Negative / Null Result ReportMedicine
Piazza FRG, Schuch JB, Ferreira DNSDS et al. · 2025 · Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)
Objective N-acetylcysteine (NAC) is a medication known for its hepatoprotective properties and potential to reduce cravings and psychoactive substance use. Vitamin D is metabolized in the liver, and individuals with alcohol abuse often…
View details →DOI: 10.47626/1516-4446-2025-4304 Negative / Null Result ReportMedicine
Chen PA, Hsueh YC, Lin YC et al. · 2026 · The Journal of arthroplasty
Background Whether the addition of magnesium sulfate (MgSO 4 ) to intra-articular analgesic cocktails improves early pain after total knee arthroplasty (TKA) remains uncertain. Methods This prospective, double-blind, within-patient…
View details →DOI: 10.1016/j.arth.2026.04.066 Replication FailureMedicine
Khadanga S, Yant B, Savage PD et al. · 2026 · Journal of cardiopulmonary rehabilitation and prevention
Purpose Despite the benefits, cardiac rehabilitation (CR) is underutilized, particularly in women. Case management (CM) has been shown to reduce the risk of cardiovascular disease and improve health outcomes. The purpose of this study was…
View details →DOI: 10.1097/hcr.0000000000001040 Negative / Null Result Report
Dinç G, Öztürk B, Ciğerim SÇ · 2026 · Preprint
Abstract Objectives Sagittal skeletal classification is central to orthodontic diagnosis. This study aimed to (1) develop and validate an interpretable machine learning (ML) model for three-class sagittal skeletal classification (Class I,…
View details →DOI: 10.21203/rs.3.rs-9470812/v1 Negative / Null Result ReportMedicine
Ptaszek B, Kurek O, Podsiadło S · 2026 · Lymphatic research and biology
Purpose In times when health and physical activity are gaining in value, the search for effective methods to support fitness and improve quality of life is becoming a priority. One of the therapies that is gaining increasing popularity is…
View details →DOI: 10.1177/15578585261461974 Negative / Null Result ReportMedicine
Toillon I, Badoud I, Ferrari S et al. · 2026 · Bone
Type 1 diabetes is associated with increased fracture risk, yet the respective contributions of insulin deficiency and replacement to skeletal fragility remain poorly understood. Using insulin-deficient male Akita mice, we characterized…
View details →DOI: 10.1016/j.bone.2026.117971 Negative / Null Result ReportMedicine
Bretzman J, Andrews J, Ge S et al. · 2026 · Journal of vascular and interventional radiology : JVIR
Purpose To determine the patency of portal vein stents in patients with pancreatic cancer, identify risk factors for stent occlusion, and determine whether anticoagulation improves stent patency. Materials and methods Patients with…
View details →DOI: 10.1016/j.jvir.2026.108852 Negative / Null Result ReportMedicine
Guo ZM, Cui F, Zhang Y et al. · 2026 · BMC anesthesiology
Background Complex spinal surgery is associated with significant trauma and pain. Herein we tested the hypothesis that increasing the dose of esketamine, as a supplement to patient-controlled analgesia, might improve pain relief after…
View details →DOI: 10.1186/s12871-026-03962-1 Negative / Null Result ReportMedicine
Gillessen S, Gobat K, Cathomas R et al. · 2026 · European urology oncology
Background and objective The aim of our study is to determine whether the addition of metformin to enzalutamide can improve the outcomes of men with metastatic castration-resistant prostate cancer (mCRPC). Methods From 2016 to 2021,…
View details →DOI: 10.1016/j.euo.2026.03.001 Negative / Null Result ReportMedicine
Aglen T, Matre KH, Selles RW et al. · 2026 · Journal of hand therapy : official journal of the American Society of Hand Therapists
Background Collagenase treatment can improve finger extension and hand function in patients with Dupuytren's disease. The role of hand therapy in enhancing or prolonging these effects remains unclear. Purpose The primary aim was to examine…
