Negative / Null Result ReportOpen accessMedicine
Rogier A. Kievit, Delia Fuhrmann, Gesa Sophia Borgeest et al. · 2018 · Wellcome Open Research
Background: Fluid intelligence declines with advancing age, starting in early adulthood. Within-subject declines in fluid intelligence are highly correlated with contemporaneous declines in the ability to live and function independently. To support healthy aging, the mechanisms underlying these declines need to be better understood. Methods: In this pre-registered analysis, we applied latent growth curve modelling to investigate the neural determinants of longitudinal changes in fluid intelligence across three time points in 185,317 individuals (N=9,719 two waves, N=870 three waves) from the U
View details →DOI: 10.12688/wellcomeopenres.14241.2 Negative / Null Result ReportOpen accessMedicine
Rogier A. Kievit, Delia Fuhrmann, Gesa Sophia Borgeest et al. · 2018 · Wellcome Open Research
Background: Fluid intelligence declines with advancing age, starting in early adulthood. Within-subject declines in fluid intelligence are highly correlated with contemporaneous declines in the ability to live and function independently. To support healthy aging, the mechanisms underlying these declines need to be better understood. Methods: In this pre-registered analysis, we applied latent growth curve modelling to investigate the neural determinants of longitudinal changes in fluid intelligence across three time points in 185,317 individuals (N=9,719 two waves, N=870 three waves) from the U
View details →DOI: 10.12688/wellcomeopenres.14241.1 Negative / Null Result ReportOpen accessDermatology
Gi-Wook Lee, Keunyoung Kim, Seong-Jang Kim et al. · 2023 · Acta Dermato-Venereologica
Atopic dermatitis (AD) is an inflammatory skin disease associated with increased systemic and vascular inflammation. Although dupilumab has been proven to be effective against severe AD, imaging studies analysing its inflammation-reducing effect have rarely been reported. The aim of this study was to evaluate the effect of dupilumab on systemic and vascular inflammation in adult patients with severe AD, using 18F-fluorodeoxyglucose positron emission tomography-computed tomography (18F-FDG PET/CT). A total of 33 adult patients with severe AD and 25 healthy controls underwent 18F-FDG PET/CT at b
View details →DOI: 10.2340/actadv.v103.5320 Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
Zhaoying Li, Shanyu Liu, Yuling Shen et al. · 2025 · Frontiers in Neuroscience
BackgroundAbnormalities in brain activity patterns during episodic memory tasks have been inconsistently reported in amnestic mild cognitive impairment (aMCI) patients using functional magnetic resonance imaging (fMRI). This study applied traditional Chinese medicine (TCM) syndrome differentiation to categorize aMCI patients into distinct subgroups, aiming to clarify the neural mechanisms underlying their cognitive profiles.MethodsParticipants included aMCI patients categorized into the turbid phlegm clouding the orifices (PCO) or spleen-kidney deficiency (SKD) syndrome subgroups, alongside co
View details →DOI: 10.3389/fnins.2025.1555365 Negative / Null Result ReportMedicine
Liang H, Gui Y, Lv K et al. · 2026 · Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae
Objective To compare the imaging efficacy and patient tolerability of a novel cellulose-based oral contrast agent with a conventional starch-based agent in gastric contrast-enhanced ultrasound,thus providing evidence-based support for…
View details →DOI: 10.3881/j.issn.1000-503x.17161 Negative / Null Result ReportOpen accessMedicine
Bellew S, Tjiattas-Saleski L, Butz D et al. · 2026 · The western journal of emergency medicine
Introduction Computed tomography (CT) is an essential diagnostic tool for evaluating emergency department (ED) patients. Between 15-20% of patients who present to the ED in the United States (US) undergo CT imaging. CT imaging with the use…
View details →DOI: 10.5811/westjem.62947 Negative / Null Result ReportOpen accessMedical physics. Medical radiology. Nuclear medicine
Yu Gao, Stephanie Yoon, Ting Martin Ma et al. · 2024 · Physics and Imaging in Radiation Oncology
Background and purpose: Magnetic Resonance Imaging (MRI)-guided Stereotactic body radiotherapy (SBRT) treatment to prostate bed after radical prostatectomy has garnered growing interests. The aim of this study is to evaluate intra-fractional anatomic and dose/volume metric variations for patients receiving this treatment. Materials and methods: Nineteen patients who received 30–34 Gy in 5 fractions on a 0.35T MR-Linac were included. Pre- and post-treatment MRIs were acquired for each fraction (total of 75 fractions). The Clinical Target Volume (CTV), bladder, rectum, and rectal wall were conto
View details →DOI: 10.1016/j.phro.2024.100573 Negative / Null Result ReportOpen accessMedical physics. Medical radiology. Nuclear medicine
