Negative / Null Result ReportOpen accessMedicine
Jennifer L. Tenor, Stefan H. Oehlers, Jialu L. Yang et al. · 2015 · mBio
UNLABELLED: The human fungal pathogen Cryptococcus neoformans is capable of infecting a broad range of hosts, from invertebrates like amoebas and nematodes to standard vertebrate models such as mice and rabbits. Here we have taken advantage of a zebrafish model to investigate host-pathogen interactions of Cryptococcus with the zebrafish innate immune system, which shares a highly conserved framework with that of mammals. Through live-imaging observations and genetic knockdown, we establish that macrophages are the primary immune cells responsible for responding to and containing acute cryptoco
View details →DOI: 10.1128/mbio.01425-15Cited by 78 Negative / Null Result ReportOpen accessMedicine
Philippa Garety, Clementine Edwards, Hassan Jafari et al. · 2024 · Nature Medicine
Distressing voices are a core symptom of psychosis, for which existing treatments are currently suboptimal; as such, new effective treatments for distressing voices are needed. AVATAR therapy involves voice-hearers engaging in a series of facilitated dialogues with a digital embodiment of the distressing voice. This randomized phase 2/3 trial assesses the efficacy of two forms of AVATAR therapy, AVATAR-Brief (AV-BRF) and AVATAR-Extended (AV-EXT), both combined with treatment as usual (TAU) compared to TAU alone, and conducted an intention-to-treat analysis. We recruited 345 participants with p
View details →DOI: 10.1038/s41591-024-03252-8Cited by 73 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Sigrid Hatse, Barbara Brouwers, Bruna Dalmasso et al. · 2014 · PLoS ONE
Circulating microRNAs (miRNAs) hold great promise as easily accessible biomarkers for diverse (patho)physiological processes, including aging. We have compared miRNA expression profiles in cell-free blood from older versus young breast cancer patients, in order to identify "aging miRNAs" that can be used in the future to monitor the impact of chemotherapy on the patient's biological age. First, we assessed 175 miRNAs that may possibly be present in serum/plasma in an exploratory screening in 10 young and 10 older patients. The top-15 ranking miRNAs showing differential expression between young
View details →DOI: 10.1371/journal.pone.0110644Cited by 67 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Annette A. Angus, David J. Evans, Joseph Barbieri et al. · 2010 · Infection and Immunity
Pseudomonas aeruginosa can establish a niche within the plasma membrane of epithelial cells (bleb niches) within which bacteria can survive, replicate, and swim at speeds detectable by real-time phase-contrast imaging. This novel virulence…
View details →DOI: 10.1128/iai.00417-10Cited by 67 Negative / Null Result ReportOpen accessMedicine
Yoshiyuki Konishi, Yoshihiro Muragaki, Hiroshi Iseki et al. · 2012 · Neurologia medico-chirurgica
The present retrospective study evaluated the recurrence patterns after aggressive surgical removal of intracranial glioblastomas in 43 consecutive adult patients. The resection rate of the enhanced lesion on magnetic resonance imaging was…
View details →DOI: 10.2176/nmc.52.577Cited by 67 Negative / Null Result ReportOpen accessPsychology
Tammi R. A. Kral, Kaley Davis, Cole Korponay et al. · 2022 · Science Advances
Studies purporting to show changes in brain structure following the popular, 8-week mindfulness-based stress reduction (MBSR) course are widely referenced despite major methodological limitations. Here, we present findings from a large, combined dataset of two, three-arm randomized controlled trials with active and waitlist (WL) control groups. Meditation-naïve participants ( n = 218) completed structural magnetic resonance imaging scans during two visits: baseline and postintervention period. After baseline, participants were randomly assigned to WL ( n = 70), an 8-week MBSR program ( n = 75)
View details →DOI: 10.1126/sciadv.abk3316Cited by 67 Negative / Null Result Report
Shuming Jiao, Yang Gao, Jun Feng et al. · 2020 · Optics Express
