Negative / Null Result ReportMedicine
Miftakhov R, Fortygina P, Zuzina A et al. · 2026 · Scientific reports
Astrocytes communicate bidirectionally with neurons by releasing various signaling molecules. This astrocyte-neuron "dialogue" is essential for long-term processes in the nervous system, and its disruption correlates with various…
View details →DOI: 10.1038/s41598-026-56373-0 Negative / Null Result ReportMedicine
Duque-Estrada P, Markussen B, Schutyser M et al. · 2026 · Food chemistry
Thermal treatment can improve plant protein digestibility by inactivating antinutrients and partially denaturing proteins, but depending on the conditions applied, heating may also promote aggregation and amino acid modifications that…
View details →DOI: 10.1016/j.foodchem.2026.149181 Negative / Null Result ReportMedicine
Su Y, Hu Q, Dou Z et al. · 2026 · Food research international (Ottawa, Ont.)
κ-Carrageenase with alkaline resistance can promote the resource utilization of κ-carrageenan industrial residues. In this study, a rational design strategy integrating surface charge optimization and consensus sequence analysis was…
View details →DOI: 10.1016/j.foodres.2026.119085 Negative / Null Result ReportMedicine
Peng Z, Xu C, Zhang Y et al. · 2026 · Innovative Food Science and Emerging Technologies.
Radio frequency (RF) heating, as a promising alternative roasting method, could effectively improve peanut oil quality and degrade aflatoxins. However, during the peanut oil processing, the modification effect and mechanism on protein by…
Negative / Null Result ReportMedicine
Littmann J, Steiner N, Cabrejo-Jones K et al. · 2026 · The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons
Background A Moberg osteotomy is a dorsal closing wedge osteotomy of the base of the first proximal phalanx that is thought to augment the effect of cheilectomy by increasing dorsiflexion and ultimately improve patient outcomes in Hallux…
View details →DOI: 10.1053/j.jfas.2025.11.019 Negative / Null Result ReportMedicine
Sun Q, Miao Z, Bian L et al. · 2026 · Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
Methionine oxidation in monoclonal antibodies (mAbs) could critically compromise drug stability and efficacy. This investigation comprehensively evaluated the structural and functional impacts of oxidation on a mAb An under long-term…
View details →DOI: 10.1016/j.jchromb.2026.124920 Negative / Null Result ReportMedicine
Chen W, Zhang C, Guo W et al. · 2026 · Journal of experimental botany
Apple is an important economic species, but it suffers from biotic stress during its growth and development. Fungi and pests are two types of biotic stress that have significant destructive effects on apple. Members of the leucine-rich…
View details →DOI: 10.1093/jxb/erag089 Negative / Null Result Report
Selimović-Pašić A, Haglund L, Bensberg M et al. · 2026 · Preprint
The BCL-2 inhibitor venetoclax (VEN) in combination with hypomethylating agents (HMAs) has improved treatment responses in acute myeloid leukaemia (AML), but the mechanisms underlying their synergy remain unclear. We investigated the role…
View details →DOI: 10.64898/2026.04.13.718134 Negative / Null Result Report
Gama de Matos D, de Santana JL, Aidar FJ et al. · 2025 · Preprint
Background: Frailty is a multifactorial condition that significantly impacts older adults health and independence, which can be mitigated through training. This study examined the effects of a 12-week progressive strength training (PST)…
View details →DOI: 10.20944/preprints202511.1155.v1 Negative / Null Result Report
Lima LC, Caetano D, Pinto L et al. · 2026 · Preprint
Abstract The global burden of bone fractures is projected to double by 2050, and this trend is driven by an aging population, higher incidence of car accidents, cancer-related bone damage, and osteoporosis, which compromises bone…
View details →DOI: 10.21203/rs.3.rs-8722217/v1 Negative / Null Result ReportMedicine
Oncul S, Lee H, Singh S et al. · 2026 · Journal of immunology (Baltimore, Md. : 1950)
B cells constitute ∼15% to 20% of tumor-infiltrating lymphocytes in melanoma. Their presence in the tumor microenvironment correlates with improved survival and enhanced response to immune checkpoint blockade therapy. Yet, the functional…
View details →DOI: 10.1093/jimmun/vkag004 Negative / Null Result ReportMedicine
Riesenbach IC, Tsomik G, Chiasson M et al. · 2026 · Aquaculture.
