Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
Nicholas M. Vogt, Jack F. V. Hunt, Yue Ma et al. · 2021 · Annals of Clinical and Translational Neurology
Abstract Background The brain is the most cholesterol‐rich organ and myelin contains 70% of total brain cholesterol. Statins are potent cholesterol‐lowing medications used by millions of adults for prevention of vascular disease, yet the effect of statins on cholesterol‐rich brain white matter (WM) is largely unknown. Methods We used longitudinal neuroimaging data acquired from 73 healthy, cognitively unimpaired, statin‐naïve, middle‐aged adults during an 18‐month randomized controlled trial of simvastatin 40 mg daily (n = 35) or matching placebo (n = 38). ANCOVA models (covariates: age, sex,
View details →DOI: 10.1002/acn3.51421 Negative / Null Result Report
Daniel I. Rhon, Tina A. Greenlee, Rachel Mayhew et al. · 2022 · Journal of the American Academy of Orthopaedic Surgeons
Introduction: After elective orthopaedic surgery, many individuals go on to become long-term opioid users. Mitigating this risk has become a priority for surgeons, other members of the medical care team, and healthcare systems. The purpose…
View details →DOI: 10.5435/jaaos-d-21-00603 Negative / Null Result ReportOpen accessMedicine
Patel DM, Wilson RF, Gharibani T et al. · 2026 · Journal of patient-reported outcomes
BACKGROUND: Patient-reported outcomes (PROs) are key outcomes of importance for people with chronic kidney disease (CKD), and may be of even higher relevance for patients with concomitant anemia which can often be symptomatic. Thus, PROs…
View details →DOI: 10.1186/s41687-026-01007-2 Negative / Null Result ReportMedicine
Moranne O, Gerbal M, Chkair S et al. · 2026 · Blood purification
Introduction This single center randomized controlled trial (NCT03562754) compared pre-diluted IHDF (PIHDF) without systemic anticoagulation and the Prometheus system with regional citrate anticoagulation (IHD-RCA) in high-bleeding-risk…
View details →DOI: 10.1159/000552412 Negative / Null Result ReportMedicine
Kacaroglu Vicdan A, Gibyeli Genek D · 2026 · BMC complementary medicine and therapies
Background Hemodialysis often leads to various physiological, psychological, and social challenges for individuals receiving this treatment. This study was conducted to determine the effects of stress ball use on stress, sleep quality, and…
View details →DOI: 10.1186/s12906-026-05429-9 Negative / Null Result ReportMedicine
Haidar M, Raslan N · 2026 · Scientific reports
The use of local anesthesia is essential for pain control during the treatment of MIH-affected molars. This study aimed to compare injection-related pain and anesthetic efficacy between 2% lidocaine with epinephrine (LE) and 4% articaine…
View details →DOI: 10.1038/s41598-026-54698-4 Negative / Null Result ReportOpen accessMedicine
Gao J, Hu CC, Wang XY et al. · 2026 · Frontiers in medicine
Background Perinatal sleep disturbance is highly prevalent among women undergoing elective cesarean section. Dexmedetomidine has been proven effective in improving sleep quality in patients undergoing general surgery, and this study aimed…
View details →DOI: 10.3389/fmed.2026.1823100 Negative / Null Result ReportOpen accessMedicine
Gonultas D, Kulcu DG, Kaymaz EP et al. · 2026 · Turkish journal of physical medicine and rehabilitation
Objectives This study aims to investigate the effectiveness of mesotherapy in patients with acute or subacute neck pain compared to oral medications with the same active ingredients. Patients and methods In this randomized, single-blind…
View details →DOI: 10.5606/tftrd.2025.16956 Negative / Null Result ReportOpen accessMedicine
Abjar R, NasiriFormi E, Kazemi AH et al. · 2026 · Health science reports
Background and aims High-quality sleep, calmness, and lack of fatigue are vital for the health of critical hospital staff. Operating room personnel experience significant mental and physical stress, including anxiety and sleep…
View details →DOI: 10.1002/hsr2.72680 Negative / Null Result ReportOpen accessMedicine
Ruengsiriphakakul S, Bumrerraj S, Thaenkham T · 2026 · Journal of education and health promotion
Background Iodine deficiency remains a global public health problem. Urinary iodine concentration (UIC) in pregnant women is a key indicator of iodine status in the population. Knowledge (K), attitude (A), and practice (P) levels of…
View details →DOI: 10.4103/jehp.jehp_815_25 Negative / Null Result ReportMedicine
Çi̇men HN, Uğur S, Çıralı A et al. · 2026 · Nurse education in practice