Deep learning has been extensively applied in many optical imaging problems in recent years. Despite the success, the limitations and drawbacks of deep learning in optical imaging have been seldom investigated. In this work, we show that…
View details →DOI: 10.1364/oe.382319Cited by 63 Negative / Null Result ReportOpen accessMedicine
Harri Merisaari, Parisa Movahedi, Ileana Montoya Perez et al. · 2016 · Magnetic Resonance in Medicine
Purpose To evaluate different fitting methods for intravoxel incoherent motion (IVIM) imaging of prostate cancer in the terms of repeatability and Gleason score prediction. Methods Eighty‐one patients with histologically confirmed prostate…
View details →DOI: 10.1002/mrm.26169Cited by 60 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Katarzyna A. Cieslik, George E. Taffet, Jeffrey R. Crawford et al. · 2013 · Journal of Molecular and Cellular Cardiology
We have demonstrated that scar formation after myocardial infarction (MI) is associated with an endogenous pool of CD44(pos)CD45(neg) multipotential mesenchymal stem cells (MSC). MSC differentiate into fibroblasts secreting collagen that forms a scar and mature into myofibroblasts that express alpha smooth muscle actin (α-SMA) that stabilizes the scar. In the aging mouse, cardiac repair after MI is associated with impaired differentiation of MSC; MSC derived from the aged hearts form dysfunctional fibroblasts that deposit less collagen in response to transforming growth factor beta-1 (TGF-β1)
View details →DOI: 10.1016/j.yjmcc.2013.07.005Cited by 58 Negative / Null Result ReportOpen accessNeuroscience
Adrienne L. Romer, Annchen R. Knodt, Maria L. Sison et al. · 2019 · Molecular Psychiatry
Transdiagnostic research has identified a general psychopathology factor-often called the 'p' factor-that accounts for shared variation across internalizing, externalizing, and thought disorders in diverse samples. It has been argued that the p factor may reflect dysfunctional thinking present in serious mental illness. In support of this, we previously used a theory-free, data-driven multimodal neuroimaging approach to find that higher p factor scores are associated with structural alterations within a cerebello-thalamo-cortical circuit (CTCC) and visual association cortex, both of which are
View details →DOI: 10.1038/s41380-019-0621-zCited by 56 Negative / Null Result Report
Safina Islam, Olivia Joseph, Atiha Chaudry et al. · 2021 · Research Involvement and Engagement
Abstract Background Public involvement in clinical translational research is increasingly recognised as essential for relevant and reliable research. Public involvement must be diverse and inclusive to enable research that has the…
View details →DOI: 10.1186/s40900-021-00292-zCited by 55 Negative / Null Result ReportSocial Sciences
Richard Stansfield, Thomas J. Mowen, Thomas P. O’Connor et al. · 2016 · Journal of Research in Crime and Delinquency
Objective: Research on the relationship between religion and criminal recidivism has produced encouraging but ultimately inconclusive findings. This study offers a new direction for studying the role of religious support in reentry,…
View details →DOI: 10.1177/0022427816657578Cited by 54 Negative / Null Result ReportOpen accessMedicine
Andrew Poppe, Deanna M. Barch, Cameron S. Carter et al. · 2016 · Schizophrenia Bulletin
Patients with schizophrenia (SZ) previously demonstrated specific deficits in an executive function known as goal maintenance, associated with reduced middle frontal gyrus (MFG) activity. This study aimed to validate a new tool-the Dot…
View details →DOI: 10.1093/schbul/sbw036Cited by 52 Negative / Null Result ReportOpen accessNeuroscience
Kai Schreiber, Bart Krekelberg · 2013 · PLoS ONE
The goal of multi-voxel pattern analysis (MVPA) in BOLD imaging is to determine whether patterns of activation across multiple voxels change with experimental conditions. MVPA is a powerful technique, its use is rapidly growing, but it poses serious statistical challenges. For instance, it is well-known that the slow nature of the BOLD response can lead to greatly exaggerated performance estimates. Methods are available to avoid this overestimation, and we present those here in tutorial fashion. We go on to show that, even with these methods, standard tests of significance such as Students' T