Insects, such as black soldier flies (BSF), have garnered attention in the aquaculture industry as a sustainable protein and lipid alternative to fishmeal and fish oil. However, research is lacking on which components of BSF improve fish…
Negative / Null Result ReportMedicine
Lagravinese G, Castellana G, Genco M et al. · 2026 · Applied psychophysiology and biofeedback
Chronic obstructive pulmonary disease (COPD) is associated with persistent dyspnea, reduced functional capacity, and significant cognitive and affective impairments. Pulmonary rehabilitation improves the physical and psychological…
View details →DOI: 10.1007/s10484-025-09763-5 Negative / Null Result Report
Nilsson M, Berrebi J, Nikkhou-Aski S et al. · 2025 · Preprint
BackgroundThe hippocampus is crucial for learning, memory, and stress regulation but is vulnerable to biological and environmental influences that compromise its structural and metabolic integrity. Proton magnetic resonance spectroscopy…
View details →DOI: 10.31234/osf.io/gcmsq_v1 Negative / Null Result Report
Karademir G, Durbas A, Diril SK et al. · 2025 · Preprint
Abstract Background Superior capsular reconstruction (SCR) is a treatment option for irreparable rotator cuff tears (IRCTs), but graft failure remains a significant limitation. While fascia (FA) grafts are commonly utilized, their…
View details →DOI: 10.21203/rs.3.rs-8001106/v1 Negative / Null Result ReportMedicine
Broll A, Goldhacker M, Hahnel S et al. · 2025 · Journal of dentistry
Objectives This retrospective in vitro study evaluated the impact of input data quantity on the morphology of dental crowns generated by AI-based software. The hypothesis suggests that increased input data quantity improves the quality of…
View details →DOI: 10.1016/j.jdent.2025.105767 Negative / Null Result Report
Toshida K, Sugitani Y, Itoh S et al. · 2025 · Preprint
Abstract Background: Hepatocellular carcinoma (HCC) is a major cause of cancer-related mortality worldwide. While systemic therapies have improved outcomes, predicting tumor histopathology remains difficult. Machine learning (ML) offers a…
View details →DOI: 10.21203/rs.3.rs-7704748/v1 Negative / Null Result Report
Chen W, Zhang C, Guo W et al. · 2025 · Preprint
Apple is an important economic species, and it always suffered by biotic stress during its growth and development. Fungi and pests are two types of biotic stress that have significant destructive effects on apples. Besides, the LRR-RLKs…
View details →DOI: 10.22541/au.175022852.28343178/v1 Negative / Null Result Report
Zhang X, Li F, Li J et al. · 2025 · Preprint
Introduction Supervised physical activity (PA) interventions have demonstrated efficacy and safety in improving health outcomes among frail populations. However, the growing disparity between limited healthcare resources and the rapidly…
View details →DOI: 10.1101/2025.06.26.25330386 Negative / Null Result Report
Lagravinese G, Castellana G, Genco M et al. · 2025 · Preprint
Abstract Background: Chronic obstructive pulmonary disease (COPD) is associated with persistent dyspnea, reduced functional capacity, and significant cognitive and affective impairments. Pulmonary rehabilitation improves the physical and…
View details →DOI: 10.21203/rs.3.rs-6974767/v1 Negative / Null Result Report
Pulliainen H, Kataja E, Löyttyniemi E et al. · 2025 · Preprint
Abstract Background We examined whether an interactive four-dimensional (4D) ultrasound intervention decreases prenatal and early postnatal depressive symptoms and improves maternal-fetal attachment. Methods This randomized controlled…
View details →DOI: 10.21203/rs.3.rs-6672112/v1 Negative / Null Result ReportMedicine
