Negative / Null Result ReportOpen accessMedicine
Andersson Y, Løvstakken E, Herud TM et al. · 2025 · Annals of surgical oncology
Background Hyperthermic intraperitoneal chemotherapy (HIPEC) following cytoreductive surgery is a potentially curative treatment for patients with peritoneal metastases. Currently, there is no standardized protocol for performing HIPEC and…
View details →DOI: 10.1245/s10434-025-18025-x Failed Experiment ReportOpen accessMedicine
de Zeeuw D · 2020 · Journal of nephrology
Patients with type 2 diabetes run a high risk for progressive renal function loss. Many interventions have been tested to reduce the risk, but we are nowadays still confronted with a high unmet need. To improve on this unmet need, we will…
View details →DOI: 10.1007/s40620-020-00820-2 Negative / Null Result ReportMedicine
Dijk SW, Wollny C, Barkhausen J et al. · 2025 · JAMA
Importance Given the widespread use of medical imaging, evaluating the effectiveness of interventions to improve appropriateness is crucial for optimizing health care resources and patient outcomes. Objective To assess the effects of…
View details →DOI: 10.1001/jama.2024.27853 Negative / Null Result ReportOpen accessMedicine
Yurttas C, Horvath P, Fischer I et al. · 2024 · Journal of clinical medicine
(1) Background: Laparoscopic staging is essential in gastric cancer (GC) to rule out peritoneal metastasis (PM). Hypericin, a plant-derived fluorescent compound, has been suggested to improve laparoscopic visualization of PM from GC. This…
View details →DOI: 10.3390/jcm13082422 Negative / Null Result ReportMedicine
Wulff KC, Miller FG, Pearson SD · 2011 · Health affairs (Project Hope)
To attain the anticipated benefits of increased investments in comparative effectiveness research, the results must translate into improved medical practice and policy. In this article we present an analysis of a case study of percutaneous…
View details →DOI: 10.1377/hlthaff.2011.0159 Failed Experiment ReportMedicine
Coxon AT, Johanns TM, Dunn GP · 2020 · Missouri medicine
Glioblastoma is a devastating disease with a dismal prognosis. While recent advancements in cancer immunotherapy have led to improvements in treating other types of cancer, patients with glioblastoma have not benefited from these new…
Negative / Null Result ReportOpen accessMedicine
Mitting RB, Ray S, Raffles M et al. · 2019 · PloS one
Background Methylprednisolone remains a commonly used ancillary therapy for paediatric acute respiratory distress syndrome (PARDS), despite a lack of level 1 evidence to justify its use. When planning prospective trials it is useful to…
View details →DOI: 10.1371/journal.pone.0225737 Negative / Null Result ReportMedicine
Galloway NL, Sargeant GA, Powers JG et al. · 2026 · Journal of wildlife diseases
Effective wildlife disease management and research rely on trustworthy disease diagnostics. For chronic wasting disease (CWD), immunohistochemistry (IHC) is recognized as the gold standard, and ELISA is a reliable high-throughput screening…
View details →DOI: 10.7589/jwd-d-25-00164 Negative / Null Result ReportOpen accessMedicine
Boardman-Pretty F, Kumar J, Grant C et al. · 2026 · Orphanet journal of rare diseases
BACKGROUND: Accurate and early diagnosis to optimise rare disease care is a global priority. With recent developments in artificial intelligence (AI)-based solutions, a promising area to improve rare disease diagnosis is the application of…
View details →DOI: 10.1186/s13023-026-04240-6 Negative / Null Result ReportOpen accessMedicine
Atobatele S, Mpimbaza A, Ngufor C et al. · 2025 · Malaria journal
Background Malaria rapid diagnostic tests (RDTs) have improved case management and surveillance across sub-Saharan Africa by reducing presumptive treatment and enhancing diagnostic specificity. However, healthcare workers' (HCWs) concerns…
View details →DOI: 10.1186/s12936-025-05674-2 Negative / Null Result Report
Atobatele S, Mpimbaza A, Ngufor C et al. · 2025 · Preprint
