Negative / Null Result Report
Hornsby G, Pu C, Badamikar A et al. · 2025 · Preprint
ABSTRACT Introduction While improving water, sanitation, and hygiene (WASH) service delivery in schools supports the Sustainable Development Goals, rigorous trials have recently reported inconsistent effects of WASH in schools (WinS)…
View details →DOI: 10.1101/2025.10.23.25338677 Negative / Null Result ReportMedicine
Newton JD, Ellis T, Ruther M et al. · 2026 · Environmental research
Living near green areas with high vegetation may contribute to an active lifestyle, stress reduction, and enhance social cohesion, and consequently may be associated with improved cancer survival. Epidemiologic studies focused on greenness…
View details →DOI: 10.1016/j.envres.2025.123574 Negative / Null Result ReportOpen accessMedicine
Hiredesai AN, Martinez CJ, Hinckley NB et al. · 2026 · Cureus
Purpose Shear wave elastography (SWE) is a non-invasive technique for assessing median nerve (MN) stiffness in carpal tunnel syndrome (CTS). This study evaluated whether SWE measurements of the MN improve after corticosteroid injection…
View details →DOI: 10.7759/cureus.102587 Negative / Null Result ReportOpen accessMedicine
Pater WJ, Buller LT, Ziemba-Davis M et al. · 2026 · Arthroplasty today
Background Tourniquet use in revision total knee arthroplasty (rTKA) enhances visualization and improves cement penetration. However, concerns exist about muscle injury, pain, wound complications, and venous thromboembolism (VTE). This…
View details →DOI: 10.1016/j.artd.2026.102028 Negative / Null Result ReportOpen accessMedicine
Dragan KL · 2026 · Journal of policy analysis and management : [the journal of the Association for Public Policy Analysis and Management]
Low-income housing is often of substandard quality. Health care payers like Medicaid and Medicare are piloting reimbursement for housing quality improvement with the rationale of reducing expenses from acute care use, but little is known…
View details →DOI: 10.1002/pam.70074 Negative / Null Result ReportOpen accessMedicine
Liu J, Long Y, Yang Z · 2026 · Nutrients
Background Growing evidence suggests that vitamin D plays a role in the pathophysiology of childhood asthma. However, its effectiveness in reducing asthma exacerbations and improving asthma-related outcomes remains controversial. Methods…
View details →DOI: 10.3390/nu18101560 Negative / Null Result ReportMedicine
Fertig A, Hartman A, Iyer L et al. · 2026 · The journal of politics
Can financial incentives lead households to register land in women's names, thereby providing them with formal property rights? Can formal property ownership improve women's economic outcomes and change decision-making dynamics within the…
View details →DOI: 10.1086/734236 Negative / Null Result ReportMedicine
Kumar AR, Sanford NN · 2025 · Seminars in radiation oncology
Based on available Level 1 evidence, standard dose conventional chemoradiation does not improve survival in patients with locally advanced pancreas cancer (LAPC), thus chemotherapy remains the only widely accepted therapy. Yet prognosis…
View details →DOI: 10.1016/j.semradonc.2025.07.002 Negative / Null Result ReportOpen accessMedicine
Van der Helm-van Mil AHM · 2023 · Joint bone spine
During the last decade, the outlook for patients with rheumatoid arthritis (RA) has improved greatly, especially for patients with autoantibody-positive RA. To further improve long-term disease outcomes, the field has turned to…
View details →DOI: 10.1016/j.jbspin.2023.105543 Negative / Null Result ReportOpen accessMedicine
Gatto L, Di Nunno V, Tosoni A et al. · 2023 · Cancers
The lack of significant improvement in the prognosis of patients with GB over the last decades highlights the need for innovative treatments aimed at fighting this malignancy and increasing survival outcomes. The results of the phase III…
View details →DOI: 10.3390/cancers15123251 Negative / Null Result ReportMedicine