View details →DOI: 10.1016/j.jht.2026.02.004 Negative / Null Result ReportMedicine
McClure Z, Fuller-Tyszkiewicz M, Messer M et al. · 2026 · The International journal of eating disorders
Objective Although a range of evidence-based treatments for eating disorders exist, treatment response varies substantially. The ability to match individuals to a treatment which they are most likely to benefit from may help improve…
View details →DOI: 10.1002/eat.70112 Negative / Null Result ReportMedicine
Khatri D, Poudel S, Pun Magar L et al. · 2026 · Frontiers in plant science
Soybean meal quality for monogastric animals is limited by low sulfur-containing amino acids, especially methionine and cysteine, while oil oxidative stability is restricted by the high polyunsaturated fatty acid content. This two-year…
View details →DOI: 10.3389/fpls.2026.1849670 Negative / Null Result ReportMedicine
Müller D, Gillani A, Hirschmann MT et al. · 2026 · Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA
Purpose Accurate risk adjustment in total knee arthroplasty (TKA) is essential for outcome prediction and quality assessment. Most existing prediction models rely solely on patient demographics and comorbidities and do not account for…
View details →DOI: 10.1002/ksa.70480 Negative / Null Result ReportMedicine
Stanula A, Strzała M, Sadowski W et al. · 2026 · Scientific reports
Post-activation performance enhancement (PAPE) has been proposed as an acute strategy to improve explosive performance, yet its effects on sprint-swimming performance remain unclear, particularly when individualized recovery timing is…
View details →DOI: 10.1038/s41598-026-51746-x Negative / Null Result ReportMedicine
Papadogiorgou G, Koskinioti P, Rodovitis V et al. · 2026 · Bulletin of entomological research
Thermal stress can affect the field performance of sterile males used in the sterile insect technique (SIT). We tested whether adding autoclaved Enterobacter as a dietary supplement improves thermal tolerance in sterile Vienna 8 genetic…
View details →DOI: 10.1017/s0007485326101035 Negative / Null Result ReportMedicine
Perez SB, Lau JA · 2026 · Ecology
Identifying the factors mediating the resilience and invariability of plant communities and their associated ecosystem functions is critical to understand the ecological impacts of climate change. Prior work has explored how classic…
View details →DOI: 10.1002/ecy.70421 Negative / Null Result ReportMedicine
Ekhaguere OA, Kesman R, Reiter J et al. · 2026 · The Journal of pediatrics
Objective To evaluate whether static ultrasound improves first-attempt, nontraumatic lumbar puncture (LP) success compared with the traditional landmark technique in infants admitted to a neonatal intensive care unit (NICU). Study design…
View details →DOI: 10.1016/j.jpeds.2026.115139 Negative / Null Result ReportMedicine
Al-Ibraheem A, Moghrabi S, Alsyouf B et al. · 2026 · Cancers
Background : [ 68 Ga]Ga-FAPI PET/CT demonstrates high sensitivity for tumor detection but limited specificity because benign fibro-inflammatory conditions may also show tracer uptake. Dual-time-point imaging has been proposed to improve…
View details →DOI: 10.3390/cancers18121963 Negative / Null Result ReportMedicine
Herrera-Elizondo JL, Jiménez-Castillo RA, García-Compeán D et al. · 2026 · Revista de gastroenterologia de Mexico (English)
Introduction and aims The usefulness of metoclopramide for improving endoscopic visualization in upper gastrointestinal bleeding (UGIB) is controversial. Our primary aim was to evaluate the utility of metoclopramide 20 mg/IV for endoscopic…
View details →DOI: 10.1016/j.rgmxen.2026.05.005 Negative / Null Result ReportMedicine
Naghizade B, Özyazgan İ, Bozkurt F et al. · 2026 · Journal of plastic, reconstructive & aesthetic surgery : JPRAS
Background Autologous fat grafting is widely used in plastic surgery, but graft survival remains unpredictable, particularly under compromised conditions such as cigarette smoking. Smoking impairs microcirculation and tissue oxygenation,…