Aim The aim of this study was to evaluate the effect of podcast-based educational content delivered to students on their knowledge, awareness and anxiety levels regarding Human Papillomavirus (HPV). Method This randomized controlled…
View details →DOI: 10.1016/j.nepr.2026.104902 Negative / Null Result ReportOpen accessMedicine
Abdelkader AM, Osama H, Hassan ES et al. · 2026 · European journal of clinical pharmacology
Purpose Gliflozins (SGLT2 inhibitors) and statins are key treatments commonly used in patients with ischemic heart failure. Although both are well known for diminishing cardiovascular risk and heart failure-related mortality, the possible…
View details →DOI: 10.1007/s00228-026-04050-6 Negative / Null Result ReportMedicine
de Azevedo Ferreira, Fitz, Gimenez et al. · 2026 · International urogynecology journal
Seventy percent of women with pelvic floor muscle (PFM) dysfunction are unable to contract these muscles correctly. Instruction to contract properly is essential for effective PFM training (PFMT). The study aimed to compare two…
View details →DOI: 10.1007/s00192-026-06775-5 Negative / Null Result ReportMedicine
Peng, Wang, Gong et al. · 2026 · International ophthalmology
To compare the outcomes of conjunctival graft (CAG) versus limbal-conjunctival autograft (LCAG) in preventing recurrence after surgery for recurrent pterygium with intraoperative application of 0.02% mitomycin C(MMC). This prospective…
View details →DOI: 10.1007/s10792-026-04121-8 Negative / Null Result ReportMedicine
Serttas, Uysal, Deği̇rmenci̇ et al. · 2026 · Injury
Urinary tract infection(UTI) is a common complication following hip fracture surgery in elderly patients. Urinary catheterization is frequently used to improve patient comfort during prolonged preoperative immobilization; however, its…
View details →DOI: 10.1016/j.injury.2026.113449 Negative / Null Result ReportOpen accessMedicine
Alsaid HM, Khadour YA, Zakaria HM et al. · 2026 · Journal of musculoskeletal & neuronal interactions
Objectives This study evaluated the effect of sensory re-education on quality of life and sensation in patients with post-COVID-19 polyneuropathy. Methods Forty patients with post-COVID-19 polyneuropathy were randomly assigned to a study…
Negative / Null Result ReportMedicine
Erdoğan, Ayaz-Alkaya · 2026 · Nurse education in practice
To evaluate the effect of crossword puzzle activities on nursing students' willingness to work with older adults and their competence in gerontological nursing. Although crossword puzzles are widely used learning tools, their effects in…
View details →DOI: 10.1016/j.nepr.2026.104844 Negative / Null Result Report
Claire M. Douglas, Marnie Newell, Susan Goruk et al. · 2025 · PLOS One
Supplementation of omega-3 (n-3) polyunsaturated fatty acids has been associated with reduced side effects and improved quality of life (QoL) in breast cancer patients receiving chemotherapy. The current study reports secondary outcomes…
View details →DOI: 10.1371/journal.pone.0322178 Negative / Null Result ReportMedicine
Wang, Li, Zhang et al. · 2026 · Child development
This study examines how center-based parenting interventions aimed at improving early child development in rural China affect the mental health of caregivers. Data from an analytic sample of 615 caregiver-child dyads (children aged 6 to 24…
View details →DOI: 10.1093/chidev/aacag099 Negative / Null Result ReportOpen accessMedicine (General)
Nahla Tharwat Moussa Ahmed, Hany Ezzat Obaya, Azza Abd Elaziz Abd Elhadi et al. · 2025 · Вестник восстановительной медицины
INTRODUCTION. The double chin is an excessive accumulation of fat in the pre- and post-platysma that can manifest in various forms and sizes. Thin individuals might manifest a double chin, similar to those who are afflicted by obesity. It may result in a reduction in the definition of the mandible and give the perception of obesity or aging. AIM. To evaluate any effect of High-Intensity Focused Ultrasound (HIFU) on sleep quality measures in obese women with a double chin. MATERIALS AND METHODS. Typically, 60 women aged 35–50 years were selected from AL Qasr-Alaini Hospital and were equally div
View details →DOI: 10.38025/2078-1962-2025-24-1-47-54 Negative / Null Result ReportMedicine
van Keulen, Voogt, Kleinjan et al. · 2026 · JMIR mHealth and uHealth
Excessive alcohol consumption among adolescents and young adults is a serious health problem. Dynamically tailored interventions could reduce their excessive drinking. We therefore developed "What Do You Drink" (WDYD), a 17-week…
View details →DOI: 10.2196/68468 Negative / Null Result ReportMedicine
Le, Chotikkakamthorn, Kasetsuwan et al. · 2026 · Clinical ophthalmology (Auckland, N.Z.)