Y. S. Kudryavtsev, M. M. Beregov, A. B. Berdalin et al. · 2021 · Вестник рентгенологии и радиологии
Objective: to compare the results of staging the severity of viral pneumonia in patients with COVID-19 based on the results of chest computed tomography (CT) using the empirical visual scale CT 0–4 and chest CT severity score (CT-SS) point scale, as well as to assess their prognostic value.Material and methods. Chest CT scans and anamnestic data in patients hospitalized to a non-specialized center repurposed for the treatment of new coronavirus infection, were analyzed. Chest CT analysis was performed by two radiologists using CT 0–4 and CT-SS scales.Results. The time course of changes in the
View details →DOI: 10.20862/0042-4676-2021-102-5-296-303 Negative / Null Result ReportMedicine
Kaba M, Eyüboğlu GB, Karadas M · 2026 · Polymers
This study aimed to assess the effect of etching protocols on the bonding performance of three universal adhesives to dentin under different aging conditions. Specimens were obtained from human molars and randomly allocated to 6 groups ( n…
View details →DOI: 10.3390/polym18121516 Negative / Null Result ReportMedicine
Alwadani B · 2026 · Healthcare (Basel, Switzerland)
Purpose Variation in knee MRI diagnostic yield is often interpreted as reflecting imaging effectiveness. However, in real-world healthcare systems, diagnostic yield may instead be driven by referral behavior and patient selection.…
View details →DOI: 10.3390/healthcare14121628 Negative / Null Result ReportOpen accessGeriatrics
Lars Donath, Sebastian Ludyga, Daniel Hammes et al. · 2017 · BMC Geriatrics
Abstract Background Aging is accompanied by a decline of executive function. Aerobic exercise training induces moderate improvements of cognitive domains (i.e., attention, processing, executive function, memory) in seniors. Most conclusive data are obtained from studies with dementia or cognitive impairment. Confident detection of exercise training effects requires adequate between-day reliability and low day-to-day variability obtained from acute studies, respectively. These absolute and relative reliability measures have not yet been examined for a single aerobic training session in seniors.
View details →DOI: 10.1186/s12877-017-0634-x Negative / Null Result ReportOpen accessMedicine
Zeren G, Bakır EO, Tufaro V et al. · 2026 · Journal of cardiovascular development and disease
Intravascular imaging (IVI) was introduced 35 years ago to assess coronary artery pathology and plaque vulnerability. However, from its first applications it became apparent that it can also be useful in percutaneous coronary intervention…
View details →DOI: 10.3390/jcdd13010038 Negative / Null Result ReportMedicine
Guo Y, Wei D, Xu S et al. · 2026 · Risk analysis : an official publication of the Society for Risk Analysis
This study examines the potential of comics as an infotainment strategy for engaging the public in climate change mitigation from the perspective of the situational theory of public. A 2 × 2 × 2 factorial experiment (N = 320) was conducted…
View details →DOI: 10.1111/risa.70234 Negative / Null Result Report
Zhao Y, Zhao Q, Yu X et al. · 2026 · Preprint
Abstract Learning behavior is an important acquired behavior in fish, and the capacity for learning and memory plays a crucial role in foraging or anti-predator behavior. In this study, we selected the juveniles of S. schlegelii as the…
View details →DOI: 10.21203/rs.3.rs-9638734/v1 Negative / Null Result ReportMedicine
Wu, Xu · 2026 · Medicine
This study aims to compare the consistency of the Gleason score after radical prostatectomy between cognitive multi-parametric magnetic resonance imaging (mpMRI)-guided transperineal ultrasound-guided transperineal prostate biopsy…
View details →DOI: 10.1097/md.0000000000049053 Negative / Null Result ReportMedicine
Rawal, Asawa, Das et al. · 2026 · Cureus
Background Gingivitis, a reversible inflammatory condition of the gingiva, is primarily caused by plaque accumulation. Chlorhexidine is the gold standard for plaque control, but it is associated with side effects on prolonged use.…
View details →DOI: 10.7759/cureus.109382 Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens
Hironori Sadamatsu, Yuki Kurihara, Koichiro Takahashi et al. · 2019 · Case Reports in Oncology
Paraneoplastic limbic encephalitis (PLE) is a rare neurologic disorder that can complicate various malignancies, including lung cancer. PLE is most frequently found the initial presentation of lung cancer. In this study, we reported the case of a 74-year-old Japanese woman who developed PLE after partial remission of small cell lung cancer (SCLC) by first-line systemic chemotherapy. Brain magnetic resonance imaging showed no metastatic tumor or cerebrovascular disease. Anti-glutamic acid decarboxylase (GAD) and anti-amphiphysin antibodies were detected in her serum. She was diagnosed as having
