Negative / Null Result ReportMedicine
Forville H, Coppla FM, Naupari-Villasante R et al. · 2026 · Journal of dentistry
Objective To evaluate whether dentin airborne-particle abrasion (APA) with aluminum oxide affects the retention and clinical performance of composite resin restorations in non-carious cervical lesions (NCCLs). Methods This prospective,…
View details →DOI: 10.1016/j.jdent.2026.106759 Replication FailureMedicine
Chau IJ, Dixon PR, Lin V et al. · 2026 · Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
Objective To identify patient characteristics associated with improvements in speech recognition scores (SRS) and Cochlear Implant Quality of Life (CIQOL-35) scores following cochlear implantation. Study design Multi-institutional…
View details →DOI: 10.1097/mao.0000000000004755 Negative / Null Result ReportMedicine
Yoshida M, Urabe Y, Kadota T et al. · 2026 · Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society
Objectives To investigate whether considering the B2 vessel area (B2VA) size and macroscopic type improves diagnostic performance. Methods In total, 136 esophageal squamous cell carcinoma (ESCCs) with B2 but not B3 vessels were…
View details →DOI: 10.1111/den.70173 Negative / Null Result ReportMedicine
Acar C, Şahin G, Yüksel HÇ et al. · 2026 · Immunotherapy
Background Malnutrition is common in metastatic cancer and may compromise outcomes. We evaluated whether oral nutritional supplementation (ONS) improves survival and compared the performance of nutritional risk scores in immune checkpoint…
View details →DOI: 10.1080/1750743x.2026.2660558 Negative / Null Result Report
Bansaghi S, Klein J · 2026 · Preprint
Background Cruise ships are relatively small, crowded spaces where many people travel in a new environment, making infection control especially important. Proper hand hygiene is the first line of defense against the spread of infection.…
View details →DOI: 10.12688/openreseurope.20172.3 Negative / Null Result ReportMedicine
Kuula L, Pesonen AK · 2026 · The Journal of adolescent health : official publication of the Society for Adolescent Medicine
Purpose Many adolescents develop very late circadian rhythms, indicating delayed sleep phase. Interventions are sparse, and the stability of any improvements is rarely reported. To evaluate how late sleep patterns can be improved, we…
View details →DOI: 10.1016/j.jadohealth.2025.12.247 Negative / Null Result ReportMedicine
Hoyle JD Jr, Ekblad G, Dunwoody S et al. · 2026 · Prehospital emergency care
Objectives We sought to decrease pediatric prehospital dosing errors by implementing a bundled drug dosing safety system (DDSS). Multiple studies have demonstrated that pediatric prehospital drug-dosing errors occur at rates of > 30% for…
View details →DOI: 10.1080/10903127.2025.2609784 Negative / Null Result ReportOpen accessMedicine
Allotey J, Junaid F, Peréz T et al. · 2026 · BMJ neurology open
Background Serum lamotrigine concentrations fall during pregnancy, and therapeutic drug monitoring is often used to guide dose adjustment. We do not know whether serial antenatal measurements improve prediction of seizure risk in pregnant…
View details →DOI: 10.1136/bmjno-2026-001547 Negative / Null Result ReportMedicine
Li JL, Wu JH, Zhao X et al. · 2026 · Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing
BACKGROUND: The role of prophylactic cavotricuspid isthmus (CTI) ablation remains controversial in atrial fibrillation (AF) patients without atrial flutter (AFL). Given the strong association between AF, AFL, and age, this study aimed to…
View details →DOI: 10.1007/s10840-026-02305-x Negative / Null Result ReportOpen accessMedicine
Hertig D, Furian M, Müller J et al. · 2026 · ERJ open research
Background Little is known about the effects of portable supplemental oxygen therapy (SOT) to improve exercise performance in highlanders at risk for high-altitude pulmonary hypertension (HAPH). We aimed to investigate whether SOT improves…
View details →DOI: 10.1183/23120541.00724-2025 Negative / Null Result ReportMedicine
Jeon SH, Song C, Jeon JH et al. · 2026 · Cancer research and treatment
Purpose The aim of this study was to identify subgroups of patients with pathologic N2 (pN2) non-small cell lung cancer (NSCLC) who may benefit from postoperative radiotherapy (PORT). Particular attention was given to evaluating whether…
View details →DOI: 10.4143/crt.2025.644 Negative / Null Result ReportMedicine
Andriotti NM, Paris W, Maia FJ et al. · 2026 · Animal Feed Science and Technology.