View details →DOI: 10.1016/j.bjps.2026.05.060 Negative / Null Result ReportMedicine
Schlaepfer CH, Lange SM, Lau GA et al. · 2026 · JAMA pediatrics
Importance People with spina bifida historically have worse survival. Despite health care improvements, survival improvement data are mixed. Objectives To compare survival for people with spina bifida to an unaffected cohort and to…
View details →DOI: 10.1001/jamapediatrics.2026.2241 Negative / Null Result ReportMedicine
Morningstar M, Edwards M, Yang L et al. · 2026 · CJEM
Objectives To systematically identify and describe optimal methodology used to improve the diagnostic accuracy of high-sensitivity cardiac troponin for diagnosis of myocardial infarction in patients with kidney dysfunction. Methods…
View details →DOI: 10.1007/s43678-026-01168-5 Negative / Null Result ReportMedicine
Sroypechr K, Hutchinson C, Satheannoppakao W et al. · 2026 · BMC nutrition
Background The folate status of women of reproductive age (WRA) in Thailand is suboptimal for reducing risk of neural tube defects (NTD). This research aimed to compare the effect of dietary folate education based on the health belief…
View details →DOI: 10.1186/s40795-026-01375-4 Negative / Null Result ReportOpen accessMedicine
Hong S, Lee S, Park JS et al. · 2026 · Journal of clinical medicine
Background : We evaluated whether adding S100B to NSE improved discrimination or high-specificity rule-in of poor neurological outcome after out-of-hospital cardiac arrest (OHCA). Methods : In this single-center retrospective cohort study,…
View details →DOI: 10.3390/jcm15083043 Negative / Null Result ReportMedicine
Leake HB, Wallwork SB, Moseley GL · 2026 · The journal of pain
Pain science education (PSE) aims to shift unhelpful beliefs about pain and improve clinical outcomes. However, some people report little improvement after receiving PSE-informed care. Understanding their perspectives may help refine…
View details →DOI: 10.1016/j.jpain.2026.106304 Negative / Null Result ReportMedicine
Nehme Z, Mahony E, Nehme E et al. · 2026 · Resuscitation
Aim To determine whether defibrillation with manual pressure augmentation (MPA) reduces transthoracic impedance and improves cardioversion and survival from initially shockable out-of-hospital cardiac arrest (OHCA) compared with standard…
View details →DOI: 10.1016/j.resuscitation.2026.111121 Negative / Null Result ReportMedicine
Allende JB, Campos-Bijit V, Morales-Gómez C et al. · 2026 · Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.]
Objective To synthesize umbrella-level evidence on laser or light activation and photobiomodulation in in-office dental bleaching, including whitening efficacy, tooth sensitivity, and biological safety. Systematic reviews were searched in…
View details →DOI: 10.1111/jerd.70176 Negative / Null Result ReportMedicine
Melamed A, Small K, McCourt C et al. · 2026 · Midwifery
Problem Antenatal risk assessment and classification dominates midwifery care but may not be improving outcomes and may introduce iatrogenic harm. Background Midwifery-led care and birth settings promote good birth outcomes and women's…
View details →DOI: 10.1016/j.midw.2026.104789 Negative / Null Result ReportMedicine
Kiraly P, Lippera M, Ally N et al. · 2026 · Retina (Philadelphia, Pa.)
Purpose To assess whether external drainage of subretinal fluid (SRF) improves anatomical or visual outcomes in scleral buckle surgery for rhegmatogenous retinal detachment (RRD). Methods Retrospective review of 609 primary scleral buckles…
View details →DOI: 10.1097/iae.0000000000004856 Negative / Null Result ReportMedicine
Azulay N, Singstad BJ, Schirmer H et al. · 2026 · Scientific reports
In Norway, NORRISK2 is the government-recommended risk model for predicting an individual's 10-year probability of getting cardiovascular disease (CVD). This study aims to investigate the potential for improvement of CVD prediction by…
View details →DOI: 10.1038/s41598-026-57003-5 