Negative / Null Result ReportOpen accessPhysics and Astronomy
C. Abel, N. J. Ayres, G. Ban et al. · 2017 · Physical Review X
We report on a search for ultralow-mass axionlike dark matter by analyzing the ratio of the spinprecession frequencies of stored ultracold neutrons and 199 Hg atoms for an axion-induced oscillating electric dipole moment of the neutron and an axion-wind spin-precession effect. No signal consistent with dark matter is observed for the axion mass range 10 -24 m a 10 -17 eV. Our null result sets the first laboratory constraints on the coupling of axion dark matter to gluons, which improve on astrophysical limits by up to 3 orders of magnitude, and also improves on previous laboratory constraints
View details →DOI: 10.1103/physrevx.7.041034Cited by 171 Negative / Null Result ReportOpen accessMedicine
Richard Aplenc, Soheil Meshinchi, Lillian Sung et al. · 2020 · Haematologica
New therapeutic strategies are needed for pediatric acute myeloid leukemia (AML) to reduce disease recurrence and treatment-related morbidity. The Children’s Oncology Group Phase III AAML1031 trial tested whether the addition of bortezomib…
View details →DOI: 10.3324/haematol.2019.220962Cited by 169 Negative / Null Result ReportOpen accessMedicine
Hendrikus J. A. van Os, Lucas A. Ramos, Adam Hilbert et al. · 2018 · Frontiers in Neurology
Background: Endovascular treatment (EVT) is effective for stroke patients with a large vessel occlusion (LVO) of the anterior circulation. To further improve personalized stroke care, it is essential to accurately predict outcome after EVT. Machine learning might outperform classical prediction methods as it is capable of addressing complex interactions and non-linear relations between variables. Methods: We included patients from the Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands (MR CLEAN) Registry, an observational cohort of LVO
View details →DOI: 10.3389/fneur.2018.00784Cited by 164 Negative / Null Result ReportOpen accessMedicine
Sandy R. Shultz, David Wright, Ping Zheng et al. · 2015 · Brain
Traumatic brain injury is a common and serious neurodegenerative condition that lacks a pharmaceutical intervention to improve long-term outcome. Hyperphosphorylated tau is implicated in some of the consequences of traumatic brain injury…
View details →DOI: 10.1093/brain/awv053Cited by 159 Negative / Null Result ReportOpen accessMedicine
Allison Bond, Heather Mason, Chelsey Lemaster et al. · 2013 · Medical Education Online
OBJECTIVE: An effective career in medicine requires empathy and compassion, yet the demands of a medical education increase stress and decrease students' ability to connect with patients. However, research suggests mind-body practices improve psychological well-being. This study aimed to evaluate the psychological effects on medical students of an 11-week elective course, Embodied Health or EH, which combines yoga and meditation with neuroscience didactics. METHODS: The effects on 27 first- and second-year medical students were evaluated via surveys in four areas: empathy, perceived stress, se
View details →DOI: 10.3402/meo.v18i0.20699Cited by 156 Negative / Null Result ReportOpen accessComputer Science
Sunbok Lee, Jae Young Chung · 2019 · Applied Sciences
A dropout early warning system enables schools to preemptively identify students who are at risk of dropping out of school, to promptly react to them, and eventually to help potential dropout students to continue their learning for a better future. However, the inherent class imbalance between dropout and non-dropout students could pose difficulty in building accurate predictive modeling for a dropout early warning system. The present study aimed to improve the performance of a dropout early warning system: (a) by addressing the class imbalance issue using the synthetic minority oversampling t
View details →DOI: 10.3390/app9153093Cited by 155 Negative / Null Result ReportPsychology
Guillermo Campitelli, Fernand Gobet · 2011 · Current Directions in Psychological Science
Deliberate practice (DP) occurs when an individual intentionally repeats an activity in order to improve performance. The claim of the DP framework is that such behavior is necessary to achieve high levels of expert performance. The…
View details →DOI: 10.1177/0963721411421922Cited by 155 Negative / Null Result ReportMedicine
Gerrit Fischer, Axel Stadie, Róbert Reisch et al. · 2011 · Operative Neurosurgery
