A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
697 results in Negative / Null Result Report for "aging" · page 21 of 24
Salman A · 2026 · Journal of ophthalmology
Purpose To evaluate and compare the topographic and tomographic characteristics of post-laser in situ keratomileusis (LASIK) ectasia (PLE) with keratoconus (KC) and normal control eyes using the Sirius imaging system. Methods This…
Golal E, Balci CN, Acar N · 2026 · Aging cell
Successful embryo development, acquisition of uterine receptivity, implantation, and decidualization during the peri-implantation window are essential events that ensure a healthy pregnancy. While ovarian aging has long been considered the…
William MFGBMF, Jamil NAB, Leong SS et al. · 2026 · Australasian journal of ultrasound in medicine
Aim Stand-off gel pads made of natural ingredients may provide a low-cost option in clinical ultrasound imaging. This study investigated the performance and safety of homemade pads. Methods Thirty stand-off gel pads were made of aloe vera,…
Ha D, Jung K, Choi H et al. · 2026 · Veterinary medicine and science
Background Botanical ingredients can function as adjunctive therapies for managing inflammatory skin diseases. Objectives This study aimed to investigate the anti-inflammatory effects of a mixture of Boswellia serrata, Commiphora myrrha,…
Konukoglu O, Kaya M, Arslan BC · 2026 · Journal of clinical ultrasound : JCU
Purpose To investigate the role of diffusion-weighted imaging (DWI) in the differential diagnosis of breast lesions and to determine whether there is an association with histological subtypes and prognostic factors. Materials & methods…
Dhungana SK, Gautam SG · 2026 · Journal of economic entomology
European earwig (Forficula auricularia L.) is an omnivorous insect commonly found in California citrus orchards. Often considered a beneficial predator, earwigs can damage young fruit, causing rind scarring and reducing the market value.…
Wang G, Yu Y, Han Y et al. · 2026 · BMC cancer
Purpose To characterize the imaging features of succinate dehydrogenase-deficient renal cell carcinoma (SDH-RCC) and compare them with those of renal oncocytoma (RO) and chromophobe RCC (chRCC). Methods This retrospective two-center study…
Margaret J. Couvillon, Ginny Fitzpatrick, Anna Dornhaus · 2010 · Psyche: A Journal of Entomology
Bumble bees are important pollinators of crops and other plants. However, many aspects of their basic biology remain relatively unexplored. For example, one important and unusual natural history feature in bumble bees is the massive size variation seen between workers of the same nest. This size polymorphism may be an adaptation for division of labor, colony economics, or be nonadaptive. It was also suggested that perhaps this variation allows for niche specialization in workers foraging at different temperatures: larger bees might be better suited to forage at cooler temperatures and smaller
Mirela Iličić, Spasenija Milanović, Marijana Carić et al. · 2016 · Mljekarstvo
The aim of this work was to investigate the application of common packaging materials polypropylene (PP) and polystyrene (PS) in the probiotic fresh cheese production packaging. Probiotic and traditional cheeses were produced from milk with standardized milk fat content of 2.3 g/100 g including the application of two cultures (probiotic and traditional). The samples were packed in the PP and PS cups and stored at 4 ºC for 30 days. The observed permeability of gases through the two applied packaging materials was significantly different. Cheese samples were analysed for microbiological properti
Yuyun Sumirat, Rhian Indradewa · 2023 · Jurnal Ekonomi dan Bisnis
Emotional exhaustion, frustration or emotional or what is called burnout is the cause of bad work attitudes, unfocused concentration, and negative assessment of employees, in the world of work there are many things that affect a worker in achieving job satisfaction, factors that cause leaders and workers itself is not satisfied with the results of the work that has been completed due to fatigue, emotions, frustration. In this study, researchers used a sample of 166 employees of the Goods and Services Procurement Unit with a functional position as Goods/Services Procurement Manager for the Stat
Mehrvash Moradi, Zahra Karimian, Nahid Zarifsanaiey · 2023 · Interdisciplinary Journal of Virtual Learning in Medical Sciences
