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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

1896 results for "Mpro" · page 32 of 64

Negative / Null Result ReportMedicine

Redefining the role of carbon nanoparticles in colorectal cancer surgery: From lymph node yield to diagnostic paradox.

Lv Y, Wang F, Shen Y et al. · 2026 · European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

Background Accurate lymph node (LN) staging is critical in colorectal cancer (CRC). Carbon nanoparticles (CNPs), used as a tumor localization agent, incidentally stain LNs, creating uncertainty about their utility for improving staging and…

View details →DOI: 10.1016/j.ejso.2026.111782
Failed Experiment ReportMedicine

Phillyrin improves pulmonary epithelial barrier dysfunction in LPS-induced acute lung injury through the RhoA/ROCK signaling pathway.

Wang Y, Wu Q, Li L et al. · 2026 · The Journal of pharmacy and pharmacology

Objective Forsythiae Fructus, the fruit of Forsythia suspensa (Thunb.) Vahl, is a traditional Chinese medicine widely used for clearing heat and detoxifying and for treating inflammatory conditions such as fever and respiratory infection.…

View details →DOI: 10.1093/jpp/rgaf115
Negative / Null Result ReportMedicine

Psychological Resilience Moderates Autonomous Motivation After Mild Traumatic Brain Injury: A Randomized Controlled Trial of a Remote Walking Program.

Chang YC, Tsai HF, Shi RS et al. · 2026 · The Journal of head trauma rehabilitation

Objective The aim of this study was to evaluate whether a 12-week remotely delivered walking program based on self-determination theory (SDT) improves autonomous exercise motivation in adults with mild traumatic brain injury (mTBI) versus…

View details →DOI: 10.1097/htr.0000000000001153
Negative / Null Result ReportMedicine

Exopolysaccharide biosynthesis and regulation in Leuconostoc mesenteroides influences water holding capacity of fermented plant-based milks.

Sukarno AS, Dong A, Gumulya Y et al. · 2026 · International journal of food microbiology

Physical instability remains a major challenge in fermented plant-based yoghurts in the absence of added texturizing agents. Cultures can improve water holding capacity (WHC) through production of exopolysaccharide (EPS). This study…

View details →DOI: 10.1016/j.ijfoodmicro.2026.111797
Negative / Null Result ReportOpen accessMedicine

Impact of offset polyethylene liners on acetabular component loosening : an Australian Orthopaedic Association National Joint Replacement Registry-based analysis.

Shafiei SH, Latorre MR, Shimmin A · 2026 · Bone & joint open

Aims Restoring native hip biomechanics is essential for the long-term success of total hip arthroplasty (THA). Lateralized (offset) acetabular liners were developed to increase global offset and improve soft-tissue tension, but their…

View details →DOI: 10.1302/2633-1462.76.bjo-2026-0033.r1
Negative / Null Result ReportMedicine

Examination of Gait Asymmetry During Walking With Additional Arm Weights.

Yang HS, Atkins LT, James CR · 2026 · Journal of applied biomechanics

Gait symmetry is often assumed in healthy individuals, yet functional asymmetries arise from biomechanical and neurophysiological factors. Although light upper body loading can improve walking performance, its effect on lower limb joint…

View details →DOI: 10.1123/jab.2025-0159
Negative / Null Result ReportMedicine

PolyDeep Advance 3: Randomized Clinical Trial comparing PolyDeep-assisted and conventional colonoscopy for adenoma detection rate in a colorectal cancer screening program.

Davila-Piñón P, Díez-Martín AI, Nogueira-Rodríguez A et al. · 2026 · Endoscopy

Background and study aim The impact of computer-aided detection (CADe) systems remains uncertain. We evaluated whether PolyDeep, a CADe system, improves adenoma detection rate (ADR) in a colorectal cancer (CRC) screening program. Patients…

View details →DOI: 10.1055/a-2895-1613
Negative / Null Result ReportMedicine

Improving sleep on the inpatient general, non-stroke neurology service: A quasi-experimental interventional trial.

Shaik NF, Denison L, Venezia GMA et al. · 2026 · Journal of hospital medicine

Background Hospitalized patients often experience poor sleep, which is associated with worse health outcomes, increased rates of delirium, and readmissions. Objective To improve overnight sleep for clinically stable general neurology…

View details →DOI: 10.1002/jhm.70223
Negative / Null Result ReportMedicine

Developing more effective phosphorus-loaded iron modified biochar fertilisers for improvement of peanut yield and regulation of soil phosphorus fractions

Zhang J, Wu Q, Chi D et al. · 2025 · Soil & tillage research

Phosphorus-loaded iron-modified biochar (Fe-BP) can be used as farmlands' slow-release phosphorus (P) fertilizer. This study aimed to explore the effects of Fe-BP on soil P composition, phosphatase activity, peanut P accumulation, and P…

Negative / Null Result ReportMedicine

Cytomegalovirus DNAemia in the lower respiratory tract in nontransplant patients with hematologic malignancies.