Abstract Background Malaria rapid diagnostic tests (RDTs) have improved case management and surveillance across sub-Saharan Africa by reducing presumptive treatment and enhancing diagnostic specificity. However, healthcare workers’ (HCWs)…
View details →DOI: 10.21203/rs.3.rs-7194605/v1 Negative / Null Result ReportOpen accessMedicine
Sheybani L · 2026 · The European journal of neuroscience
A recent study by Hausdorf et al. reported that combining closed-loop acoustic stimulation with transcranial direct current stimulation during sleep does not improve memory consolidation. This contrasts with past studies that reported a…
View details →DOI: 10.1111/ejn.70400 Negative / Null Result Report
Ngufor C, Lindblade KA, Atobatele S et al. · 2025 · Preprint
Abstract Background Rapid diagnostic tests (RDTs) have improved malaria case management by enabling point-of-care confirmation of infection, particularly in low-resource settings. In addition to clinical use, RDT results recorded in health…
View details →DOI: 10.21203/rs.3.rs-6760274/v1 Negative / Null Result ReportOpen access
Dätwyler I, Kuster H, Greiner MA et al. · 2025 · Preprint
Introduction Pneumocystis jirovecii (PJ) causes pneumonia primarily in immunocompromised individuals. Although direct immunofluorescence (IF) remains the diagnostic standard, PCR assays are increasingly used because of higher sensitivity…
View details →DOI: 10.1101/2025.11.18.25340486 Negative / Null Result ReportMedicine
Russo F, Chatterjee D, DeMaria N et al. · 2024 · Journal of community genetics
DNA-based population screening for adult-onset diseases holds promise for advancing personalized medicine and improving public health. Yet as most individuals pursuing such screening receive negative results, the return of results process…
View details →DOI: 10.1007/s12687-024-00736-5 Negative / Null Result ReportOpen accessMedicine
Triantafyllidou O, Panagodimou E, Chasiakou S et al. · 2026 · Cureus
Objective To evaluate whether the addition of clomiphene citrate (CC) to a low-dose recombinant follicle-stimulating hormone (FSH) (r-FSH) gonadotropin-releasing hormone (GnRH)-antagonist protocol improves clinical outcomes in women with…
View details →DOI: 10.7759/cureus.108079 Negative / Null Result ReportMedicine
Liu Q, Liu X, Chang L et al. · 2025 · Clinica chimica acta; international journal of clinical chemistry
Introduction Accurate and early HIV detection is crucial for improving outcomes and controlling transmission. This study compares HIV marker patterns and evaluates detection assay performance in general screening and ART-treated…
View details →DOI: 10.1016/j.cca.2025.120207 Failed Experiment Report
Kawamura T, Koyama S, Karaushi H et al. · 2026 · Preprint
Introduction: The Gram stain is a fundamental and widely used technique in clinical microbiology for its simplicity and diagnostic value, particularly in bacterial meningitis. However, its reliability can be compromised by contamination…
View details →DOI: 10.1099/acmi.0.001219.v1 Negative / Null Result ReportOpen accessMedicine
Wang H, Ardura MI, Oyeniran SJ et al. · 2026 · ASM case reports
Background Cytomegalovirus (CMV) continues to be a significant cause of morbidity and mortality in immunocompromised patients. Nucleic acid amplification tests (NAATs) are the preferred method for both diagnosing CMV infection and…
View details →DOI: 10.1128/asmcr.00159-25 Negative / Null Result ReportMedicine
Pantazis JC, Palmer AC · 2026 · Molecular cancer therapeutics
The phase III study of romidepsin plus CHOP for peripheral T-cell lymphoma (PTCL) yielded negative results in the overall analysis and showed that outcomes were only improved in the T follicular helper (TFH) subgroup of PTCL, with no…
View details →DOI: 10.1158/1535-7163.mct-25-0941 Negative / Null Result ReportOpen accessMedicine
Badelita SN, Sandu HM, Coriu D et al. · 2026 · Frontiers in oncology