Janeway KA, Chou AJ, Buxton A et al. · 2026 · Clinical cancer research : an official journal of the American Association for Cancer Research
Purpose Mouse models demonstrate a role for RANK and its ligand, RANKL, in osteosarcoma. The primary objective of this single-arm, open-label phase 2 trial was to determine whether denosumab, a RANKL mAb, improved disease control in…
View details →DOI: 10.1158/1078-0432.ccr-24-2885 Negative / Null Result ReportOpen accessMedicine
Andersson Y, Løvstakken E, Herud TM et al. · 2025 · Annals of surgical oncology
Background Hyperthermic intraperitoneal chemotherapy (HIPEC) following cytoreductive surgery is a potentially curative treatment for patients with peritoneal metastases. Currently, there is no standardized protocol for performing HIPEC and…
View details →DOI: 10.1245/s10434-025-18025-x Negative / Null Result ReportMedicine
Dijk SW, Wollny C, Barkhausen J et al. · 2025 · JAMA
Importance Given the widespread use of medical imaging, evaluating the effectiveness of interventions to improve appropriateness is crucial for optimizing health care resources and patient outcomes. Objective To assess the effects of…
View details →DOI: 10.1001/jama.2024.27853 Negative / Null Result ReportOpen accessMedicine
Yurttas C, Horvath P, Fischer I et al. · 2024 · Journal of clinical medicine
(1) Background: Laparoscopic staging is essential in gastric cancer (GC) to rule out peritoneal metastasis (PM). Hypericin, a plant-derived fluorescent compound, has been suggested to improve laparoscopic visualization of PM from GC. This…
View details →DOI: 10.3390/jcm13082422 Negative / Null Result ReportMedicine
Wulff KC, Miller FG, Pearson SD · 2011 · Health affairs (Project Hope)
To attain the anticipated benefits of increased investments in comparative effectiveness research, the results must translate into improved medical practice and policy. In this article we present an analysis of a case study of percutaneous…
View details →DOI: 10.1377/hlthaff.2011.0159 Negative / Null Result ReportOpen accessMedicine
Mitting RB, Ray S, Raffles M et al. · 2019 · PloS one
Background Methylprednisolone remains a commonly used ancillary therapy for paediatric acute respiratory distress syndrome (PARDS), despite a lack of level 1 evidence to justify its use. When planning prospective trials it is useful to…
View details →DOI: 10.1371/journal.pone.0225737 Negative / Null Result ReportMedicine
Galloway NL, Sargeant GA, Powers JG et al. · 2026 · Journal of wildlife diseases
Effective wildlife disease management and research rely on trustworthy disease diagnostics. For chronic wasting disease (CWD), immunohistochemistry (IHC) is recognized as the gold standard, and ELISA is a reliable high-throughput screening…
View details →DOI: 10.7589/jwd-d-25-00164 Negative / Null Result ReportOpen accessMedicine
Boardman-Pretty F, Kumar J, Grant C et al. · 2026 · Orphanet journal of rare diseases
BACKGROUND: Accurate and early diagnosis to optimise rare disease care is a global priority. With recent developments in artificial intelligence (AI)-based solutions, a promising area to improve rare disease diagnosis is the application of…
View details →DOI: 10.1186/s13023-026-04240-6 Negative / Null Result ReportOpen accessMedicine
Atobatele S, Mpimbaza A, Ngufor C et al. · 2025 · Malaria journal
Background Malaria rapid diagnostic tests (RDTs) have improved case management and surveillance across sub-Saharan Africa by reducing presumptive treatment and enhancing diagnostic specificity. However, healthcare workers' (HCWs) concerns…
View details →DOI: 10.1186/s12936-025-05674-2 Negative / Null Result Report
Atobatele S, Mpimbaza A, Ngufor C et al. · 2025 · Preprint
Abstract Background Malaria rapid diagnostic tests (RDTs) have improved case management and surveillance across sub-Saharan Africa by reducing presumptive treatment and enhancing diagnostic specificity. However, healthcare workers’ (HCWs)…
