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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

1934 results for "Mpro" · page 32 of 65

Negative / Null Result ReportMedicine

Evaluating the Quality of Artificial Intelligence-Generated Rubrics and Grading Reliability in Student-Written Reflection Assignments.

Dicken S, DeLeon N, Gutierrez EJ et al. · 2026 · American journal of pharmaceutical education

Objective To investigate whether generative artificial intelligence (genAI) can improve pharmacy assessment practices, specifically, rubric development, and the grading of student-written reflection assignments. Methods Sample…

View details →DOI: 10.1016/j.ajpe.2026.102014
Negative / Null Result ReportMedicine

Frailty in a low-risk elective setting: a quality improvement study at Shouldice Hospital.

Paasch C, Svendrovski A, Usher J et al. · 2026 · Hernia : the journal of hernias and abdominal wall surgery

Purpose This study aims to evaluate the impact of frailty on postoperative outcomes after Shouldice primary inguinal hernia Repair (SPIHR) as a quality control measure in a highly standardized elective setting. Methods This quality…

View details →DOI: 10.1007/s10029-026-03760-1
Negative / Null Result Report

Impact of co-administration of proton pump inhibitors on efficacy and safety of oral semaglutide in patients with type 2 diabetes: a single-center retrospective study

Yokoyama T, Uchino T, Yazawa Y et al. · 2026 · Preprint

Abstract Background Oral semaglutide, a glucagon-like peptide-1 receptor agonist, improves glycemic control and reduces body weight in patients with type 2 diabetes. Although proton pump inhibitors (PPIs) have been reported to slightly…

View details →DOI: 10.21203/rs.3.rs-9444720/v1
Negative / Null Result ReportMedicine

Impact of the amotosalen/UVA process to reduce pathogens in platelet concentrates on transfusion efficiency in cardiac surgery.

Bouali B, Rezzaoui A, Hamzeh-Cognasse H et al. · 2026 · Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine

Background Pathogen reduction treatment (PRT) of platelet concentrates (PC) is one of the most recent advances in improving blood safety and lowering the risk of transfusion-transmitted diseases. The characteristics of PR-treated PC differ…

View details →DOI: 10.1016/j.tracli.2026.02.005
Negative / Null Result ReportMedicine

Effectiveness of a standardized patient simulation training programme on nursing students' skill in dementia screening in Malawi: A quasi-experimental study.

Chiona BC, Mbakaya BC, Liu MF · 2026 · Nurse education in practice

Aim To evaluate the effectiveness of Standardized Patient Simulation (SPS) compared with lecture-based teaching in improving dementia knowledge, dementia screening skills and mild cognitive impairment (MCI) classification accuracy among…

View details →DOI: 10.1016/j.nepr.2026.104884
Negative / Null Result ReportMedicine

The Clinical Impact of Team Triage vs Conventional Triage on Patients With Acute Surgical Appendicitis or Cholecystitis.

Adams JL, Tong A, Chen P et al. · 2026 · Journal of emergency nursing

Introduction Team triage incorporates collaborative evaluation by physicians and nurses during initial assessment, differing from conventional nurse-only triage models. Although previous studies have demonstrated improvements in wait times…

View details →DOI: 10.1016/j.jen.2026.04.016
Negative / Null Result ReportMedicine

Pediatric Robotic Cochlear Implantation: Hearing Outcomes.

Marie A, Leclere JC, Fleming Y et al. · 2026 · Audiology & neuro-otology

Introduction Cochlear implantation is the standard of care for children with severe-to-profound sensorineural hearing loss, offering substantial improvements in speech intelligibility, tonal audiometry perception, language acquisition, and…

View details →DOI: 10.1159/000551887
Negative / Null Result ReportMedicine

Combining structural and microvascular parameters via machine learning for enhanced diagnosis of normal-tension glaucoma among highly myopic eyes: a prospective cross-sectional diagnostic accuracy study.

He CZ, Qiu Q, Lai H et al. · 2026 · BMC ophthalmology

This study aimed to evaluate whether a combination of optical coherence tomography (OCT) and OCT angiography (OCTA) parameters could improve the discrimination between clinically diagnosed normal-tension glaucoma (NTG) and non-glaucomatous…

View details →DOI: 10.1186/s12886-026-05065-4
Negative / Null Result ReportMedicine

Long-term outcomes of tacrolimus conversion to sirolimus in kidney transplant recipients: an eight-year follow-up.