Background: Medical students receive health information from various media sources and messages. Receiving health information can have a significant impact on the students’ dietary habits and healthy lifestyles. This study aimed to investigate the status of medical students’ use of health media and messaging, as well as the contextual variables that affect it.Methods: A survey study was conducted on 500 students of Shiraz University of Medical Sciences during September to December 2022 that were selected by simple random sampling. The research tool was a researcher-made questionnaire consistin
Biljana Ječmenica, Louie Taylor, Jelena Kralj et al. · 2026 · Avian Research
The Yellow-legged Gull (Larus michahellis) is a widespread and opportunistic central-place forager during the breeding season, yet its spatial behavior and habitat use in Adriatic Sea remain poorly understood. Our aim was to investigate their foraging ranges, movement patterns, and habitat selection during the breeding season. In this study, we tracked 45 adult gulls from 9 breeding colonies distributed along the Adriatic coast using high-resolution GPS devices. Most individuals foraged relatively close to their breeding sites, typically within 20–50 km. However, some gulls demonstrated the ca
N. Piaskowska, T. Daszkiewicz, D. Kubiak et al. · 2016 · Asian-Australasian Journal of Animal Sciences
This study evaluated the effect of vacuum and modified atmosphere (40% CO2+60% N2, MA) packaging on the chemical composition, physicochemical properties and sensory attributes of chill-stored meat from 10 fallow deer (Dama dama) bucks at 17 to 18 months of age. The animals were hunter-harvested in the forests of north-eastern Poland. During carcass dressing (48 to 54 h post mortem), both musculus longissimus muscles were cut out. Each muscle was divided into seven sections which were allocated to three groups: 0, A, and B. Samples 0 were immediately subjected to laboratory analyses. Samples A
Nahla Tharwat Moussa Ahmed, Hany Ezzat Obaya, Azza Abd Elaziz Abd Elhadi et al. · 2025 · Вестник восстановительной медицины
INTRODUCTION. The double chin is an excessive accumulation of fat in the pre- and post-platysma that can manifest in various forms and sizes. Thin individuals might manifest a double chin, similar to those who are afflicted by obesity. It may result in a reduction in the definition of the mandible and give the perception of obesity or aging. AIM. To evaluate any effect of High-Intensity Focused Ultrasound (HIFU) on sleep quality measures in obese women with a double chin. MATERIALS AND METHODS. Typically, 60 women aged 35–50 years were selected from AL Qasr-Alaini Hospital and were equally div
Anna Keodara, Lukas Jeker, Lars Straub et al. · 2024 · Scientific Reports
Abstract Bees are often exposed to pesticides affecting physiological functions and molecular mechanisms. Studies showed a potential link between altered expression of energy metabolism related transcripts and increased homing flight time of foragers exposed to pesticides. In this study, we investigated the effects of thiamethoxam and pyraclostrobin on longevity, flight behavior, and expression of transcripts involved in endocrine regulation (hbg-3, buffy, vitellogenin) and energy metabolism (cox5a, cox5b, cox17) using radio frequency identification (RFID) technology and quantitative polymeras
Wu S, Yang L, Cai Y et al. · 2026 · Eye (London, England)
Objective This study aimed to compare the diagnostic performance of Dixon T2-weighted imaging (Dixon-T2WI), T2 mapping, and T1 mapping in evaluating orbital activity in Graves' orbitopathy (GO). Methods Seventy-three GO patients were…
Nicholas M. Vogt, Jack F. V. Hunt, Yue Ma et al. · 2021 · Annals of Clinical and Translational Neurology
Abstract Background The brain is the most cholesterol‐rich organ and myelin contains 70% of total brain cholesterol. Statins are potent cholesterol‐lowing medications used by millions of adults for prevention of vascular disease, yet the effect of statins on cholesterol‐rich brain white matter (WM) is largely unknown. Methods We used longitudinal neuroimaging data acquired from 73 healthy, cognitively unimpaired, statin‐naïve, middle‐aged adults during an 18‐month randomized controlled trial of simvastatin 40 mg daily (n = 35) or matching placebo (n = 38). ANCOVA models (covariates: age, sex,
Mohammad Hassan Sohouli, Ghazaleh Eslamian, Nasser Malekpour Alamdari et al. · 2023 · Frontiers in Nutrition
