459 results in Negative / Null Result Report for "randomized controlled trial" · page 2 of 16
Negative / Null Result Report
Suzanne Lockyer, Rob Hodgson, Jo C Dumville et al. · 2013 · Trials
Abstract Background Spin in the reporting of randomized controlled trials, where authors report research in a way that potentially misrepresents results and mislead readers, has been demonstrated in the broader medical literature. We…
View details →DOI: 10.1186/1745-6215-14-371Cited by 55 Negative / Null Result ReportOpen accessPsychology
Stanisław Karkosz, Robert Szymański, Katarzyna Sanna et al. · 2023 · JMIR Formative Research
BACKGROUND: There has been an increased need to provide specialized help for people with depressive and anxiety symptoms, particularly teenagers and young adults. There is evidence from a 2-week intervention that chatbots (eg, Woebot) are effective in reducing depression and anxiety, an effect that was not detected in the control group that was provided self-help materials. Although chatbots are a promising solution, there is limited scientific evidence for the efficacy of agent-guided cognitive behavioral therapy (CBT) outside the English language, especially for highly inflected languages. O
View details →DOI: 10.2196/47960Cited by 52 Negative / Null Result ReportOpen accessSocial Sciences
Rachel Hayes, Daniel Titheradge, Kate Allen et al. · 2019 · British Journal of Educational Psychology
BACKGROUND: Teaching is a stressful occupation with poor retention. The Incredible Years® Teacher Classroom Management (TCM) programme is a training programme that research has demonstrated may be an effective intervention for improving…
View details →DOI: 10.1111/bjep.12284Cited by 41 Negative / Null Result ReportOpen accessMedicine
Ruby Yu, Grace Leung, Jean Woo · 2021 · International Journal of Environmental Research and Public Health
(1) Objective: This study examined the effects of a combined intervention of Brainastic computerized cognitive training (CCT) preceded by physical exercise (PE) for improving frailty status and cognitive function in older adults. (2) Methods: Older adults aged 50 years or older attending elderly centers, without frailty/history of cognitive impairment, were randomly allocated into either a 12-week (i) multi-domain CCT + PE (n = 117), (ii) two-domain CCT + PE (n = 116) or (iii) video watching + PE (i.e., control, n = 114). Brainastic is an online application for cognitive training through video
View details →DOI: 10.3390/ijerph18041396Cited by 40 Negative / Null Result ReportOpen accessMedicine
Tory A. Eisenlohr‐Moul, Susan S. Girdler, Jacqueline L. Johnson et al. · 2017 · Depression and Anxiety
BACKGROUND: Although traditionally dosed combined oral contraceptives (COCs) (21 days of active pills, 7 days of inactive pills) have not been demonstrated as superior to placebo for the treatment of premenstrual dysphoria (PMD), some…
View details →DOI: 10.1002/da.22673Cited by 40 Negative / Null Result ReportOpen accessMedicine
Junjie Ding, Nguyễn Thụy Thương Thương, Toi Van Pham et al. · 2020 · Clinical Pharmacology & Therapeutics
The most effective antituberculosis drug treatment regimen for tuberculous meningitis is uncertain. We conducted a randomized controlled trial comparing standard treatment with a regimen intensified by rifampin 15 mg/kg and levofloxacin for the first 60 days. The intensified regimen did not improve survival or any other outcome. We therefore conducted a nested pharmacokinetic/pharmacodynamic study in 237 trial participants to define exposure-response relationships that might explain the trial results and improve future therapy. Rifampin 15 mg/kg increased plasma and cerebrospinal fluid (CSF) e
View details →DOI: 10.1002/cpt.1783Cited by 40 Negative / Null Result ReportOpen accessMedicine
Khrongwong Musikatavorn, Poj Plitawanon, Suthaporn Lumlertgul et al. · 2021 · Western Journal of Emergency Medicine
INTRODUCTION: The ultrasound measurement of inferior vena cava (IVC) diameter change during respiratory phase to guide fluid resuscitation in shock patients is widely performed, but the benefit on reducing the mortality of sepsis patients is questionable. The study objective was to evaluate the 30-day mortality rate of patients with sepsis-induced tissue hypoperfusion (SITH) and septic shock (SS) treated with ultrasound-guided fluid management (UGFM) using ultrasonographic change of the IVC diameter during respiration compared with those treated with the usual-care strategy. METHODS: This was