Tawhari I, Park S, Yamani F et al. · 2026 · Frontiers in nephrology

Objective Calcineurin inhibitors, such as tacrolimus, are associated with long-term nephrotoxicity and renal allograft dysfunction despite evidence of improved kidney transplantation outcomes. Consequently, minimizing calcineurin inhibitor…

View details →DOI: 10.3389/fneph.2026.1813146
Negative / Null Result ReportMedicine

Does a Brochure Reduce Dental Anxiety in Patients Undergoing Third Molar Extraction? A Randomized Clinical Trial.

Schemel-Suarez M, Egido-Moreno S, Martínez-Lizan I et al. · 2026 · Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons

Background Dental anxiety frequently compromises patient cooperation and outcomes during third molar (3M) extraction prompting the use of nonpharmacological strategies such as detailed written information. Evidence on reducing preoperative…

View details →DOI: 10.1016/j.joms.2026.05.063
Negative / Null Result ReportMedicine

Mediating effects of depression, stigma, and self-efficacy on self-management improvement in an evidence-based epilepsy self-management program.

Armah L, Tan L, Branning R et al. · 2026 · Epilepsy & behavior : E&B

Aims To evaluate whether improvements in depressive symptoms, epilepsy self-efficacy, and perceived stigma mediate the association between the SMART intervention and epilepsy self-management. Methods 160 people with epilepsy were enrolled…

View details →DOI: 10.1016/j.yebeh.2026.111117
Negative / Null Result ReportMedicine

Non-alcoholic beverage provision reduces alcohol consumption and improves health-related outcomes, with no effect on presenteeism: a randomized controlled trial.

Dobashi S, Hotoge S, Kikuchi A et al. · 2026 · Scientific reports

Excessive alcohol consumption contributes to mortality and productivity losses, yet evidence for workplace-based substitution interventions remains limited. This randomized controlled trial examined whether providing non-alcoholic…

View details →DOI: 10.1038/s41598-026-58855-7
Negative / Null Result ReportMedicine

Investigating compensatory adjustments induced by rhythmic auditory stimulation for changes in temporal gait symmetry in lower-limb prosthetic users.

Gouda A, Arshad MZ, Andrysek J · 2026 · PloS one

Gait training is an important part of rehabilitation for prosthetic users, improving mobility and long-term health outcomes. This study investigated the effects of rhythmic auditory stimulation (RAS) on gait symmetry and overall movement…

View details →DOI: 10.1371/journal.pone.0351930
Negative / Null Result ReportMedicine

Design and Preliminary Evaluation of a Hand-Held Surgical Robot for Enhanced Intuitive Control in Laparoscopy.

Kong K, Qiang Z, Yang Y et al. · 2026 · The international journal of medical robotics + computer assisted surgery : MRCAS

Background Surgical robots offer improved precision and stability for laparoscopy; nevertheless, their limited portability and high cost impede broader clinical applications. Methods This paper proposes a hand-held surgical robot with an…

View details →DOI: 10.1002/rcs.70176
Negative / Null Result ReportMedicine

A Community Located Insurance Navigation Intervention to Link Sexual and Gender Minorities in Status Neutral Care: Results From the Navigating Insurance Coverage Expansion Randomized Controlled Trial.

Umutoni V, Eavou R, Almirol E et al. · 2026 · Journal of acquired immune deficiency syndromes (1999)

Background Black and Hispanic/Latino sexual gender minorities are disproportionately affected by HIV. Structural determinants of health, such as health insurance coverage, drive care engagement and improve HIV care outcomes. Methods Black…

View details →DOI: 10.1097/qai.0000000000003788
Negative / Null Result ReportMedicine

Evaluation of acellular dermal matrix efficacy in immunocompromised patients' wounds: a retrospective matched-cohort study.

Zheng S, Shi Y, Feng Z et al. · 2026 · Journal of wound care

Objective The efficacy of acellular dermal matrix (ADM) in immunocompromised patients' wounds has been little studied. The present study aimed to determine the wound healing effects of ADM in immunocompromised patients compared with…

View details →DOI: 10.12968/jowc.2022.0061
Negative / Null Result ReportMedicine

Efficacy of a Brief Video Intervention to Improve Parenting Attitudes, Knowledge, and Use of Time-Out: A Randomized Control Trial.

Portell AL, Niec LN · 2026 · Behavior modification

Time-out from positive reinforcement (TOPR) is an effective limit-setting strategy for decreasing disruptive behaviors in young children. However, most publicly available information on TOPR (e.g., social media and other internet outlets)…

View details →DOI: 10.1177/01454455261449744
Negative / Null Result ReportMedicine

Comparative assessment of behavioural alterations induced by common laboratory solvents in zebrafish (Danio rerio) larvae.