BACKGROUND: Improvements in preoperative imaging and intraoperative visualization have led to a refinement in surgical techniques. OBJECTIVE: Report of a 20-year experience with application of the keyhole technique as a contribution to the…
View details →DOI: 10.1227/neu.0b013e31820934caCited by 155 Negative / Null Result ReportAgricultural and Biological Sciences
Kazushi Takahashi, Christopher B. Barrett · 2013 · American Journal of Agricultural Economics
Abstract The yield potential of a set of improved rice management practices, known as the System of Rice Intensification (SRI), has attracted much attention. Yet we know surprisingly little about SRI's socio‐economic impact. Using data…
View details →DOI: 10.1093/ajae/aat086Cited by 152 Negative / Null Result ReportEconomics, Econometrics and Finance
Jill R. Horwitz, Brenna D. Kelly, John DiNardo · 2013 · Health Affairs
The Affordable Care Act encourages workplace wellness programs, chiefly by promoting programs that reward employees for changing health-related behavior or improving measurable health outcomes. Recognizing the risk that unhealthy employees…
View details →DOI: 10.1377/hlthaff.2012.0683Cited by 147 Negative / Null Result ReportOpen accessSocial Sciences
Stephen J. Macdonald, John Clayton · 2012 · Disability & Society
The aim of this article is to explore disability and the digital divide using a quantitative methodology. The research investigates what impact digital technologies have had in improving the life-chances for disabled people from deprived neighbourhoods in the northeast of England. The study explores how disabled people engage with digital and assistive technologies in order to overcome disabling barriers and social exclusion. Unfortunately, the analysis found no evidence that digital and assistive technologies had any impact on reducing social exclusion for disabled people. In fact, the resear
View details →DOI: 10.1080/09687599.2012.732538Cited by 146 Negative / Null Result ReportHealth Professions
Heribert Limm, Harald Gündel, Mechthild Heinmüller et al. · 2010 · Occupational and Environmental Medicine
OBJECTIVE: To examine the long-term effects of a stress management intervention (SMI) based on the effort-reward imbalance (ERI) model, on psychological and biological reactions to work stress. METHODS: 174 lower or middle management…
View details →DOI: 10.1136/oem.2009.054148Cited by 143 Negative / Null Result ReportOpen accessImmunology and Microbiology
Ravi A. Madan, James L. Gulley, Tito Fojo et al. · 2010 · The Oncologist
Therapeutic cancer vaccines represent a new class of agents in the treatment of cancer. Sipuleucel-T is an antigen-presenting cell-based vaccine that recently demonstrated a significant 4.8-month improvement in overall survival in advanced…
View details →DOI: 10.1634/theoncologist.2010-0129Cited by 142 Negative / Null Result ReportOpen accessNeuroscience
U. Müller, James B. Rowe, Timothy Rittman et al. · 2012 · Neuropharmacology
BACKGROUND: Modafinil, a putative cognitive enhancing drug, has previously been shown to improve performance of healthy volunteers as well as patients with attention deficit disorder and schizophrenia, mainly in tests of executive functions. The aim of this study was to investigate the effects of modafinil on non-verbal cognitive functions in healthy volunteers, with a particular focus on variations of cognitive load, measures of motivational factors and the effects on creative problem-solving. METHODS: A double-blind placebo-controlled parallel design study evaluated the effect of 200 mg of m
View details →DOI: 10.1016/j.neuropharm.2012.07.009Cited by 142 Negative / Null Result ReportOpen accessMedicine
Timothy F. Cloughesy, Kevin Petrecca, Tobias Walbert et al. · 2020 · JAMA Oncology
Importance: New treatments are needed to improve the prognosis of patients with recurrent high-grade glioma. Objective: To compare overall survival for patients receiving tumor resection followed by vocimagene amiretrorepvec (Toca 511)…
View details →DOI: 10.1001/jamaoncol.2020.3161Cited by 140 Negative / Null Result ReportOpen accessMedicine
Petra Langerbeins, Michael Hallek · 2022 · Blood
The coronavirus infectious disease (COVID-19) shows a remarkable symptomatic heterogeneity. Several risk factors including advanced age, previous illnesses, and a compromised immune system contribute to an unfavorable outcome. In patients…