BackgroundWe decided to conduct this study with the aim of investigating the effects of N-Acetylcysteine (NAC) on obesity complications and senescence of visceral adipose tissue in obese adults.Methods and analysisThe present study was conducted as a randomized clinical trial (RCT) (Clinical trial registry number: IRCT20220727055563N1) on 40 obese adults candidates for bariatric surgery, who were randomly assigned to receive 600 mg of NAC (n = 20) or placebo as a control (n = 20) for 4 weeks. During bariatric surgery, visceral adipose tissue was used to examine gene expression and senescence c
Stanley N. Caroff, Fan Mu, Rajeev Ayyagari et al. · 2018 · BMC Psychiatry
Abstract Background Data are limited on the benefits and risks of dose reduction in managing side effects associated with antipsychotic treatment. As an example, antipsychotic dose reduction has been recommended in the management of tardive dyskinesia (TD), yet the benefits of lowering doses are not well studied. However, stable maintenance treatment is essential to prevent deterioration and relapse in schizophrenia. Methods A retrospective cohort study was conducted to analyze the healthcare burden of antipsychotic dose reduction in patients with schizophrenia. Medical claims from six US stat
Erika C. S. Künstler, Melanie D. Penning, Natan Napiórkowski et al. · 2018 · Frontiers in Psychology
Older adults show higher dual task performance decrements than younger adults. While this is assumed to be related to attentional capacity reductions, the precise affected functions are not specified. Such specification is, however, possible based on the “theory of visual attention” (TVA) which allows for modeling of distinct attentional capacity parameters. Furthermore, it is unclear whether older adults show qualitatively different attentional effects or whether they show the same effects as younger adults experience under more challenging conditions. By varying the complexity of the seconda
Olga Maria Nardone, Giulio Calabrese, Alessia La Mantia et al. · 2025 · Therapeutic Advances in Gastroenterology
Background: Managing extraintestinal manifestations (EIMs) in inflammatory bowel disease (IBD) patients remains challenging due to considerable heterogeneity in diagnostic criteria and the lack of a standardised definition and validated diagnostic pathways. Delays in recognising and treating EIMs can lead to significant disease progression. Therefore, early detection and treatment are crucial. Objectives: We aimed to assess the effectiveness of a dedicated immune-mediated inflammatory diseases (IMIDs) clinic in reducing EIM diagnostic delays and improving patients’ outcomes. Design: A single-c
Mohaddeseh Badpeyma, Roghayeh Molani-Gol, Fatemeh Sistanian et al. · 2024 · Iranian Journal of Neonatology
Background: This study aims to determine the effect of different GnRH agonist brands on body mass index (BMI), weight, and height in patients referred to the pediatric endocrinology clinic of Akbar Hospital.Methods: In this cohort study, 80 girls aged 5-8 years diagnosed with precocious puberty cases were included according to the Tanner staging and at the second puberty stage. The patients were classified into three groups of GnRH agonists, A, B, and C, receiving Diphereline, Microrelin, and Variopeptyl, respectively. Height, weight, and BMI were calculated every three months.Results: In grou
Andra DEGAN, Ruxandra TUDOR, Ruxandra COSTEA et al. · 2019 · Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca: Veterinary Medicine
General anesthesia produces different degrees of central nervous depression and changes in the peripheral circulation, therefore affecting the patient’s thermoregulatory mechanism. Moreover, the lack of proper, specially designed equipment for magnetic resonance imaging (MRI) environment monitoring can represent a challenge for the anesthetist. We examined the temperature variations correlated with different anesthetic protocols in dogs that underwent general anesthesia in order to evaluate changes in rectal and distal extremities temperature, before and after anesthesia. This study was conduc
Gan Gao, Fang‐bin Hao, Qian‐Nan Wang et al. · 2023 · Brain and Behavior