View details →DOI: 10.1159/000501305 Negative / Null Result ReportOpen accessSurgery
A. Samarbakhsh, M. Shojaeei, M. Hami · 2014 · Global Spine Journal
Introduction Finding evidence based and effective method of managing low back pain (LBP) has been always a major dilemma in the field of neuromusculoskeletal system. The focus of this investigation is to establish a treatment regime for the discopathy origin of LBP using low level laser (LLL). This type of LBP is the cause of a significant number of days of sick leave in many countries. LLLT has not yet been fully adopted as a treatment method. Results of studies on LLL suggest that it reduces pain by a range of physiologic responses, such as increase in b-endorphins and depolarization blockag
View details →DOI: 10.1055/s-0034-1376737 Negative / Null Result ReportOpen accessMedicine
Dawid Schellingerhout, Lucia G LeRoux, Brian P Hobbs et al. · 2012 · PLoS ONE
Background and purpose The purpose of our study was to utilize a molecular imaging technology based on the retrograde axonal transport mechanism (neurography), to determine if oxaliplatin-induced neurotoxicity affects retrograde axonal transport in an animal model. Materials and methods Mice (n = 8/group) were injected with a cumulative dose of 30 mg/kg oxaliplatin (sufficient to induce neurotoxicity) or dextrose control injections. Intramuscular injections of Tetanus Toxin C-fragment (TTc) labeled with Alexa 790 fluorescent dye were done (15 ug/20 uL) in the left calf muscles, and in vivo flu
View details →DOI: 10.1371/journal.pone.0045776 Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
Julie Van, Sam E. Nielsen, C. Brock Kirwan · 2022 · NeuroImage: Reports
Common research practices in neuroimaging studies using functional magnetic resonance imaging may produce outcomes that are difficult to replicate. Results that cannot be replicated have contributed to a replication crisis in psychology, neuroscience, and other disciplines over the years. Here we replicate two previous papers in which the authors present two analysis paths for a dataset in which participants underwent fMRI while performing a recognition memory test for old and new words. Both studies found activation in the medial temporal lobe including the hippocampus, with the first demonst
View details →DOI: 10.1016/j.ynirp.2022.100135 Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
Lars Hausfeld, Lars Hausfeld, Niels R. Disbergen et al. · 2021 · Frontiers in Neuroscience
Numerous neuroimaging studies demonstrated that the auditory cortex tracks ongoing speech and that, in multi-speaker environments, tracking of the attended speaker is enhanced compared to the other irrelevant speakers. In contrast to speech, multi-instrument music can be appreciated by attending not only on its individual entities (i.e., segregation) but also on multiple instruments simultaneously (i.e., integration). We investigated the neural correlates of these two modes of music listening using electroencephalography (EEG) and sound envelope tracking. To this end, we presented uniquely com
View details →DOI: 10.3389/fnins.2021.635937 Negative / Null Result ReportOpen accessInfectious and parasitic diseases
Pylväläinen J, Talala K, Murtola T et al. · 2019 · Clinical Epidemiology
Juho Pylväläinen,1–3 Kirsi Talala,4 Teemu Murtola,5–7 Kimmo Taari,8 Jani Raitanen,1,9 Teuvo L Tammela,6 Anssi Auvinen1 1Tampere University, Faculty of Social Sciences (Health Sciences), Tampere, Finland; 2Helsinki University, Faculty of Medicine, Department of Diagnostics and Therapeutics, Helsinki, Finland; 3Helsinki University Central Hospital, Medical Imaging Center, Helsinki, Finland; 4Cancer Society of Finland, Finnish Cancer Registry, Mass Screening Registry, Helsinki, Finland; 5Tampere University, Faculty of Medicine and Health Technology, Prostate Cancer Research
Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Yiyi Chen, Yiyi Chen, Yiyi Chen et al. · 2021 · Frontiers in Neurology
Background: High plasma levels of trimethylamine N-oxide (TMAO) and its precursor choline have been linked to stroke; however, their association with cerebral small vessel disease remains unclear. Here we evaluated the association of plasma levels of TMAO and choline with imaging markers of cerebral small vessel disease, including white matter hyperintensities, lacunes, and cerebral microbleeds.Methods: We performed a baseline cross-sectional analysis of a multicenter hospital-based cohort study from 2015 to 2018. The data were collected from 30 hospitals in China and included 1,098 patients w
View details →DOI: 10.3389/fneur.2021.648702 Negative / Null Result ReportOpen accessMedicine
Anjali B Susan, Uttam B George, Jeyaraj D Pandian · 2022 · Journal of Clinical and Diagnostic Research
