examines how center-based parenting interventions aimed at improving early child development in rural China affect the mental health of caregivers. Data from an analytic sample of 615 caregiver-child dyads (children aged 6 to 24…
View details →DOI: 10.1093/chidev/aacag099 Negative / Null Result ReportMedicine
Chen X, Wen W, Zheng L · 2026 · Shock (Augusta, Ga.)
Background Sepsis is a clinical syndrome marked by a dysregulated host response to infection, impairing oxygen delivery and utilization and causing organ dysfunction. Hypoxemia, which can cause significant tissue and organ damage, commonly…
View details →DOI: 10.1097/shk.0000000000002865 Negative / Null Result ReportMedicine
van Keulen, Voogt, Kleinjan et al. · 2026 · JMIR mHealth and uHealth
Excessive alcohol consumption among adolescents and young adults is a serious health problem. Dynamically tailored interventions could reduce their excessive drinking. We therefore developed "What Do You Drink" (WDYD), a 17-week…
View details →DOI: 10.2196/68468 Negative / Null Result ReportMedicine
Le, Chotikkakamthorn, Kasetsuwan et al. · 2026 · Clinical ophthalmology (Auckland, N.Z.)
This study aims to compare the effect of meibomian gland expression (MGX) combined with lid hygiene versus lid hygiene alone on the meibomian gland's morphology and function for obstructive meibomian gland dysfunction (oMGD). In this…
View details →DOI: 10.2147/opth.s607078 