Abstract Introduction This study investigated the effect of indirect revascularization surgery in adult patients with moyamoya disease (MMD) complicated with hyperhomocysteinemia (HHcy), and the effect of HHcy on the progression of adult MMD. Methods A retrospective case‐control study was conducted in patients with MMD, with or without HHcy (n = 123). Postoperative collateral angiogenesis was evaluated using the Matsushima grading system and disease progression using the Suzuki staging system. Cerebral blood flow was evaluated before and after surgery using dynamic susceptibility contrast magn
Barjor Gimi, Lara Leoni, Jose Oberholzer et al. · 2006 · Cell Transplantation
The increasing incidence of diabetes and the need to further understand its cellular basis has resulted in the development of new diagnostic and therapeutic techniques. Nonetheless, the quest to noninvasively ascertain β-cell mass and function has not been achieved. Manganese (Mn)-enhanced MRI is presented here as a tool to image β-cell functionality in cell culture and isolated islets. Similar to calcium, extracellular Mn was taken up by glucose-activated β-cells resulting in 200% increase in MRI contrast enhancement, versus nonactivated cells. Similarly, glucose-activated islets showed an in
Anqi Wang, Anqi Wang, Xuan Meng et al. · 2024 · Frontiers in Neurology
ObjectiveTo determine the efficacy of mechanical thrombectomy combined with prolonged mild hypothermia compared with conventional treatment in managing acute middle cerebral artery occlusion, and to explore whether extending the duration of hypothermia can improve neurological function.MethodFrom 2018 to June 2023, a retrospective analysis was conducted on 45 patients with acute middle cerebral artery occlusion treated at the NICU of Suzhou Kowloon Hospital, affiliated with Shanghai Jiao Tong University School of Medicine. After thrombectomy, patients were admitted to the neurological intensiv
Avita Rath, Chong Junning, Priyadarshini HR et al. · 2021 · Dentistry 3000
AIM:To compare the effects of a plaque disclosing toothpaste with a regular fluoridated toothpaste for supragingival biofilm reduction in patients with chronic gingivitis. MATERIALS AND METHODS:This study was a randomized controlled trial with a parallel design. Forty patients, both males and females aged 18-25 years with chronic generalized gingivitis (N=40) were randomly allocated to two groups of twenty each (n=20), using lottery method. Participants in the experimental group brushed with a plaque disclosing toothpaste, while participants in the control group brushed with regular fluoridate
Nikola Jajcay, David Tomeček, Iveta Fajnerová et al. · 2026 · Frontiers in Computational Neuroscience
An increasing number of studies are currently focusing on “personality neuroscience,” a term denoting the research aimed at neuroimaging correlates of inter-individual temperament and character variability. Among other methods, a graph theoretical analysis of the functional connectivity in resting-state functional magnetic resonance imaging data was applied in a study by, reporting novel functional connectivity correlates of personality traits. The current paper presents a conceptual replication of the results of this study and discusses the related challenges, including an extension of the or
Damla Erkal, Turgut Felek, Oana-Paula Butean et al. · 2025 · BMC Oral Health
Abstract Introduction This study hypothesized that large language models (LLMs) would underperform compared to expert clinicians in diagnosing and managing complex endodontic anomalies, such as dens invaginatus, when provided with periapical radiographs. Although LLMs have shown promise in dental education and basic diagnostics, their effectiveness in nuanced clinical reasoning has remained unclear. Methods Nineteen anonymized periapical radiographs depicting challenging endodontic conditions were paired with clinical vignettes. Six advanced LLMs and one expert endodontist independently answer
Simiao Chen, Pascal Geldsetzer, Till Bärnighausen · 2020 · SSM: Population Health
Population aging in middle-income countries, including China, has resulted in strong economic incentives to increase the retirement age. These economic incentives should be weighed up against the effects of later retirement on physical and mental health and wellbeing. We aimed to determine the causal effect of retirement on perceived stress, an important measure of mental well-being. We used data from the China Health and Nutrition Survey in 2015 and adopted a non-parametric regression discontinuity design (RDD) to measure the causal effect of retirement on stress. Stress was assessed using th