View details →DOI: 10.1371/journal.pone.0069328Cited by 51 Negative / Null Result ReportOpen accessMedicine
Hamzah Abu‐Sbeih, Cynthia N. Tran, Phillip S. Ge et al. · 2019 · Journal for ImmunoTherapy of Cancer
BACKGROUND: Immune checkpoint inhibitors (ICIs) represent a promising novel class of cancer therapy, but immune-mediated adverse events can complicate ICI treatment. Acute cholecystitis in patients receiving ICI therapy has not been characterized. We aimed to describe the clinical features of patients who developed ICI-related cholecystitis. METHODS: We evaluated a case series of patients at a tertiary cancer center who received ICI therapy and developed cholecystitis, diagnosed by clinical presentation and diagnostic imaging, during 2010-2018. Patients with a history of chronic cholecystitis
View details →DOI: 10.1186/s40425-019-0604-2Cited by 50 Negative / Null Result ReportOpen accessMedicine
Brian Martin, Beth A. Gabris-Weber, Rajiv P. Reddy et al. · 2018 · PLoS ONE
BACKGROUND: 'Healthy' aging drives structural and functional changes in the heart including maladaptive electrical remodeling, fibrosis and inflammation, which lower the threshold for cardiovascular diseases such as heart failure (HF) and atrial fibrillation (AF). Despite mixed results in recent clinical trials, Relaxin-therapy for 2-days could reduce mortality by 37% at 180-days post-treatment, in patients with acute decompensated HF. Relaxin's short life-span (hours) but long-lasting protective actions led us to test the hypothesis that relaxin acts at a genomic level to reverse maladaptive
View details →DOI: 10.1371/journal.pone.0190935Cited by 48 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Fabio Morgante, Wen Huang, Peter Sørensen et al. · 2020 · G3 Genes Genomes Genetics
Abstract The ability to accurately predict complex trait phenotypes from genetic and genomic data are critical for the implementation of personalized medicine and precision agriculture; however, prediction accuracy for most complex traits is currently low. Here, we used data on whole genome sequences, deep RNA sequencing, and high quality phenotypes for three quantitative traits in the ∼200 inbred lines of the Drosophila melanogaster Genetic Reference Panel (DGRP) to compare the prediction accuracies of gene expression and genotypes for three complex traits. We found that expression levels (r
View details →DOI: 10.1534/g3.120.401847Cited by 48 Negative / Null Result ReportPsychology
Irene M. Pepperberg, Leigh Ann Hartsfield · 2014 · Journal of comparative psychology
Linking specific cognitive abilities of nonhuman species on a laboratory task to their evolutionary history-ecological niche can be a fruitful exercise in comparative psychology. Crucial issues, however, are the choice of task, the…
View details →DOI: 10.1037/a0036205Cited by 46 Negative / Null Result ReportEngineering
John Keane, Wei Zhang, Chris H. Kim · 2011 · IEEE Journal of Solid-State Circuits
Variations in the number and characteristics of charges or traps contributing to transistor degradation lead to a distribution of device “ages” at any given time. This issue is well understood in the study of time dependent dielectric…
View details →DOI: 10.1109/jssc.2011.2160813Cited by 45 Negative / Null Result ReportOpen accessMedicine
Catarina Dinis Fernandes, Cuong V. Dinh, Iris Walraven et al. · 2018 · Physics and Imaging in Radiation Oncology
BACKGROUND AND PURPOSE: High-risk prostate cancer patients are frequently treated with external-beam radiotherapy (EBRT). Of all patients receiving EBRT, 15-35% will experience biochemical recurrence (BCR) within five years. Magnetic…
View details →DOI: 10.1016/j.phro.2018.06.005Cited by 43 Negative / Null Result ReportOpen accessMedicine
Fulya Akpinar, Andrea C. Timm, John Yin · 2015 · Journal of Virology
UNLABELLED: Defective interfering particles (DIPs) are virus mutants that lack essential genes for growth. In coinfections with helper virus, the diversion of viral proteins to the replication and packaging of DIP genomes can interfere…
View details →DOI: 10.1128/jvi.02190-15Cited by 43 Negative / Null Result ReportBusiness, Management and Accounting