Sadowska-Klasa A, Bełdzińska-Gądek K, Klein-Awerjanow K et al. · 2026 · International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

Objectives Cytomegalovirus (CMV) pneumonia is a serious complication in immunocompromised patients, but its role in non-transplant populations remains unclear. Methods We analyzed CMV DNA in bronchoalveolar lavage (BAL) samples from 100…

View details →DOI: 10.1016/j.ijid.2025.108231
Negative / Null Result ReportOpen accessMedicine

Extensive intraoperative peritoneal lavage (EIPL) for gastric cancer with positive peritoneal lavage and/or stamp cytology: An exploratory phase II study.

Tsujio G, Yashiro M, Miki Y et al. · 2026 · PloS one

Background Our group revealed that the combination of intra-operative stamp cytology and peritoneal lavage cytology (CY) improved the identification of individuals with high risk of peritoneal metastasis. In this exploratory Phase II…

View details →DOI: 10.1371/journal.pone.0347742
Negative / Null Result ReportMedicine

Associations between paracetamol administration and delayed intravenous antibiotic administration among patients with in-hospital sepsis.

Senangkhanikorn S, Morapun N, Samansee A et al. · 2026 · Journal of hospital medicine

Background Timely antibiotic administration is crucial for improving sepsis outcomes, but delays are common and multifactorial. Fever, a key feature of sepsis, is often treated with paracetamol, which may mask the condition and contribute…

View details →DOI: 10.1002/jhm.70347
Negative / Null Result Report

The Effect of Variability in Appearance and Context on Face Learning

Nguy K, lapadula t, Devue C · 2026 · Preprint

Exposure to multiple unique images of the same face enhances recognition. Using ambient pictures and videos, face-learning studies have shown improved generalization, suggesting more refined memory representations for faces exhibiting…

View details →DOI: 10.31234/osf.io/bytde_v1
Negative / Null Result ReportMedicine

Wearing Lower-Body Compression Tights to Bed After Cycling Exercise Does Not Affect Subsequent Sleep in Healthy Male Adults.

Sargent C, Halson SL, Morrison M et al. · 2026 · Sensors (Basel, Switzerland)

There is some evidence to indicate that lower-body compression garments aid recovery from exercise by improving sleep quality, but this evidence is based on measures derived from self-reports and accelerometers. The aim of this study was…

View details →DOI: 10.3390/s26051625
Negative / Null Result Report

Resident soil microbial diversity and urea amendment legacy interact to shape the composition and expression of a surface film-forming soil inoculant

Trexler RV, Bruns MA, Borton MA et al. · 2026 · Preprint

Soil microbial inoculants have the potential to improve crop yield, enhance agricultural sustainability, and support soil restoration, but they often display unpredictable in-field performance across varied soil conditions.…

View details →DOI: 10.64898/2026.06.08.730853
Negative / Null Result ReportMedicine

Outcomes and Complications After LUMiC<sup>®</sup> Endoprosthetic Reconstruction of Periacetabular Defects-A Retrospective Cohort Analysis.

Niemann AS, Ramon R, Mayor J et al. · 2026 · Life (Basel, Switzerland)

(1) Background: The reconstruction of periacetabular defects after tumor resection remains one of the most challenging procedures in orthopaedic oncology. The modular LUMiC ® system was designed to improve fixation stability and reduce…

View details →DOI: 10.3390/life16060955
Negative / Null Result ReportMedicine

Impact of parental psychosocial profile on the effectiveness of oral hygiene interventions in preschool children: a randomised controlled clinical trial in a rural population.

Schade AC, Vilella KD, Neves ETB et al. · 2026 · European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry

Objective To assess the impact of parental psychosocial profile on the effectiveness of educational interventions aiming to improve oral hygiene among preschool children living in a rural area. Methods A controlled randomised trial…

View details →DOI: 10.1007/s40368-026-01229-4
Negative / Null Result ReportMedicine

Partial replacement of soybean meal with sprouted peas or sprouted soybeans in dairy diets in a dual-flow continuous culture system.