Vujović T, Begić Biškup K, Bojanić K et al. · 2026 · Scientific reports

Organic solvents are routinely used to dissolve poorly water-soluble chemicals in zebrafish-based assays. However, their intrinsic biological activity may confound behavioural endpoints and compromise data interpretation. This study…

View details →DOI: 10.1038/s41598-026-59476-w
Negative / Null Result ReportMedicine

Multiple-Birth Family Knowledge in Maternity and Child Health Clinics: Filling Knowledge Gaps to Improve Multiple-Birth Family Nursing.

Heinonen K, Kaprio J, Trias T et al. · 2026 · Twin research and human genetics : the official journal of the International Society for Twin Studies

The purpose of this cross-sectional study was to investigate knowledge about multiple-birth families among midwives and public health nurses working in maternity and child health clinics in Finland. The data were collected with a Finnish…

View details →DOI: 10.1017/thg.2026.10055
Negative / Null Result ReportMedicine

Increasing Intrinsic Protein Disorder Improves CD8+ Immunogenicity for a SARS CoV2 Vaccine Candidate Antigen.

Wan L, Xie B, Shuda M et al. · 2026 · Molecular therapy : the journal of the American Society of Gene Therapy

CD8+ T cell targeting of the conserved SARS CoV2 RNA-dependent RNA polymerase (RdRp, nsp12) may offer a means for cross-protection against diverse coronavirus strains. Native RdRp, however, displays primary sequence immunoevasion (PSI)…

View details →DOI: 10.1016/j.ymthe.2026.06.027
Negative / Null Result ReportMedicine

Impact of an educational video on the quality of bowel preparation prior to colonoscopy: a randomized controlled study.

Vidon M, Wang X, Costes L et al. · 2026 · Clinics and research in hepatology and gastroenterology

Background and study aims Educational interventions have been proposed to improve adherence to bowel preparation instructions. We evaluated whether adding a short instructional video to standard written and oral information improves bowel…

View details →DOI: 10.1016/j.clinre.2026.102860
Negative / Null Result ReportMedicine

Ensuring continuous buprenorphine access: A multi-component quality improvement initiative in a university-affiliated clinic and outpatient pharmacy.

Choo LY, Zheng W, Wen S et al. · 2026 · Journal of the American Pharmacists Association : JAPhA

Background Patients with opioid use disorder encounter challenges obtaining buprenorphine (BUP) at pharmacies, increasing their risk of treatment non-adherence and illicit drug use. Objectives The purpose of this quality improvement (QI)…

View details →DOI: 10.1016/j.japh.2026.103469
Negative / Null Result ReportMedicine

Leader behaviors to improve teamwork during interprofessional rounds in the NICU.

Traylor AM, Bell EA, Lewis NCM et al. · 2026 · Journal of perinatology : official journal of the California Perinatal Association

Objective We investigated the impact of leaders' interprofessional teamwork behaviors on NICU staff perceptions of teamwork processes, trust, psychological safety, and voice behavior. Study design To develop a measure of leaders'…

View details →DOI: 10.1038/s41372-026-02689-8
Negative / Null Result ReportMedicine

Adding Self-directed Psychological Support to Usual Rehabilitation Following Anterior Cruciate Ligament Reconstruction Did Not Increase Return-to-Sport Rates at 12 Months. Results From the BAck iN the Game (BANG) Randomized Controlled Trial.

Fältström A, Hedevik H, Ardern CL et al. · 2026 · The Journal of orthopaedic and sports physical therapy

OBJECTIVE: To evaluate the efficacy of internet-delivered psychological support-the BAck iN the Game (BANG) intervention-after anterior cruciate ligament reconstruction (ACLR) for improving return to sport (RTS). DESIGN: Randomized…

View details →DOI: 10.2519/jospt.2026.13749
Negative / Null Result ReportOpen accessMedicine

Effects of an orexin receptor 2-selective agonist on salivary secretion in rats.

Ichishima J, Nakakariya M, Kimura H · 2026 · Scientific reports

Narcolepsy type 1 (NT1) is caused by a significant loss of orexin-producing neurons. In clinical trials, multiple orexin receptor 2 (OX2R)-selective agonists (e.g., danavorexton, TAK-994, and oveporexton) improved wakefulness and decreased…

View details →DOI: 10.1038/s41598-026-44080-9