View details →DOI: 10.21203/rs.3.rs-7194605/v1 Negative / Null Result ReportOpen accessMedicine
Sheybani L · 2026 · The European journal of neuroscience
A recent study by Hausdorf et al. reported that combining closed-loop acoustic stimulation with transcranial direct current stimulation during sleep does not improve memory consolidation. This contrasts with past studies that reported a…
View details →DOI: 10.1111/ejn.70400 Negative / Null Result Report
Ngufor C, Lindblade KA, Atobatele S et al. · 2025 · Preprint
Abstract Background Rapid diagnostic tests (RDTs) have improved malaria case management by enabling point-of-care confirmation of infection, particularly in low-resource settings. In addition to clinical use, RDT results recorded in health…
View details →DOI: 10.21203/rs.3.rs-6760274/v1 Negative / Null Result ReportOpen access
Dätwyler I, Kuster H, Greiner MA et al. · 2025 · Preprint
Introduction Pneumocystis jirovecii (PJ) causes pneumonia primarily in immunocompromised individuals. Although direct immunofluorescence (IF) remains the diagnostic standard, PCR assays are increasingly used because of higher sensitivity…
View details →DOI: 10.1101/2025.11.18.25340486 Negative / Null Result ReportMedicine
Russo F, Chatterjee D, DeMaria N et al. · 2024 · Journal of community genetics
DNA-based population screening for adult-onset diseases holds promise for advancing personalized medicine and improving public health. Yet as most individuals pursuing such screening receive negative results, the return of results process…
View details →DOI: 10.1007/s12687-024-00736-5 Negative / Null Result ReportOpen accessMedicine
Triantafyllidou O, Panagodimou E, Chasiakou S et al. · 2026 · Cureus
Objective To evaluate whether the addition of clomiphene citrate (CC) to a low-dose recombinant follicle-stimulating hormone (FSH) (r-FSH) gonadotropin-releasing hormone (GnRH)-antagonist protocol improves clinical outcomes in women with…
View details →DOI: 10.7759/cureus.108079 Negative / Null Result ReportMedicine
Liu Q, Liu X, Chang L et al. · 2025 · Clinica chimica acta; international journal of clinical chemistry
Introduction Accurate and early HIV detection is crucial for improving outcomes and controlling transmission. This study compares HIV marker patterns and evaluates detection assay performance in general screening and ART-treated…
View details →DOI: 10.1016/j.cca.2025.120207 Negative / Null Result ReportOpen accessMedicine
Wang H, Ardura MI, Oyeniran SJ et al. · 2026 · ASM case reports
Background Cytomegalovirus (CMV) continues to be a significant cause of morbidity and mortality in immunocompromised patients. Nucleic acid amplification tests (NAATs) are the preferred method for both diagnosing CMV infection and…
View details →DOI: 10.1128/asmcr.00159-25 Negative / Null Result ReportMedicine
Pantazis JC, Palmer AC · 2026 · Molecular cancer therapeutics
The phase III study of romidepsin plus CHOP for peripheral T-cell lymphoma (PTCL) yielded negative results in the overall analysis and showed that outcomes were only improved in the T follicular helper (TFH) subgroup of PTCL, with no…
View details →DOI: 10.1158/1535-7163.mct-25-0941 Negative / Null Result ReportOpen accessMedicine
Badelita SN, Sandu HM, Coriu D et al. · 2026 · Frontiers in oncology
Bone marrow hemodilution could compromise next generation flow cytometry based measurable residual disease evaluation in multiple myeloma and may cause false negative results. This review summarizes definitions, markers, indices,…
View details →DOI: 10.3389/fonc.2026.1849714 Negative / Null Result ReportOpen accessMedicine
Stewart SF, Enne VI, Pandolfo AM et al. · 2026 · Antimicrobial resistance and infection control
Background Rapid molecular diagnostics such as the BioFire FilmArray Pneumonia Panel (the Pneumonia Panel) can improve antibiotic stewardship by supporting doctors to make more targeted antibiotic prescribing decisions faster compared to…
View details →DOI: 10.1186/s13756-025-01690-8 