Gill P, Tao X, Zhan Y et al. · 2026 · American journal of obstetrics and gynecology
Background Preimplantation genetic testing for aneuploidy is used to improve in vitro fertilization outcomes by identifying embryos with lethal chromosomal abnormalities that impair development or lead to pregnancy loss. The adoption of…
View details →DOI: 10.1016/j.ajog.2025.12.033 Negative / Null Result ReportMedicine
Barwood M, Barwood H, Davis D et al. · 2025 · International journal of sports physiology and performance
Purpose Topical menthol application improves thermal perception and enhances performance but reduces sweat production in hot environments. In the aquatic environment, where sweat evaporation is of limited thermoregulatory benefit (ie,…
View details →DOI: 10.1123/ijspp.2025-0038 Negative / Null Result ReportMedicine
Birene B, Ferreira A, Raimond E et al. · 2025 · Journal of perinatal medicine
Objectives Large-for-gestational-age (LGA) fetuses present significant maternal and neonatal risks. However, prenatal screening is prone to inaccuracies, leading to potentially unnecessary interventions. This study aims to evaluate the…
View details →DOI: 10.1515/jpm-2025-0015 Negative / Null Result ReportMedicine
Tsai PS, Wu KC, Wu CH · 2025 · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Osteoarthritis (OA) is a degenerative and deteriorating disease. The accompanying pain, stiffness, inflammation of the synovial joint, and the loss of articular function compromise the mobility, stability, and routine of patients' lives.…
View details →DOI: 10.1016/j.biopha.2025.118519 Negative / Null Result ReportMedicine
Alstrup T, Pedersen JO, Kjær EM et al. · 2025 · Plastic and reconstructive surgery
Background Fat grafting is a gentle technique used to correct soft-tissue defects, but it is challenged by low graft survival rates. To enhance retention, mesenchymal stromal cells (MSCs) have been explored. Autologous MSC therapy has…
View details →DOI: 10.1097/prs.0000000000012121 Negative / Null Result ReportMedicine
Schmitt O, Knecht C, Sobczak B et al. · 2025 · Neuroimmunomodulation
Introduction Little is known about the effects of a positive human-animal relationship on animal health and resilience. This study investigated the effects of regular positive human-animal interactions on pigs' response to an immune…
View details →DOI: 10.1159/000544748 Negative / Null Result ReportOpen accessMedicine
López-Samanes Á, Moreno-Pérez D, Aguilar-Navarro M et al. · 2026 · Journal of the International Society of Sports Nutrition
Introduction The aim of this study was to evaluate the acute effect of beetroot juice ingestion on sprint performance and neuromuscular properties of male trained sprinters. Methods Twelve male sprinters (24.3 ± 4.8 years) participated in…
View details →DOI: 10.1080/15502783.2026.2674220 Negative / Null Result ReportMedicine
Mahieux M, Braga Nan L, Zbair M et al. · 2025 · Waste management (New York, N.Y.)
Carbon-based materials gained attention for their potential to improve anaerobic digestion (AD) performance. Meanwhile, in situ biomethanation, where external H 2 is injected into the AD process to enhance the CH 4 content in biogas, is…
View details →DOI: 10.1016/j.wasman.2025.114869 Negative / Null Result ReportMedicine
Doğan MB, Gündüz N, Kazan HÖ et al. · 2025 · European journal of radiology
Objective Muscle invasion in bladder cancer is a crucial factor influencing treatment decisions and prognosis. We hypothesize that the integration of tumor shape characteristics with the VI-RADS scoring system improves the predictive…
View details →DOI: 10.1016/j.ejrad.2025.112104 