Bone marrow hemodilution could compromise next generation flow cytometry based measurable residual disease evaluation in multiple myeloma and may cause false negative results. This review summarizes definitions, markers, indices,…
View details →DOI: 10.3389/fonc.2026.1849714 Replication FailureOpen accessMedicine
Hajkowicz K, Woodford J, Pillai ES et al. · 2025 · Emerging infectious diseases
Using metatranscriptomics, we identified Trubanaman virus in cerebrospinal fluid from a severely immunocompromised man who died of encephalitis in Queensland, Australia. Virus sequences were related to orthobunyaviruses previously detected…
View details →DOI: 10.3201/eid3112.251190 Negative / Null Result ReportOpen accessMedicine
Stewart SF, Enne VI, Pandolfo AM et al. · 2026 · Antimicrobial resistance and infection control
Background Rapid molecular diagnostics such as the BioFire FilmArray Pneumonia Panel (the Pneumonia Panel) can improve antibiotic stewardship by supporting doctors to make more targeted antibiotic prescribing decisions faster compared to…
View details →DOI: 10.1186/s13756-025-01690-8 Negative / Null Result ReportMedicine
Ceacero-Marín D, Puig-Pey Comas I, Nieto-Moragas J et al. · 2026 · Scandinavian journal of clinical and laboratory investigation
Background The direct antiglobulin test (DAT) is a key diagnostic tool in evaluating autoimmune haemolytic anaemia. However, indiscriminately ordering this test, together with certain methodological limitations, can compromise the…
View details →DOI: 10.1080/00365513.2025.2605640 Methods Dead-EndOpen accessMedicine
Some DY, Kiemde F, Kabore B et al. · 2026 · PloS one
Objective To evaluate the field accuracy of a malaria diagnostic algorithm combining sequential interpretation of two-step malaria RDT detecting PfHRP2 and pLDH with information on previous antimalarial treatments within the past four…
View details →DOI: 10.1371/journal.pone.0351990 Failed Experiment ReportOpen accessMedicine
He X, Kratochwil N, Ariño-Estrada G et al. · 2026 · Physics in medicine and biology
Positron emission tomography (PET) image quality is partially determined by PET detector performance, which can be improved by increasing the optical photon harvest from scintillator to photodetector. Due to the steep index mismatch at…
View details →DOI: 10.1088/1361-6560/ae752d Negative / Null Result ReportOpen accessMedicine
Bedoya JU, Wagner M, Malézieux E et al. · 2026 · Liver international : official journal of the International Association for the Study of the Liver
Background & aims Transjugular intrahepatic portosystemic shunt (TIPS) improves survival in refractory ascites. A careful patient's selection is mandatory as TIPS can lead to complications. Liver volumetry is predictive of outcomes before…
View details →DOI: 10.1111/liv.70691 Negative / Null Result ReportMedicine
Chu BK, Abdelbaki A, Nikahd M et al. · 2026 · Journal of clinical gastroenterology
Background The optimal timing for endoscopic retrograde cholangiopancreatography (ERCP) in managing uncomplicated acute biliary pancreatitis (ABP) remains unclear. This population-based study assessed the impact of ERCP timing on outcomes…
View details →DOI: 10.1097/mcg.0000000000002341 Negative / Null Result ReportMedicine
Halliwell C, Courish M, Moyer R et al. · 2026 · Clinical rheumatology
Background Individuals with knee osteoarthritis are at an increased risk of poor metabolic health. We tested if cross-sectionally replacing stationary time with light or moderate-to-vigorous physical activity would be associated with lower…
View details →DOI: 10.1007/s10067-026-08253-1 Negative / Null Result ReportMedicine
Mano N, Mori K, Kuwabara T et al. · 2026 · Annals of biomedical engineering
Purpose Diverse gait patterns in individuals with stroke require personalized rehabilitation to improve paretic propulsion (Pp), which reflects gait function. However, the gait characteristics associated with Pp have not been fully…
View details →DOI: 10.1007/s10439-026-04203-9 