View details →DOI: 10.5811/westjem.2020.11.48571Cited by 38 Negative / Null Result ReportOpen accessSocial Sciences
Elizabeth Ty Wilde, Zohn Rosen, Kenneth A. Couch et al. · 2013 · American Journal of Public Health
OBJECTIVES: We examined whether Jobs First, a multicenter randomized trial of a welfare reform program conducted in Connecticut, demonstrated increases in employment, income, and health insurance relative to traditional welfare (Aid to…
View details →DOI: 10.2105/ajph.2012.301072Cited by 32 Negative / Null Result ReportOpen accessMedicine
Ian Roberts · 2016 · Transfusion
Administration of tranexamic acid (TXA) to bleeding trauma patients who are within 3 hours of injury has been shown to safely reduce mortality in bleeding trauma patients. However, some believe that thromboelastography (TEG or ROTEM) can…
View details →DOI: 10.1111/trf.13490Cited by 32 Negative / Null Result ReportOpen accessMedicine
Robert G. Miller, Rongzhen Zhang, Paige M. Bracci et al. · 2022 · Muscle & Nerve
INTRODUCTION/AIMS: ALS is a heterogeneous disease that may be complicated or in part driven by inflammation. NP001, a regulator of macrophage activation, was associated with slowing disease progression in those with higher levels of the…
View details →DOI: 10.1002/mus.27511Cited by 32 Negative / Null Result ReportOpen accessPsychology
Stijn A.H. Friederichs, Anke Oenema, Catherine Bolman et al. · 2016 · Psychology and Health
OBJECTIVE: This study explores whether a web-based physical activity (PA) intervention grounded in self-determination theory (SDT) and motivational interviewing (MI) is more effective and better appreciated than a traditional web-based PA…
View details →DOI: 10.1080/08870446.2016.1151018Cited by 31 Negative / Null Result ReportOpen accessMedicine
Byung Kook Lee, In Soo Cho, Joo Suk Oh et al. · 2018 · PLoS ONE
INTRODUCTION: The aim of this trial was to investigate the effect of a continuous infusion of a neuromuscular blockade (NMB) in comatose out-of-hospital cardiac arrest (OHCA) subjects who underwent targeted temperature management (TTM). METHODS: In this open-label, multicenter trial, subjects resuscitated from OHCA were randomly assigned to receive either NMB (38 subjects) or placebo (43 subjects) for 24 hours. Sedatives and analgesics were given according to the protocol of each hospital during TTM. The primary outcome was serum lactate levels at 24 hours after drug infusion. The secondary ou
View details →DOI: 10.1371/journal.pone.0209327Cited by 31 Negative / Null Result ReportOpen accessMedicine
Pierre‐Édouard Bollaert, Alexandra Monnier, Francis Schneider et al. · 2023 · Critical Care
BACKGROUND: In critically ill patients, positive fluid balance is associated with excessive mortality. The POINCARE-2 trial aimed to assess the effectiveness of a fluid balance control strategy on mortality in critically ill patients. METHODS: POINCARE-2 was a stepped wedge cluster open-label randomized controlled trial. We recruited critically ill patients in twelve volunteering intensive care units from nine French hospitals. Eligible patients were ≥ 18 years old, under mechanical ventilation, admitted to one of the 12 recruiting units for > 48 and ≤ 72 h, and had an expected length of stay
View details →DOI: 10.1186/s13054-023-04357-1Cited by 31 Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
David H. Howard, Carolyn Kenline, Hillard M. Lazarus et al. · 2011 · Health Services Research
OBJECTIVE: In 1999, three randomized controlled trials concluded that high-dose chemotherapy followed by autologous hematopoietic stem cell transplantation (HDC/HCT) is no better than conventional chemotherapy for women with breast cancer.…
View details →DOI: 10.1111/j.1475-6773.2011.01296.xCited by 30 Negative / Null Result ReportOpen accessPsychology
Michael R. McCart, Jason E. Chapman, Kristyn Zajac et al. · 2020 · Journal of Consulting and Clinical Psychology