Introduction: Arterial Spin Labeling-Perfusion Weighted Imaging (ASL-PWI) assesses cerebral blood flow using magnetically labeled inflowing arterial blood water protons as freely diffusible tracer without exogenous contrast agent. Seizures are one of the sequelae of stroke with its mechanism not well studied. Aim: Qualitative assessment of cerebral perfusion in post stroke seizure patients using ASL-PWI and comparison of perfusion patterns in post stroke seizure patients and stroke patients. Materials and Methods: This was a case-control study among 100 stroke patients who underwent Magnetic R
View details →DOI: 10.7860/jcdr/2022/55267.16473 Negative / Null Result ReportOpen accessMedicine
Kiho Sung, Junsol Kim, Yeong-Ran Park et al. · 2026 · Scientific Reports
Abstract Cardiovascular disease (CVD) is prevalent among older adults, but studies often focus on individual spouses rather than couple dynamics. This study examines how interplay between spouses—specifically discordance in gender role attitudes—relates to CVD risk biomarkers, using couple-matched data from the Korean Social Life, Health, and Aging Project (KSHAP) on 308 older married couples (616 individuals). Actor-partner interdependence models (APIM) reveal that discordant gender role attitudes are significantly associated with higher CVD risk markers—higher systolic blood pressure, higher
View details →DOI: 10.1038/s41598-026-41697-8 Negative / Null Result ReportOpen accessGeriatrics
Han SB · 2017 · Clinical Interventions in Aging
Sang Beom HanDepartment of Ophthalmology, Kangwon National University Hospital, Kangwon National University Graduate School of Medicine, Chuncheon, Republic of KoreaI read with great interest the article by Ahn et al1 entitled “Sex differences in the effect of aging on dry eye disease”, in which the authors revealed the sex differences in the effect of aging on dry eye disease (DED) in Korean adult population. They also showed the differences in patterns of DED following ocular surgery according to sex.1 The large population-based cross-sectional study was undoubtfully well designe
Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Barrak Alahmad, Taofik Oyekunle, Claire Strohmeyer et al. · 2025 · Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Arrhythmia, particularly atrial fibrillation, is on the rise globally. While increased surveillance, aging populations, and other risk factors partially explain this rise, emerging risks such as extreme heat from climate change are underexplored. Methods We used Product Surveillance Registry by Medtronic (2016–2023) in the United States to examine patients with implantable cardioverter‐defibrillator or cardiac resynchronization therapy defibrillator devices. We identified first arrhythmic episodes (atrial tachycardia/fibrillation [AT/AF] or ventricular tachycardia/fibrillation) reco
View details →DOI: 10.1161/jaha.124.040352 Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Kollipara Sumanth, Uma Sinharoy, Anindita Joardar et al. · 2026 · Annals of Indian Academy of Neurology
Background and Objectives: Epilepsy, with its complex interplay of neurobiological, genetic, and pharmacological factors, continues to challenge neurologists worldwide—particularly in managing drug resistance. This study aimed to evaluate the frequency of the SCN1A and SCN2A gene polymorphisms among patients with epilepsy (PWE) from Eastern India to assess their relationship with clinical profiles, electroencephalography (EEG) findings, and response to antiseizure medication. Methods: In this case–control genetic association study, a total of 110 PWE were assessed for demographic and clinical
View details →DOI: 10.4103/aian.aian_616_25 Negative / Null Result ReportOpen accessOtorhinolaryngology
Fery Mai Rafanan, Eduard Alfanta, Romulus Roberto Peter Instrella · 2024 · Philippine Journal of Otolaryngology Head and Neck Surgery
Objective: To investigate the association between the time intervals of key clinical time points and tumor progression (increase in clinical staging) in head and neck cancer patients before and during the pandemic. Methods: Design: Retrospective Cohort Study Setting: Tertiary Government Training Hospital Participants: A total of 81 head and neck cancer patients who consulted at the OPD and underwent elective surgery between January 1, 2018, and December 31, 2022, under the Department of Otorhinolaryngology – Head and Neck Surgery of East Avenue Medical Center were included in the study; 40 pat
View details →DOI: 10.32412/pjohns.v39i1.2197 Negative / Null Result ReportOpen accessMedicine
Chen CD, Aguero C, Melloni A et al. · 2026 · Alzheimer's & dementia : the journal of the Alzheimer's Association
Introduction Alzheimer's disease (AD) biomarkers are assessed on their ability to detect AD pathophysiology in vivo, with confirmation of AD neuropathology only at autopsy. Methods Positron emission tomography (PET), plasma, and cognitive…
View details →DOI: 10.1002/alz.71092 