Negative / Null Result ReportOpen accessMedicine
Teng NMY, Vijayakumar B, Smith DJF et al. · 2026 · Access microbiology
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was a global pandemic where infected individuals experienced mild or severe disease. Unfortunately, some patients who experienced severe disease also had lasting abnormalities.…
View details →DOI: 10.1099/acmi.0.001103.v3 Negative / Null Result ReportMedicine
Jee J, Zhang J, Lavery JA et al. · 2026 · Cancer discovery
Real-world data suggest that SARS-CoV-2 mRNA vaccines, administered within 100 days of immune checkpoint inhibitor (ICI) treatment ("peri-ICI vaccination"), may improve ICI effectiveness through synergistic immune priming. In an…
View details →DOI: 10.1158/2159-8290.cd-26-0403 Negative / Null Result ReportMedicine
Labbani-Motlagh Z, Nozarian Z, Haghi Ashtiani MT et al. · 2025 · Iranian journal of immunology : IJI
Background Coronavirus Disease 2019 (COVID-19) typically manifests with milder symptoms and lower mortality rates in children when compared to adults. Objective To investigate potential mechanisms underlying this age-related protection, we…
View details →DOI: 10.22034/iji.2025.104055.2879 Negative / Null Result Report
Inoue H · 2025 · Preprint
Abstract The novel coronavirus SARS-CoV-2, commonly referred to as COVID-19, triggered a global pandemic. Although understanding the nature of international infection spread is critically important, extracting diffusion networks from…
View details →DOI: 10.21203/rs.3.rs-7395229/v1 Negative / Null Result ReportMedicine
Li J, Wang X, Li J et al. · 2025 · Journal of medical virology
The recently mutated Omicron variant of SARS-CoV-2 exhibits extremely high infectivity and strong evolution and immune escape capabilities. Given the unique epidemic prevention policies of China, we collected 16 sets of sera from…
View details →DOI: 10.1002/jmv.70681 Negative / Null Result ReportMedicine
Xu H, Zhao X, Zhang P et al. · 2024 · Heliyon
Association of Coronavirus disease 2019 vaccines with thrombosis has raised concerns among patients with coronary atherosclerosis disease (CAD). After vaccination against SARS-CoV-2, to detect thrombosis formation in atherosclerosis…
Negative / Null Result ReportMedicine
Kieri O, Jütte BB, Vesterbacka J et al. · 2026 · HIV medicine
Background The potent immunogenicity of mRNA vaccination raised concerns about its impact on HIV-1 viral load (VL) and reservoir size in people with HIV, which could drive vaccine hesitancy. As part of a prospective clinical trial, we…
View details →DOI: 10.1111/hiv.70235 Failed Experiment ReportOpen accessMedicine
Coker JA, Sun R, Polzer PM et al. · 2026 · ACS chemical biology
Point mutations in the exonuclease (ExoN) site of nonstructural protein 14 (NSP14) compromise the fitness of betacoronaviruses such as SARS-CoV-2, implicating NSP14 ExoN inhibition as an antiviral strategy. However, there are no advanced…
View details →DOI: 10.1021/acschembio.5c00930 Negative / Null Result ReportOpen accessMedicine
Cheng T, Zhang HY, Wang TR et al. · 2025 · Scientific reports
This study uses Mendelian randomization (MR) to investigate the potential causal relationships between viral infections, including Epstein-Barr virus (EBV), human immunodeficiency virus (HIV), SARS-CoV-2, cytomegalovirus (CMV), human…
View details →DOI: 10.1038/s41598-025-08361-z Failed Experiment ReportMedicine
Mauricio AM, Cioffi CC, Sanders AM et al. · 2025 · Psychological services
This explanatory sequential mixed methods hybrid Type 1 study examined the efficacy and implementation of Connect2Test, a brief motivational enhancement intervention to increase SARS-CoV-2 testing among people experiencing houselessness…
View details →DOI: 10.1037/ser0000939 Negative / Null Result ReportOpen accessMedicine
Pochon C, Laroye C, Kimmoun A et al. · 2023 · Frontiers in medicine