Olenka Kacperczyk, Peter Younkin · 2021 · Organization Science
There is both widespread interest in encouraging entrepreneurship and universal recognition that the vast majority of these founders will fail, which raises an important unanswered question: What happens to ex-founders when they apply for…
View details →DOI: 10.1287/orsc.2021.1456Cited by 43 Negative / Null Result ReportOpen accessBusiness, Management and Accounting
Ulrike Fasbender, Anne Burmeister, Mo Wang · 2023 · Journal of Vocational Behavior
In this paper, we investigate the risks and side effects of workplace friendships for coworkers. Combining the dialectical perspective on workplace friendships with a self-regulatory perspective, we argue that workplace friendships can…
View details →DOI: 10.1016/j.jvb.2023.103875Cited by 42 Negative / Null Result ReportOpen accessMaterials Science
Mohammad W. Marashdeh, Baker Ababneh, O. M. Lemine et al. · 2019 · Results in Physics
In this study, iron oxide (γ-Fe2O3) nanoparticles (IONs) were successfully synthesized using sol-gel method, and characterized by XRD and VSM. The potential application of the differently sized IONs (22 nm and 30 nm) as magnetic resonance…
View details →DOI: 10.1016/j.rinp.2019.102651Cited by 41 Negative / Null Result ReportOpen accessMedicine
Zhiyong Liu, Weitao Yao, Yao Zhao et al. · 2021 · Cancer Management and Research
PURPOSE: Anlotinib is a novel tyrosine kinase inhibitor with promising anti-tumor activity in patients with advanced soft tissue sarcomas (STS) in China. Liposomal doxorubicin monotherapy showed an encouraging effect on this disease. The…
View details →DOI: 10.2147/cmar.s286322Cited by 41 Negative / Null Result ReportOpen accessMedicine
Ellen W. Demerath, Nikki Lynn Rogers, Derek Reed et al. · 2010 · Annals of Human Biology
BACKGROUND: Elevated visceral adiposity is strongly predictive of cardiometabolic disease, but, due to the high cost of biomedical imaging, assessment of factors contributing to normal variation in visceral (VAT) and subcutaneous (SAT)…
View details →DOI: 10.3109/03014460.2010.524893Cited by 39 Negative / Null Result ReportOpen accessHealth Professions
Kian Zarchi, S Latif, Vibeke B. Haugaard et al. · 2014 · Acta Dermato Venereologica
Wounds represent a growing healthcare problem due to an aging population. Nurses play a key role in wound management and their theoretical understanding of basic wound management may be expected to influence the quality of wound therapy…
View details →DOI: 10.2340/00015555-1770Cited by 39 Negative / Null Result ReportOpen accessMedicine
Kosuke Kitamura, Toshiyuki China, Mayuko Kanayama et al. · 2018 · Prostate International
To determine the clinical predictive factors affecting the recovery from postoperative urinary incontinence after robot-assisted radical prostatectomy (RARP). We consecutively analyzed 320 patients who underwent RARP between January 2012…
View details →DOI: 10.1016/j.prnil.2018.06.003Cited by 37 Negative / Null Result ReportOpen accessNeuroscience
Anna Maria Matziorinis, Christian Gaser, Stefan Koelsch · 2022 · Brain Structure and Function
Music-making and engagement in music-related activities have shown procognitive benefits for healthy and pathological populations, suggesting reductions in brain aging. A previous brain aging study, using Brain Age Gap Estimation (BrainAGE), showed that professional and amateur-musicians had younger appearing brains than non-musicians. Our study sought to replicate those findings and analyze if musical training or active musical engagement was necessary to produce an age-decelerating effect in a cohort of healthy individuals. We scanned 125 healthy controls and investigated if musician status,
View details →DOI: 10.1007/s00429-022-02602-xCited by 36 Negative / Null Result ReportOpen accessMedicine
Ilkka Koskivuo, Jukka Kemppainen, Salvatore Giordano et al. · 2016 · Acta Oncologica
BACKGROUND: Whole body positron emission tomography (PET)/computed tomography (CT) is a sensitive imaging technique in patients with metastatic melanoma, but its role in the follow-up of asymptomatic high-risk patients is unclear. The aim…
View details →DOI: 10.1080/0284186x.2016.1213879Cited by 35 