This study aims to compare the effect of meibomian gland expression (MGX) combined with lid hygiene versus lid hygiene alone on the meibomian gland's morphology and function for obstructive meibomian gland dysfunction (oMGD). In this…
View details →DOI: 10.2147/opth.s607078 Negative / Null Result ReportMedicine
Rathee, Bhardwaj, Gupta et al. · 2026 · International journal of clinical pediatric dentistry
Anxiety and pain often lead to a challenging situation in a dental clinic. This study aimed to compare the efficacy of virtual reality (VR) glasses to conventional techniques for anxiety control in children. Jio Dive VR glasses (passive)…
View details →DOI: 10.5005/jp-journals-10005-3493 Negative / Null Result ReportOpen accessMedicine
Anita Raj, Mohan Ghule, Julie Ritter et al. · 2016 · PLoS ONE
Background Despite ongoing recommendations to increase male engagement and gender-equity (GE) counseling in family planning (FP) services, few such programs have been implemented and rigorously evaluated. This study evaluates the impact of CHARM, a three-session GE+FP counseling intervention delivered by male health care providers to married men, alone (sessions 1&2) and with their wives (session 3) in India. Methods and findings A two-armed cluster randomized controlled trial was conducted with young married couples (N = 1081 couples) recruited from 50 geographic clusters (25 clusters randomi
View details →DOI: 10.1371/journal.pone.0153190 Negative / Null Result ReportMedicine
Jiang, Wang, Wei et al. · 2026 · Geriatric nursing (New York, N.Y.)
Peripheral Intravenous Cannulas (PIVCs) are extensively used for infusion therapy. Although current evidence suggests that adult patients may have PIVCs removed based on clinical indications, the indication in elderly patients remains…
View details →DOI: 10.1016/j.gerinurse.2026.104100 Negative / Null Result ReportMedicine
Mokhtar, Gawish, Abdelgawad et al. · 2026 · Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA
To compare the clinical and radiological outcomes of anterior cruciate ligament reconstruction (ACLR) augmented with platelet-rich plasma (PRP) (1) or bone marrow aspirate concentrate (BMAC) (2) against a control group undergoing standard…
View details →DOI: 10.1002/ksa.70484 Negative / Null Result ReportMedicine
Villalón López, Escaffi-Schwarz · 2026 · Journal of medical Internet research
Parental burnout is an underrecognized syndrome characterized by emotional exhaustion, detachment from children, and reduced parental efficacy. It is associated with sleep disturbance, addictive behaviors, suicidal ideation, and increased…
View details →DOI: 10.2196/87416 Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
O. A. Saygina, T. S. Sukhinina, M. A. Terenicheva et al. · 2026 · Рациональная фармакотерапия в кардиологии
Aim. To study the safety of using the intravenous beta-blocker (BB) esmolol in the early stages of ST-segment elevation myocardial infarction (STEMI) before primary percutaneous coronary intervention (PCI) based on an analysis of the incidence and clinical significance of adverse events (acute heart failure, hypotension, bradycardia, disorders of atrioventricular conduction (AV conduction), etc.) compared with the control group.Material and methods. The presented study is part of the randomized controlled trial ESMO-VASCMI (ClinicalTrials.gov NCT number 06376630) on the study of the cardioprot
View details →DOI: 10.20996/1819-6446-2025-3241 Negative / Null Result ReportMedicine
Ishiwatari, Nakahara, Kawaguchi et al. · 2026 · Gastrointestinal endoscopy
Endoscopic retrograde cholangiopancreatography with metal stent (MS) placement is the standard treatment for biliary drainage in patients with unresectable pancreatic cancer. A 10-mm diameter MS is generally used; however, a larger stent…
View details →DOI: 10.1016/j.gie.2026.06.037 Negative / Null Result ReportMedicine
Esposito, Bocari, Cho et al. · 2026 · The International journal of oral & maxillofacial implants
This multicenter randomized controlled trial compared the clinical effectiveness of 7.0-mm wide-diameter implants with 5.0-mm conventional-diameter implants placed immediately after molar extraction. Thirty-nine patients needing a single…
View details →DOI: 10.11607/jomi.11536 