OBJECTIVE: The first randomized controlled trial of psychological first aid (PFA) was conducted, using crime victims as participants. For study Aim 1, investigators tested whether paraprofessional victim advocates could be trained to…
View details →DOI: 10.1037/ccp0000588Cited by 27 Negative / Null Result ReportOpen accessMedicine
Noha Mahmoud Youssef, Azza Mohammed Abdelmohsen, Ahmed Atteya Ashour et al. · 2026 · PubMed
BACKGROUND: Chronic ankle instability (CAI) is a common sequence of ankle sprain. Conservative treatment of CAI is currently accepted as a primary mean of managing the condition and preventing of recurrence. OBJECTIVES: The purpose of the…
View details →DOI: 10.82161/1vv8-sf51Cited by 25 Negative / Null Result ReportOpen accessPsychology
Marlou Poppelaars, Anna Lichtwarck‐Aschoff, Roy Otten et al. · 2021 · Frontiers in Psychology
Depressive symptoms and disorders are major public health concerns, affecting many adolescents and young adults. Despite extensive research, depression prevention programs for youth show limited effectiveness. Moreover, the maximal potential of youth psychotherapy — on which depression prevention programs are based — may have been reached. Commercial video games may offer an engaging alternative vehicle for youth to practice emotional and social skills vital to mental health. The current study investigated the potential for the commercial video game Journey to prevent the exacerbation of depre
View details →DOI: 10.3389/fpsyg.2020.575962Cited by 24 Negative / Null Result ReportOpen accessMedicine
Richard A. Brown, Susan E. Ramsey, Christopher W. Kahler et al. · 2011 · Journal of Studies on Alcohol and Drugs
OBJECTIVE: A previous pilot study found positive outcomes among alcohol-dependent individuals with elevated depressive symptoms who received cognitive-behavioral treatment for depression (CBT-D; n = 19) compared with a relaxation training…
View details →DOI: 10.15288/jsad.2011.72.286Cited by 24 Negative / Null Result ReportOpen accessMedicine
Claus Neurohr, Nikolaus Kneidinger, Alessandro Ghiani et al. · 2021 · American Journal of Transplantation
Long-term survival after lung transplantation is limited by chronic allograft dysfunction. The aim of this study was to investigate the effect of locally augmented immunosuppression with liposomal cyclosporine A for inhalation (L-CsA-i)…
View details →DOI: 10.1111/ajt.16858Cited by 24 Negative / Null Result ReportOpen accessMedicine
Majid Afshar, Mary Ryan, Felice Resnik et al. · 2025 · NEJM AI
BACKGROUND: Electronic health record (EHR) documentation is a major contributor to work-related practitioner exhaustion and the interpersonal disengagement known as burnout. Generative artificial intelligence (AI) scribes that passively…
View details →DOI: 10.1056/aioa2500945Cited by 23 Negative / Null Result ReportOpen accessPsychology
Mark A. Straccia, Adam R. Teed, Perri L. Katzman et al. · 2021 · Psychological Medicine
BACKGROUND: Although potential links between oxytocin (OT), vasopressin (AVP), and social cognition are well-grounded theoretically, most studies have included all male samples, and few have demonstrated consistent effects of either neuropeptide on mentalizing (i.e. understanding the mental states of others). To understand the potential of either neuropeptide as a pharmacological treatment for individuals with impairments in social cognition, it is important to demonstrate the beneficial effects of OT and AVP on mentalizing in healthy individuals. METHODS: = 186) of healthy individuals, we exa
View details →DOI: 10.1017/s0033291721004104Cited by 22 Negative / Null Result ReportOpen accessMedicine
Natalia Spasova, Desislava Somleva, Bozhidar Krastev et al. · 2024 · Folia Medica
Introduction : Trimethylamine-N-oxide (TMAO) is a metabolite produced by intestinal microbiota. It is well recognized as an independent risk marker for cardiovascular and renal diseases and mortality. Aim : The aim of the present study was…
View details →DOI: 10.3897/folmed.66.e132325Cited by 21 Negative / Null Result ReportOpen accessMedicine
Stefanie G. Beesems, Jocelyn Berdowski, Michiel Hulleman et al. · 2016 · Resuscitation