View details →DOI: 10.1182/blood.2021012251Cited by 140 Negative / Null Result ReportOpen accessMedicine
Weijun Xuan, Fatma Vatansever, Liyi Huang et al. · 2013 · PLoS ONE
Low-level laser (light) therapy (LLLT) has been clinically applied around the world for a spectrum of disorders requiring healing, regeneration and prevention of tissue death. One area that is attracting growing interest in this scope is the use of transcranial LLLT to treat stroke and traumatic brain injury (TBI). We developed a mouse model of severe TBI induced by controlled cortical impact and explored the effect of different treatment schedules. Adult male BALB/c mice were divided into 3 broad groups (a) sham-TBI sham-treatment, (b) real-TBI sham-treatment, and (c) real-TBI active-treatmen
View details →DOI: 10.1371/journal.pone.0053454Cited by 135 Negative / Null Result ReportHealth Professions
Pauline Stanton, Richard Gough, Ruth Ballardie et al. · 2014 · The International Journal of Human Resource Management
This article analyses a process improvement project based on Lean Six Sigma (LSS) techniques in the emergency department (ED) of a large Australian hospital. We consider perspectives of the clinical and managerial staff involved in the…
View details →DOI: 10.1080/09585192.2014.963138Cited by 133 Negative / Null Result ReportOpen accessBusiness, Management and Accounting
Annika Wahl, Michel Charifzadeh, Fabian E. Diefenbach · 2020 · Business Strategy and the Environment
Abstract This study investigates how integrated reporting (IR) creates value for investors. It examines how providers of financial capital benefit from an improved firm information environment provided by IR. Specifically, this study investigates the effect of voluntary IR disclosure on analyst earnings forecast accuracy as well as on firm value. To do so, we use an international sample of 167 listed companies that voluntarily publish an integrated report. Our analysis shows no significant effect of a voluntary IR publication on analyst earnings forecast accuracy and no significant effect on f
View details →DOI: 10.1002/bse.2519Cited by 133 Negative / Null Result ReportOpen accessPsychology
Hans Kirschner, Willem Kuyken, Kim Wright et al. · 2019 · Clinical Psychological Science
Self-compassion and its cultivation in psychological interventions are associated with improved mental health and well-being. However, the underlying processes for this are not well understood. We randomly assigned 135 participants to study the effect of two short-term self-compassion exercises on self-reported-state mood and psychophysiological responses compared to three control conditions of negative (rumination), neutral, and positive (excitement) valence. Increased self-reported-state self-compassion, affiliative affect, and decreased self-criticism were found after both self-compassion e
View details →DOI: 10.1177/2167702618812438Cited by 133 Negative / Null Result ReportOpen accessMathematics
Stanley E. Lazic, Elizaveta Semenova, Dominic P. Williams · 2020 · Scientific Reports
Regulatory authorities require animal toxicity tests for new chemical entities. Organ weight changes are accepted as a sensitive indicator of chemically induced organ damage, but can be difficult to interpret because changes in organ weight might reflect chemically-induced changes in overall body weight. A common solution is to calculate the relative organ weight (organ to body weight ratio), but this inadequately controls for the dependence on body weight - a point made by statisticians for decades, but which has not been widely adopted. The recommended solution is an analysis of covariance (
View details →DOI: 10.1038/s41598-020-63465-yCited by 131 Negative / Null Result ReportOpen accessMedicine
Alan K. Burnett, Nigel H. Russell, Ann E. Hunter et al. · 2013 · Blood
Better treatment is required for older patients with acute myeloid leukemia (AML) not considered fit for intensive chemotherapy. We report a randomized comparison of low-dose Ara-C (LDAC) vs the novel nucleoside, clofarabine, in untreated…
View details →DOI: 10.1182/blood-2013-04-496596Cited by 130 Negative / Null Result ReportOpen accessDecision Sciences
Mukelabai M. Musheke, Jackson Phiri · 2021 · Open Journal of Business and Management