Background The COVID-19 pandemic caused a wave of acute respiratory distress syndrome (ARDS) with a high in-hospital mortality, especially in patients requiring invasive mechanical ventilation. Wharton Jelly-derived Mesenchymal Stromal…
View details →DOI: 10.3389/fmed.2023.1224865 Negative / Null Result ReportOpen accessMedicine
Montagud AC, Moragues R, Gabaldón-Bravo EM et al. · 2025 · BMC public health
BACKGROUND: The primary immunization against SARS-CoV-2 has yielded protection rates of up to 95%. The evolution of the original strain of SARS-CoV-2 towards emerging variants which have higher transmissibility, severity of disease and…
View details →DOI: 10.1186/s12889-025-24077-1 Negative / Null Result ReportMedicine
Ma F, Hu J, Bai M et al. · 2024 · Clinical laboratory
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection typically relies on reverse transcription-polymerase chain reaction (RT-PCR) technology. However, there is a certain rate of missed detection of SARS-CoV-2…
View details →DOI: 10.7754/clin.lab.2024.240404 Negative / Null Result ReportOpen accessMedicine
Otwell T, Knight B, Coryell M et al. · 2025 · Frontiers in cellular and infection microbiology
Molecular diagnostic assays are critical tools to test, diagnose and treat infectious and other diseases. For example, PCR test results have been extremely valuable during the COVID-19 pandemic, not only to provide appropriate health care…
View details →DOI: 10.3389/fcimb.2025.1524025 Negative / Null Result ReportOpen accessMedicine
Khoshakhlagh M, Dehghani T, Alizadeh A et al. · 2026 · Iranian journal of pathology
Background & objective Real-time PCR is widely used to detect SARS-CoV-2, the virus responsible for COVID-19, but false-negative results can occur even with internal controls. This study aimed to investigate the impact of using alternative…
View details →DOI: 10.30699/ijp.2025.2053609.3417 Negative / Null Result ReportMedicine
Zhou G, Dael N, Verweij S et al. · 2026 · Pharmaceuticals (Basel, Switzerland)
Background: The rapid emergence of immune-evasive SARS-CoV-2 variants necessitates the identification of accessible, low-cost prophylactic strategies. While drug repurposing offers a time-efficient alternative to novel drug development,…
View details →DOI: 10.3390/ph19060861 Negative / Null Result ReportMedicine
Tall S, Pettersson J, Härkönen T et al. · 2026 · Diabetes care
Objective We assessed whether 1) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination is associated with the risk of type 1 diabetes and 2) SARS-CoV-2 vaccination or infection is associated with disease severity at type…
View details →DOI: 10.2337/dc25-2913 Negative / Null Result ReportMedicine
Velez MP, Treacy K, Shellenberger J et al. · 2025 · Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC
This population-based study evaluated the association between SARS-CoV-2 vaccination and disorders of menstruation among all women in Ontario aged 18-44 years. Study exposure was receipt of a first dose of any SARS-CoV-2 vaccine from…
View details →DOI: 10.1016/j.jogc.2025.103159 Negative / Null Result ReportOpen accessMedicine
Silva MJA, Figueira LRT, Sardinha DM et al. · 2025 · Frontiers in genetics
Coronavirus disease 2019 (COVID-19) is a multisystemic disease caused by SARS-CoV-2 that can lead to several pulmonary illnesses according to the immunological contexts of the individual. Haplotypes consist of single-nucleotide…
View details →DOI: 10.3389/fgene.2025.1659269 Negative / Null Result ReportOpen accessMedicine
Phommasone K, Souksakhone C, Chanthongthip A et al. · 2025 · PloS one
Background Lao PDR reported a low number of confirmed SARS-CoV-2 cases until the introduction of COVID-19 vaccines in April 2021. This raised doubts about whether the reported number reflected the true situation and questioned about…
View details →DOI: 10.1371/journal.pone.0336239 Negative / Null Result ReportOpen accessMedicine
Beissat K, Lattard V, Picard-Meyer E et al. · 2025 · PloS one