BACKGROUND: Previous large retrospective analyses have found an association between duration of peri-shock pauses in cardiopulmonary resuscitation (CPR) and survival. In a randomized trial, we tested whether shortening these pauses…
View details →DOI: 10.1016/j.resuscitation.2016.06.009Cited by 21 Negative / Null Result ReportOpen accessMedicine
Herbert S. B. Baraf, Puja Khanna, Alan Kivitz et al. · 2023 · Lara D. Veeken
OBJECTIVES: Serum urate (SU) lowering with PEGylated uricases in gout can reduce flares and tophi. However, treatment-emergent anti-drug antibodies adversely affect safety and efficacy and the currently approved PEGylated uricase…
View details →DOI: 10.1093/rheumatology/kead333Cited by 21 Negative / Null Result ReportOpen accessMedicine
Mohan Li, Yuelun Zhang, Lijian Pei et al. · 2022 · Frontiers in Oncology
Background Effects of anesthetic interventions on cancer prognosis remain controversial. There is evidence that estrogen receptor (ER)-negative breast cancer patients have an early recurrence peak. We aimed to assess the potential benefit of regional anesthesia-analgesia versus general anesthesia regarding early recurrence in breast cancer according to ER expression. Methods Based on a multicenter randomized controlled trial (clinicaltrials.gov, NCT00418457), we included all the patients from Peking Union Medical College Hospital research center in this study. The primary outcome was breast ca
View details →DOI: 10.3389/fonc.2022.837959Cited by 20 Negative / Null Result Report
Travis J. Matics, Nadia Khan, Priti Jani et al. · 2019 · Pediatric Critical Care Medicine
Objectives: The Fragility Index measures the number of events on which the statistical significance of a result depends and has been suggested as an adjunct statistical assessment for interpretation of trial results. This study aimed to…
View details →DOI: 10.1097/pcc.0000000000001922Cited by 19 Negative / Null Result Report
Mohammed Al-Asadi, Michelle Sherren, Hassaan Abdel Khalik et al. · 2024 · The American Journal of Sports Medicine
Background: Evidence-based care relies on robust research. The fragility index (FI) is used to assess the robustness of statistically significant findings in randomized controlled trials (RCTs). While the traditional FI is limited to…
View details →DOI: 10.1177/03635465231202522Cited by 19 Negative / Null Result ReportOpen accessMedicine
Sarah S. Mougalian, Ronda Copher, Jonathan Kish et al. · 2018 · Cancer Medicine
INTRODUCTION: Real-world data are critical to demonstrate the consistency of evidence and external generalizability of randomized controlled trials (RCTs). This study examined characteristics and outcomes of metastatic triple-negative breast cancer (mTNBC) patients treated with eribulin mesylate at community oncology practices in the United States. METHODS: Physicians identified mTNBC patients initiating eribulin between 1 January 2011 and 1 January 2014 and abstracted data into an electronic case report form (eCRF). Eribulin treatment in the metastatic setting was categorized as early use (EU
View details →DOI: 10.1002/cam4.1705Cited by 19 Negative / Null Result ReportOpen accessNursing
Paul Montgomery, Thees F. Spreckelsen, Alice Burton et al. · 2018 · PLoS ONE
BACKGROUND: Omega-3 fatty acids are central to brain-development of children. Evidence from clinical trials and systematic reviews demonstrates the potential of long-chain Omega-3 supplementation for learning and behavior. However, findings are inconclusive and in need of robust replication studies since such work is lacking. OBJECTIVES: Replication of the 2012 DOLAB 1 study findings that a dietary supplementation with the long-chain omega-3 docosahexaenoic acid (DHA) had beneficial effects on the reading, working memory, and behavior of healthy schoolchildren. DESIGN: Parallel group, fixed-do
View details →DOI: 10.1371/journal.pone.0192909Cited by 17 Negative / Null Result ReportOpen accessMedicine
Tarek Mohamed Ashoor, Ahmad Mahmoud Hasseb, Ibrahim M. Esmat · 2020 · Korean journal of anesthesiology
Background: Nebulized heparin has been effectively used in the management of many pulmonary diseases. However, its effect on mechanically ventilated patients with acute exacerbation chronic obstructive pulmonary disease (AECOPD) has never…
View details →DOI: 10.4097/kja.19418Cited by 17 