Feed additives that improve energy metabolism efficiency can enhance cattle performance and nitrogen use. This study evaluated the effects of guanidinoacetic acid (GAA) and methionine (MET) supplementation, alone or combined, on…
Negative / Null Result ReportMedicine
Perton FT, Pouw JN, Spierings J et al. · 2026 · Arthritis research & therapy
Background To investigate the associations of circulating immune cell biomarkers with clinical manifestations and treatment response in Psoriatic Arthritis (PsA), and to evaluate whether these biomarkers improve prediction of individual…
View details →DOI: 10.1186/s13075-026-03833-7 Negative / Null Result ReportMedicine
Avsar FN, Erinc O, Sahutoglu T · 2026 · Hemodialysis international. International Symposium on Home Hemodialysis
Introduction Depression is prevalent in maintenance hemodialysis patients and is influenced by the interplay of physical and mental health. Rather than a direct antidepressant effect of dialyzer membrane type, improved clearance of middle…
View details →DOI: 10.1111/hdi.70091 Negative / Null Result ReportMedicine
Iurchenkov A, Danilova A, Shilo P et al. · 2026 · Cancers
Background : Immune checkpoint inhibitors have significantly improved survival in metastatic melanoma. Combination nivolumab plus ipilimumab demonstrated superior efficacy in randomized trials, including CheckMate 067, but data beyond the…
View details →DOI: 10.3390/cancers18121994 Negative / Null Result ReportMedicine
Guan X, Li X, Yue M et al. · 2026 · Scientific reports
Pressure injury (PI) prevention requires sustained nursing behaviors from patients, caregivers, and nurses. This single-center quasi-experimental, non-randomized, non-equivalent control group study enrolled 60 inpatients with PI or high PI…
View details →DOI: 10.1038/s41598-026-59843-7 Negative / Null Result ReportOpen accessMedicine
Chen Z, Wang S, Palus S et al. · 2026 · Journal of cachexia, sarcopenia and muscle
Background Cancer cachexia is associated with rapid body wasting and cardiac dysfunction. Bisoprolol (BIS) and megestrol acetate (MA) improve selected cachexia phenotypes in the Yoshida AH-130 model, but their combined effects are not…
View details →DOI: 10.1002/jcsm.70313 Negative / Null Result Report
Miyauchi K, Narita T, Morishita S et al. · 2026 · Preprint
Abstract Background Whether initial dose reduction of apalutamide compromises clinical outcomes in patients with androgen pathway modulation–naïve metastatic prostate cancer remains uncertain. In routine practice, reduced dosing is often…
View details →DOI: 10.21203/rs.3.rs-9259006/v1 Negative / Null Result ReportOpen accessMedicine
Hegde P, Acharya SR, Mayya A et al. · 2026 · International journal of dentistry
Background White spot lesions (WSLs) represent the earliest clinical manifestations of enamel demineralization. Resin infiltration (RI) is a minimally invasive method used to mask WSLs for esthetic improvement; however, infiltrated enamel…
View details →DOI: 10.1155/ijod/9917511 Failed Experiment Report
Bleckwedel J, Nieva RE, González V et al. · 2026 · Preprint
Soybean ( Glycine max [L.] Merr.) productivity is frequently compromised by soil-borne pathogens. Macrophomina phaseolina (Mp), the causal agent of charcoal rot, can produce important soybean yield losses especially when hot and dry…
View details →DOI: 10.64898/2026.05.11.724353 Negative / Null Result Report
Akdag A, Aktas E, Kutlu A et al. · 2026 · Preprint
Abstract Purpose: Residual fragments after retrograde intrarenal surgery (RIRS) may compromise delayed stone-free (SF) status and increase the likelihood of secondary intervention. This study evaluated the association between postoperative…