Communication is a very crucial and significant element in an organization, and it is necessary for creating collaboration within the work environment that has effects on organizational performance and decision making. This study on effects of effective communications on organizational performance using the systems theory is thus essential. The objectives of this study were to firstly identify the factors affecting effective communication based on the systems theory and secondly to devise a communication model that addresses these factors to improve organisational performance. A quantitative a
View details →DOI: 10.4236/ojbm.2021.92034Cited by 130 Negative / Null Result ReportOpen accessMedicine
Máté Rudas, Ian Seppelt, Robert Herkes et al. · 2014 · Critical Care
INTRODUCTION: Long-term ventilated intensive care patients frequently require tracheostomy. Although overall risks are low, serious immediate and late complications still arise. Real-time ultrasound guidance has been proposed to decrease complications and improve the accuracy of the tracheal puncture. We aimed to compare the procedural safety and efficacy of real-time ultrasound guidance with the traditional landmark approach during percutaneous dilatational tracheostomy (PDT). METHODS: A total of 50 patients undergoing PDT for clinical indications were randomly assigned, after obtaining infor
View details →DOI: 10.1186/s13054-014-0514-0Cited by 126 Negative / Null Result Report
KJ Dodd, NF Taylor, N Shields et al. · 2011 · Multiple Sclerosis Journal
Background: Few high-quality trials have examined the effects of progressive resistance training (PRT) on people with multiple sclerosis (MS). Objective: To determine the effectiveness of PRT for people with MS, focusing on improving the…
View details →DOI: 10.1177/1352458511409084Cited by 126 Negative / Null Result ReportOpen accessHealth Professions
Sisay Demissew Beyene · 2023 · BMC Public Health
BACKGROUND: Food insecurity adversely affects human health, which means food security and nutrition are crucial to improving people's health outcomes. Both food insecurity and health outcomes are the policy and agenda of the 2030 Sustainable Development Goals (SDGs). However, there is a lack of macro-level empirical studies (Macro-level study means studies at the broadest level using variables that represent a given country or the whole population of a country or economy as a whole. For example, if the urban population (% of the total population) of XYZ country is 30%, it is used as a proxy va
View details →DOI: 10.1186/s12889-023-15244-3Cited by 125 Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Andrea Pescatori, Damiano Sandri, John Simon et al. · 2014 · IMF Working Paper
Using a novel empirical approach and an extensive dataset developed by the Fiscal Affairs Department of the IMF, we find no evidence of any particular debt threshold above which medium-term growth prospects are dramatically compromised.…
View details →DOI: 10.5089/9781484306444.001Cited by 123 Negative / Null Result ReportOpen accessMedicine
Laura Salvador, Gunasekaran Singaravelu, Calvin B. Harley et al. · 2016 · Rejuvenation Research
TA-65 is a dietary supplement based on an improved formulation of a small molecule telomerase activator that was discovered in a systematic screening of natural product extracts from traditional Chinese medicines. This study summarizes the findings on telomere length (TL) changes from a randomized, double blind, placebo controlled study of TA-65 over a 1 year period. The study was conducted on 117 relatively healthy cytomegalovirus-positive subjects aged 53-87 years old. Subjects taking the low dose of TA-65 (250 U) significantly increased TL over the 12 months period (530 ± 180 bp; p = 0.005)
View details →DOI: 10.1089/rej.2015.1793Cited by 120 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Roisín M. Connolly, Fengmin Zhao, Kathy D. Miller et al. · 2021 · Journal of Clinical Oncology
PURPOSE Endocrine therapy resistance in advanced breast cancer remains a significant clinical problem that may be overcome with the use of histone deacetylase inhibitors such as entinostat. The ENCORE301 phase II study reported improvement…
View details →DOI: 10.1200/jco.21.00944Cited by 119 Negative / Null Result Report
Clive S. Lennox · 2015 · The Accounting Review
ABSTRACT In 2005–2006, the PCAOB imposed restrictions on auditors' tax services in order to strengthen auditor independence and improve audit quality. The restrictions resulted in a significant drop in auditor-provided tax services (APTS).…
View details →DOI: 10.2308/accr-51356Cited by 118 