Since the beginning of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, a wide range of animal species (pets, mink…) have been naturally infected with this betacoronavirus. The emergence of new variants has…
View details →DOI: 10.1371/journal.pone.0316882 Negative / Null Result ReportMedicine
Buchta C, Aberle SW, Allerberger F et al. · 2023 · The Lancet. Microbe
Background The aim of external quality assessment (EQA) schemes is to evaluate the analytical performance of laboratories and test systems in a near-to-real-life setting. This monitoring service provides feedback to participant…
View details →DOI: 10.1016/s2666-5247(23)00286-0 Negative / Null Result ReportOpen accessMedicine
Buchta C, Aberle SW, Görzer I et al. · 2024 · Wiener klinische Wochenschrift
Background External quality assessment (EQA) schemes provide objective feedback to participating laboratories about the performance of their analytical systems and information about overall regional analytical performance. The EQAs are…
View details →DOI: 10.1007/s00508-024-02353-1 Negative / Null Result ReportOpen accessMedicine
La Jeon Y, Lee SG, Lee EH et al. · 2023 · Diagnostic microbiology and infectious disease
We investigated whether inconclusive results could be interpreted differently depending on the situation. First, data from retesting of the initial samples from subjects without a confirmed COVID-19 history were analyzed. And by analyzing…
View details →DOI: 10.1016/j.diagmicrobio.2022.115888 Negative / Null Result ReportOpen accessMedicine
Palomino-Padilla S, Caceres-Cardenas G, Calderon R et al. · 2024 · Frontiers in public health
Objectives The COVID-19 pandemic caused a global shortage of nasopharyngeal (NP) swabs, required for RT-PCR testing. Canadian manufacturers were contacted to share NP swab innovations. The primary objective was to determine whether novel…
View details →DOI: 10.3389/fpubh.2024.1344295 Negative / Null Result ReportOpen accessMedicine
Walmsley SL, Nabipoor M, Qi F et al. · 2026 · Clinical & translational immunology
Objectives To assess neutralizing antibody responses to emerging SARS-CoV-2 variants. Methods We explored SARS-CoV-2 neutralizing antibodies in140 adults participating in a longitudinal study of antibody responses to COVID vaccines.…
View details →DOI: 10.1002/cti2.70095 Negative / Null Result ReportMedicine
Carretero D, Giménez E, Pérez A et al. · 2026 · Enfermedades infecciosas y microbiologia clinica (English ed.)
Introduction Studies assessing SARS-CoV-2 antibodies and functional T-cell responses in hematological patients following receipt of a three-dose mRNA vaccine schedule have yielded conflicting results. Methods We conducted a retrospective…
View details →DOI: 10.1016/j.eimce.2026.503146 Negative / Null Result ReportOpen accessMedicine
Willems R, Cappelletti M, Schüre JR et al. · 2026 · Scientific reports
Messenger ribonucleic acid (mRNA)-based vaccines delivered via lipid nanoparticles (LNP) were pivotal in managing the severe acute respiratory syndrome coronavirus (SARS-CoV-2) pandemic. While mild systemic reactions are common after…
View details →DOI: 10.1038/s41598-026-56181-6 Abandoned HypothesisOpen accessMedicine
Ghosh AK, Bhattacharjee A, Jayashankar U et al. · 2026 · Organic & biomolecular chemistry
We have investigated diastereoselective Ugi-multicomponent reactions (Ugi-MCR) relevant to bis-amide scaffolds related to SARS-CoV-2 main protease (Mpro) inhibitors. The studies were mainly focussed on development of diastereoselective…
View details →DOI: 10.1039/d5ob01897h Negative / Null Result ReportMedicine
Saeed, Jalal · 2026 · Pulmonary medicine
The COVID-19 pandemic, caused by SARS-CoV-2, has led to significant global mortality and morbidity. Angiotensin-converting Enzyme 2 (ACE2) has been identified as the primary receptor for viral entry into host cells and is believed to play…
View details →DOI: 10.1155/pm/1013605 