View details →DOI: 10.21203/rs.3.rs-9849277/v1 Replication Failure
Ho CB, Tran TT, Ngo LT · 2026 · Preprint
Background: /Objectives: Glass-hybrid and high-viscosity glass-ionomer systems aim to improve conventional glass-ionomer performance. This in vitro study compared Vickers hardness and microleakage of a coated glass-hybrid system and a…
View details →DOI: 10.20944/preprints202606.0957.v1 Negative / Null Result ReportMedicine
Dicken S, DeLeon N, Gutierrez EJ et al. · 2026 · American journal of pharmaceutical education
Objective To investigate whether generative artificial intelligence (genAI) can improve pharmacy assessment practices, specifically, rubric development, and the grading of student-written reflection assignments. Methods Sample…
View details →DOI: 10.1016/j.ajpe.2026.102014 Negative / Null Result ReportMedicine
Paasch C, Svendrovski A, Usher J et al. · 2026 · Hernia : the journal of hernias and abdominal wall surgery
Purpose This study aims to evaluate the impact of frailty on postoperative outcomes after Shouldice primary inguinal hernia Repair (SPIHR) as a quality control measure in a highly standardized elective setting. Methods This quality…
View details →DOI: 10.1007/s10029-026-03760-1 Negative / Null Result ReportMedicine
Abdelsalam H, Abdalla M, Aied N et al. · 2026 · Medicina (Kaunas, Lithuania)
Background and Objectives : Adenoidectomy is a common pediatric procedure performed and endoscopic, instrumented techniques such as a powered microdebrider and coblation aim to improve visualization and completeness of resection while…
View details →DOI: 10.3390/medicina62061048 Negative / Null Result Report
Yokoyama T, Uchino T, Yazawa Y et al. · 2026 · Preprint
Abstract Background Oral semaglutide, a glucagon-like peptide-1 receptor agonist, improves glycemic control and reduces body weight in patients with type 2 diabetes. Although proton pump inhibitors (PPIs) have been reported to slightly…
View details →DOI: 10.21203/rs.3.rs-9444720/v1 Negative / Null Result ReportMedicine
Aydilek A, Erdem Y · 2026 · BMC surgery
Background Posterior malleolar fractures accompanying trimalleolar ankle injuries may compromise joint stability and lead to long-term functional impairment. However, the impact of posterior malleolar fragment (PMF) size on postoperative…
View details →DOI: 10.1186/s12893-026-03910-3 Negative / Null Result ReportMedicine
Bouali B, Rezzaoui A, Hamzeh-Cognasse H et al. · 2026 · Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine
Background Pathogen reduction treatment (PRT) of platelet concentrates (PC) is one of the most recent advances in improving blood safety and lowering the risk of transfusion-transmitted diseases. The characteristics of PR-treated PC differ…
View details →DOI: 10.1016/j.tracli.2026.02.005 Negative / Null Result ReportMedicine
Chiona BC, Mbakaya BC, Liu MF · 2026 · Nurse education in practice
Aim To evaluate the effectiveness of Standardized Patient Simulation (SPS) compared with lecture-based teaching in improving dementia knowledge, dementia screening skills and mild cognitive impairment (MCI) classification accuracy among…
View details →DOI: 10.1016/j.nepr.2026.104884 Negative / Null Result ReportMedicine
Adams JL, Tong A, Chen P et al. · 2026 · Journal of emergency nursing
Introduction Team triage incorporates collaborative evaluation by physicians and nurses during initial assessment, differing from conventional nurse-only triage models. Although previous studies have demonstrated improvements in wait times…
View details →DOI: 10.1016/j.jen.2026.04.016 