Vicente ACS, Salas-Solis GK, Johnson ML et al. · 2026 · Journal of dairy science

Peas (Pisum sativum L.) have 24% CP and could have the potential to partially replace soybean meal (SBM), which is the most used protein source in dairy diets in the USA. Sprouting can improve nutrient availability via enzymatic and…

View details →DOI: 10.3168/jds.2025-27713
Negative / Null Result Report

Effect of social media on patient’s awareness of orthodontic treatment

Sanei A, Asgarian FS, Ebrahiminezhad M · 2026 · Preprint

Abstract Background The lack of studies and sometimes conflicting results in this field, has required that this study be conducted with the aim of improving treatment results in dental health care system. Methods The present study was…

View details →DOI: 10.21203/rs.3.rs-8080200/v1
Negative / Null Result ReportMedicine

Evaluating the need for omentectomy during laparoscopic placement of tunneled peritoneal dialysis catheters in pediatrics: a multicenter comparative study.

Shehata MA, Khirallah MG, Al Nafesa A et al. · 2026 · Pediatric surgery international

Purpose To evaluate whether routine omentectomy improves outcomes during laparoscopic placement of peritoneal dialysis (PD) catheters in children. Methods This multicenter retrospective study included children ≤ 5 years who underwent…

View details →DOI: 10.1007/s00383-026-06464-w
Negative / Null Result ReportMedicine

Rigorous Donor Selection for Fecal Microbiota Transplantation in Active Ulcerative Colitis: Key Lessons From a Randomized Controlled Trial Halted for Futility.

Caenepeel C, Deleu S, Vazquez Castellanos JF et al. · 2025 · Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

Background & aims Rigorous donor preselection on microbiota level, strict anaerobic processing, and repeated fecal microbiota transplantation (FMT) administration were hypothesized to improve FMT induction of remission in ulcerative…

View details →DOI: 10.1016/j.cgh.2024.05.017
Negative / Null Result ReportMedicine

Effect of dietary phosphorus and calcium depletion-repletion on pig performance and bone quality.

Palacios-Duchicela R, Létourneau-Montminy MP, Lizardo R et al. · 2026 · Animal : an international journal of animal bioscience

Feeding strategies such as P and Ca depletion and repletion have been proposed to reduce the use of phosphate or improve P utilisation efficiency in pig diets, thereby contributing to the sustainability of the sector. A total of 48 entire…

View details →DOI: 10.1016/j.animal.2026.101865
Negative / Null Result ReportMedicine

How does prescribed burning in grasslands of coastal southern Texas, USA, impact butterfly populations?

Zerlin RR, Elissetche JC, Avila-Sanchez JS et al. · 2025 · Journal of environmental management

Butterflies are important pollinators worldwide and are often sensitive indicators of ecosystem health. Prescribed fire is used in grassland to mimic historic wildfires, improve forage nutritional value, and increased forb production and…

View details →DOI: 10.1016/j.jenvman.2025.128034
Negative / Null Result ReportMedicine

Cynandione A improves white adipose tissue homeostasis in high-fat diet-fed mice.

Sawamoto A, Shiba M, Okuyama S et al. · 2026 · The Journal of pharmacy and pharmacology

Objectives Cynandione A (CA), a major bioactive compound isolated from Cynanchum wilfordii Radix, is a crude drug traditionally used in East Asia. We have previously demonstrated that CA induces a beige adipocyte-like phenotype in vitro.…

View details →DOI: 10.1093/jpp/rgag038
Negative / Null Result ReportMedicine

Co-administration of digoxin and trans-2-decenoic acid ethyl ester improves motor learning performance in mice.

Fujita E, Hadano J, Hashimoto J et al. · 2026 · Behavioural brain research

Neural circuit formation through synaptogenesis plays a crucial role in learning, memory, and the recovery of neural function following brain dysfunction. We previously reported that administering the low-dose cardiac glycoside digoxin,…

View details →DOI: 10.1016/j.bbr.2026.116225
Negative / Null Result ReportMedicine

Exposure to a high-fat diet compromises gut health, behavior, and HPA axis function, with partial reversal when limited to adolescence.

Ott A, Gül AZ, Löber U et al. · 2026 · Brain research bulletin

High-fat diet (HFD) consumption contributes to obesity, yet its impact on females of (pre)reproductive age and the effects of dietary modification after adolescence remain underexplored. This study examined how continuous HFD exposure or…

View details →DOI: 10.1016/j.brainresbull.2026.111883
Negative / Null Result ReportMedicine

Magnesium supplements, sleep quality, and nocturnal leg cramps: a combination of cross-sectional and prospective studies.

Stadie N, Heinzer R, Marques-Vidal P · 2026 · European journal of nutrition

PURPOSE: Many individuals turn to supplements like magnesium, believing them to offer a natural way to improve sleep quality. Yet, research on magnesium’s effects has produced inconsistent results. We assessed the relationships between…

View details →DOI: 10.1007/s00394-026-03910-2